摘要:
Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKKβ and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.
摘要:
A solder drawing member (402) is detachably attached on the outer side of a jet nozzle (303) that jets molten solder pumped from a solder tank (102) storing the molten solder. The solder drawing member (402) is made of a material having higher wettability to the molten solder than the surface material of the jet nozzle (303). Thus a force of separating the solder from a point to be soldered can be increased by a surface tension of the molten solder flowing on the solder drawing member (402), thereby reducing bridge phenomena and icicle phenomena.
摘要:
A method of preventing or treating a glucocorticoid receptor-related disease involving administering a therapeutically effective amount of a 1,2-dihydroquinoline compound or a pharmaceutically acceptable salt thereof.
摘要:
Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.
摘要翻译:本发明的目的是研究具有脲基和氨基羰基作为取代基或其盐的新型吡咯衍生物的合成,以发现其衍生物或其盐的药理作用,并找到药剂 其通过口服给药对视网膜疾病等具有预防和/或治疗作用。 由通式(1)表示的化合物或其盐对白介素-6的产生具有抑制活性和/或对脉络膜新生血管形成的抑制作用,因此可用作疾病的预防和/或治疗剂 与白介素-6相关,眼炎和/或视网膜疾病。 在该式中,环A表示苯环等; R1表示卤素原子,氢原子,低级烷基等; R 2表示卤原子,可以具有取代基的低级烷基,低级烯基,可具有取代基的低级炔基,低级环烷基,芳基,羟基,可以具有取代基的低级烷氧基 具有取代基等; n表示0,1,2,3等。
摘要:
A test recording method capable of preventing omission of tests for software to be delivered. When test input data is entered from a testing client, a data transmitter transmits the data to a testing server. Upon reception of test output data and a hash value from the testing server, an evaluation unit determines a test result, pass or fail, by comparing the test output data with the output pattern described in a test specification. The result recorder stores a test log in a log memory, the test log including the test result and the hash value received from the testing server.
摘要:
A pigment aqueous-medium dispersion and coating material which have no particle feeling and exhibit a highly excellent silky feeling, the pigment aqueous-medium dispersion is a dispersion of a photoluminescent pigment in an aqueous medium, characterized in that the photoluminescent pigment is flaky titanic acid obtained by treating layered titanate with acid and then reacting an organic basic compound with the treated layered titanate to delaminate, and the flaky titanic acid has an average longer diameter of 5 to 30 μm and an average thickness of 0.5 to 300 nm.
摘要:
Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.
摘要翻译:本发明的目的是研究具有脲基和氨基羰基作为取代基或其盐的新型吡咯衍生物的合成,以发现其衍生物或其盐的药理作用,并找到药剂 其通过口服给药对视网膜疾病等具有预防和/或治疗作用。 由通式(1)表示的化合物或其盐对白介素-6的产生具有抑制活性和/或对脉络膜新生血管形成的抑制作用,因此可用作疾病的预防和/或治疗剂 与白介素-6相关,眼炎和/或视网膜疾病。 在该式中,环A表示苯环等; R1表示卤素原子,氢原子,低级烷基等; R 2表示卤原子,可以具有取代基的低级烷基,低级烯基,可具有取代基的低级炔基,低级环烷基,芳基,羟基,可以具有取代基的低级烷氧基 具有取代基等; n表示0,1,2,3等。
摘要:
When an engine operates at low engine speed, the tip end of a cam nose of an intake cam is at a second position. As the engine speed increases and exceeds a first engine speed, the tip end of the cam nose of the intake cam moves to a first position. When the engine operates at high engine speed, the tip end of the cam nose of the intake cam is at the first position. As the engine speed decreases and becomes lower than a second engine speed smaller than the first engine speed, the tip end of the cam nose of the intake cam moves to the second position different from the first position.
摘要:
The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R1 and R2 represent a hydrogen atom, a lower alkyl group, or the like; R3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R4 and R5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.
摘要:
An object of the present invention is to synthesize a novel 1,2,3,4-tetrahydroquinoxaline derivative represented by formula (1) and to find a pharmacological action of the derivative. In the formula, the R1 represents a halogen, an alkyl, cycloalkyl, aryl or heterocyclic group, or the like; p represents 0 to 5; R2 represents a halogen, an alkyl, hydroxyl or alkoxy group, or the like; q represents 0 to 2; R3 represents hydrogen, an alkyl, alkenyl, alkylcarbonyl or arylcarbonyl group, or the like; R4 and R5 independently represent hydrogen, a halogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; R6 represents hydrogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; and X represents O or S.
摘要翻译:本发明的目的是合成由式(1)表示的新型1,2,3,4-四氢喹喔啉衍生物,并找到该衍生物的药理学作用。 在该式中,R 1表示卤素,烷基,环烷基,芳基或杂环基等; p表示0〜5; R2表示卤素,烷基,羟基或烷氧基等; q表示0〜2; R3表示氢,烷基,烯基,烷基羰基或芳基羰基等; R4和R5独立地表示氢,卤素,烷基,烯基,炔基,环烷基,芳基或杂环基等; R6表示氢,烷基,烯基,炔基,环烷基,芳基或杂环基等; A表示亚烷基; R 7表示OR 8,NR 8 R 9,SR 8,S(O)R 8,S(O) 而X代表O或S.