公开(公告)号：USRE41762E1

公开(公告)日：2010-09-28

申请号：US12215893

申请日：2008-06-30

Applicant: Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

Inventor： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

IPC: C02F1/00

CPC classification number: G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

Abstract translation: 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

公开(公告)号：US07656912B2

公开(公告)日：2010-02-02

申请号：US12056454

申请日：2008-03-27

Applicant: Steven R. J. Brueck ,  Liang Xue ,  Ron Kaspi

Inventor： Steven R. J. Brueck ,  Liang Xue ,  Ron Kaspi

IPC: H01S3/10 ,  H01S3/08

CPC classification number: H01S5/12 ,  B82Y20/00 ,  H01S5/041 ,  H01S5/1212 ,  H01S5/3422

Abstract: Exemplary embodiments provide tunable laser devices, methods for making the laser devices and methods for tuning the laser devices. The tunable laser devices can include an optically pumped semiconductor laser heterostructure, on which a distributed-feedback (DFB) laser grating having variable grating spacings (or chirps) can be formed. The optically pumped semiconductor laser heterostructure can be an optically pumped type-II quantum well laser structure. The emission wavelength of the tunable laser devices can be tuned by changing positions of the region illuminated by the pump laser and with respect to the chirped DFB grating. The disclosed laser devices and methods can provide tunable laser emission with a combination of narrow linewidth and high output power that can be used for remote sensing applications and/or spectroscopic applications across the entire mid infrared (IR) spectral region.

Abstract translation: 示例性实施例提供可调激光器件，用于制造激光器件的方法和用于调谐激光器件的方法。 可调激光器件可以包括光泵浦的半导体激光异质结构，其上可以形成具有可变光栅间隔（或线性调频脉冲）的分布反馈（DFB）激光光栅。 光泵浦半导体激光异质结构可以是光泵浦型II量子阱激光器结构。 可调谐激光器件的发射波长可以通过改变由泵激光器照射的区域和相对于啁啾DFB光栅的位置来调节。 所公开的激光器件和方法可以提供具有窄线宽和高输出功率的组合的可调谐激光发射，其可用于整个中红外（IR）光谱区域的遥感应用和/或光谱应用。

公开(公告)号：US07589674B2

公开(公告)日：2009-09-15

申请号：US11488142

申请日：2006-07-18

Applicant: Dimitrios Anagnostou ,  Guizhen Zheng ,  Ioannis Papapolymerou ,  Christos Christodoulou

Inventor： Dimitrios Anagnostou ,  Guizhen Zheng ,  Ioannis Papapolymerou ,  Christos Christodoulou

IPC: H01Q1/38

CPC classification number: H01Q9/285

Abstract: A self-similar multiband reconfigurable antenna includes a planar antenna structure formed on a surface of a substrate, the antenna structure including symmetrically opposed self-similar geometry antenna arms defining a self-similar or Sierpinski gasket configuration for each arm of the antenna. MEMS type switches are provided for operatively connecting adjacent antenna patches on each arm of the antenna configuration, and a voltage source is provided for selectively actuating the switches. Selective actuation of the switches enables up to four different antenna configurations each having a different resonant frequency, and wherein each resonant frequency demonstrates a similar radiation pattern.

Abstract translation: 自相似的多频带可重构天线包括形成在基板的表面上的平面天线结构，天线结构包括对称地相对的自相似几何形状的天线臂，其限定天线的每个臂的自相似或Sierpinski垫圈配置。 提供MEMS型开关用于可操作地连接天线配置的每个臂上的相邻天线贴片，并提供用于选择性地启动开关的电压源。 开关的选择性致动能够实现多达四种不同的天线配置，每种具有不同的谐振频率，并且其中每个谐振频率表现出类似的辐射图。

公开(公告)号：US07583715B2

公开(公告)日：2009-09-01

申请号：US11153245

申请日：2005-06-15

Applicant: Peter O. Hill ,  Larry R. Dawson ,  Philip Dowd ,  Sanjay Krishna

Inventor： Peter O. Hill ,  Larry R. Dawson ,  Philip Dowd ,  Sanjay Krishna

IPC: H01S5/00

CPC classification number: H01S5/20 ,  H01L33/305

Abstract: Structures and methods for electronic devices with improved conductive regions are provided. The conductive region may include digital alloy superlattice structures, which allow higher doping levels to be achieved than for a bulk (random) alloy with the same average composition. Furthermore, the superlattice structures may improve the resistivity of the region, improving the current spreading of the region and hence the electronic properties of electronic devices such as optoelectronic devices.

