公开(公告)号：US09970891B2

公开(公告)日：2018-05-15

申请号：US15033911

申请日：2014-11-04

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： Nirit Dudovich ,  Oren Raz ,  Boaz Nadler ,  Dan Oron

IPC分类号： G06K9/00 ,  G01N23/205 ,  G03H1/08 ,  G03H1/12 ,  G02B21/00 ,  G02B21/36 ,  G06T7/30 ,  G01N23/20 ,  G03H5/00 ,  G03H1/04

CPC分类号： G01N23/2055 ,  G01N23/20 ,  G02B21/0056 ,  G02B21/367 ,  G03H1/0443 ,  G03H1/0866 ,  G03H1/12 ,  G03H5/00 ,  G03H2001/0447 ,  G03H2001/045 ,  G03H2001/0454 ,  G03H2222/42 ,  G06T7/30

摘要： A method and system for use in reconstruction and retrieval of phase information associated with a two-dimensional diffractive response are presented. The method comprising: providing (75) input data indicative of one or more diffractive patterns corresponding to diffractive responses from one or more objects (50). Dividing (130) said input data into a plurality of one-dimensional slices and determining (140) one-dimensional phase data for at least some of said one-dimensional slices. Tailoring (150) the reconstructed phase data of said one-dimensional slices to form a two-dimensional phase solution. The two-dimensional phase solution is defined by phase shifts of said reconstructed one-dimensional phase data of said one-dimensional slices. The two-dimensional phase solution thus enables obtaining two-dimensional reconstructed phase data suitable for reconstruction of image data (250).

公开(公告)号：US20180128590A1

公开(公告)日：2018-05-10

申请号：US15802779

申请日：2017-11-03

申请人： miDiagnostics NV

发明人： Benjamin D. HAEFFELE ,  René VIDAL

IPC分类号： G01B9/021 ,  G02B21/36 ,  G03H1/04 ,  G03H1/08 ,  G03H1/00

CPC分类号： G01B9/021 ,  G01N21/00 ,  G02B21/367 ,  G03H1/00 ,  G03H1/0005 ,  G03H1/0443 ,  G03H1/0486 ,  G03H1/0866 ,  G03H2001/005 ,  G03H2001/0447 ,  G03H2210/62

摘要： The present disclosure provides a system for lens-free imaging that includes a processor in communication with a lens-free imaging sensor. The processor is programmed to operate the imaging sensor to obtain a holographic image and to extract, from the holographic image, a plurality of patches, wherein the plurality of patches is a set of all fixed-size patches of the holographic image. The processor is also programmed to generate a dictionary D comprising a plurality of atoms, wherein the dictionary is generated by solving min α , D  ∑ i = 1 N  E  ( x i , D , α i ) + λ   R  ( α i ) , where N is the number of patches in the plurality of patches, xi is the ith patch of the plurality of patches, αi represents the coefficients encoding the ith patch, E(xi, D, αi) is a function measuring the squared error of the approximation of xi by the weighted combination of dictionary elements, and λR (αi) is sparsity term.

公开(公告)号：US20180033128A1

公开(公告)日：2018-02-01

申请号：US15553630

申请日：2016-02-25

申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Antonio Carlos SOBIERANSKI ,  Utkan Demirci ,  Huseyin Cumhur Tekin ,  Fatih Inci

IPC分类号： G06T5/50 ,  G03H1/26 ,  H04N5/232 ,  G03H1/04

CPC分类号： G06T5/50 ,  G03H1/0443 ,  G03H1/0866 ,  G03H1/265 ,  G03H2001/0447 ,  G03H2001/0825 ,  G03H2001/2655 ,  G03H2222/15 ,  G03H2226/11 ,  G03H2227/03 ,  G03H2240/56 ,  G06T2207/20056 ,  G06T2207/20221 ,  H04N5/23232

摘要： Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.

