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    Process for producing optically active amines
    41.
    发明授权
    Process for producing optically active amines 失效
    生产光活性胺的方法

    公开(公告)号：US5200561A

    公开(公告)日：1993-04-06

    申请号：US771569

    申请日：1991-10-07

    Applicant: Naoto Konya ,  Yukio Yoneyoshi ,  Yoji Sakito ,  Shinji Nishii ,  Gohfu Suzukamo ,  Hiroko Sakane

    Inventor： Naoto Konya ,  Yukio Yoneyoshi ,  Yoji Sakito ,  Shinji Nishii ,  Gohfu Suzukamo ,  Hiroko Sakane

    IPC: C07B53/00 ,  C07C209/40 ,  C07C209/52 ,  C07C211/03 ,  C07C211/27

    CPC classification number: C07C209/40

    Abstract: Disclosed is a process for producing an optically active amine represented by the formula (IV) ##STR1## wherein R.sub.7 and R.sub.8 each denote an alkyl group, aryl group or aralkyl group, providing that they do not denote the same group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) ##STR2## wherein R.sub.1 denotes an alkyl group, aryl group or aralkyl group; R.sub.2 denotes a hydrogen atom, alkyl group or aralkyl group; R.sub.3 denotes an aryl group or a substituent represented by the formula (II) ##STR3## wherein R.sub.4 and R.sub.5 each denote a hydrogen atom, aryl group or aralkyl group, and * is as defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers ##STR4## wherein R.sub.6 denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R.sub.7 and R.sub.8 are as defined above.The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof.

    Cyclopent [a] indene compounds
    48.
    发明授权
    Cyclopent [a] indene compounds 失效
    Cyclopent {8 a {9 {0茚化合物

    公开(公告)号：US3952050A

    公开(公告)日：1976-04-20

    申请号：US347477

    申请日：1973-04-03

    Applicant: Barry John Price

    Inventor： Barry John Price

    IPC: C07C215/08 ,  C07C49/683 ,  C07C67/00 ,  C07C209/00 ,  C07C209/02 ,  C07C209/16 ,  C07C209/26 ,  C07C209/40 ,  C07C209/66 ,  C07C211/41 ,  C07C211/42 ,  C07C213/00 ,  C07C225/16 ,  C07C231/00 ,  C07C231/12 ,  C07D295/02 ,  C07D295/033 ,  C07C87/40

    CPC classification number: C07D295/033 ,  C07C49/683

    Abstract: Indane derivatives of general formula (I): ##SPC1##in which:R.sub.1 and R.sub.2 represent a hydrogen atom, a lower alkyl group, preferably containing 1 to 6 and particularly 1 to 4 carbon atoms, or an arylalkyl group, or together form a cycloalkyl ring containing 3-6 carbon atoms; R.sub.3 is a hydrogen atom or a lower alkyl preferably containing 1 to 6 and particularly 1 to 4 carbon atoms; R.sub.4 represents the group --NR.sub.5 R.sub.6 in which R.sub.5 and R.sub.6 may be the same or different and each represent a hydrogen atom, a carbamoyl group or a lower alkyl radical preferably containing 1 to 6 and particularly 1 to 4 carbon atoms which may optionally be substituted by amino, alkylamino, dialkylamino, hydroxy, aryl or aroyl groups which aroyl groups may be substituted; or in which R.sub.5 and R.sub.6 may be joined to form a ring optionally containing other hetero atoms; and non-toxic pharmaceutically acceptable salts and esters thereof. The compounds have marked analgetic activity and are devoid of respiratory depressant action.

    Abstract translation: 通式（I）的茚满衍生物：

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