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    DRYING TECHNIQUES FOR MICROFLUIDIC AND OTHER SYSTEMS
    71.
    发明申请
    DRYING TECHNIQUES FOR MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
    微流控和其他系统的干燥技术

    公开(公告)号：US20160271513A1

    公开(公告)日：2016-09-22

    申请号：US15032920

    申请日：2014-10-29

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： David A. Weitz ,  Esther Amstad ,  Frans Spaepen

    IPC: B01D1/18 ,  C01F11/46 ,  B01L3/00 ,  A61K9/16 ,  A61K31/216 ,  A61K31/58 ,  C01F11/18 ,  C01G49/02

    CPC classification number: B01D1/18 ,  A61K9/16 ,  A61K9/1641 ,  A61K31/216 ,  A61K31/58 ,  B01D1/14 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0896 ,  B22F1/0018 ,  B22F9/002 ,  B22F9/24 ,  C01F11/181 ,  C01F11/462 ,  C01G49/02 ,  F26B3/12

    Abstract: The present invention generally relates to microfluidics, and to spray drying and other drying techniques. Various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, the fluids may be dried relatively rapidly, resulting in spray-dried particles that are partially or completely amorphous. For instance, the fluid may contain salts, drugs, small molecules, ceramics, inorganic species, metals, sugars, polymers, etc., which may be dried to form partially or completely amorphous nanoparticles containing these species.

    Abstract translation: 本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。 本发明的各种实施方案通常涉及用于干燥包含在通道（例如微流体通道）内的流体的系统和方法。 例如，在喷射到收集区域之前，流体可以在微流体通道内部分或完全干燥。 在一些实施方案中，可以相对快速地干燥流体，导致部分或完全无定形的喷雾干燥颗粒。 例如，流体可以含有盐，药物，小分子，陶瓷，无机物质，金属，糖，聚合物等，其可以被干燥以形成包含这些物质的部分或完全无定形纳米颗粒。

    SPRAY DRYING TECHNIQUES
    72.
    发明申请
    SPRAY DRYING TECHNIQUES 审中-公开
    喷雾干燥技术

    公开(公告)号：US20160023126A1

    公开(公告)日：2016-01-28

    申请号：US14835508

    申请日：2015-08-25

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： Adam R. Abate ,  Julian W.P. Thiele ,  David A. Weitz ,  Christian Holtze ,  Maike Windbergs

    IPC: B01D1/18 ,  A61K31/58

    CPC classification number: B01D1/18 ,  A61K31/58 ,  F26B3/12

    Abstract: The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfluidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.

    Abstract translation: 本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。 在一些方面，使用含有一种或多种通道或微流体通道的制品在喷雾干燥之前混合一种或多种流体。 在流体通过喷嘴或其它开口排出到喷雾干燥器的干燥区域之前，混合可能发生。 在一组实施例中，例如，第一流体暴露于第二流体，然后在通过喷嘴排出之前将流体暴露于空气或其它气体。 在某些情况下，第一流体可以含有在暴露于第二流体时可能沉淀的溶解物质; 这样的沉淀可以在通过喷嘴或其他开口排出之前立即发生，从而导致作为喷雾干燥过程的一部分的受控沉淀。

    FORMATION AND CONTROL OF FLUIDIC SPECIES
    76.
    发明申请
    FORMATION AND CONTROL OF FLUIDIC SPECIES 审中-公开
    流体物种的形成与控制

    公开(公告)号：US20150283546A1

    公开(公告)日：2015-10-08

    申请号：US14662668

    申请日：2015-03-19

    Applicant: President and Fellows of Harvard College

    Inventor： Darren Roy Link ,  David A. Weitz ,  Manuel Marquez-Sanchez ,  Zhengdong Cheng

    IPC: B01L3/00

    CPC classification number: B01L3/502784 ,  B01F5/0682 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0431 ,  B01J2/04 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2300/0867 ,  B01L2400/02 ,  B01L2400/0415 ,  B01L2400/0424 ,  B05B5/03 ,  B05B7/061

    Abstract: This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.