公开(公告)号：US20180011443A1

公开(公告)日：2018-01-11

申请号：US15545611

申请日：2016-02-04

申请人： IMEC VZW

发明人： Richard Stahl ,  Tom Claes ,  Xavier Rottenberg ,  Geert Vanmeerbeeck ,  Andy Lambrechts

IPC分类号： G03H1/04 ,  G02B6/122 ,  G02B27/00 ,  H04N5/225 ,  H04N5/374 ,  G02B6/12

CPC分类号： G03H1/0465 ,  G01N15/1434 ,  G01N15/147 ,  G01N15/1484 ,  G01N2015/1454 ,  G02B6/122 ,  G02B21/0008 ,  G02B27/0087 ,  G02B2006/12061 ,  G03H1/0443 ,  G03H2001/0447 ,  G03H2222/34 ,  G03H2222/35 ,  G03H2222/53 ,  H04N5/2256 ,  H04N5/374

摘要： Embodiments described herein relate to a large area lens-free imaging device. One example is a lens-free device for imaging one or more objects. The lens-free device includes a light source positioned for illuminating at least one object. The lens-free device also includes a detector positioned for recording interference patterns of the illuminated at least one object. The light source includes a plurality of light emitters that are positioned and configured to create a controlled light wavefront for performing lens-free imaging.

公开(公告)号：US09810894B2

公开(公告)日：2017-11-07

申请号：US14446306

申请日：2014-07-29

申请人： NEW YORK UNIVERSITY

发明人： David G. Grier ,  Sang-Hyuk Lee ,  Fook C. Cheong

IPC分类号： G02B21/36 ,  G01N15/02 ,  G01N15/14 ,  G01P5/00 ,  G01P5/20 ,  G03H1/00 ,  G01B9/02 ,  G01N15/10 ,  G01N15/00 ,  G03H1/08 ,  G03H1/04

CPC分类号： G02B21/361 ,  G01B9/02001 ,  G01N15/0227 ,  G01N15/10 ,  G01N15/1463 ,  G01N2015/0038 ,  G01N2015/025 ,  G01N2015/1075 ,  G01P5/001 ,  G01P5/20 ,  G03H1/0005 ,  G03H1/0866 ,  G03H2001/0033 ,  G03H2001/005 ,  G03H2001/0447 ,  G03H2001/0825 ,  G03H2240/56

摘要： In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the particles' sizes with nanometer resolution, their refractive indexes to within one part in a thousand, and their three dimensional positions with nanometer resolution. This procedure can rapidly and directly characterize mechanical, optical and chemical properties of the specimen and its medium.

公开(公告)号：US20170307497A1

公开(公告)日：2017-10-26

申请号：US15526287

申请日：2015-11-11

申请人： NEW YORK UNIVERSITY

发明人： David G. GRIER ,  David B. RUFFNER ,  Aaron YEVICK ,  Mark HANNEL

IPC分类号： G01N15/02 ,  G06K9/00 ,  G03H1/00 ,  G01N15/00

CPC分类号： G01N15/0227 ,  B01L3/5027 ,  G01N2015/0053 ,  G01N2015/0233 ,  G01N2015/03 ,  G01N2021/4707 ,  G03H1/0005 ,  G03H1/0443 ,  G03H2001/0033 ,  G03H2001/005 ,  G03H2001/0447 ,  G06K9/00127 ,  G06K9/00577 ,  G06K9/2018

摘要： Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.

公开(公告)号：US09715099B2

公开(公告)日：2017-07-25

申请号：US14356131

申请日：2012-07-20

申请人： Aydogan Ozcan ,  Alon Greenbaum

发明人： Aydogan Ozcan ,  Alon Greenbaum

IPC分类号： H04N5/89 ,  G02B21/36 ,  G03H1/08 ,  G03H1/00 ,  G06T3/00 ,  G03H1/04 ,  G03H1/26

CPC分类号： G02B21/365 ,  G02B21/367 ,  G03H1/0005 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/005 ,  G03H2001/0447 ,  G03H2001/0454 ,  G03H2001/2655 ,  G03H2210/12 ,  G03H2210/55 ,  G03H2240/56 ,  G06T3/0068

摘要： A method of imaging includes illuminating a sample spaced apart from an image sensor at a multiple distances. Image frames of the sample obtained at each distance are registered to one another and lost phase information from the registered higher resolution image frames is iteratively recovered. Amplitude and/or phase images of the sample are reconstructed based at least in part on the recovered lost phase information.

