公开(公告)号：US20180221631A1

公开(公告)日：2018-08-09

申请号：US15949170

申请日：2018-04-10

申请人： The Spectranetics Corporation

发明人： Patrick H. Ruane

IPC分类号： A61M25/10 ,  A61L29/16 ,  A61L2/20 ,  B05D3/10 ,  A61L29/08 ,  C09D171/02 ,  A61L2/00 ,  B05D1/18

CPC分类号： A61M25/1029 ,  A61L2/00 ,  A61L2/206 ,  A61L29/085 ,  A61L29/16 ,  A61L2202/24 ,  B05D1/18 ,  B05D3/107 ,  C09D171/02

摘要： A method of forming a coated medical device is described in which a coating including a therapeutic agent dispersed in a polymer or oligomer matrix is applied to an outer surface of the medical device. The coating is then post-processed to selectively remove a substantial portion of the polymer or oligomer matrix from the coating. The post-processed coating is then sterilized.

公开(公告)号：US20180185551A1

公开(公告)日：2018-07-05

申请号：US15736685

申请日：2016-06-15

申请人： Hollister Incorporated

发明人： Horacio Montes de Oca Balderas ,  John T. Clarke

IPC分类号： A61L29/04 ,  A61L29/08 ,  A61L29/14

CPC分类号： A61L29/049 ,  A61L29/085 ,  A61L29/141 ,  A61L2420/06 ,  C08L29/04

摘要： Polymeric materials that are blends of polymers having differing water solubility rates are disclosed. The blends may be incorporated into at least a portion of a medical devices such as the shafts of flushable urinary catheters to provide suitable catheter stiffness/flexibility and catheter disintegration in water receptacles such as toilets. The blended material may provide the substrate of the catheter shaft or may provide one or more layers of the catheter

公开(公告)号：US10004831B2

公开(公告)日：2018-06-26

申请号：US15598544

申请日：2017-05-18

申请人： South Dakota Board of Regents ,  SANFORD HEALTH

发明人： Gopinath Mani ,  Sujan Lamichhane ,  Jordan Anderson ,  Tyler Remund ,  Patrick W. Kelly

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61M25/10

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105

摘要： The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

公开(公告)号：US09957395B2

公开(公告)日：2018-05-01

申请号：US13621505

申请日：2012-09-17

申请人： AllAccem, Inc.

发明人： Jeffery A. Whiteford ,  William P. Freeman

IPC分类号： C07D259/00 ,  C09D5/14 ,  A01N43/90 ,  A61K8/81 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61Q11/00 ,  B82Y30/00 ,  C08K5/00 ,  G02C7/04 ,  A45D29/00 ,  A45D29/18 ,  A61H35/00

CPC分类号： C09D5/14 ,  A01N43/90 ,  A45D29/00 ,  A45D29/18 ,  A61H35/006 ,  A61K8/8152 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/208 ,  A61L2300/404 ,  A61Q11/00 ,  B82Y30/00 ,  C07D259/00 ,  C08K5/0058 ,  G02C7/04 ,  Y10T428/31598 ,  Y10T428/31725 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L101/02

摘要： An antimicrobial coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at least two of the cyclic groups may include quaternary ammonium moieties. In some embodiments, a method may include applying an antimicrobial coating to an oral surface, a surface of a construction substrate, a surface of a marine substrate, a surface of a medical device, or a surface of a personal care device. The protective coating may be antimicrobial. A protective coating may include antimicrobial bridged polycyclic compounds. Bridged polycyclic compounds may include quaternary ammonium compounds. Bridged polycyclic compounds based coating systems may impart self-cleaning properties to a surface (e.g., a tooth surface).

公开(公告)号：US09956385B2

公开(公告)日：2018-05-01

申请号：US13926515

申请日：2013-06-25

申请人： The Spectranetics Corporation

发明人： Patrick H. Ruane

IPC分类号： A61M25/10 ,  A61L2/00 ,  A61L29/08 ,  A61L29/16 ,  A61L2/20 ,  B05D3/10 ,  B05D1/18 ,  C09D171/02

CPC分类号： A61M25/1029 ,  A61L2/00 ,  A61L2/206 ,  A61L29/085 ,  A61L29/16 ,  A61L2202/24 ,  B05D1/18 ,  B05D3/107 ,  C09D171/02

摘要： A method of forming a coated medical device is described in which a coating including a therapeutic agent dispersed in a polymer or oligomer matrix is applied to an outer surface of the medical device. The coating is then post-processed to selectively remove a substantial portion of the polymer or oligomer matrix from the coating. The post-processed coating is then sterilized.

