公开(公告)号：US20140275603A1

公开(公告)日：2014-09-18

申请号：US14000502

申请日：2012-03-26

Applicant: Raymond J. Swedo ,  George David Green ,  Charles E. Coburn

Inventor： Raymond J. Swedo ,  George David Green ,  Charles E. Coburn

IPC: C07C201/12 ,  C07C211/15 ,  C07C215/76 ,  C07C211/48 ,  C07C211/52 ,  C07C205/54 ,  C07C205/51

CPC classification number: C07C201/12 ,  C07C205/51 ,  C07C205/54 ,  C07C211/15 ,  C07C211/48 ,  C07C211/52 ,  C07C215/76 ,  C07C253/30 ,  C07D319/06 ,  C07C255/10

Abstract: A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.

Abstract translation: 制备式III的2-硝基-1-乙醇衍生物的方法：其中R3如本文所述。 提供新的2-硝基-1-乙醇衍生物。

公开(公告)号：US20140213796A1

公开(公告)日：2014-07-31

申请号：US14085003

申请日：2013-11-20

Applicant: Universidad De Guanajuato

Inventor： Ignacio Rene GALINDO ESQUIVEL ,  Juan Manuel JUAREZ RUIZ ,  Orlando REGALADO OLIVA

IPC: C07C201/12 ,  B01J31/06

CPC classification number: C07F7/1804 ,  B01J31/061 ,  B01J31/062 ,  B01J31/069 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/348 ,  C07C201/12 ,  C07D209/34

Abstract: This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.

Abstract translation: 本发明描述了可用于缩合反应的固体异构手性有机催化剂的制备方法。 催化剂可以通过过滤以简单的方式回收，也可以重复使用。

公开(公告)号：US20130289278A1

公开(公告)日：2013-10-31

申请号：US13834106

申请日：2013-03-15

Applicant: Kelly Sullivan Kraft ,  John J. Freeman ,  Paul Serwinski ,  Vinnie Pavia ,  Otto Phanstiel, IV ,  Navneet Kaur

Inventor： Kelly Sullivan Kraft ,  John J. Freeman ,  Paul Serwinski ,  Vinnie Pavia ,  Otto Phanstiel, IV ,  Navneet Kaur

IPC: C07D241/08 ,  C07C67/39 ,  C07C201/12

CPC classification number: C07D241/08 ,  C07C67/30 ,  C07C67/39 ,  C07C201/12 ,  C07C69/60 ,  C07C205/43

Abstract: Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

公开(公告)号：US20130245257A1

公开(公告)日：2013-09-19

申请号：US13828411

申请日：2013-03-14

Applicant: Yoshiji TAKEMOTO ,  Kazuo MURAKAMI

Inventor： Yoshiji TAKEMOTO ,  Kazuo MURAKAMI

IPC: C07C253/30 ,  C07D239/95 ,  C07C241/02 ,  C07C231/14 ,  C07C67/343 ,  C07D233/88 ,  C07C201/12

CPC classification number: C07C253/30 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/343 ,  C07C201/12 ,  C07C205/53 ,  C07C231/08 ,  C07C231/14 ,  C07C241/02 ,  C07C281/02 ,  C07C2602/10 ,  C07D233/88 ,  C07D235/30 ,  C07D239/95 ,  C07C69/757 ,  C07C233/92 ,  C07C255/41

Abstract: The invention provides a compound having a heterocyclic skeleton of formula (I): wherein the substituents are as defined in the specification, as well as a tautomer thereof or a salt thereof. The invention also provides asymmetric synthesis methods involving the use of such a compound, tautomer thereof, or salt thereof, as a catalyst.

Abstract translation: 本发明提供具有式（I）的杂环骨架的化合物：其中取代基如说明书中所定义，以及其互变异构体或其盐。 本发明还提供涉及使用这种化合物，其互变异构体或其盐作为催化剂的不对称合成方法。

公开(公告)号：US20130096338A1

公开(公告)日：2013-04-18

申请号：US13541648

申请日：2012-07-03

Applicant: Guofu Zhong ,  Bin Tan ,  Pei Juan Chua ,  Zugui Shi

Inventor： Guofu Zhong ,  Bin Tan ,  Pei Juan Chua ,  Zugui Shi

IPC: C07C201/12

CPC classification number: C07C201/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/54 ,  C07D333/24 ,  C07C205/55

Abstract: Disclosed are processes of forming a compound (33), (35) or (37)

