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公开(公告)号：US10265271B2
公开(公告)日：2019-04-23
申请号：US12122590
申请日：2008-05-16
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/16 , A61K31/715 , A61K45/06
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
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公开(公告)号：US08778333B2
公开(公告)日：2014-07-15
申请号：US12009181
申请日：2008-01-16
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K35/12 , A61K9/14 , A61K9/50 , A61F2/02 , C12N11/08 , C12N5/071 , C12N5/074 , C12N5/0775 , C12N5/07
CPC classification number: A61L27/3834 , A61K9/0024 , A61K9/08 , A61K9/1635 , A61K9/1658 , A61K9/167 , A61K35/12 , A61K35/28 , A61K35/34 , A61K35/36 , A61L2400/06 , C12N5/0075 , C12N2533/30
Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.
Abstract translation: 本发明涉及包含与用于组织构建和产生的干细胞相关的生物相容性，亲水性，无毒性和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物来治疗各种组织损伤和缺陷的组织结构和产生方法。
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公开(公告)号：US20120141379A1
公开(公告)日：2012-06-07
申请号：US13371964
申请日：2012-02-13
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
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74.发明申请CHROMATOGRAPHIC MATERIAL FOR THE ABSORPTION OF PROTEINS AT PHYSIOLOGICAL IONIC STRENGTH 审中-公开用于吸收生物离子强度的蛋白质的色谱材料公开(公告)号：US20110313147A1
公开(公告)日：2011-12-22
申请号：US13210568
申请日：2011-08-16
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: C08B15/00 , C07C217/06 , C07F7/00 , C07C323/16 , C07C323/12 , C07C323/25 , C07C323/52
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01J20/289 , B01J20/3242 , B01J20/3285 , B01J41/20 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/0074 , B01J2220/54 , C07K1/16 , C07K1/18 , G01N30/02 , G01N33/54353 , G01N2035/00158 , Y10S435/803
Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。
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公开(公告)号：US20100173791A1
公开(公告)日：2010-07-08
申请号：US12651942
申请日：2010-01-04
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
CPC classification number: G01N33/6848 , C07K1/16 , G01N30/8675 , G01N2030/8831
Abstract: The present invention provides a facile and efficient method for determining a chromatographic protocol for separating a target protein from one or more second protein impurity. Also provided is a database facilitating the determination of an appropriate separation protocol.
Abstract translation: 本发明提供了一种用于确定用于从一种或多种第二种蛋白质杂质分离靶蛋白质的色谱方案的简便有效的方法。 还提供了便于确定适当分离方案的数据库。
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Patent Agency Ranking
76.发明申请公开(公告)号：US20080090737A1
公开(公告)日：2008-04-17
申请号：US11757260
申请日：2007-06-01
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: C40B30/04
CPC classification number: G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。
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公开(公告)号：US07338657B2
公开(公告)日：2008-03-04
申请号：US10220984
申请日：2001-03-15
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61L27/3834 , A61K9/0024 , A61K9/08 , A61K9/1635 , A61K9/1658 , A61K9/167 , A61K35/12 , A61K35/28 , A61K35/34 , A61K35/36 , A61L2400/06 , C12N5/0075 , C12N2533/30
Abstract: The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.
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公开(公告)号：US20070082019A1
公开(公告)日：2007-04-12
申请号：US10546173
申请日：2004-02-20
Applicant: Wenxi Huang , Yury Agroskin , Egisto Boschetti
Inventor： Wenxi Huang , Yury Agroskin , Egisto Boschetti
CPC classification number: H01J49/0418 , A61L27/52
Abstract: A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. A hydrogel-coated substrate thus obtained is particularly useful as a probe for mass spectroscopic analysis, including SELDI analysis. Hydrogel particles also can be used for SELDI analysis.
Abstract translation: 使用聚合物或共聚物前体分别形成具有光可交联官能团的单体亚单位和具有化学选择性功能性用于结合生物分子分析物的单体亚单位，当层原位形成时，水凝胶层有利地施加到基底上， 如蛋白质。 由此获得的水凝胶涂覆的基底特别可用作用于质谱分析的探针，包括SELDI分析。 水凝胶颗粒也可用于SELDI分析。
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79.发明申请Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces 审中-公开用于在吸附剂表面上表达和捕获生物分子和复合物的装置和方法公开(公告)号：US20060110819A1
公开(公告)日：2006-05-25
申请号：US10528820
申请日：2003-09-29
Applicant: Lee Lomas , Egisto Boschetti , Tai-Tung Yip
Inventor： Lee Lomas , Egisto Boschetti , Tai-Tung Yip
IPC: C12M1/34
CPC classification number: G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。 所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。
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80.发明申请公开(公告)号：US20060021941A1
公开(公告)日：2006-02-02
申请号：US11236650
申请日：2005-09-28
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01D15/08
CPC classification number: B01J20/282 , B01J20/0211 , B01J20/0292 , B01J20/0296 , B01J20/048 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/28004 , B01J20/28078 , B01J20/28085 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3064 , B01J20/3071 , B01J20/3078 , B01J20/3204 , B01J20/3234 , B01J20/3236 , B01J20/3242 , B01J20/3268 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3282 , B01J20/3293 , B01J2220/42 , B01J2220/52 , B01J2220/58 , C07K1/20
Abstract: A new adsorbent of a porous mineral oxide material with apatite crystals, preferably hydroxyapatite crystals, in the pores of the mineral oxide material is disclosed. The adsorbent is useful for protein and nucleic acid separations
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