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    Fibrin pad matrix with suspended heat activated beads of adhesive
    52.
    发明授权
    Fibrin pad matrix with suspended heat activated beads of adhesive 有权
    纤维蛋白垫基质与悬浮热活化的粘合剂珠

    公开(公告)号：US08814025B2

    公开(公告)日：2014-08-26

    申请号：US13233633

    申请日：2011-09-15

    申请人： Matthew C. Miller ,  Yi-Lan Wang ,  Israel Nur ,  Aron O. Zingman

    发明人： Matthew C. Miller ,  Yi-Lan Wang ,  Israel Nur ,  Aron O. Zingman

    IPC分类号： A61B17/068 ,  A61B17/00 ,  A61B17/072 ,  A61B17/29

    CPC分类号： A61B17/07207 ,  A61B17/00491 ,  A61B17/07292 ,  A61B2017/005 ,  A61B2017/2929

    摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue.

    摘要翻译： 手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切断组件。 下颚构造成在处于打开位置时接收盒。 盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。 甲板限定孔，每个孔基本上设置在每个钉上。 墨盒进一步接收包括悬浮在基质中的胶珠的基质。 订书钉被驱动通过矩阵将矩阵固定在组织上。 当基质被固定到组织上时，胶珠被活化，使得活化的粘合剂进一步固定组织中的缝合线。

    Device, system and method for dispensing a fixed dose of fluid
    53.
    发明授权
    Device, system and method for dispensing a fixed dose of fluid 有权
    用于分配固定剂量流体的装置，系统和方法

    公开(公告)号：US08640921B2

    公开(公告)日：2014-02-04

    申请号：US13209650

    申请日：2011-08-15

    申请人： Moti Meron ,  Aner Tsuk ,  Roee Atlas ,  Israel Nur

    发明人： Moti Meron ,  Aner Tsuk ,  Roee Atlas ,  Israel Nur

    IPC分类号： B67D7/70

    CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61M5/19 ,  A61M5/204 ,  A61M5/31586 ,  A61M35/003

    摘要： The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel.

    摘要翻译： 本发明涉及一种用于分配固定剂量的流体的装置，该装置包括至少一个桶; 至少一个柱塞至少部分地封闭在所述筒体内; 运动转换机构，用于将施加到所述筒外部的致动压力传递到所述至少一个柱塞在分配方向上的运动，其中所述运动转换机构包括至少一个旋转齿轮; 以及用于将活塞与运动转换机构分离的释放机构，其中在释放位置，所述至少一个柱塞可以在与所述分配方向相反的方向上移动，而与所述至少一个齿轮的旋转运动无关，并且其中 柱塞在与分配相反的方向上的运动使得能够将流体装载到筒中。

    Stabilized mixture comprising fibrinogen
    55.
    发明授权
    Stabilized mixture comprising fibrinogen 失效
    包含纤维蛋白原的稳定混合物

    公开(公告)号：US6121232A

    公开(公告)日：2000-09-19

    申请号：US797328

    申请日：1997-02-10

    申请人： Israel Nur ,  Lilliana Bar ,  Oded Lieberman

    发明人： Israel Nur ,  Lilliana Bar ,  Oded Lieberman

    IPC分类号： A61L24/00 ,  A61K38/36 ,  A61L24/10 ,  C07K14/75 ,  A61K38/00

    CPC分类号： A61L24/106 ,  A61K38/363 ,  C07K14/75

    摘要： A stabilized solution of fibrinogen containing samples, in particular a stabilized solution of the biological active component (BAC) which is a solution of proteins derived from blood plasma comprising fibrinogen, tranexamic acid and arginine or lysine or mixtures or arginine and lysine, their pharmaceutically acceptable salts, as well as, optionally, substances forming a buffered solution in aqueous medium.

    摘要翻译： 含有纤维蛋白原的样品的稳定化溶液，特别是生物活性成分（BAC）的稳定溶液，其为来自血浆的蛋白质的溶液，其包含纤维蛋白原，氨甲环酸和精氨酸或赖氨酸或其混合物或精氨酸和赖氨酸，其药学上可接受的 盐，以及任选的在水性介质中形成缓冲溶液的物质。

    Attachment of surgical staple buttress to cartridge
    57.
    发明授权
    Attachment of surgical staple buttress to cartridge 有权
    手术支架附着到药筒

    公开(公告)号：US08899464B2

    公开(公告)日：2014-12-02

    申请号：US13251682

    申请日：2011-10-03

    申请人： Geoffrey C. Hueil ,  John V. Hunt ,  Venkataramanan Madakolathur Vasudevan ,  Israel Nur ,  Greg J. Fanuele

    发明人： Geoffrey C. Hueil ,  John V. Hunt ,  Venkataramanan Madakolathur Vasudevan ,  Israel Nur ,  Greg J. Fanuele

