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    ANIMAL MODEL OF AUTISM
    42.
    发明申请
    ANIMAL MODEL OF AUTISM 审中-公开
    动物模型

    公开(公告)号：US20140298494A1

    公开(公告)日：2014-10-02

    申请号：US14234696

    申请日：2012-07-23

    Applicant: Matthew P. Anderson

    Inventor： Matthew P. Anderson

    IPC: A01K67/027 ,  C12Q1/25 ,  G01N33/573 ,  C12N15/85

    CPC classification number: A01K67/0278 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/93 ,  C12N15/8509 ,  C12N2015/8536 ,  C12N2517/02 ,  C12Q1/25 ,  G01N33/573

    Abstract: Some aspects of this invention provide a non-human animal model of autism. Some aspects of this invention provide a non-human animal model for diseases or disorders associated with an overexpression or a copy number variance of a Ube3a gene. Transgenic mammals and transgenic mammalian cells comprising an exogenous copy or exogenous copies of a ube3a protein-encoding nucleic acid sequence are also provided. Some aspects of this invention further provide methods for using the animal models, cells, and transgenic animals for identifying agents or interventions that can alleviate a pathogenic characteristic observed in the animal model, cell, or transgenic animal.

    Abstract translation: 本发明的一些方面提供了一种非人类自闭症动物模型。 本发明的一些方面提供了与Ube3a基因的过度表达或拷贝数变异相关的疾病或病症的非人动物模型。 还提供了转基因哺乳动物和包含外源拷贝或编码ube3a蛋白的核酸序列的外源拷贝的转基因哺乳动物细胞。 本发明的一些方面进一步提供了使用动物模型，细胞和转基因动物来鉴定可以减轻在动物模型，细胞或转基因动物中观察到的致病特征的试剂或干预的方法。

    Method for identifying immune response modulators
    45.
    发明授权
    Method for identifying immune response modulators 有权
    识别免疫反应调节剂的方法

    公开(公告)号：US08846308B2

    公开(公告)日：2014-09-30

    申请号：US12663635

    申请日：2008-06-06

    Applicant: Mark I. Greene ,  Bin Li

    Inventor： Mark I. Greene ,  Bin Li

    IPC: C12Q1/00 ,  C12Q1/68 ,  C12Q1/25 ,  A61K39/00 ,  G01N33/68

    CPC classification number: G01N33/6872 ,  G01N2500/00

    Abstract: Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise identifying chemical candidates that modulate interaction of IL-2 promoter with FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating individuals who have or are suspected of having autoimmune disease, inflammatory disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of treating individuals who have or are suspected of having infectious disease, cancer, or who are immunocompromised or undergoing vaccination are disclosed.

    Abstract translation: 公开了鉴定免疫应答调节剂的方法。 一些方法包括鉴定调节FOXP3和/或其包含Z-LeuZip结构域的片段的寡聚化的化学候选物。 一些方法包括鉴定用FOXP3调节FOXP1的异源寡聚化的化学候选物和/或其包含Z-LeuZip结构域的片段。 一些方法包括鉴定调节IL-2启动子与FOXP3和/或其包含Zinc-LeuZip结构域的片段的相互作用的化学候选物。 治疗患有或怀疑患有自身免疫疾病，炎性疾病，细胞，组织或器官移植或冠状动脉疾病的个体的方法，以及治疗患有或怀疑患有感染性疾病，癌症或免疫受损的个体的方法 或接受疫苗接种。

    CELL CULTURING FORMULATION AND CULTURING AND QUANTIFICATION METHOD OF CD140B+ CELLS THEREOF
    46.
    发明申请
    CELL CULTURING FORMULATION AND CULTURING AND QUANTIFICATION METHOD OF CD140B+ CELLS THEREOF 审中-公开
    CD140B +细胞的细胞培养制备及其培养及定量方法

    公开(公告)号：US20130309659A1

    公开(公告)日：2013-11-21

    申请号：US13614044

    申请日：2012-09-13

    Applicant: CHAO-HUNG WANG

    Inventor： CHAO-HUNG WANG

    IPC: C12N5/071 ,  C12Q1/68 ,  C12Q1/25 ,  C12Q1/02

    CPC classification number: G01N33/56972 ,  C12N5/0647 ,  C12N2501/15 ,  C12Q1/04 ,  G01N33/5073 ,  G01N2333/70596

    Abstract: The present invention discloses a cell culturing formulation and a culturing and quantification method of CD140b+ cells thereof. The cell culturing formulation is applicable for inducing the growth of the CD140b+ cells in peripheral blood. The cell culturing formulation comprises a culturing medium, a serum, a mixed additive and a defined factor. Wherein, concentrations of the culturing medium, the serum, the mixed additive and the defined factor are 59˜98% (v/v), 0.1˜20% (v/v), 1˜10% (v/v) and 10−7˜10% (v/v) respectively.

