公开(公告)号：US09796583B2

公开(公告)日：2017-10-24

申请号：US13488355

申请日：2012-06-04

Applicant: Jonathan R. Coppeta ,  Kurt Shelton ,  Norman F. Sheppard, Jr. ,  Douglas Snell ,  Catherine M. B. Santini

Inventor： Jonathan R. Coppeta ,  Kurt Shelton ,  Norman F. Sheppard, Jr. ,  Douglas Snell ,  Catherine M. B. Santini

IPC: B81C1/00 ,  A61K9/00 ,  B23K20/02 ,  F16B4/00 ,  F16B5/08 ,  F16B11/00 ,  H01L23/10 ,  H01L23/31 ,  B33Y80/00 ,  A61M5/142

CPC classification number: B81C1/00269 ,  A61K9/0097 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2207/00 ,  B23K20/02 ,  B33Y80/00 ,  B81B2201/06 ,  B81C1/00047 ,  B81C1/00095 ,  B81C2203/0109 ,  B81C2203/019 ,  B81C2203/038 ,  F16B4/004 ,  F16B5/08 ,  F16B11/004 ,  H01L23/10 ,  H01L23/3142 ,  H01L2224/05001 ,  H01L2224/05023 ,  H01L2224/051 ,  H01L2224/05568 ,  H01L2224/056 ,  H01L2224/16237 ,  H01L2224/81193 ,  H01L2924/01322 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/16315 ,  Y10T403/477 ,  H01L2924/00 ,  H01L2924/00014

Abstract: Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.

公开(公告)号：US20170135592A1

公开(公告)日：2017-05-18

申请号：US15421283

申请日：2017-01-31

Applicant: Kabushiki Kaisha Toshiba

Inventor： Yoshihiko Fuji ,  Hideaki Fukuzawa ,  Shiori Kaji

IPC: A61B5/021 ,  G01L9/00 ,  G01L9/16 ,  H04R19/04 ,  G01L1/12

CPC classification number: A61B5/02141 ,  B81B3/0078 ,  B81B2201/0257 ,  B81B2201/06 ,  G01L1/125 ,  G01L9/0041 ,  G01L9/16 ,  G06F3/0414 ,  H04R3/00 ,  H04R19/04 ,  H04R23/00 ,  H04R23/006 ,  H04R31/006 ,  H04R2201/003 ,  H04R2410/03 ,  H04R2420/07 ,  H04R2499/11

Abstract: According to one embodiment, a strain sensing element provided on a deformable substrate includes: a first magnetic layer; a second magnetic layer; a spacer layer; and a bias layer. Magnetization of the second magnetic layer changes according to deformation of the substrate. The spacer layer is provided between the first magnetic layer and the second magnetic layer. The second magnetic layer is provided between the spacer layer and the bias layer. The bias layer is configured to apply a bias to the second magnetic layer.

公开(公告)号：US20170043147A1

公开(公告)日：2017-02-16

申请号：US15275776

申请日：2016-09-26

Applicant: Shanghai Xinshenpai Technology Co., Ltd.

Inventor： Chris Yu

IPC: A61M37/00 ,  B81B7/00 ,  B81C1/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B01L3/502707 ,  B81B7/008 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00119 ,  B81C1/00246 ,  B81C1/00341 ,  B82Y5/00 ,  Y10T29/49124

Abstract: The present invention provides methods utilizing current nano-technological processes for fabricating a range of micro-devices with significantly expanded capabilities, unique functionalities at microscopic levels, enhanced degree of flexibilities, reduced costs and improved performance in the fields of bioscience and medicine. Such fabricated micro-devices have significant improvements in many areas over the existing, conventional methods, which include, but are not limited to reduced overall costs, early disease detection, targeted drug delivery, targeted disease treatment and reduced degree of invasiveness in treatment.

Abstract translation: 本发明提供了利用当前纳米技术方法制造具有显着扩展的能力的微量器件的范围，在微观水平上的独特功能，增强的柔性程度，降低的成本以及在生物科学和医学领域中改进的性能的方法。 这种制造的微器件在现有的常规方法中在许多领域具有显着的改进，其包括但不限于降低总体成本，早期疾病检测，靶向药物递送，靶向疾病治疗和降低的治疗侵袭程度。

公开(公告)号：US20160203258A1

公开(公告)日：2016-07-14

申请号：US14596284

申请日：2015-01-14

Applicant: International Business Machines Corporation

Inventor： Effendi Leobandung

IPC: G06F19/22

CPC classification number: C12Q1/6869 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B81B2201/058 ,  B81B2201/06 ,  C12Q2565/629 ,  G01N27/4145 ,  G01N27/4146 ,  G01N27/4148 ,  G01N27/44791 ,  G01N33/48721 ,  H01L21/266 ,  H01L21/31111 ,  H01L21/762 ,  H01L29/78696

Abstract: Embodiments of the invention include a method for fabricating a semiconductor device, the resulting structure, and a method for using the resulting structure. A substrate is provided. A hard mask layer is patterned over at least a portion of the substrate. Regions of the substrate not protected by the hard mask are doped to form a source region and a drain region. The hard mask layer is removed. A dielectric layer is deposited on the substrate. An insulative layer is deposited on the dielectric layer. A nano-channel is created by etching a portion of the insulative layer which passes over the source region and the drain region.

