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    Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity
    49.
    发明授权
    Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity 有权
    具有I 11和bgr的杂环化合物 羟类固醇脱氢酶抑制活性

    公开(公告)号：US08952176B2

    公开(公告)日：2015-02-10

    申请号：US11916173

    申请日：2006-06-06

    申请人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

    发明人： Tomoyuki Ogawa ,  Noriyuki Kurose ,  Satoru Tanaka ,  Koichi Nishi

    IPC分类号： C07D261/12 ,  C07D261/18 ,  C07D413/12 ,  C07D261/10 ,  C07D413/06 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08

    CPC分类号： C07D261/10 ,  C07D261/18 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08

    摘要： Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, One of R2 and R3 is a group of the formula: —C(═O)—Y—R4, wherein Y is —NR9— or the like, R4 is optionally substituted cycloalkyl or the like, R9 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, The other is a group of the formula: —V—R5, wherein V is a bond, —O— or the like, R6 is hydrogen or optionally substituted alkyl, R5 is hydrogen, optionally substituted alkyl or the like, X is a bond, —S—, —SO— or the like, U is a bond or optionally substituted alkylene, R7 is hydrogen or optionally substituted alkyl, Z is —S—, —O— or —NR8—, R8 is hydrogen, optionally substituted alkyl or the like.

    摘要翻译： 公开了可用作I 11和Bgr的羟基类固醇脱氢酶抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是任选取代的环烷基，任选取代的环烯基等，R 2和R 3中的一个是下式的基团：-C（= O）-Y- R4，其中Y是-NR9-等，R4是任选取代的环烷基等，R 9是氢或任选取代的烷基，W是任选取代的亚烷基，另一个是下式基团：-V-R5，其中 V是键，-O-等，R6是氢或任选取代的烷基，R 5是氢，任选取代的烷基等，X是一个键，-S-，-SO-等，U是 键或任选取代的亚烷基，R 7是氢或任选取代的烷基，Z是-S-，-O-或-NR 8 - ，R 8是氢，任选取代的烷基等。