Abstract translation: 公开了形成化合物（33），（35）或（37）的方法，

公开(公告)号：US20120316341A1

公开(公告)日：2012-12-13

申请号：US13444676

申请日：2012-04-11

Applicant: Tobias Ritter ,  Pingping Tang

Inventor： Tobias Ritter ,  Pingping Tang

IPC: C07D233/28 ,  C07C41/22 ,  C07C205/12 ,  C07C201/12 ,  C07C69/78 ,  C07C67/307 ,  C07C49/807 ,  C07C45/63 ,  C07C47/55 ,  C07C25/13 ,  C07C17/16 ,  C07C211/45 ,  C07C209/74 ,  C07D213/61 ,  C07D215/18 ,  C07D453/04 ,  C07D491/22 ,  C07J1/00 ,  C07J75/00 ,  C07C43/225

CPC classification number: C07D233/28 ,  C07B39/00 ,  C07B2200/05 ,  C07C17/16 ,  C07C41/22 ,  C07C45/63 ,  C07C67/307 ,  C07C201/12 ,  C07C209/74 ,  C07D233/10 ,  C07J1/0059 ,  C07C205/12 ,  C07C211/52 ,  C07C25/13 ,  C07C25/18 ,  C07C43/225 ,  C07C69/734 ,  C07C49/697 ,  C07C69/76

Abstract: Methods for fluorinating organic compounds are described herein.

Abstract translation: 本文描述了氟化有机化合物的方法。

公开(公告)号：US20120245348A1

公开(公告)日：2012-09-27

申请号：US13437415

申请日：2012-04-02

Applicant: Herbert PLENIO ,  Christoph FLECKENSTEIN ,  Renat KADYROV ,  Juan ALMENA ,  Axel MONSEES ,  Thomas RIERMEIER

Inventor： Herbert PLENIO ,  Christoph FLECKENSTEIN ,  Renat KADYROV ,  Juan ALMENA ,  Axel MONSEES ,  Thomas RIERMEIER

IPC: C07F9/50 ,  C07F19/00 ,  C07C45/68 ,  C07C41/30 ,  C07C209/68 ,  C07C201/12 ,  C07C253/30 ,  C07C231/12 ,  C07C303/40 ,  C07D213/16 ,  C07D213/73 ,  C07D401/04 ,  C07D295/033 ,  C07D295/155 ,  C07C1/32 ,  C07F9/54

CPC classification number: C07C2/88 ,  B01J31/2404 ,  B01J31/2447 ,  B01J2231/321 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2231/4283 ,  B01J2531/824 ,  C07C17/26 ,  C07C41/30 ,  C07C45/62 ,  C07C201/12 ,  C07C209/68 ,  C07C253/30 ,  C07D213/16 ,  C07D213/22 ,  C07D213/73 ,  C07D265/30 ,  C07F9/5022 ,  C07F9/5442

Abstract: Disclosed herein are phosphine compounds represented by the general formula (4): and corresponding phosphonium salts represented by the general formula (4a): Also disclosed are processes for the preparation of these phosphines and phosphonium salts as well as their use as ligands in catalytic reactions.

Abstract translation: 本文公开了由通式（4）表示的膦化合物：和由通式（4a）表示的相应的鏻盐：还公开了制备这些膦和鏻盐以及它们在催化反应中作为配体的用途的方法 。

公开(公告)号：US20120157692A1

公开(公告)日：2012-06-21

申请号：US13406677

申请日：2012-02-28

Applicant: Hu Yang ,  Eduardo J. Baralt

Inventor： Hu Yang ,  Eduardo J. Baralt

IPC: C07D207/323 ,  C07C45/27 ,  C07C201/12

CPC classification number: C07C201/12 ,  C07C45/294 ,  C07D207/32 ,  C07C49/12 ,  C07C205/45

Abstract: The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.

Abstract translation: 本发明公开了γ-硝基羰基和γ-二羰基化合物的制备方法，其可以作为吡咯化合物的合成中的前体。 还公开了一种制备吡咯的方法，例如2,5-二甲基吡咯和结构相似的吡咯化合物。

公开(公告)号：US20120115714A1

公开(公告)日：2012-05-10

申请号：US13384281

申请日：2010-07-16

Applicant: Mitsuhiro Arisawa ,  Satoshi Shuto ,  Naoyuki Hoshiya

Inventor： Mitsuhiro Arisawa ,  Satoshi Shuto ,  Naoyuki Hoshiya

IPC: B01J27/045 ,  B01J27/02 ,  C07D295/033 ,  C07D491/113 ,  C07F15/00 ,  C07C1/20 ,  C07C231/12 ,  C07C27/00 ,  C07C41/30 ,  C07C201/12 ,  C07C17/26 ,  B01J19/00 ,  C07C67/347

