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61.发明申请MULTILAYER MICROFLUIDIC PROBE HEAD WITH IMMERSION CHANNELS AND FABRICATION THEREOF 有权多层微流体探头，具有浸没通道及其制造公开(公告)号：US20130333761A1
公开(公告)日：2013-12-19
申请号：US13881989
申请日：2011-10-18
IPC分类号： F03B11/00
CPC分类号： F03B11/00 , B01L3/502707 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2200/0694 , B01L2200/12 , B01L2300/0887 , Y10T137/0318 , Y10T137/8593
摘要： The invention is directed to a microfluidic probe head (100) with a base layer (120) comprising: at least two processing liquid microchannel (123, 124) in fluid communication with a processing liquid aperture (121, 122) on a face of the base layer; and an immersion liquid microchannel (223, 224) in fluid communication with a immersion liquid aperture (221, 222) on a face of the base layer, wherein the microfluidic probe head is configured to allow, in operation, processing liquid provided through the processing liquid aperture to merge into immersion liquid provided through the immersion liquid aperture. An additional layer can be provided to close the microchannels. Such a multilayered head is compact and easier to fabricate than heads made with unitary construction. The head can further be interfaced with tubing using e.g. a standard fitting for tubing port.
摘要翻译： 本发明涉及一种具有基层（120）的微流体探针头（100），包括：至少两个处理液体微通道（123,124），其与所述基底层（120）的表面上的处理液孔（121,122）流体连通 基层; 以及与所述基底层的表面上的浸没液体孔（221,222）流体连通的浸没液体微通道（223,224），其中所述微流体探针头被配置为允许在操作中通过所述处理提供的处理液体 液体孔径合并成通过浸没液体孔提供的浸液。 可以提供一个附加层来封闭微通道。 这种多层头部比用单一构造的头部紧凑并且容易制造。 头部可以进一步与管道连接，使用例如 油管口的标准配件。
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公开(公告)号：US08580129B2
公开(公告)日：2013-11-12
申请号：US13525843
申请日：2012-06-18
CPC分类号： C12N11/14 , C23F1/02 , C23F1/18 , C23F1/34 , H05K3/06 , H05K3/061 , H05K3/108 , H05K2203/1163
摘要： A method for processing a surface involves depositing at least one class of enzymes (2) onto the surface (1); introducing at least a reactant (3) into an environment of the surface (1), and causing interaction between the enzymes (2) and the reactant (3), thereby to cause processing of a region of the surface (1), the processed region of the surface (1) being defined with respect to a region thereof that is proximate (4) to where the enzymes (3) have been deposited.
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63.发明授权Stamp with drainage channels for transferring a pattern in the presence of a third medium 有权在第三种介质的存在下用排水通道印上图案公开(公告)号：US08267011B2
公开(公告)日：2012-09-18
申请号：US12748624
申请日：2010-03-29
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译： 描述了在存在第三介质的情况下将图案从弹性印模转移到基板的方法。 在印模和基板之间实现接近接触。 将印模和基板之间的第三介质层控制到预定厚度。 还描述了用于执行该方法的邮票。
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公开(公告)号：US20120048391A1
公开(公告)日：2012-03-01
申请号：US13318675
申请日：2010-05-07
CPC分类号： B01J19/0046 , B01J2219/00367 , B01J2219/00527 , B01J2219/00743 , B01L3/0241 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , Y10T29/494 , Y10T137/0318 , Y10T137/0402 , Y10T137/2224 , Y10T137/8359 , Y10T137/8593 , Y10T137/87153 , Y10T137/87885
摘要： A micro fluidic probe head includes a first layer, a second layer, and a first tubing port extending from an upper face of the first layer. The first layer has a first via, enabling fluid communication between the first port and a lower face of the first layer. The second layer includes a first aperture on a face, and a first microchannel enabling fluid communication between an upper face of the second layer, facing the lower face of the first layer, and the first aperture. The head enables fluid communication between the first via and the first microchannel. At least a portion of the first microchannel is a groove open on the upper face of the second layer, closed by a portion of a lower face of a layer of the head. The probe head further comprises a second tubing port, a second via, a second aperture and a second micro channel.
摘要翻译： 微流体探针头包括从第一层的上表面延伸的第一层，第二层和第一管口。 第一层具有第一通孔，使得能够在第一端口和第一层的下表面之间进行流体连通。 第二层包括面上的第一孔，以及第一微通道，其使第二层的上表面与第一层的下表面和第一孔之间能够流体连通。 头部使得第一通孔和第一微通道之间能够流体连通。 第一微通道的至少一部分是在第二层的上表面上开口的凹槽，由头部的一层的下表面的一部分封闭。 探头还包括第二管口，第二通孔，第二孔和第二微通道。
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公开(公告)号：US07891295B2
公开(公告)日：2011-02-22
申请号：US12249322
申请日：2008-10-10
IPC分类号： B41M9/00
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译： 描述了在存在第三介质的情况下将图案从弹性印模转移到基板的方法。 在印模和基板之间实现接近接触。 将印模和基板之间的第三介质层控制到预定厚度。 还描述了用于执行该方法的邮票。
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公开(公告)号：US20100180782A1
公开(公告)日：2010-07-22
申请号：US12748624
申请日：2010-03-29
IPC分类号： B41K1/42
CPC分类号： B01J19/0093 , B01J2219/00382 , B01J2219/00527 , B01J2219/0072 , B01J2219/0074 , B01J2219/00745 , B01J2219/00747 , B01J2219/00783 , B01J2219/00833 , B01L3/0293 , B01L2300/0819 , B41K1/30 , B41M3/006 , C40B30/08 , C40B40/18 , C40B60/14 , G01N35/1002 , G01N2035/1034 , H05K3/12 , Y10S977/887
摘要： A method for transferring a pattern from an elastic stamp to a substrate in the presence of a third medium is described. A proximity contact is achieved between the stamp and the substrate. A layer of the third medium between the stamp and the substrate is controlled to a predetermined thickness. Stamps for carrying out this method are also described.
