公开(公告)号：US20140243341A1

公开(公告)日：2014-08-28

申请号：US14347756

申请日：2012-09-27

Applicant: Kansas State University Research Foundation ,  Wichita State University ,  The Ohio State University

Inventor： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC: A61K31/5377 ,  A61K31/4015 ,  A61K45/06 ,  C07D207/27

CPC classification number: A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfite salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，亚硫酸氢盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超集群的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。

公开(公告)号：US20130250278A1

公开(公告)日：2013-09-26

申请号：US13848523

申请日：2013-03-21

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Weixin Zhao ,  Burdette Terry Beck ,  Robert Peterman ,  Chih-Hang Wu

IPC: G01B11/16

CPC classification number: G01B11/162

Abstract: A portable optical sensor for measuring surface strain in an object, such as pre-stressed concrete articles, is provided. The sensor is a modular device comprising at least first and second modules, each of which includes a laser and image sensor. When placed adjacent to the object, the laser of each module illuminates respective, spaced-apart areas of the object's surface and each module's image sensor captures at least a portion of the light reflected from the illuminated area and generates a speckle image of the area. Speckle images of the areas taken at various times and/or under various object stress conditions are compared to arrive at a surface strain measurement for the object.

Abstract translation: 提供了用于测量物体中的表面应变的便携式光学传感器，例如预应力混凝土制品。 传感器是包括至少第一和第二模块的模块化装置，每个模块包括激光和图像传感器。 当放置在物体附近时，每个模块的激光照射物体表面的相应的间隔开的区域，并且每个模块的图像传感器捕获从照明区域反射的光的至少一部分并产生该区域的斑点图像。 比较在不同时间和/或各种物体应力条件下拍摄的区域的斑点图像，以获得物体的表面应变测量。

公开(公告)号：US20130183702A1

公开(公告)日：2013-07-18

申请号：US13800456

申请日：2013-03-13

Applicant: Kansas State University Research Foundation

Inventor： Stefan H. Bossmann ,  Deryl L. Troyer ,  Matthew T. Basel ,  Tej B. Shrestha ,  Hongwang Wang

IPC: C12Q1/37 ,  A61K9/127 ,  C12N11/06

CPC classification number: A61K9/127 ,  A61K47/48238 ,  A61K47/48815 ,  A61K47/62 ,  A61K47/6911

Abstract: Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.

Abstract translation: 提供了用于将活性剂递送至受试者中的癌性或癌前组织的超分子组装体。 这些超分子组装也可用于癌和癌前细胞的检测和成像检测。 组装体是蛋白酶敏感的并且包含含有蛋白酶共有序列的肽键。 组装可以选择性地靶向癌组织，其中蛋白酶降解肽键，从而释放在超分子组装中物理或机械包含或保留的活性剂。

公开(公告)号：US20030219893A1

公开(公告)日：2003-11-27

申请号：US10144294

申请日：2002-05-13

Applicant: Kansas State University Research Foundation

Inventor： Scott C. Todd ,  Paul W. Baures

IPC: C12N005/06 ,  C12N005/16 ,  G01N033/566 ,  G01N033/564 ,  G01N033/53

CPC classification number: G01N33/5091 ,  A61K31/4164 ,  C07D233/92 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/505 ,  G01N2333/18

Abstract: This invention relates to methods and compositions directed towards the diagnosis and treatment of Hepatitis C virus infection and the screening of potential therapeutic compounds using novel small molecules based on imidazole-4,5-dicarboxylic acids scaffolds.

Abstract translation: 本发明涉及针对丙型肝炎病毒感染的诊断和治疗以及使用基于咪唑-4,5-二羧酸支架的新型小分子筛选潜在治疗化合物的方法和组合物。

公开(公告)号：US20240400476A1

公开(公告)日：2024-12-05

申请号：US18697081

申请日：2022-09-30

Applicant: Kansas State University Research Foundation

Inventor： Peter Sues

IPC: C07C6/04 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07F15/00

Abstract: Catalyst materials for olefin metathesis reactions. The catalyst materials comprise a ruthenium phosphinimine complex. The ruthenium phosphinimine may be synthesized without bound N-heterocyclic carbene (NHC) or phosphine ligands, thereby providing significant advantageous in conversion, selectivity, and stability compared to existing ruthenium-based catalysts.