CPC classification number: C07D491/113 ,  B01J23/44 ,  B01J23/52 ,  B01J27/04 ,  B01J31/06 ,  B01J35/002 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0207 ,  B01J37/0209 ,  B01J37/0225 ,  B01J37/20 ,  B01J2231/42 ,  B01J2231/4211 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/4266 ,  B01J2231/4283 ,  C07C1/321 ,  C07C17/263 ,  C07C41/30 ,  C07C231/12 ,  C07C2523/44 ,  C07C2523/52 ,  C07C15/52 ,  C07C25/18 ,  C07C43/225 ,  C07C233/11

Abstract: The present invention provides the catalyst precursor that has excellent safety and stability, has high stable activity retention rate, can be recycled, increases yield resulted from a reaction, and is easily processed into various forms. The catalyst precursor comprises a structure in which the entire structure is composed of gold or a gold-based alloy and the surface of the structure is modified with elemental sulfur, or at least the surface of the structure is composed of gold or a gold-based alloy and the surface of the structure is modified with elemental sulfur, and a catalytic metal compound supported on the structure, wherein the catalyst precursor has peaks derived from the catalytic metal compound and also sulfur as analyzed by photoelectron spectroscopy, and wherein the peak derived from sulfur is of the sulfur 1s orbital observed within a range of 2470 eV±2 eV in terms of the peak top position.

Abstract translation: 本发明提供了具有优异的安全性和稳定性，具有高稳定活性保持率，可回收利用，增加反应产率的催化剂前体，易于加工成各种形式。 催化剂前体包括其中整个结构由金或金基合金构成并且结构表面用元素硫改性的结构，或至少该结构的表面由金或金基组成 合金，结构表面用元素硫改性，负载在该结构上的催化金属化合物，其中催化剂前体具有衍生自催化金属化合物的峰和通过光电子能谱分析的硫，并且其中衍生自 在峰顶位置方面，硫是在2470eV±2eV的范围内观察到的硫1s轨道。

公开(公告)号：US20110137049A1

公开(公告)日：2011-06-09

申请号：US13003146

申请日：2009-07-06

Applicant: Erick M. Carreira

Inventor： Erick M. Carreira

IPC: C07F15/00 ,  C07C253/30 ,  C07D307/54 ,  C07D333/24 ,  C07C201/12 ,  C07C311/09

CPC classification number: C07C311/18 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/143 ,  C07C201/12 ,  C07C247/10 ,  C07C253/30 ,  C07C311/09 ,  C07D307/54 ,  C07D333/24 ,  C07F17/02 ,  C07C33/46 ,  C07C255/36 ,  C07C255/37 ,  C07C205/04 ,  C07C205/16 ,  C07C205/26

Abstract: The invention provides a chiral iridium aqua complex which has good preservation stability, can be easily produced, and enables asymmetric transfer hydrogenation in a higher yield and with higher stereoselectivity. The chiral iridium aqua complex has the formula (1A): wherein Ra, Rb, Rc, Rd and Re are the same or different and each is a hydrogen atom, a methyl group, an ethyl group or a phenyl group, R1 and R2 are the same or different and each is an aryl group optionally having substituent(s), or R1 and R2 in combination show a C3-4 straight chain alkylene group optionally having substituent(s) to form a ring, R3 is an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), R4 is a hydrogen atom, an alkylsulfonyl group optionally having substituent(s) or an arylsulfonyl group optionally having substituent(s), X is a monovalent or divalent anion, and n is 2 when X is a monovalent anion, or n is 1 when X is a divalent anion, and a production method of an optically active hydroxy compound using the complex.

Abstract translation: 本发明提供了具有良好的保存稳定性，易于制备的手性铱水性络合物，能够以较高的收率和更高的立体选择性进行不对称的转移氢化。 手性铱水性络合物具有式（1A）：其中R a，R b，R c，R d和R Re相同或不同，各自为氢原子，甲基，乙基或苯基，R 1和R 2为 相同或不同，并且各自为任选具有取代基的芳基，或者R 1和R 2组合​​表示任选具有取代基以形成环的C 3-4直链亚烷基，R 3是任选具有 取代基或任选具有取代基的芳基磺酰基，R4是氢原子，任选具有取代基的烷基磺酰基或任选具有取代基的芳基磺酰基，X是一价或二价阴离子，和 当X为一价阴离子时，n为2，X为二价阴离子时，n为1，使用该络合物的光学活性羟基化合物的制造方法。