    Abstract translation: 本发明公开了一种细胞培养制剂及其CD140b +细胞的培养和定量方法。 细胞培养制剂适用于诱导外周血中CD140b +细胞的生长。 细胞培养制剂包含培养基，血清，混合添加剂和限定因子。 其中培养基，血清，混合添加剂和定义因子的浓度分别为59〜98％（v / v），0.1〜20％（v / v），1〜10％（v / v） -7〜10％（v / v）。

    Paper roll and waste water enzyme treatment
    47.
    发明授权
    Paper roll and waste water enzyme treatment 有权
    纸卷和废水酶处理

    公开(公告)号：US08584892B2

    公开(公告)日：2013-11-19

    申请号：US12689272

    申请日：2010-01-19

    Applicant: Joseph R. Lira

    Inventor： Joseph R. Lira

    IPC: B65D25/00 ,  C12N11/18 ,  C12N11/12 ,  C12N11/10 ,  C12N9/14 ,  C12N9/20 ,  C12Q1/40 ,  C12Q1/37 ,  C12Q1/44 ,  C12Q1/25 ,  C12Q1/02

    CPC classification number: A47K10/16

    Abstract: A packet of an enzyme and/or enzyme producing bacteria is contained within the core of a roll of toilet tissue or similar paper product wound on a core. The packet has a cover that dissolves or disintegrates on contact with water and disperses its contents into the aqueous waste stream. The packet may contain a mixture of bacterial cultures that produce enzymes to attack the greasy or fatty components of the waste stream. An additional article such as a sample of a liquid or creme personal care product may also be contained within the tissue paper core.

    Abstract translation: 酶和/或酶产生细菌的一包被包含在一卷卫生纸或卷绕在核心上的类似纸制品的芯中。 该包装具有在与水接触时溶解或分解并将其内容物分散到含水废物流中的盖子。 该包可以含有产生酶以消除废物流的油脂或脂肪成分的细菌培养物的混合物。 另外的制品例如液体或奶油个人护理产品的样品也可以包含在纸巾纸芯内。

    Ubiquitin ligase and use thereof
    48.
    发明授权
    Ubiquitin ligase and use thereof 有权
    泛素连接酶及其用途

    公开(公告)号：US08546094B2

    公开(公告)日：2013-10-01

    申请号：US13389065

    申请日：2010-08-06

    Applicant: Kazuhiro Iwai

    Inventor： Kazuhiro Iwai

    IPC: C12Q1/25 ,  C12N9/00

    CPC classification number: C12Y304/19012 ,  C12N9/93

    Abstract: Provided is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified. It was found out that a complex of (a) a protein having a part of HOIP and at least having a UBA region and a RING-IBR-RING region thereof, and (b) One or more kinds of proteins which individually form a complex with the above (a) is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified.

    Abstract translation: 提供了具有线性多聚泛素化活性并可以有效表达和纯化的新型泛素连接酶。 发现（a）具有部分HOIP并且至少具有UBA区域和RING-IBR-RING区域的蛋白质的复合物，和（b）单独形成复合物的一种或多种蛋白质 上述（a）是具有线性多聚泛素化活性并可以有效表达和纯化的新型泛素连接酶。

    HOLLOW PARTICULATE BODY
    50.
    发明申请
    HOLLOW PARTICULATE BODY 审中-公开
    中空颗粒体

    公开(公告)号：US20120237606A1

    公开(公告)日：2012-09-20

    申请号：US13496277

    申请日：2010-09-16

    Applicant: Donald A. Wellings

    Inventor： Donald A. Wellings

    IPC: B32B5/16 ,  G01N33/53 ,  C12P7/64 ,  C08J7/04 ,  C07K2/00 ,  C07K1/04 ,  C12Q1/25 ,  B01J31/06 ,  A61K9/14 ,  C07H21/00

    CPC classification number: C08J9/32 ,  B01J13/22 ,  B01J20/28011 ,  B01J20/28021 ,  B01J20/286 ,  B01J20/3268 ,  C08J9/224 ,  C11C1/045 ,  C11C3/003 ,  C12N11/08 ,  C12P7/6418 ,  C12P7/649 ,  Y02E50/13 ,  Y10T428/2982 ,  Y10T428/2993 ,  Y10T428/2998

    Abstract: A particulate body having a hollow particle and a surface polymer disposed on the outside of the hollow particle and suitable for use in solid phase synthesis, especially production of peptides and oligonucleotides. The particulate body may be used as a chromatography stationary phase column and the buoyancy of the body allows the column to be packed efficiently from the bottom reducing the risk of damage to the stationary phase. The buoyancy of the particulate body may also allow species for example a catalyst to be suspended in a liquid phase to allow reactions, for example hydrolysis of vegetable oil and esterification to produce biodiesel to be carried out with a reduced risk of catalyst loss from a reaction zone.

    Abstract translation: 具有中空颗粒和表面聚合物的颗粒体，其设置在中空颗粒的外部，并且适用于固相合成，特别是肽和寡核苷酸的生产。 颗粒体可用作色谱固定相柱，并且主体的浮力允许柱从底部有效地包装，减少了对固定相的损害风险。 颗粒体的浮力还可以使物质例如催化剂悬浮在液相中以允许反应，例如水解植物油并进行酯化以生产生物柴油以降低催化剂从反应中损失的风险 区。

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