公开(公告)号：US20200033322A1

公开(公告)日：2020-01-30

申请号：US16045987

申请日：2018-07-26

Applicant: International Business Machines Corporation

Inventor： Harikilia Deligianni ,  Bruce B. Doris ,  Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin

IPC: G01N33/487 ,  B01L3/00 ,  C12Q1/00

Abstract: In an approach, a biomedical device comprises at least one electrode, wherein the at least one electrode is coupled with a computer chip; at least two chemical sensors, wherein the at least two chemical sensors are coupled with the computer chip; the computer chip, wherein the computer chip comprises: a semiconductor substrate, and a processor; a microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer; a power supply device coupled to the computer chip; and an antenna configured to send data collected onto the computer chip to a remote server. In an approach, a processor stimulating a cell sample. A processor senses the presence of at least two types of biomolecules released by the cell sample. A processor records data collected by the at least two chemical sensors. A processor sends the recorded data to a remote server.

公开(公告)号：US20180339321A1

公开(公告)日：2018-11-29

申请号：US15810483

申请日：2017-11-13

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin ,  Nathan P. Marchack ,  Roy R. Yu

IPC: B08B17/02 ,  A61B5/00 ,  A61B5/04

CPC classification number: B08B17/02 ,  A61B5/04001 ,  A61B5/4839 ,  A61B2562/0209 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/125 ,  B08B17/065 ,  B82Y15/00 ,  B82Y40/00

Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.

公开(公告)号：US20180339320A1

公开(公告)日：2018-11-29

申请号：US15602363

申请日：2017-05-23

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin ,  Nathan P. Marchack ,  Roy R. Yu

IPC: B08B17/02 ,  A61B5/04 ,  A61B5/00

Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.

公开(公告)号：US20170320058A1

公开(公告)日：2017-11-09

申请号：US15655330

申请日：2017-07-20

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: B01L3/00 ,  G01N27/447 ,  G01N33/487

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

公开(公告)号：US09705077B2

公开(公告)日：2017-07-11

申请号：US14840176

申请日：2015-08-31

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Anthony J. Annunziata ,  Armand A. Galan ,  Steve Holmes ,  Eric A. Joseph ,  Gen P. Lauer ,  Qinghuang Lin ,  Nathan P. Marchack

IPC: H01L43/10 ,  H01L43/12 ,  H01L43/02 ,  H01L43/08

CPC classification number: H01L43/12 ,  G03F7/70325 ,  G03F7/70425 ,  G11C11/161 ,  G11C2211/5615 ,  H01L27/222 ,  H01L27/228 ,  H01L43/02 ,  H01L43/08 ,  H01L43/10

Abstract: A method for forming a memory device includes masking a photoresist material using a reticle and a developer having a polarity opposite that of the photoresist to provide an island of photoresist material. A planarizing layer is etched to establish a pillar of planarizing material defined by the island of photoresist material. A metal layer is etched to form a metal pillar having a diameter about the same as the pillar of planarizing material. A memory stack is etched to form a memory stack pillar having a diameter about the same as the metal pillar. A magnetoresistive memory cell includes a magnetic tunnel junction pillar having a circular cross section. The pillar has a pinned magnetic layer, a tunnel barrier layer, and a free magnetic layer. A first conductive contact is disposed above the magnetic tunnel junction pillar. A second conductive contact is disposed below the magnetic tunnel junction pillar.

公开(公告)号：US20170162782A1

公开(公告)日：2017-06-08

申请号：US15403830

申请日：2017-01-11

Applicant: International Business Machines Corporation

Inventor： Anthony J. Annunziata ,  Chandrasekharan Kothandaraman ,  Qinghuang Lin

IPC: H01L43/12 ,  H01L43/08 ,  H01L43/02

CPC classification number: H01L27/222 ,  G11C11/161 ,  H01L43/02 ,  H01L43/08 ,  H01L43/10 ,  H01L43/12

Abstract: Methods and devices are provided to construct magnetic devices, such as magnetic random access memory devices, having MTJ (magnetic tunnel junction) structures encapsulated in organic photopatternable dielectric material. For example, a method includes forming an MTJ structure on a semiconductor substrate, encapsulating the MTJ structure in a layer of organic photopatternable dielectric material, patterning the layer of organic photopatternable dielectric material to form a contact opening in the layer of organic photopatternable dielectric material to the MTJ structure, and filling the contact opening with metallic material.

公开(公告)号：US20160220996A1

公开(公告)日：2016-08-04

申请号：US15096933

申请日：2016-04-12

Applicant: International Business Machines Corporation

Inventor： Jingwei Bai ,  Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang

IPC: B01L3/00 ,  G01N33/487 ,  C12Q1/68

Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.

公开(公告)号：US20160209394A1

公开(公告)日：2016-07-21

申请号：US15085394

申请日：2016-03-30

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N33/487 ,  B01L3/00

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

公开(公告)号：US09364832B2

公开(公告)日：2016-06-14

申请号：US13944552

申请日：2013-07-17

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N27/447 ,  B01L3/00 ,  G01N33/487

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

Abstract translation: 用于通过生物聚合物分子的装置包括形成在表面起伏结构，形成纳米通道的侧壁的图案化层和形成在图案化层上以封装纳米通道的密封层之间的纳米通道。 表面浮雕结构包括三维圆形表面，其减小了在纳米通道的一部分处的纳米通道的通道尺寸，并且将纳米通道的尺寸逐渐增加到构造成接收生物聚合物的开口位置。

公开(公告)号：US09322061B2

公开(公告)日：2016-04-26

申请号：US14199248

申请日：2014-03-06

Applicant: International Business Machines Corporation

Inventor： Jingwei Bai ,  Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: C12Q1/68

CPC classification number: B01L3/502707 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0896 ,  B01L2300/12 ,  B01L2400/0415 ,  B01L2400/086 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0392 ,  B81C1/00103 ,  B82Y40/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/48721

Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.

Abstract translation: 一种技术包括形成具有宽度和深度梯度的梯度通道。 掩模设置在基板的顶部。 掩模被图案化为具有不同细长通道图案宽度的至少一个细长通道图案。 在单个蚀刻步骤中在衬底中蚀刻沟道，根据掩模中不同的细长沟道图案宽度，通道具有在单个蚀刻步骤中同时蚀刻的宽度梯度和相应的深度梯度。