摘要翻译： 描述了在存在第三介质的情况下将图案从弹性印模转印到基板上的方法。 在印模和基板之间实现接近接触。 将印模和基板之间的第三介质层控制到预定厚度。 还描述了用于执行该方法的邮票。
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67.发明申请METHODS FOR SCREENING AND ARRAYING MICRORGANISMS SUCH AS VIRUSES USING SUBTRACTIVE CONTACT PRINTING BACKGROUND 有权使用隐性接触印刷技术来筛选和形成微阵列的方法作为病毒公开(公告)号：US20100048428A1
公开(公告)日：2010-02-25
申请号：US12195577
申请日：2008-08-21
IPC分类号： C40B50/18
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00677 , B01J2219/00725 , B01J2219/0074 , C40B60/08 , C40B60/12 , G01N33/6845 , G01N2333/005
摘要： Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.
摘要翻译： 提供了使用减法接触印刷来筛选和排列诸如病毒的微生物阵列的方法。 在一个实施方案中，用于形成微生物受体阵列的方法包括：在第一基底上图案化结构阵列以在第一基底的表面上形成模板; 将受体材料施加到第二基底的表面; 以及使所述第二基板的表面与所述模板接触以从所述第二基板移除所述受体材料的一部分，从而在所述第二基板上形成受体阵列。
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公开(公告)号：US20090318303A1
公开(公告)日：2009-12-24
申请号：US12143314
申请日：2008-06-20
CPC分类号： C40B60/12 , B01J2219/00353 , B01J2219/00414 , B01J2219/00418 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/0631 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0851 , B01L2300/0887 , B01L2300/12 , B01L2300/163 , B01L2400/0406 , B01L2400/049 , G01N33/54366
摘要： Disclosed herein is a system comprising a chip; a flow channel disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channel; and a receptor; the receptor being disposed on the substrate; the receptor being operative to interact with a component from the library.
摘要翻译： 本文公开了一种包括芯片的系统; 设置在所述芯片中的流路; 所述流通道与入口和出口通信; 所述流动通道可操作以允许库从入口到出口的流动; 底物; 所述基板设置在所述芯片上; 所述基底可用作所述流动通道的上壁; 和受体; 所述受体被设置在所述基底上; 受体可操作以与文库中的组分相互作用。
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公开(公告)号：US20090318302A1
公开(公告)日：2009-12-24
申请号：US12143272
申请日：2008-06-20
CPC分类号： C40B30/04 , B01J2219/00389 , B01J2219/00418 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/5025 , B01L3/5027 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0487 , B01L2400/06 , C40B60/12 , G01N33/54366
摘要： Disclosed herein is a microfluidic device comprising a chip; a flow channel being disposed in the chip; the flow channel being in communication with an entry port and an exit port; the flow channel being operative to permit the flow of a library from the entry port to the exit port; a substrate; the substrate being disposed upon the chip; the substrate being operative to act as an upper wall for the flow channels; and a plurality of receptors; the plurality of receptors being disposed on the substrate; the plurality of receptors being operative to interact with an element from the library.
摘要翻译： 本文公开了一种包括芯片的微流体装置; 流通道设置在芯片中; 所述流通道与入口和出口通信; 所述流动通道可操作以允许库从入口到出口的流动; 底物; 所述基板设置在所述芯片上; 所述基底可用作所述流动通道的上壁; 和多个受体; 所述多个受体被设置在所述基底上; 多个受体可操作以与来自文库的元件相互作用。
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公开(公告)号：US20090135471A1
公开(公告)日：2009-05-28
申请号：US12271135
申请日：2008-11-14
IPC分类号： G02F1/00
CPC分类号： G02B26/004 , G06K19/07703 , G06K19/07749
摘要： A display element having circuitry adapted to at least partially electrochemically dissolve a first layer by means of supplying an electrical current through the first layer. The first layer separates a first reservoir filled with a liquid from a second reservoir. By dissolving the first layer at least partially, at least a portion of the liquid can flow from the first to the second reservoir. Consequently, the display element transitions from a first to a second optical state.
摘要翻译： 一种显示元件，其具有适于通过提供电流通过第一层至少部分地电化学溶解第一层的电路。 第一层将装有液体的第一容器与第二储存器分开。 通过至少部分地溶解第一层，液体的至少一部分可以从第一储存器流到第二储存器。 因此，显示元件从第一光学状态转变到第二光学状态。
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