    Abstract translation: 本发明一般涉及用于形成和/或控制流体物质的系统和方法，以及由这些系统和方法生产的制品。 在一些情况下，本发明涉及独特的流体通道，系统，控制和/或限制及其组合。 在某些实施方案中，本发明允许流体流（其可以是连续的或不连续的，即液滴）以各种尺度形成和/或组合，包括微流体尺度。 在一组实施例中，流体流可以从通道产生，其中流体流的横截面尺寸小于通道的横截面尺寸，例如通过使用结构元件，其它流体和/或 应用外场等。在某些情况下，可能产生泰勒锥。 在另一组实施例中，可以以某种方式操纵流体流，例如以产生管（其可以是中空或固体），液滴，嵌套管或液滴，管或液滴阵列，管的网格等。 在一些情况下，使用本发明的某些实施方案产生的液滴可能被充电或基本上带电，这可能允许它们进一步操作，例如使用外部应用场。 这种操作的非限制性实例包括产生带电液滴，聚集液滴（特别是微量级），同步液滴形成，使液滴中的分子对齐等。在一些情况下，液滴和/或流体流可包括胶体，细胞 ，治疗剂等。

    ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS
    78.
    发明申请
    ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS 有权
    测量和其他涉及倾销的反应

    公开(公告)号：US20140199730A1

    公开(公告)日：2014-07-17

    申请号：US14172266

    申请日：2014-02-04

    Applicant: President and Fellows of Harvard College

    Inventor： Jeremy Agresti ,  Liang-Yin Chu ,  David A. Weitz ,  Jin-Woong Kim ,  Amy Rowat ,  Morten Sommer ,  Gautam Dantas ,  George Church

    IPC: C12P19/34

    CPC classification number: C12P19/34 ,  B01F3/0807 ,  B01F3/0811 ,  B01F13/0062 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J13/0052 ,  B01J13/0065 ,  B01L3/502784 ,  C12Q1/6834 ,  C12Q1/6848 ,  C12Q1/686 ,  G01N15/1404 ,  G01N2015/1006

    Abstract: The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. In some aspects, a heterogeneous assay can be performed using a gel. For example, a droplet may be hardened to form a gel, where the droplet contains a cell, DNA, or other suitable species. The gel may be exposed to a reactant, and the reactant may interact with the gel and/or with the cell, DNA, etc., in some fashion. For example, the reactant may diffuse through the gel, or the hardened particle may liquefy to form a liquid state, allowing the reactant to interact with the cell. As a specific example, DNA contained within a gel particle may be subjected to PCR (polymerase chain reaction) amplification, e.g., by using PCR primers able to bind to the gel as it forms. As the DNA is amplified using PCR, some of the DNA will be bound to the gel via the PCR primer. After the PCR reaction, unbound DNA may be removed from the gel, e.g., via diffusion or washing. Thus, a gel particle having bound DNA may be formed in one embodiment of the invention.

    Abstract translation: 本发明通常涉及液滴和/或乳液，例如多重乳液。 在一些情况下，液滴和/或乳液可用于测定中，并且在某些实施方案中，液滴或乳液可被硬化以形成凝胶。 在一些方面，可以使用凝胶进行异质测定。 例如，液滴可以被硬化以形成凝胶，其中液滴包含细胞，DNA或其它合适的物质。 凝胶可以暴露于反应物，并且反应物可以以某种方式与凝胶和/或与细胞，DNA等相互作用。 例如，反应物可以扩散通过凝胶，或者硬化的颗粒可以液化以形成液体状态，允许反应物与细胞相互作用。 作为具体实例，包含在凝胶颗粒内的DNA可以进行PCR（聚合酶链式反应）扩增，例如通过使用能够在形成凝胶时结合凝胶的PCR引物。 当使用PCR扩增DNA时，一些DNA将通过PCR引物与凝胶结合。 PCR反应后，未结合的DNA可以从凝胶中去除，例如通过扩散或洗涤。 因此，可以在本发明的一个实施方案中形成具有结合DNA的凝胶颗粒。

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