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71.发明授权Use of variable XIC widths of TOF-MSMS data for the determination of background interference in SRM assays 有权使用TOF-MSMS数据的可变XIC宽度来确定SRM测定中的背景干扰公开(公告)号：US09583323B2
公开(公告)日：2017-02-28
申请号：US14123185
申请日：2012-05-30
申请人： Stephen A. Tate , David M. Cox
发明人： Stephen A. Tate , David M. Cox
CPC分类号： H01J49/02 , G06F19/703 , H01J49/0031
摘要： Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.
摘要翻译： 系统和方法识别不包括干扰的产物离子。 从串联质谱仪接收样品中分析物质量范围的完整产品离子谱。 使用第一XIC窗口宽度，对全产物离子谱中的产物离子计算第一组一个或多个峰参数。 使用第二XIC窗口宽度为产品离子计算第二组一个或多个峰值参数。 如果第一组一个或多个峰值参数和第二组一个或多个峰值参数基本上相同，则产物离子被识别为不包括干扰。 通过将产物与分析物的前体离子相关联，产物离子被进一步确认或确定为来自分析物而不是来自样品的基质。
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公开(公告)号：US09513232B2
公开(公告)日：2016-12-06
申请号：US13995816
申请日：2011-12-22
CPC分类号： G01N23/00 , H01J49/0031 , H01J49/0045 , H01J49/025
摘要： Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.
摘要翻译： 提供了实时触发信息依赖质谱扫描的方法和系统。 分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。 质谱仪从分离装置接收分离样品混合物。 在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。 如果两个或更多个时变离子信号的特征满足选择标准，则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。
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73.发明授权Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow 有权使用试剂化合物，标记策略和质谱工作流程对酮和醛分析物进行具体分析公开(公告)号：US09500622B2
公开(公告)日：2016-11-22
申请号：US13897628
申请日：2013-05-20
IPC分类号： G01N24/00 , G01N27/62 , G01N30/72 , G01N33/64 , G01N33/74 , G01N30/04 , G01N30/88 , H01J49/00
CPC分类号： G01N30/72 , G01N27/62 , G01N33/64 , G01N33/743 , G01N2030/045 , G01N2030/884 , H01J49/00 , H01J49/0045 , H01J49/164 , Y10T436/147777 , Y10T436/200833
摘要： Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
摘要翻译： 提供了标记试剂，一组标记试剂和标记技术用于酮或醛化合物的相对定量，绝对定量或两者，包括但不限于包含类固醇或酮类固醇的分析物。 分析物可以是生物样品中的医药或药物化合物。 还公开了用于标记，分析和定量酮或醛化合物的方法，也是也使用质谱法的方法。
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公开(公告)号：US09360455B2
公开(公告)日：2016-06-07
申请号：US14655263
申请日：2013-12-13
发明人： John L. Campbell , Yves Leblanc
CPC分类号： G01N27/624 , G01N27/622 , G01N33/92 , G01N2458/15 , H01J49/0031 , H01J49/0422 , Y10T436/24
摘要： A method for analyzing a sample that contains a plurality of lipid isomers is described that involves forming one or more lipid metal ion adducts and transporting the one or more lipid metal ion adducts through a differential mobility spectrometer to cause separation of the one or more lipid metal ion adducts from each other. The lipid isomers can be chosen, for example, from fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, polyketides, sterol lipids, and prenol lipids. Particular examples include phosphatidylcholine regioisomers such as 1-palmatoyl-2-oleoyl-sn-phosphatidylcholine (POPC) and 1-oleoyl-2-palmatoyl-sn-phosphatidylcholine and triacylglycerols containing palmetic and oleic acid groups. The metal chosen can include a cationization reagent that contains sodium, potassium, silver or lithium.
摘要翻译： 描述了分析含有多种脂质异构体的样品的方法，其涉及形成一种或多种脂质金属离子加合物并将一种或多种脂质金属离子加合物输送通过差速迁移谱仪，以引起一种或多种脂质金属 离子加合物彼此。 脂质异构体可以选自例如脂肪酸，甘油脂，甘油磷脂，鞘脂，蔗糖脂，聚酮化合物，甾醇脂质和牛油醇脂质。 特别的实例包括磷脂酰胆碱区域异构体如1-棕榈酰-2-油酰-sn-磷脂酰胆碱（POPC）和1-油酰-2-棕榈酰-sn-磷脂酰胆碱和含有油酸和油酸基团的三酰基甘油。 所选择的金属可以包括含有钠，钾，银或锂的阳离子化试剂。
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公开(公告)号：US09343282B2
公开(公告)日：2016-05-17
申请号：US14922823
申请日：2015-10-26
发明人： Stephen A. Tate , Ronald F. Bonner
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8631 , G06F19/703 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.
