公开(公告)号：US5589069A

公开(公告)日：1996-12-31

申请号：US661892

申请日：1996-06-12

Applicant: Hu Wenzhi

Inventor： Hu Wenzhi

IPC: G01N30/02 ,  B01D15/08 ,  B01J20/286 ,  B01J20/32 ,  G01N30/64 ,  G01N30/74 ,  G01N30/88 ,  G01N30/96

CPC classification number: G01N30/96 ,  B01D15/364 ,  B01J20/2804 ,  B01J20/289 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3285 ,  B01J20/3289 ,  B01D15/3833 ,  B01J2220/54 ,  B01J2220/58 ,  G01N2030/8868 ,  G01N30/02

Abstract: The present invention relates to a method for separating and analyzing ions by electrostatic ion chromatography using water as the eluent not only for the analysis of the group of anions or cations but also for the simultaneous and simple analysis of the two groups of analyte ions. A solid phase packed in a separation column to be used therefor is a zwitterionic stationary phase, comprising a support carrier and a zwitterionic layer formed by directly or indirectly coating or immobilized a compound having both of a positive-charge portion and a negative-charge portion (an ammonium salt or amide portion, and a sulfonate ion portion or carboxylate ion portion) on the surface of the support carrier for detecting given separated ions by ultraviolet method etc. And another present invention relates to a method for separating and analyzing inorganic and organic components etc. simultaneously by multi-functional liquid chromatography.

Abstract translation: 本发明涉及一种通过静电离子色谱法分离和分析离子的方法，使用水作为洗脱液，不仅用于阴离子或阳离子的分析，而且用于同时和简单地分析两组分析物离子。 填充在用于其的分离柱中的固相是两性离子固定相，其包含支撑载体和通过直接或间接涂覆或固定化具有正电荷部分和负电荷部分的化合物形成的两性离子层 （铵盐或酰胺部分，磺酸根离子部分或羧酸根离子部分），用于通过紫外线法检测给定的分离离子。另外本发明涉及一种分离和分析无机和有机物的方法 组分等通过多功能液相色谱同时进行。

公开(公告)号：US5514668A

公开(公告)日：1996-05-07

申请号：US205629

申请日：1994-03-04

Applicant: Henry M. Christensen ,  Hans B. Andreasen

Inventor： Henry M. Christensen ,  Hans B. Andreasen

IPC: A61K31/335 ,  A61K31/00 ,  A61K31/075 ,  A61K31/357 ,  A61K31/715 ,  A61L2/00 ,  A61P31/12 ,  A61P39/02 ,  B01J20/32 ,  C07D323/00 ,  C08B37/02

CPC classification number: C08B37/0021 ,  A61L2/0088 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/4825 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/836

Abstract: A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crown ether compound substituted on a polysaccharide, preferably dextran. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.

Abstract translation: 用于从血液或其它细胞外液体中去除或灭活包括病毒的有害成分的组合物包括在多糖上优选葡聚糖取代的冠醚化合物。 该组合物可溶于水，优选用于荚膜内施用，或不溶于体外应用。

公开(公告)号：US5407581A

公开(公告)日：1995-04-18

申请号：US32487

申请日：1993-03-17

Applicant: Hirokazu Onodera ,  Makoto Yoshida

Inventor： Hirokazu Onodera ,  Makoto Yoshida

IPC: B01D39/16 ,  B01D67/00 ,  B01D71/38 ,  B01D71/42 ,  B01J20/32 ,  B01D37/00

CPC classification number: B01D67/0093 ,  B01D39/1623 ,  B01D71/38 ,  B01D71/42 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3276 ,  A61M2202/0441 ,  A61M2202/0445 ,  B01D2323/385 ,  Y10S210/929

Abstract: Disclosed is a filter medium for treating a blood material selected from the group consisting of a leukocyte-containing suspension and plasma, comprising a polymeric, porous element having, in a surface portion thereof, a negative charge and having a surface electric charge of not smaller than -30 .mu.eq/g of the polymeric, porous element. The filter medium and an apparatus having the filter medium packed in a casing having an inlet and an outlet, can be advantageously used for treating a blood material, for example, for separating leukocytes from a leukocyte-containing suspension including whole blood, for blood dialysis or for removing undesired proteinous substances and the like from whole blood or plasma by adsorption-filtration, while effectively controlling a concentration of bradykinin (which is causative of anaphylactic reactions) in a treated blood to a level not exceeding 4,000 pg/ml.

