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公开(公告)号：US09353342B2
公开(公告)日：2016-05-31
申请号：US13761130
申请日：2013-02-06
Applicant: EMD Millipore Corporation
Inventor： Ju-Sung Paul Hung , Philip J. Lee , Amedeo J. Cappione, III
CPC classification number: C12M23/16 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0647 , B01L2200/0694 , B01L2300/0681 , B01L2300/0877 , B01L2300/14 , C12M23/34 , C12M23/40 , C12M27/18 , C12M29/10 , C12M41/46 , C12Q1/02 , C12Q1/025
Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system.
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公开(公告)号：US09289703B2
公开(公告)日：2016-03-22
申请号：US13868372
申请日：2013-04-23
Applicant: EMD Millipore Corporation
Inventor： Martin Morrissey , Dennis Wong
CPC classification number: B01D35/14 , B01D61/20 , B01D63/084 , B01D2313/04 , B01D2313/23 , B01D2313/44 , B01D2313/54 , C02F2209/03 , G01L7/082 , G01N1/10 , G01N1/4005 , Y10T436/25 , Y10T436/25375
Abstract: Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path.
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63.发明申请公开(公告)号：US20160059159A1
公开(公告)日：2016-03-03
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 描述了一种过滤液体进料的方法，包括使液体进料通过单程切向流过滤（SPTFF）系统，并在分离的容器中回收系统中的渗余物和渗透物。 还描述了过滤液体进料的方法，包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从系统中回收渗透物和一部分滞留物，而不通过TFF系统再循环，并将剩余物 的滞留物通过TFF系统至少一次。 本发明的方法可以使用包括歧管段的SPTFF或TFF系统来进行，以串行化进料和滞留物的流动路径，而不需要转向板。
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公开(公告)号：US09274092B2
公开(公告)日：2016-03-01
申请号：US14819806
申请日：2015-08-06
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Anthony Frederick Mann , Daniel Schubnel
CPC classification number: G01N30/56 , B01D15/206 , B01D15/3809 , G01N2030/565
Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.
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公开(公告)号：US09259085B2
公开(公告)日：2016-02-16
申请号：US14265429
申请日：2014-04-30
Applicant: EMD Millipore Corporation
Inventor： Rene Reinbigler , Jean-Louis Weissenbach
CPC classification number: A47B81/00 , A47B57/04 , A47B91/002 , A47F5/0037 , A61G12/001 , B62B3/006
Abstract: A device for supporting a plurality of flexible containers for liquid, including a plurality of baskets, each containing at least one of the flexible containers, a magazine to receive the baskets, able to adopt an operating configuration in which the baskets are disposed inclined one above the other, which magazine includes supports for the baskets, able to adopt a loading/unloading position such that each basket can be loaded/unloaded along a horizontal path, and able to adopt an operating position to maintain each basket in an inclined position to make the magazine adopt the operating configuration, and a driver for driving the supports between the loading/unloading position and the operating position.
Abstract translation: 一种用于支撑多个用于液体的柔性容器的装置，包括多个篮子，每个篮子包含至少一个柔性容器，用于容纳篮子的盒子，能够采用操作构型，其中篮子设置在倾斜的上方 另一个，哪个杂志包括篮子的支撑，能够采用装载/卸载位置，使得每个篮子可以沿着水平路径装载/卸载，并且能够采取操作位置以将每个篮子保持在倾斜位置，以使 该仓库采用操作配置，以及用于在装载/卸载位置和操作位置之间驱动支撑件的驱动器。
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Patent Agency Ranking
公开(公告)号：US20160022979A1
公开(公告)日：2016-01-28
申请号：US14773426
申请日：2014-03-26
Applicant: EMD MILLIPORE CORPORATION
Inventor： James VIGNA , Joseph MULDOON , John CIECIUCH , Robert LANGLOIS
IPC: A61M39/18 , F16L55/07 , F16L37/367
CPC classification number: A61M39/18 , F16L37/36 , F16L37/367 , F16L55/07 , F16L2201/44
Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.