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76.发明授权Methods and systems for providing a substantially quadrupole field with significant hexapole and octapole components 有权用于提供具有显着的六极和八极组分的基本四极场的方法和系统公开(公告)号：US09324554B2
公开(公告)日：2016-04-26
申请号：US13818570
申请日：2011-08-25
申请人： Mircea Guna
发明人： Mircea Guna
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/422 , H01J49/4225
摘要： A system and method involving processing ions in a linear ion trap are provided, involving a two-dimensional asymmetric substantially quadrupole field having a hexapole and octopole component.
摘要翻译： 提供了涉及在线性离子阱中处理离子的系统和方法，涉及具有六极和八极分量的二维不对称基本四极场。
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77.发明授权公开(公告)号：US09305762B2
公开(公告)日：2016-04-05
申请号：US13693837
申请日：2012-12-04
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译： 质量分析系统，包括低压解离区域和差动迁移谱仪。 差速迁移谱仪包括至少一对限定离子流路的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。 差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口 其输出所选择的样本离子部分。 质谱仪接收样品离子的部分或全部选定部分。
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公开(公告)号：US09305757B2
公开(公告)日：2016-04-05
申请号：US14369344
申请日：2012-12-06
发明人： Takashi Baba
CPC分类号： H01J49/06 , H01J49/26 , H01J49/4225 , H01J49/4255
摘要： A method is provided for processing ions in a multipole ion trap, comprising generating RF radial confinement fields within a first and second multipole rod set positioned in tandem, a ratio of q value exhibited by the second rod set relative to the first rod set being greater than one for any m/z, said RF axial confinement fields within the first and second rod sets interacting in an interaction region between the first and second rod sets so as to produce a fringing field; transmitting ions through said first rod set towards said second rod set; and increasing the radial oscillation amplitude of at least a portion of the ions within said first rod set such that at least a portion of said ions having an increased radial oscillation amplitude are repulsed by said fringing field.
摘要翻译： 提供了一种用于处理多极离子阱中的离子的方法，包括在串联定位的第一和第二多极棒组内产生RF径向限制场，第二棒组相对于第一棒组显示的q值的比值更大 所述第一和第二杆组内的所述RF轴向限制场在所述第一和第二杆组之间的相互作用区域中相互作用以产生边缘场; 将离子通过所述第一杆组传递到所述第二杆组; 并且增加所述第一棒组中的离子的至少一部分的径向振荡振幅，使得具有增加的径向振荡幅度的所述离子的至少一部分被所述边缘场排斥。
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公开(公告)号：US20160025741A1
公开(公告)日：2016-01-28
申请号：US14342079
申请日：2012-09-02
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2030/8831 , G01N2333/415 , G01N2333/4713 , G01N2333/4731 , G01N2333/77 , G01N2333/976 , G01N2800/24
摘要： Methods and systems for detecting allergens using mass spectrometry are provided herein. In some aspects, a sample can be screened for the presence or quantity of ovalbumin, lysozyme, casein (isoform S1 and S2), lactoglobulin, high and low glutens, wheat, rye, oats, barley, mustard, sesame, and various types of nuts including macadamia, pistachio, brazil, walnuts, peanuts and hazelnuts by detecting one or more peptides specific to the allergen of interest using selected MRM transitions.
摘要翻译： 本文提供了使用质谱检测过敏原的方法和系统。 在一些方面，可以筛选样品的卵白蛋白，溶菌酶，酪蛋白（同种型S1和S2），乳球蛋白，高低谷蛋白，小麦，黑麦，燕麦，大麦，芥末，芝麻和各种类型的 通过使用选择的MRM转变检测感兴趣的变应原特异性的一种或多种肽，包括澳洲坚果，开心果，巴西，核桃，花生和榛子。
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80.发明授权Systems and methods for using interleaving window widths in tandem mass spectrometry 有权在串联质谱中使用交织窗口宽度的系统和方法公开(公告)号：US09202677B2
公开(公告)日：2015-12-01
申请号：US14401032
申请日：2013-04-19
发明人： Stephen A. Tate , Ronald F. Bonner
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8631 , G06F19/703 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.
摘要翻译： 提供了系统和方法，用于使用重叠的测量质量选择窗口宽度来分析样本。 使用处理器将样本的质量范围分为两个或更多个目标质量选择窗口宽度。 两个或多个目标宽度可以具有相同的宽度或可变宽度。 指示串联质谱仪使用处理器在质量范围内执行两次或更多次碎片扫描。 两个或多个碎片扫描的每个碎片扫描包括测量的质量选择窗口宽度。 两个或更多个碎片扫描的两个或多个测量宽度可以具有相同的宽度或可变宽度。 两个或更多个测量质量选择窗口宽度中的至少两个重叠。 测量的质量选择窗口宽度中的重叠对应于至少一个目标质量选择窗口宽度。
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