Abstract translation: 公开了一种用于处理选自含白细胞悬浮液和血浆的血液材料的过滤介质，其包含聚合物多孔元件，其表面部分具有负电荷并且表面电荷不小于 高于-30μeq / g的聚合多孔元素。 过滤介质和具有填充在具有入口和出口的壳体中的过滤介质的装置可以有利地用于处理血液材料，例如用于从包含全血的含白细胞的悬浮液中分离白细胞用于血液透析 或通过吸附过滤从全血或血浆中除去不想要的蛋白质等，同时有效地控制治疗血液中缓激肽的浓度（其是过敏反应的原因）至不超过4,000pg / ml的水平。

公开(公告)号：US5314878A

公开(公告)日：1994-05-24

申请号：US806206

申请日：1991-12-13

Applicant: Henry M. Christensen ,  Hans B. Andreasen

Inventor： Henry M. Christensen ,  Hans B. Andreasen

IPC: A61K31/335 ,  A61K31/00 ,  A61K31/075 ,  A61K31/357 ,  A61K31/715 ,  A61L2/00 ,  A61P31/12 ,  A61P39/02 ,  B01J20/32 ,  C07D323/00 ,  C08B37/02 ,  C07D321/00 ,  C07D321/10 ,  C08B31/10

CPC classification number: C08B37/0021 ,  A61L2/0088 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/4825 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/836

Abstract: A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crownether compound substituted on a polysaccharide, preferably dextrane. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.

Abstract translation: 用于从血液或其他细胞外液体中除去或灭活包括病毒的有害成分的组合物包括在多糖上取代的冠醚化合物，优选为葡聚糖。 该组合物可溶于水，优选用于荚膜内施用，或不溶于体外应用。

公开(公告)号：US5231063A

公开(公告)日：1993-07-27

申请号：US683317

申请日：1991-04-10

Applicant: Kazuhiro Fukumoto ,  Masahiro Sugiura

Inventor： Kazuhiro Fukumoto ,  Masahiro Sugiura

IPC: A61L9/01 ,  B01D53/38 ,  B01D53/81 ,  B01J20/22 ,  B01J20/28 ,  B01J20/32

CPC classification number: B01D53/02 ,  B01J20/0225 ,  B01J20/0237 ,  B01J20/0288 ,  B01J20/12 ,  B01J20/20 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28045 ,  B01J20/3204 ,  B01J20/3236 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3253 ,  B01D2257/304 ,  B01D2257/306 ,  B01D2257/406 ,  B01D2257/704 ,  B01J2220/44 ,  B01J2220/46 ,  B01J2220/4812 ,  Y10T428/24149 ,  Y10T428/249953 ,  Y10T428/30 ,  Y10T442/2508

Abstract: A composite adsorbent comprising an acid salt of an m- or p-aromatic amino acid and an acid. The adsorbent may further contain a transition metal compound. The former removes aldehydes, ammonias and amines simultaneously, and the latter further removes hydrogen sulfide.The composite adsorbent is used in the form of a powder, a solution, or a solid supported on a carrier.

Abstract translation: 包含m-或p-芳族氨基酸的酸盐和酸的复合吸附剂。 吸附剂还可以含有过渡金属化合物。 前者同时去除醛，氨和胺，后者进一步除去硫化氢。 复合吸附剂以支撑在载体上的粉末，溶液或固体的形式使用。

公开(公告)号：US4962073A

公开(公告)日：1990-10-09

申请号：US265243

申请日：1988-10-31

Applicant: Edward S. Martin ,  Larry F. Wieserman

Inventor： Edward S. Martin ,  Larry F. Wieserman

IPC: B01J20/32

CPC classification number: B82Y30/00 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3225 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3257 ,  B01J20/3274 ,  B82Y40/00

Abstract: A treated permeable inorganic membrane is disclosed comprising a metal oxide/hydroxide capable of reacting with a phosphoric acid ester. The treated membrane has good chemical stability over a pH range of from 2 to 12. Chemically bonded to the metal oxide/hydroxide surface of the membrane is a monomolecular layer of one or more phosphoric acid esters selected from the class consisting of one or more phosphoric acid monoesters having the formula (RO)PO(OH).sub.2, one or more phosphoric acid diesters having the formula (RO)(R'O)PO(OH), and mixtures of same where R comprises a 1-30 carbon-containing group and R'comprises hydrogen or a 1-30 carbon-containing group. Excess phosphoric acid esters not bonded to the underlying membrane surface is removed to ensure formation of the monomolecular layer of the phosphoric acid esters on the surfaces of the membrane.