公开(公告)号：US09937255B2

公开(公告)日：2018-04-10

申请号：US13474342

申请日：2012-05-17

申请人： Matthew F. Ogle ,  Wenda C. Carlyle ,  Edward J. Anderson ,  Kishore Udipi

发明人： Matthew F. Ogle ,  Wenda C. Carlyle ,  Edward J. Anderson ,  Kishore Udipi

IPC分类号： A61L29/08 ,  A61K47/32 ,  A61K31/11 ,  A61K31/7024 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61M25/10

CPC分类号： A61K47/32 ,  A61K31/11 ,  A61K31/7024 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L2300/102 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1075 ,  A61M2025/1086 ,  A61M2025/1097 ,  F04C2270/0421 ,  A61K2300/00 ,  C08L75/04 ,  C08L29/04

摘要： A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.

公开(公告)号：US20180078682A1

公开(公告)日：2018-03-22

申请号：US15815522

申请日：2017-11-16

申请人： Massachusetts Institute of Technology

发明人： Thomas P. Schaer ,  Suzanne Stewart ,  Alexander M. Klibanov

IPC分类号： A61L31/16 ,  A61L27/50 ,  A61L31/10 ,  A61L29/08 ,  A61L29/16 ,  A61L27/54 ,  A61F2/02 ,  A61L27/34 ,  A01N33/12 ,  A01N25/10 ,  A01N25/34 ,  C08L33/14

CPC分类号： A61L31/16 ,  A01N33/12 ,  A61F2/02 ,  A61F2/14 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2430/14 ,  C08L33/14 ,  A01N25/10 ,  A01N25/34 ,  C08L79/02 ,  C08L71/02

摘要： Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with the surface. As shown in the examples below, clinical observations, digital radiography, and a battery of well-accepted ex vivo analytical methods show that the presence of a hydrophobic polycationic polymer coating, such as N,N-dodecyl,methyl-PEI coating on the surface of a metal implant, was effective in eliminating the clinical signs of infection in vivo in a large animal infection model. Moreover, the coated plates supported bone healing, and in fact decreased healing times, even in the presence of significant bacterial contamination compared to a control.

公开(公告)号：US09913933B2

公开(公告)日：2018-03-13

申请号：US14214548

申请日：2014-03-14

申请人： St. Jude Medical, Cardiology Division, Inc.

发明人： Xiaoping Guo ,  David P. Johnson

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61L29/04 ,  A61L29/12 ,  A61L29/14 ,  A61L29/08

CPC分类号： A61L29/126 ,  A61L29/085 ,  A61L2400/10 ,  A61M25/0045 ,  A61M25/0053 ,  A61M25/0054 ,  C08L79/02 ,  C08L27/16

摘要： In various embodiments of the present disclosure, a surgical catheter is provided. The present disclosure provides a catheter shaft that includes a distal portion and a proximal portion. The proximal portion comprises a handle operably connected to the distal portion of the elongated structure. The distal portion three radially positioned polymeric layers. At least two of the layers include chemically dissimilar polymers and at least one of the three layers includes functionalized polyvinylidene fluoride (PVDF).

公开(公告)号：US20180064916A1

公开(公告)日：2018-03-08

申请号：US15810721

申请日：2017-11-13

申请人： Cook Medical Technologies LLC

发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Joseph M. Stewart, IV ,  William J. Bourdeau ,  Brian D. Choules ,  James D. Purdy ,  Neal E. Fearnot

IPC分类号： A61M25/10 ,  A61L29/08 ,  A61F2/844 ,  A61F2/958 ,  A61L27/54 ,  A61F2/82 ,  A61L29/16 ,  A61L31/16

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

公开(公告)号：US09907935B2

公开(公告)日：2018-03-06

申请号：US14404643

申请日：2013-06-03

申请人： Alexander Rübben

发明人： Alexander Rübben

IPC分类号： A61M25/10 ,  A61L29/16 ,  A61L29/08

CPC分类号： A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  A61M2025/1031 ,  A61M2025/105 ,  C08L5/02

摘要： The invention relates to a method for coating the balloon of a balloon catheter, wherein the surface of the balloon is at least partially wetted with a first solution of an active ingredient, the part of the surface of the balloon wetted with the first solution of the active ingredient is wetted with a liquid containing water and/or at least one alcohol, and the part of the surface of the balloon wetted with the first solution and the liquid containing water and/or at least one alcohol is wetted with an additional solution that contains a polysaccharide. In this way, the balloon is provided with an active ingredient layer, which during the balloon dilatation is effectively applied to the vessel inner wall due to the embrittlement of the surface and cases a slowed, long lasting release of the active ingredient.