Abstract translation: 本发明的实施例包括制造半导体器件的方法，所得结构以及使用所得结构的方法。 提供基板。 在掩模的至少一部分上形成硬掩模层。 不经硬掩模保护的衬底的区域被掺杂以形成源极区域和漏极区域。 去除硬掩模层。 介电层沉积在基片上。 绝缘层沉积在电介质层上。 通过蚀刻通过源极区域和漏极区域的绝缘层的一部分来产生纳米通道。

公开(公告)号：US20150162141A1

公开(公告)日：2015-06-11

申请号：US14414174

申请日：2013-07-22

Applicant: MYCARTIS NV

Inventor： Raphael Tornay ,  Nicolas Demierre ,  Stephan Gamper ,  Philippe Renaud

IPC: H01G13/06

CPC classification number: H01G13/06 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00556 ,  B01J2219/00637 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/508 ,  B01L3/54 ,  B01L3/545 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0803 ,  B01L2300/0819 ,  B01L2300/0851 ,  B01L2300/0893 ,  B81B2201/058 ,  B81B2201/06 ,  B81C99/008 ,  G01N33/54313

Abstract: The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer having a sandwich structure comprising a bottom layer, a top layer and an insulating layer located between said bottom and top layers, (b) etching away the top layer to delineate lateral walls of bodies of the microcarriers, (c) depositing a first active layer at least on a top surface of the bodies, (d) applying a continuous polymer layer over the first active layer, (e) etching away the bottom layer and the insulating layer, (f) removing the polymer layer to release the microcarriers.

Abstract translation: 本发明涉及一种生产微载体的方法，包括以下步骤：（a）提供具有夹层结构的晶片，该夹层结构包括位于所述底层和顶层之间的底层，顶层和绝缘层，（b）蚀刻掉 描绘微载体的主体的侧壁的顶层，（c）至少在主体的顶表面上沉积第一有源层，（d）在第一有源层上施加连续聚合物层，（e）蚀刻掉 底层和绝缘层，（f）去除聚合物层以释放微载体。

公开(公告)号：US20140299574A1

公开(公告)日：2014-10-09

申请号：US14292396

申请日：2014-05-30

Applicant: Chang He Bio-Medical Science (Yangzhou) Co., Ltd.

Inventor： CHRIS YU

IPC: B81C1/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B01L3/502707 ,  B81B7/008 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00119 ,  B81C1/00246 ,  B81C1/00341 ,  B82Y5/00 ,  Y10T29/49124

Abstract: The present invention provides methods utilizing current nano-technological processes for fabricating a range of micro-devices with significantly expanded capabilities, unique functionalities at microscopic levels, enhanced degree of flexibilities, reduced costs and improved performance in the fields of bioscience and medicine. Such fabricated micro-devices have significant improvements in many areas over the existing, conventional methods, which include, but are not limited to reduced overall costs, early disease detection, targeted drug delivery, targeted disease treatment and reduced degree of invasiveness in treatment. Compared with existing, conventional approaches, the said inventive approach disclosed in this patent application is much more microscopic, sensitive, accurate, precise, flexible and effective.

Abstract translation: 本发明提供了利用当前纳米技术方法制造具有显着扩展的能力的微量器件的范围，在微观水平上的独特功能，增强的柔性程度，降低的成本以及在生物科学和医学领域中改进的性能的方法。 这种制造的微器件在现有的常规方法中在许多领域具有显着的改进，其包括但不限于降低总体成本，早期疾病检测，靶向药物递送，靶向疾病治疗和降低的治疗侵袭程度。 与现有的常规方法相比，本专利申请中公开的所述发明方法更微观，灵敏，准确，精确，灵活和有效。

公开(公告)号：US20130149196A1

公开(公告)日：2013-06-13

申请号：US13805491

申请日：2011-06-29

Applicant: Vincent Agache ,  Antoine Hoang ,  Francoise Vinet

Inventor： Vincent Agache ,  Antoine Hoang ,  Francoise Vinet

IPC: G03F7/24

CPC classification number: G03F7/24 ,  B81B2201/0214 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00206 ,  B81C2201/0154 ,  F04B19/006

Abstract: The present invention relates to a method for functionalising fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalising a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a). The method includes the following steps: a) providing a device, the peripheral wall (5) of which at least partially includes a silicon layer (5a) having, at least locally, a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm; c) silanising at least the inner surface of the fluid line; d) the localised, selective photo-deprotection on at least the inner surface of the silanised device by exposing the peripheral wall (5) at the point at which said wall has a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm.

