公开(公告)号：US06176874B1

公开(公告)日：2001-01-23

申请号：US08477226

申请日：1995-06-07

申请人： Joseph P. Vacanti ,  Linda G. Cima ,  Michael J. Cima

发明人： Joseph P. Vacanti ,  Linda G. Cima ,  Michael J. Cima

IPC分类号： A61F200

CPC分类号： A61F2/105 ,  A61F2/022 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/0086 ,  A61F2002/009 ,  A61F2002/30011 ,  A61F2002/30032 ,  A61F2002/30034 ,  A61F2002/30062 ,  A61F2002/30199 ,  A61F2002/3028 ,  A61F2002/30677 ,  A61F2002/3093 ,  A61F2002/30932 ,  A61F2002/30962 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/003 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L27/3808 ,  A61L27/40 ,  A61L27/56 ,  A61L27/60 ,  B29C64/135 ,  B29C64/165 ,  B29K2995/0064 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y80/00 ,  Y10S623/901 ,  A61L27/38

摘要： Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents, wherein the matrix is characterized by a network of lumens functionally equivalent to the naturally occurring vasculature of the tissue formed by the implanted cells, and which can be lined with endothelial cells and coupled to blood vessels at the time of implantation to form a vascular network throughout the matrix. The SFF methods can be adapted for use with a variety of polymeric, inorganic and composite materials to create structures with defined compositions, strengths, and densities, using computer aided design (CAD). Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP).

摘要翻译： 固体自由形式制造（SFF）方法用于制造用于允许组织再生和用于种植和植入细胞以形成器官和结构组分的装置，其可另外提供生物活性剂的受控释放，其中所述基质的特征在于： 流体功能上等同于由植入的细胞形成的组织的天然存在的脉管系统，并且其可以在植入时与内皮细胞排列并耦合到血管，以在整个基质中形成血管网络。 SFF方法可以适用于各种聚合物，无机和复合材料，以使用计算机辅助设计（CAD）创建具有确定的组成，强度和密度的结构。SFF方法的实例包括立体光刻（SLA）， 选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维打印（3DP）。

公开(公告)号：US06172009B2

公开(公告)日：2001-01-09

申请号：US09470926

申请日：1999-12-22

申请人： John A. Smith ,  Michael J. Cima ,  Neville Sonnenberg

发明人： John A. Smith ,  Michael J. Cima ,  Neville Sonnenberg

IPC分类号： H01L3924

CPC分类号： H01L39/2451 ,  Y10S428/93 ,  Y10S505/742

摘要： An oxide superconductor article is provided having an oxide superconductor film having a thickness of greater than 0.5 microns disposed on a substrate, said article having a transport critical current density (Jc) of greater than or equal to about 105 A/cm2 at 77 K, zero field. The oxide superconductor film is characterized by high Jc and high volume percent of c-axis epitaxial oxide grains, even with thicknesses of up to 1 micron. The oxide superconductor article is prepared by providing a metal oxyfluoride film, said metal oxyfluoride film comprising the constituent metallic elements of an oxide superconductor in substantially stoichiometric proportions; and converting the metal oxyfluoride into the oxide superconductor at a rate of conversion selected by adjusting a reaction parameter selected from the group consisting of temperature, PH2O, PO2, and time and combinations thereof, such that an oxide superconductor film having a transport critical current density of greater than or equal to about 105 A/cm2 at 77 K, zero field is obtained.

摘要翻译： 提供氧化物超导体制品，其具有设置在基底上的具有大于0.5微米厚度的氧化物超导体膜，所述制品在77K下具有大于或等于约105A / cm 2的输送临界电流密度（Jc） 零场。 氧化物超导体膜的特征在于高Jc和高体积百分比的c轴外延氧化物晶粒，即使厚度高达1微米。 通过提供金属氟氧化物膜制备氧化物超导体制品，所述金属氟氧化物膜包含基本上化学计量比的氧化物超导体的构成金属元素; 以及通过调节从由温度，PH 2 O，PO 2及其组合组成的组中选择的反应参数所选择的转化率将金属氟氧化物转化为氧化物超导体，使得具有传输临界电流密度的氧化物超导体膜 在77K下大于或等于约105A / cm 2，获得零场。