    IPC分类号： A61B17/068 ,  A61B17/072 ,  A61B17/064 ,  A61B17/00

    CPC分类号： A61B17/07207 ,  A61B17/0644 ,  A61B17/07292 ,  A61B2017/00477 ,  A61B2017/00884 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07264 ,  A61B2017/07271

    摘要： A surgical instrument includes an end effector and a staple cartridge that is insertable into the end effector. The staple cartridge includes a buttress material that is selectively coupled to the staple cartridge. In some versions the buttress material may be stapled to the staple cartridge by one or more attachment staples. Such attachment staples may be inserted into staple apertures formed through an upper deck of the staple cartridge. The attachment staples may include resiliently biased legs to frictionally resist removal. In some versions the attachment staples may be sized to form an interference fit in the staple apertures. Alternatively, the attachment staples may include barbs. A staple driver may be used to decouple the attachment staples. The staple driver may include staple forming pockets to bend the legs of the attachment staple when decoupling the attachment staple.

    摘要翻译： 外科器械包括末端执行器和可插入末端执行器的钉仓。 钉仓包括选择性地联接到钉仓的支撑材料。 在一些版本中，支撑材料可以通过一个或多个附接钉装订到钉仓上。 这种连接钉可以插入通过钉仓的上甲板形成的钉孔中。 附接订书钉可以包括弹性偏置的腿以摩擦抵抗移除。 在一些形式中，附件订书钉的尺寸可以在钉孔中形成过盈配合。 或者，附件订书钉可以包括倒钩。 可以使用订书钉驱动器来解耦连接订书钉。 订书钉驱动器可以包括订书钉成型袋，以在拆卸附件订书钉时弯曲附件订书钉的腿部。

    Method for obtaining anti-idiotype antibodies
    58.
    发明授权
    Method for obtaining anti-idiotype antibodies 有权
    获得抗独特型抗体的方法

    公开(公告)号：US08450067B2

    公开(公告)日：2013-05-28

    申请号：US10515499

    申请日：2003-05-22

    申请人： Israel Nur ,  Yehuda Shoenfeld ,  Miri Blank

    发明人： Israel Nur ,  Yehuda Shoenfeld ,  Miri Blank

    IPC分类号： G01N33/53

    CPC分类号： C07K16/4241 ,  A61K38/06 ,  A61K38/12 ,  A61K39/00 ,  C07K7/06 ,  C07K16/065 ,  C07K16/18 ,  C07K2317/565 ,  C40B30/04 ,  G01N33/564 ,  G01N33/686 ,  G01N2500/04 ,  G01N2800/24 ,  Y02A50/401 ,  Y02A50/414

    摘要： A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components; (d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix; (e) providing a molecular library comprising a plurality of molecule members; and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.

    摘要翻译： 用于鉴定模拟自身免疫性疾病相关自身抗体（自身抗体）的独特型的分子的方法。 该方法包括以下步骤：（a）从患有自身免疫性疾病的一种或多种患者的血清中纯化自身抗体; （b）将自身抗体结合到固相以形成亲和基质; （c）使包含免疫球蛋白的合并血浆或B细胞与亲和基质接触，然后除去未结合的血浆成分; （d）从基质中洗脱结合的免疫球蛋白，作为自身抗体的抗独特型抗体（抗-Id）; （e）提供包含多个分子成员的分子文库; 和（e）使抗-Id与分子文库接触并分离由抗-Id结合的结合分子，结合分子是模拟自身抗体的独特型的分子。 还公开了这样的分子。

    FIBRIN PAD MATRIX WITH SUSPENDED HEAT ACTIVATED BEADS OF ADHESIVE
    59.
    发明申请
    FIBRIN PAD MATRIX WITH SUSPENDED HEAT ACTIVATED BEADS OF ADHESIVE 有权
    FIBRIN PAD MATRIX具有悬挂的热激活的胶带

    公开(公告)号：US20130068820A1

    公开(公告)日：2013-03-21

    申请号：US13233633

    申请日：2011-09-15

    申请人： Matthew C. Miller ,  Yi-Lan Wang ,  Israel Nur ,  Aron O. Zingman

    发明人： Matthew C. Miller ,  Yi-Lan Wang ,  Israel Nur ,  Aron O. Zingman

    IPC分类号： A61B17/068

    CPC分类号： A61B17/07207 ,  A61B17/00491 ,  A61B17/07292 ,  A61B2017/005 ,  A61B2017/2929

    摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue.

    摘要翻译： 手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切断组件。 下颚构造成在处于打开位置时接收盒。 盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。 甲板限定孔，每个孔基本上设置在每个钉上。 墨盒进一步接收包括悬浮在基质中的胶珠的基质。 订书钉被驱动通过矩阵将矩阵固定在组织上。 当基质被固定到组织上时，胶珠被活化，使得活化的粘合剂进一步固定组织中的缝合线。