Abstract translation: 提供了具有改进的导电区域的电子器件的结构和方法。 导电区域可以包括数字合金超晶格结构，其允许实现比具有相同平均组成的块状（随机）合金更高的掺杂水平。 此外，超晶格结构可以提高该区域的电阻率，改善该区域的电流扩展，并因此改善诸如光电器件的电子器件的电子特性。

公开(公告)号：US20090075393A1

公开(公告)日：2009-03-19

申请号：US12102663

申请日：2008-04-14

Applicant: Gabriel Lopez ,  Linnea Ista ,  Steven RJ Brueck ,  Aurelio Evangelista Lara ,  Mangesh Bore

Inventor： Gabriel Lopez ,  Linnea Ista ,  Steven RJ Brueck ,  Aurelio Evangelista Lara ,  Mangesh Bore

IPC: G01N33/53 ,  B01J19/00

CPC classification number: G01N27/44721 ,  G01N33/5304 ,  G01N33/54366 ,  Y10S977/92

Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.

Abstract translation: 用于检测流体样品中已知或未知毒物的存在的装置和方法。 样品中的靶标与固定在微流体或纳米流体装置的反应区域中的可释放受体结合。 基于它们对已知毒性剂类的亲和性来选择受体。 受体被释放，并且结合和未结合的受体在移动到检测装置的同时基于差异电动迁移率分离。

公开(公告)号：US20080312073A1

公开(公告)日：2008-12-18

申请号：US11872836

申请日：2007-10-16

Applicant: Tim Olson ,  Plamen Atanassov

Inventor： Tim Olson ,  Plamen Atanassov

IPC: B05D5/12 ,  C07D487/22 ,  B01J31/12

CPC classification number: B01J31/06 ,  B01J31/183 ,  B01J2531/025 ,  B01J2531/845 ,  C07D487/22 ,  H01M4/9008 ,  H01M4/9091

Abstract: A highly dispersed, unsupported, electrocatalyst made of pyrolyzed porphyries and a method for synthesizing the same. The disclosed synthesis procedure allows for optimization of pore size and therefore transport properties. Compounds suitable for use include transition metal N4-chelates such as, but not necessarily limited to, N4-chelates containing different metal centers including Co, Fe, Mn, Ni, Ru, Cu, etc., and other N4-chelates such as porphyrin, phthalocyanies, and structures based on their pyro products.

Abstract translation: 由热解斑斑形成的高度分散，无支撑的电催化剂及其合成方法。 所公开的合成方法允许优化孔径并因此优化输送性质。 适合使用的化合物包括过渡金属N 4 - 螯合物，例如但不一定限于含有不同金属中心的包括Co，Fe，Mn，Ni，Ru，Cu等的N 4 - 螯合物和其它N 4 - 螯合物如卟啉 ，酞菁，以及基于其产品的结构。

公开(公告)号：US20080292500A1

公开(公告)日：2008-11-27

申请号：US12151252

申请日：2008-05-05

Applicant: Larry A. Sklar ,  Bruce S. Edwards ,  Frederick W. Kuckuck

Inventor： Larry A. Sklar ,  Bruce S. Edwards ,  Frederick W. Kuckuck

IPC: B01J19/00

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。

公开(公告)号：US07432161B2

公开(公告)日：2008-10-07

申请号：US11326431

申请日：2006-01-06

Applicant: Seung-Chang Lee ,  Steven R. J. Brueck

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/336

CPC classification number: H01L21/02642 ,  H01L21/02373 ,  H01L21/02387 ,  H01L21/02433 ,  H01L21/02609 ,  H01L33/007 ,  H01S5/0205

Abstract: Methods for forming {110} type facets on a (001) oriented substrate of Group III-V compounds and Group IV semiconductors using selective epitaxial growth is provided. The methods include forming a dielectric film on a (100) substrate. The dielectric film can then be patterned to expose a portion of the substrate and to form a substrate-dielectric film boundary substantially parallel to a direction. A {110} type sidewall facet can then be formed by epitaxially growing a semiconductor layer on the exposed portion of the substrate and the dielectric film.