Abstract translation: 公开了一种经处理的渗透性无机膜，其包含能够与磷酸酯反应的金属氧化物/氢氧化物。 经处理的膜在2至12的pH范围内具有良好的化学稳定性。与膜的金属氧化物/氢氧化物表面化学结合是一种或多种磷酸酯的单分子层，其选自一种或多种磷酸 具有式（RO）PO（OH）2的酸单酯，一种或多种具有式（RO）（R'O）PO（OH）的磷酸二酯及其混合物，其中R包含含1-30碳 组和R'包括氢或含1-30个碳的基团。 除去未结合到下面的膜表面的过量磷酸酯以确保在膜的表面上形成磷酸酯的单分子层。

公开(公告)号：US4491660A

公开(公告)日：1985-01-01

申请号：US374442

申请日：1982-05-03

Applicant: Ronald L. Gendrich ,  William H. Holleman

Inventor： Ronald L. Gendrich ,  William H. Holleman

IPC: A61K35/16 ,  A61L2/00 ,  A61L2/16 ,  B01J20/32 ,  C08F8/00 ,  C07H1/00

CPC classification number: C08F8/30 ,  A61K35/16 ,  A61L2/0082 ,  A61L2/16 ,  B01J20/28014 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3253 ,  B01J2220/4825 ,  B01J2220/58 ,  B01J2220/62

Abstract: An endotoxin binding material affixed to a support is disclosed. One embodiment is a matrix material capable of binding endotoxins and comprising a polar, water-insoluble, high molecular weight polymer support to which is attached groups which adsorb endotoxin molecules. The groups comprise bifunctional aliphatic molecules, one end of which is bound to the support, the other end of which is bound to an aryl molecule. The invention has utility in the removal of endotoxins from biological fluids and other solutions and for concentrating endotoxins so that they may be subsequently detected and quantified.

Abstract translation: 公开了固定在载体上的内毒素结合材料。 一个实施方案是能够结合内毒素并且包含极性的，不溶于水的高分子量聚合物载体的基质材料，其是吸附内毒素分子的连接基团。 这些基团包括双官能脂族分子，其一端与载体结合，另一端与芳基分子结合。 本发明可用于从生物流体和其它溶液中除去内毒素，并用于浓缩内毒素，以便随后检测和量化它们。

公开(公告)号：US20230264171A1

公开(公告)日：2023-08-24

申请号：US18307991

申请日：2023-04-27

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： CHRISTOPHER BELISLE ,  HONG CHEN ,  YUEPING XU ,  JIALI LIAO ,  XUEMEI HE

IPC: B01J20/26 ,  B01D15/36 ,  B01J20/32 ,  C07K16/06 ,  B01J20/289

CPC classification number: B01J20/262 ,  B01D15/363 ,  B01J20/3285 ,  B01J20/3227 ,  B01J20/3208 ,  B01J20/3219 ,  C07K16/065 ,  B01J20/289 ,  B01J20/3248 ,  B01J20/3253 ,  B01D15/3847

Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.

公开(公告)号：US11718643B2

公开(公告)日：2023-08-08

申请号：US14441129

申请日：2013-11-11

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Jean-Luc Maloisel ,  Gustav Rodrigo ,  Bjorn Noren ,  Virendra Kumbhar

IPC: B01D15/32 ,  B01D15/36 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/286 ,  B01J20/289 ,  B01J20/32 ,  B01J41/20 ,  C07K1/16 ,  C07K1/36 ,  C07K16/00 ,  C07K16/06 ,  G01N33/544

CPC classification number: C07K1/165 ,  B01D15/327 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/265 ,  B01J20/286 ,  B01J20/289 ,  B01J20/28016 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  B01J41/20 ,  C07K1/36 ,  C07K16/00 ,  C07K16/065 ,  G01N33/544 ,  B01D15/3809 ,  B01D15/3885 ,  B01J2220/52 ,  B01J2220/80 ,  B01D15/363 ,  B01D15/327

Abstract: The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five- or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.

公开(公告)号：US11685912B2

公开(公告)日：2023-06-27

申请号：US16978417

申请日：2019-03-05

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Brian Dwyer ,  Bohong Zhang ,  Jun Hu ,  Muthuraman Meiyappan ,  Thomas Miller ,  Paul McLean ,  Clark Pan

IPC: C12N9/40 ,  B01J20/286 ,  B01J20/289 ,  B01J20/32

CPC classification number: C12N9/2465 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3255 ,  C12Y302/01022

Abstract: The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.