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113 条记录 (耗时 0.036 秒)

    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    51.
    发明申请
    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    取代三唑作为PPAR的调节剂及其制备方法

    公开(公告)号：US20080108630A1

    公开(公告)日：2008-05-08

    申请号：US11932755

    申请日：2007-10-31

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    IPC分类号： A61K31/497 ,  A61P3/06 ,  A61P3/10 ,  A61K31/4192 ,  C07D403/06 ,  C07D249/04

    CPC分类号： C07D249/06 ,  C07D409/10

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    Encapsulation compositions, and methods
    56.
    发明授权
    Encapsulation compositions, and methods 失效
    包封组合物和方法

    公开(公告)号：US5916790A

    公开(公告)日：1999-06-29

    申请号：US399295

    申请日：1995-03-03

    申请人： Karl C. Enevold

    发明人： Karl C. Enevold

    IPC分类号： C12N11/00 ,  A61K9/16 ,  A61K9/50 ,  A61K35/39 ,  A61K47/30 ,  A61P3/08 ,  C12N1/04 ,  C12N5/00 ,  C12N11/02 ,  C12N11/10

    CPC分类号： B82Y30/00 ,  A61K9/1652 ,  A61K9/5052 ,  B82Y5/00 ,  C12N5/0012 ,  C12N2533/54 ,  C12N2533/74 ,  Y10S514/866 ,  Y10S514/965 ,  Y10T428/2984 ,  Y10T428/2989

    摘要： The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods for their preparation. The encapsulated compositions may comprise the crosslinked polymer matrix layer as an inner layer, an outer layer, or an intermediate layer of an overall encapsulated composition. The compositions will generally also comprise a biological material, e.g., cells, proteins, and the like, encapsulated within the composition. The compositions and methods of the invention are useful in a variety of applications, including cell culturing and transplant therapy.

    摘要翻译： 本发明一般涉及新颖的包封组合物和方法。 特别地，本发明涉及包含交联的混合官能团层，聚合物基质层及其制备方法的稳定的微胶囊组合物。 包封的组合物可以包含作为整体封装组合物的内层，外层或中间层的交联聚合物基质层。 组合物通常还包含封装在组合物内的生物材料，例如细胞，蛋白质等。 本发明的组合物和方法可用于各种应用，包括细胞培养和移植治疗。

    Method of solution overcoating with gelling polymer
    57.
    发明授权
    Method of solution overcoating with gelling polymer 失效
    用胶凝聚合物涂布溶液的方法

    公开(公告)号：US5738876A

    公开(公告)日：1998-04-14

    申请号：US713138

    申请日：1996-09-20

    申请人： Karl C. Enevold

    发明人： Karl C. Enevold

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K35/39 ,  A61K47/30 ,  A61P3/08 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  A61K9/14

    CPC分类号： A61K9/5073 ,  A61K9/1652 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/74

    摘要： The present invention generally relates to novel overcoating/encapsulation processes which are carried out in solution without the use of droplet generation devices. The processes may be used in the overcoating or encapsulation of a variety of materials, such as biological material, e.g., cells, proteins, etc., as well as pharmaceuticals. Compositions prepared using the methods of the present invention may find use in pharmaceutical formulation as well as coating biological material for a number of applications, including cell culturing and transplant therapy.

    摘要翻译： 本发明一般涉及在不使用液滴产生装置的情况下在溶液中进行的新的外涂/包封方法。 该方法可以用于各种材料（例如生物材料，例如细胞，蛋白质等）以及药物的外敷或包封。 使用本发明的方法制备的组合物可用于药物制剂以及包衣生物材料用于许多应用，包括细胞培养和移植治疗。