公开(公告)号：US20240334922A1

公开(公告)日：2024-10-10

申请号：US18131739

申请日：2023-04-06

Applicant: CNH Industrial America LLC ,  Kansas State University Research Foundation

Inventor： Rex Leroy Ruppert ,  Brent David Bast ,  Ajay Sharda

IPC: A01M7/00

CPC classification number: A01M7/0089 ,  A01M7/0057

Abstract: An agricultural system can include a product application system including one or more nozzle assemblies. A sensing system can be configured to capture data indicative of a condition of a spray operation. An input device can be configured to receive a first command to alter an application parameter for an agricultural product to be exhausted from a nozzle assembly. A computing system can be communicatively coupled to the product application system, the sensing system, and the input device. The computing system can be configured to receive the first command to alter the parameter, alter a first component based on the first command, determine whether the condition of the spray operation deviates from a defined condition range in response to altering the first component, and generate a second command to alter a second component based on the first command.

公开(公告)号：US20240208811A1

公开(公告)日：2024-06-27

申请号：US18550752

申请日：2022-03-16

Applicant: Kansas State University Research Foundation ,  Hydrograph Clean Power Inc.

Inventor： Christopher M. Sorensen ,  Stefan H. Bossmann ,  Justin Wright ,  Shusil Sigdel ,  Jose Covarrubias ,  Arjun Nepal ,  Harold Charles Davidson

IPC: C01B3/36

CPC classification number: C01B3/36 ,  C01B2203/0255 ,  C01B2203/0405 ,  C01B2203/1217 ,  C01B2203/1235 ,  C01B2203/1276 ,  C01B2203/1614 ,  C01B2203/169

Abstract: Apparatus and processes for high-yield production of syngas components via combustion of a carbon-containing material and an oxygen-containing material are provided. Syngas components are generated in an exothermic, combustion reaction with only minor quantities of carbon dioxide, water, and elemental carbon produced.

公开(公告)号：US20240156129A1

公开(公告)日：2024-05-16

申请号：US18417359

申请日：2024-01-19

Applicant: Kansas State University Research Foundation

Inventor： Cassandra K. Jones ,  Roger A. Cochrane ,  Jason C. Woodworth ,  Steven S. Dritz

IPC: A23K30/00 ,  A23K20/158 ,  A23K20/22 ,  A23K50/30 ,  A23K50/42 ,  A23L3/3472 ,  A23L3/3508 ,  A23L3/358

CPC classification number: A23K30/00 ,  A23K20/158 ,  A23K20/22 ,  A23K50/30 ,  A23K50/42 ,  A23L3/3472 ,  A23L3/3508 ,  A23L3/358

Abstract: Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet rood. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

公开(公告)号：US11967629B2

公开(公告)日：2024-04-23

申请号：US17253180

申请日：2019-06-22

Applicant: Kansas State University Research Foundation ,  Purdue Research Foundation

Inventor： Suprem R. Das ,  David B. Janes ,  Jiseok Kwon

IPC: H01L21/02 ,  H01L29/24 ,  H01L29/43 ,  H01L29/66 ,  H01L29/76

CPC classification number: H01L29/435 ,  H01L21/02568 ,  H01L29/24 ,  H01L29/66969 ,  H01L29/7606

Abstract: A semiconductor device and methods of fabricating and using the same are provided. The semiconductor device comprises a channel region and at least a first, second, and third electrode. The channel region includes a compound having a transition metal and a chalcogen. The thickness of the channel region is about 3 to about 40 atomic layers.

公开(公告)号：US11965881B2

公开(公告)日：2024-04-23

申请号：US16088407

申请日：2017-03-24

Applicant: The Board of Regents of The University of Texas System ,  Kansas State University Research Foundation

Inventor： Massoud Motamedi ,  Allan R. Brasier ,  Stefan H. Bossmann ,  Christopher T. Culbertson ,  Deryl Troyer

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/574

CPC classification number: G01N33/54346 ,  B01L3/502715 ,  G01N33/574 ,  B01L2300/0636 ,  B01L2300/0816 ,  G01N2333/70596

Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.