Abstract translation: 本发明涉及一种在微机械装置中功能化流体管线（1b）的方法，其中壁部包括不透明层。 为此，本发明提供了一种功能化微机械装置的方法，该微机械装置具有流体管线，该流体管线包括具有在管线外部的表面（2）的周壁（5）和限定空间（1b）的内表面（3），其中 流体可以循环，周壁至少部分地包括硅层（5a）。 该方法包括以下步骤：a）提供一种器件，其外围壁（5）至少部分地包括硅层（5a），该硅层至少局部地具有大于100nm的厚度（e）并且小于 200nm，有利地为160〜180nm; c）至少对流体管线的内表面进行硅烷化; d）通过在所述壁的厚度（e）大于100nm且小于200nm的点处暴露周壁（5），至少在硅烷化装置的内表面上进行局部选择性光 - 去保护 ，有利地为160至180nm。

公开(公告)号：US08425828B2

公开(公告)日：2013-04-23

申请号：US13279036

申请日：2011-10-21

Applicant: Joanna Aizenberg ,  Thomas Nikita Krupenkin ,  Oleksander Sydorenko ,  Joseph Ashley Taylor

Inventor： Joanna Aizenberg ,  Thomas Nikita Krupenkin ,  Oleksander Sydorenko ,  Joseph Ashley Taylor

IPC: F03G7/06

CPC classification number: C09D5/00 ,  B81B3/0089 ,  B81B2201/06 ,  B81B2203/0361 ,  B82Y30/00 ,  Y10T428/24 ,  Y10T428/24174 ,  Y10T428/24273 ,  Y10T428/24355 ,  Y10T428/24496 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31511 ,  Y10T428/31663

Abstract: An apparatus includes a substrate having a top surface, a substantially regular array of raised structures located over the top surface, and a layer located on the top surface between the structures. Distal surfaces of the structures are farther from the top surface than remaining portions of the structures. The layer is able to contract such that the distal surfaces of the structures protrude through the layer. The layer is able to swell such that the distal surfaces of the structures are closer to the top surface of the substrate than one surface of the layer.

Abstract translation: 一种装置包括具有顶表面，位于顶表面上方的基本上规则的凸起结构阵列的基底和位于结构之间的顶表面上的层。 结构的远端表面比结构的剩余部分远离顶表面。 该层能够收缩，使得结构的远端表面突出穿过该层。 该层能够膨胀，使得结构的远端表面比该层的一个表面更靠近衬底的顶表面。

公开(公告)号：US08273533B2

公开(公告)日：2012-09-25

申请号：US11670207

申请日：2007-02-01

Applicant: Jong-suk Chung ,  Kyu-youn Hwang ,  Jeo-young Shim

Inventor： Jong-suk Chung ,  Kyu-youn Hwang ,  Jeo-young Shim

IPC: C12Q1/68

CPC classification number: B81C1/00206 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00722 ,  B81B2201/06 ,  B82Y30/00 ,  C40B50/18

Abstract: Provided is a method of preparing a patterned spot microarray using a photocatalyst. The method comprises coating the photocatalyst on a substrate to form a photocatalyst layer, coating a composition comprising a functional group to be connected to a biomolecule on the photocatalyst layer to form an organic layer, spotting the biomolecule on the organic layer, positioning a photomask above a spot of the biomolecule; and irradiating the spot through the photomask to pattern the spot.

Abstract translation: 提供了使用光催化剂制备图案化斑点微阵列的方法。 该方法包括将光催化剂涂覆在基材上以形成光催化剂层，涂覆包含要连接到光催化剂层上的生物分子的官能团的组合物以形成有机层，将生物分子点在有机层上，将光掩模放在上面 生物分子的一个点; 并通过光掩模照射斑点以对斑点进行图案化。

公开(公告)号：US20120145572A1

公开(公告)日：2012-06-14

申请号：US13265044

申请日：2010-04-20

Applicant: Juergen Brugger ,  Cristina Martin-Olmos ,  Alcherio Martinoli ,  Gregory Mermoud

Inventor： Juergen Brugger ,  Cristina Martin-Olmos ,  Alcherio Martinoli ,  Gregory Mermoud

IPC: B65D25/08 ,  B32B1/06 ,  B32B5/16

CPC classification number: B81C1/00007 ,  A61J3/07 ,  A61K9/0097 ,  A61K9/5089 ,  B81B2201/06 ,  B81C99/0095 ,  B81C2201/038 ,  B81C2203/051 ,  C09B67/0097 ,  Y10T428/2984

Abstract: A method for fabricating a fluid container, wherein at least two half containers are mated in said fluid to be contained in said container. This method allows the incorporation of prefabricated devices into each half containers as well as the functional coupling of these devices after mating of the half containers, thus resulting in a functional hybrid MEMS fluid container.

Abstract translation: 一种用于制造流体容器的方法，其中至少两个半容器在所述待容纳在所述容器中的流体中配合。 这种方法允许将预制装置并入每个半容器以及这些装置在半容器配合之后的功能耦合，从而导致功能性混合MEMS流体容器。