Abstract translation: 允许无菌湿连接的流体输送装置和方法允许连接被反向，并且允许连接被重新连接，同时使连接器无菌并在压力下可重复使用。 在某些实施例中，该装置包括第一构件和第二构件，后者适于在致动装置时接收前者，以在无菌方式之间产生两者之间的流体连通。 每个构件包括门，其在打开时允许第一构件线性移位到第二构件中以允许流体被转移。 当流体传送完成时，第一构件可以从第二构件缩回，并且门关闭。
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67.发明授权Chromatography matrices including novel Staphylococcus aureus protein A based ligands 有权色谱基质包括新型金黄色葡萄球菌蛋白A基配体公开(公告)号：US09234010B2
公开(公告)日：2016-01-12
申请号：US14683738
申请日：2015-04-10
Applicant: EMD Millipore Corporation
Inventor： Shari Spector , Robert Smith , Joe Orlando , Nanying Bian
CPC classification number: C07K14/31 , B01D15/3809 , B01J20/286 , B01J20/3272 , B01J20/3274 , C07K1/22 , C07K16/1271 , C07K2319/21
Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.
Abstract translation: 本发明涉及包括基于免疫球蛋白结合蛋白（例如金黄色葡萄球菌蛋白A（SpA））的一个或多个结构域的配体的色谱基质，以及使用它们的方法。
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公开(公告)号：US20150361129A1
公开(公告)日：2015-12-17
申请号：US14736596
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
CPC classification number: C07K1/18 , A61L2/0017 , B01D15/08 , B01D15/12 , B01D61/145 , B01D2311/08 , B01D2313/58 , B01D2315/10 , B01D2315/16 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/00 , C07K16/065 , C07K2317/14 , B01D2311/2626
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
Abstract translation: 在各种实施方案中，本发明提供了从样品中分离靶蛋白与非靶蛋白的方法，包括增加样品中靶蛋白和非靶蛋白的浓度，并随后将浓缩样品递送至色谱装置。 在其它实施方案中，本发明涉及通过将含有靶蛋白的浓缩样品递送至色谱装置来增加靶蛋白色谱装置的容量的方法。
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公开(公告)号：US09206384B2
公开(公告)日：2015-12-08
申请号：US13692869
申请日：2012-12-03
Applicant: EMD Millipore Corporation
Inventor： Philip J. Lee , Terry Gaige , Wei Hsuan (Jessie) Ho
CPC classification number: C12M23/16 , B01L3/502715 , B01L3/502761 , B01L3/563 , B01L7/00 , B01L2200/0689 , B01L2200/143 , B01L2200/146 , B01L2200/147 , B01L2300/048 , B01L2300/0829 , B01L2300/14 , B01L2300/18 , B01L2300/1894 , B01L2400/0487 , C12M23/36 , C12M23/40 , C12M29/10 , C12M29/24 , C12M41/14 , C12M41/18 , C12M41/34 , C12M41/36 , C12M41/40 , C12M41/46 , C12M41/48 , C12Q1/02 , G01N33/5005 , G01N33/574
Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems.
Abstract translation: 用于改进微流体结构的微型培养箱歧管以及用于歧管和自动微流体系统的制造和操作的系统和方法。
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公开(公告)号：US20150298070A1
公开(公告)日：2015-10-22
申请号：US14648925
申请日：2013-12-10
Applicant: EMD MILLIPORE CORPORATION
Inventor： Mikhail Koslov , Gabriel Tkacik , Onur Y. Kas , Ajish Potty , Jigneshkumar Patel
CPC classification number: B01D71/56 , A61L2/022 , B01D39/1623 , B01D61/145 , B01D67/0004 , B01D69/06 , B01D2239/025 , B01D2239/0631 , B01D2239/0654 , B01D2239/1233 , B01D2323/39
Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 um to about 0.03 um, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 um to about 100 um, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electro-spun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.
Abstract translation: 用于从流体流中除去病毒颗粒（例如细小病毒）和其他颗粒的多孔电纺聚合物纳米纤维液体过滤介质，例如电纺丝垫，其具有测量的平均流动泡点 全氟己烷高于100psi。 电纺介质包括平均纤维直径为约6nm至约13nm的纳米纤维，纳米纤维液体过滤介质的平均孔径为约0.01μm至约0.03μm，孔隙率为约80％至约95 ％，约1μm至约100μm的厚度，以及大于约10LHH / psi的液体渗透性。 电纺垫的高孔隙度使得能够获得更高的水通量，从而减少在流体流上完成病毒过滤步骤所需的时间。
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