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    Method for triggering dependent spectra for data acquisition
    1.
    发明授权
    Method for triggering dependent spectra for data acquisition 有权
    触发依赖光谱数据采集的方法

    公开(公告)号：US09513232B2

    公开(公告)日：2016-12-06

    申请号：US13995816

    申请日：2011-12-22

    申请人： David M. Cox ,  Stephen A. Tate ,  Matthias Glueckmann

    发明人： David M. Cox ,  Stephen A. Tate ,  Matthias Glueckmann

    IPC分类号： H01J49/00 ,  G01N23/00 ,  H01J49/02

    CPC分类号： G01N23/00 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/025

    摘要： Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.

    摘要翻译： 提供了实时触发信息依赖质谱扫描的方法和系统。 分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。 质谱仪从分离装置接收分离样品混合物。 在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。 如果两个或更多个时变离子信号的特征满足选择标准，则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。

    Method for Triggering Dependent Spectra for Data Acquisition
    2.
    发明申请
    Method for Triggering Dependent Spectra for Data Acquisition 有权
    用于触发依赖光谱数据采集的方法

    公开(公告)号：US20130289894A1

    公开(公告)日：2013-10-31

    申请号：US13995816

    申请日：2011-12-22

    申请人： David M. Cox ,  Stephen A. Tate ,  Matthias Glueckmann

    发明人： David M. Cox ,  Stephen A. Tate ,  Matthias Glueckmann

    IPC分类号： G01N23/00 ,  H01J49/02

    CPC分类号： G01N23/00 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/025

    摘要： Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.

    摘要翻译： 提供了实时触发信息依赖质谱扫描的方法和系统。 分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。 质谱仪从分离装置接收分离样品混合物。 在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。 如果两个或更多个时变离子信号的特征满足选择标准，则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。

    Use of variable XIC widths of TOF-MSMS data for the determination of background interference in SRM assays
    3.
    发明授权
    Use of variable XIC widths of TOF-MSMS data for the determination of background interference in SRM assays 有权
    使用TOF-MSMS数据的可变XIC宽度来确定SRM测定中的背景干扰

    公开(公告)号：US09583323B2

    公开(公告)日：2017-02-28

    申请号：US14123185

    申请日：2012-05-30

    申请人： Stephen A. Tate ,  David M. Cox

    发明人： Stephen A. Tate ,  David M. Cox

    IPC分类号： H01J49/02 ,  H01J49/00 ,  G06F19/00

    CPC分类号： H01J49/02 ,  G06F19/703 ,  H01J49/0031

    摘要： Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.

    摘要翻译： 系统和方法识别不包括干扰的产物离子。 从串联质谱仪接收样品中分析物质量范围的完整产品离子谱。 使用第一XIC窗口宽度，对全产物离子谱中的产物离子计算第一组一个或多个峰参数。 使用第二XIC窗口宽度为产品离子计算第二组一个或多个峰值参数。 如果第一组一个或多个峰值参数和第二组一个或多个峰值参数基本上相同，则产物离子被识别为不包括干扰。 通过将产物与分析物的前体离子相关联，产物离子被进一步确认或确定为来自分析物而不是来自样品的基质。

    Use of Variable XIC Widths of TOF-MSMS Data for the Determination of Background Interference in SRM Assays
    4.
    发明申请
    Use of Variable XIC Widths of TOF-MSMS Data for the Determination of Background Interference in SRM Assays 有权
    使用TOF-MSMS数据的可变XIC宽度来确定SRM分析中的背景干扰

    公开(公告)号：US20140095084A1

    公开(公告)日：2014-04-03

    申请号：US14123185

    申请日：2012-05-30

    申请人： Stephen A. Tate ,  David M. Cox

    发明人： Stephen A. Tate ,  David M. Cox

    IPC分类号： H01J49/02

    CPC分类号： H01J49/02 ,  G06F19/703 ,  H01J49/0031

    摘要： Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.

    摘要翻译： 系统和方法识别不包括干扰的产物离子。 从串联质谱仪接收样品中分析物质量范围的完整产品离子谱。 使用第一XIC窗口宽度，对全产物离子谱中的产物离子计算第一组一个或多个峰参数。 使用第二XIC窗口宽度为产品离子计算第二组一个或多个峰值参数。 如果第一组一个或多个峰值参数和第二组一个或多个峰值参数基本上相同，则产物离子被识别为不包括干扰。 通过将产物与分析物的前体离子相关联，产物离子被进一步确认或确定为来自分析物而不是来自样品的基质。

    Liquid processing device including gas trap, and system and method
    5.
    发明授权
    Liquid processing device including gas trap, and system and method 有权
    液体处理装置，包括气体捕集器，以及系统和方法

    公开(公告)号：US07432106B2

    公开(公告)日：2008-10-07

    申请号：US10808229

    申请日：2004-03-24

    申请人： David M. Cox

    发明人： David M. Cox

    IPC分类号： B01L3/00 ,  G01N31/22 ,  G01N9/30

    CPC分类号： B01L3/502738 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/0683 ,  Y10T436/11 ,  Y10T436/111666

    摘要： A device is provided that can include at least one gas trap that can be arranged in fluid communication with a sample-containment feature formed in or on the device. The gas trap can be arranged to trap gas or air displaced from the sample-containment feature as the sample-containment feature is loaded with a liquid. The trapped gas in the gas trap can assist in breaking-up and expelling the liquid from the sample-containment feature during a subsequent liquid transfer operation, for example, to an adjacent sample-containment feature. Systems for processing such a device and methods using such a device are also provided.

    摘要翻译： 提供了一种装置，其可以包括至少一个气体捕集器，其可以被布置成与形成在装置中或装置上的样品容纳特征流体连通。 气体捕集器可以布置成捕集从样品容纳特征中移出的气体或空气，因为样品容纳特征装载有液体。 在随后的液体转移操作期间，例如在相邻的样品容纳特征中，气阱中的被捕获的气体可以帮助分解和排出来自样品容纳特征的液体。 还提供了用于处理这种设备的系统和使用这种设备的方法。