Abstract translation: 提供了使用选择性外延生长在III-V族化合物和IV族半导体的（001）取向衬底上形成{110}型面的方法。 所述方法包括在（100）衬底上形成电介质膜。 然后可以对电介质膜进行构图以暴露衬底的一部分并且形成基本上平行于<110>方向的衬底 - 电介质膜边界。 然后可以通过在衬底和电介质膜的暴露部分上外延生长半导体层来形成{110}型侧壁面。

公开(公告)号：US07416903B2

公开(公告)日：2008-08-26

申请号：US10428931

申请日：2003-05-05

Applicant: Larry A. Sklar ,  Andrea A. Mammoli ,  Richard A. Truesdell ,  Peter V. Vorobieff

Inventor： Larry A. Sklar ,  Andrea A. Mammoli ,  Richard A. Truesdell ,  Peter V. Vorobieff

IPC: G01N1/10 ,  G01N1/00 ,  G01N1/68 ,  G01N15/06 ,  C12Q33/00

CPC classification number: B01L3/502776 ,  B01F13/0059 ,  B01F15/024 ,  B01F2215/0459 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  Y10T137/2496 ,  Y10T137/2499 ,  Y10T137/2559 ,  Y10T137/2562 ,  Y10T137/2564 ,  Y10T137/2567 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention provides methods and apparatus for mixing samples in-line in a microfluidic system, comprising methods of and means for introducing a first fluid sample into a flow-tube at a first end at a first velocity via a first conduit; methods of and means for introducing a second fluid sample into the flow-tube at the first end at a second velocity, the second velocity different from the first velocity, via a second conduit, wherein the first fluid sample and the second fluid sample converge in the flow tube to form an interface; whereby the first fluid sample and the second fluid sample mix at the interface within the flow-tube, wherein fluid flow at the first end of the flow-tube is laminar and fluid flow at a second end of the flow-tube is laminar, and wherein the flow-tube has a constant diameter between the first end and the second end of the flow-tube.

Abstract translation: 本发明提供了在微流体系统中在线混合样品的方法和装置，包括用于经由第一导管以第一速度在第一端将第一流体样品引入流管的方法和装置; 通过第二导管以第二速度（第二速度不同于第一速度）将第二流体样品引入流管中的方法和装置，其中第一流体样品和第二流体样品收敛于 流管形成界面; 由此所述第一流体样品和所述第二流体样品在所述流动管内的界面处混合，其中在所述流动管的所述第一端处的流体流是层流的，并且在所述流动管的第二端的流体流是层流的，以及 其中所述流管在所述流管的所述第一端和所述第二端之间具有恒定的直径。

公开(公告)号：US20070244328A1

公开(公告)日：2007-10-18

申请号：US11628818

申请日：2005-06-30

Applicant: Wie Wang ,  Jian Wang ,  Hao Li

Inventor： Wie Wang ,  Jian Wang ,  Hao Li

IPC: C07D207/10 ,  C07C205/04 ,  C07C381/00 ,  C07D315/00 ,  C07F11/00 ,  C07D333/22 ,  C07D211/00 ,  C07C45/00

CPC classification number: C07D207/09 ,  C07B2200/07 ,  C07C45/511 ,  C07C45/54 ,  C07C45/72 ,  C07C45/74 ,  C07C47/56 ,  C07C49/203 ,  C07C49/21 ,  C07C49/235 ,  C07C49/647 ,  C07C49/653 ,  C07C49/683 ,  C07C49/697 ,  C07C49/753 ,  C07C49/86 ,  C07C67/343 ,  C07C201/12 ,  C07C205/44 ,  C07C205/45 ,  C07C213/02 ,  C07C215/42 ,  C07C227/32 ,  C07C239/20 ,  C07C253/30 ,  C07C319/14 ,  C07C391/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07D309/30 ,  C07D317/72 ,  C07D333/22 ,  C07C49/258 ,  C07C49/245 ,  C07C69/76 ,  C07C323/22 ,  C07C255/56 ,  C07C229/22 ,  C07C229/28 ,  C07C229/30 ,  C07C229/36

Abstract: The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH2, N—Ra, O, S or C═O; Y is CH2, N—Ra, O, S or C═O, with the proviso that at least one of X or Y is CH2, and preferably both of X and Y are CH2; Ra is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6alkyl including a C3-C6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; Rb is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 acyclic or a a C3-C6 cyclic alkyl group, CIIO, N(Me)O, CO(S)Ra or the group of Formula (III). Where Rc and Rd are each independently H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C12 alkyl, more preferably a C1-C6 alkyl, and an optionally substituted aryl group, or together Rc and Rd form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R1 is OH, OR, NR′R″, NHC(═O)R, NHSO2R; R2 is H, F, Cl, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1C6 alkyl, an optionally substituted aryl group or a ═O group (which establishes a carbonyl group with the carbon to which ═O is attached; R3 is H, OH, F, Cl, Br, I, Cl, an optionally substituted C1-C20 alkyl, alkenyl or alkynyl (“hydrocarbyl”) group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl, such that the carbon to which R3 is attached has an R or S configuration; R is II, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group, R′ and R″ are each independently H, an optionally substituted C1-C20 alkyl group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group; or together R′ and R″ form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R′ and R″ are attached; and wherein said compound is free from a metal catalyst.