公开(公告)号：US20170131681A1

公开(公告)日：2017-05-11

申请号：US15337702

申请日：2016-10-28

申请人： CANON KABUSHIKI KAISHA

发明人： Toshiyuki Sudo

IPC分类号： G03H1/00 ,  F21V8/00 ,  G03H1/04 ,  G03H1/22 ,  H04N5/225 ,  G02B23/24

CPC分类号： G03H1/0005 ,  A61B1/00009 ,  A61B1/00165 ,  A61B1/063 ,  A61B1/07 ,  G02B6/0008 ,  G02B6/02057 ,  G02B6/264 ,  G02B23/2453 ,  G02B23/2461 ,  G02B23/2469 ,  G02B23/2484 ,  G03H1/0402 ,  G03H1/041 ,  G03H1/0443 ,  G03H1/2205 ,  G03H1/2286 ,  G03H2001/0088 ,  G03H2001/0216 ,  G03H2001/0434 ,  G03H2001/0447 ,  G03H2001/0452 ,  G03H2001/2278 ,  G03H2222/42 ,  G03H2222/43 ,  G03H2223/16 ,  G03H2270/55 ,  H04N5/2256 ,  H04N2005/2255

摘要： The image observation apparatus introduces an object light, which is at least part of an object illumination light emitted from a light source and projected onto an object and which is reflected by the object, through a first optical waveguide to an image sensor, introduces a reference light, which is emitted from the light source and passes through an optical path different from that of the object light, to the image sensor, and records an interference fringe through the image sensor as a hologram. The apparatus forms the recorded hologram on a spatial light modulator and illuminate the modulator with a hologram illumination light corresponding to the reference light to generate a reconstruction light, and causes the reconstruction light entering a second optical waveguide optically equivalent to the first optical waveguide and exiting from the second optical waveguide to form an object reconstructed image.

公开(公告)号：US09594346B2

公开(公告)日：2017-03-14

申请号：US13260569

申请日：2010-03-31

申请人： Joseph Rosen ,  Barak Katz

发明人： Joseph Rosen ,  Barak Katz

IPC分类号： G03H1/04 ,  G03H1/02 ,  G03H1/06

CPC分类号： G03H1/041 ,  G03H1/0443 ,  G03H1/06 ,  G03H2001/0224 ,  G03H2001/0447 ,  G03H2001/0452 ,  G03H2001/0458 ,  G03H2001/046 ,  G03H2223/23

摘要： A method of generating a hologram of an object is disclosed. The method comprises: receiving data corresponding to a plurality of non-coherent sub-holograms acquired by an optically passive synthetic aperture holographic apparatus, combining the sub-holograms to generate a mosaic hologram of the object, and transmitting the mosaic hologram to a computer readable medium.

摘要翻译： 公开了一种产生物体的全息图的方法。 该方法包括：接收对应于由光学无源合成孔径全息装置获取的多个非相干子全息图的数据，组合子全息图以产生物体的镶嵌全息图，并将马赛克全息图传送到计算机可读 中。

公开(公告)号：US09588037B2

公开(公告)日：2017-03-07

申请号：US14412984

申请日：2013-07-12

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Aydogan Ozcan ,  Ting-Wei Su

IPC分类号： G01N15/14 ,  G06T7/20 ,  G06T19/20 ,  G01B11/24 ,  G01B11/00 ,  G01N15/10

CPC分类号： G01N15/1463 ,  G01B11/00 ,  G01B11/24 ,  G01N2015/1006 ,  G01N2015/1075 ,  G03H1/0443 ,  G03H1/0465 ,  G03H1/0866 ,  G03H2001/0033 ,  G03H2001/0447 ,  G03H2210/30 ,  G03H2222/34 ,  G06T19/20 ,  G06T2200/04 ,  G06T2207/30004

摘要： A system for three dimensional imaging of motile objects includes an image sensor and a sample holder disposed adjacent to the image sensor. A first illumination source is provided and has a first wavelength and positioned relative to the sample holder at a first location to illuminate the sample. A second illumination source is also provided having a second wavelength, different from the first wavelength, and positioned relative to the sample holder at a second location, different from the first location, to illuminate the sample. The first and second illumination sources are configured to simultaneously, or alternatively, sequentially illuminate the sample contained within the sample holder. Three dimensional positions of the motile objects in each frame are obtained based on digitally reconstructed projection images of the mobile objects obtained from the first and second illumination sources. This positional data is connected for each frame to obtain 3D trajectories of motile objects.

摘要翻译： 用于运动物体的三维成像的系统包括图像传感器和邻近图像传感器设置的样本保持器。 提供第一照明源并且具有第一波长并且在第一位置处相对于样品保持器定位以照亮样品。 还提供第二照明源，其具有不同于第一波长的第二波长，并且在与第一位置不同的第二位置处相对于样品保持器定位以照射样品。 第一和第二照明源被配置为同时或替代地顺序地照射样品保持器中包含的样品。 基于从第一和第二照明光源获得的移动物体的数字重建的投影图像，获得每帧中运动物体的三维位置。 该位置数据被连接到每个帧以获得运动对象的3D轨迹。