公开(公告)号：US5204055A

公开(公告)日：1993-04-20

申请号：US447677

申请日：1989-12-08

申请人： Emanuel M. Sachs ,  John S. Haggerty ,  Michael J. Cima ,  Paul A. Williams

发明人： Emanuel M. Sachs ,  John S. Haggerty ,  Michael J. Cima ,  Paul A. Williams

IPC分类号： B22F7/04 ,  B05C19/04 ,  B22F3/00 ,  B28B1/32 ,  B28B7/00 ,  B29C41/00 ,  B29C41/12 ,  B29C41/36 ,  B29C67/00 ,  B29C67/02 ,  B29C67/04 ,  B29C67/24 ,  B30B15/30 ,  B32B27/00 ,  B41J2/01 ,  B41J2/085 ,  B41J2/09 ,  B65G65/48 ,  G06T11/00 ,  H05K3/10

CPC分类号： B29C67/0081 ,  B05C19/04 ,  B22F3/004 ,  B22F3/008 ,  B28B1/001 ,  B29C41/006 ,  B29C41/12 ,  B29C41/36 ,  B29C67/0059 ,  B29C67/02 ,  B29C67/04 ,  B29C67/243 ,  B30B15/302 ,  B41J2/01 ,  B41J2/085 ,  B41J2/09 ,  H05K3/102 ,  B22F2998/00 ,  G05B2219/49013 ,  H05K2203/013 ,  H05K2203/0522 ,  Y10T428/12014 ,  Y10T428/12021

摘要： A process for making a component by depositing a first layer of a fluent porous material, such as a powder, in a confined region and then depositing a binder material to selected regions of the layer of powder material to produce a layer of bonded powder material at the selected regions. Such steps are repeated a selected number of times to produce successive layers of selected regions of bonded powder material so as to form the desired component. The unbonded powder material is then removed. In some cases the component may be further processed as, for example, by heating it to further strengthen the bonding thereof.

摘要翻译： （A）在密闭区域中沉积第一层粉末材料，然后（B）将粘合剂材料沉积到粉末材料层的选定区域以在该区域形成粘结粉末材料层的方法 选定地区。 这样的步骤重复选定次数以产生粘结粉末材料（C）的选定区域的连续层，以便形成所需组分（D）。 然后除去未结合的粉末材料（E）。 在一些情况下，可以例如通过加热组分进一步加强其粘合来进一步加工组分。

公开(公告)号：US09586035B2

公开(公告)日：2017-03-07

申请号：US12333182

申请日：2008-12-11

申请人： Michael J. Cima ,  Heejin Lee

发明人： Michael J. Cima ,  Heejin Lee

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K31/167

CPC分类号： A61M25/0102 ,  A61F2250/0068 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/167 ,  A61M25/0108 ,  A61M31/002 ,  A61M2205/0216 ,  A61M2210/1085

摘要： An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

摘要翻译： 提供可植入的医疗装置用于膀胱或其他体内囊泡内的受控药物输送。 该装置可以包括至少一个包含药物的药物储存器部件; 以及囊泡保持框架，其包括具有第一端，相对的第二端和在其间的中间区域的弹性线，其中所述药物储存部件附接到所述囊泡保持框架的中间区域。 保持框架防止装置从膀胱意外排空，并且其优选地具有选择用于装置的弹簧常数，以在排尿期间有效地停留在膀胱中，同时使膀胱的刺激最小化。

公开(公告)号：US09395286B2

公开(公告)日：2016-07-19

申请号：US13977108

申请日：2011-12-30

申请人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

发明人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

IPC分类号： C12M1/34 ,  C12M1/00 ,  C12Q1/70 ,  G01N33/53 ,  G01N1/34 ,  A61F2/01 ,  G01N33/543

CPC分类号： G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

摘要翻译： 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置是否存在医用分析物。

公开(公告)号：US20130150707A1

公开(公告)日：2013-06-13

申请号：US13806348

申请日：2011-06-27

申请人： Michael J. Cima ,  Paul Huang ,  Yibo Ling ,  Terrence Pong ,  Christophoros C. Vassiliou

发明人： Michael J. Cima ,  Paul Huang ,  Yibo Ling ,  Terrence Pong ,  Christophoros C. Vassiliou

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0031 ,  A61B5/14546 ,  A61B2562/0285 ,  G01R33/302 ,  G01R33/50 ,  G01R33/5601

摘要： An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.

摘要翻译： 提供了一种可植入磁性松弛传感器，其包括用与感兴趣的生物标志物结合的一种或多种试剂官能化的超顺磁性纳米颗粒。 该传感器被配置为用于对人或动物的微创植入，并且被配置为通过使用磁共振弛豫测定的分析来指示植入的传感器对感兴趣的生物标志物的累积暴露。

公开(公告)号：US08378552B2

公开(公告)日：2013-02-19

申请号：US13316833

申请日：2011-12-12

申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

IPC分类号： H01L41/08

CPC分类号： F03G7/005 ,  H01M2/16 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M6/30 ,  H01M2004/021 ,  H01M2010/4292

摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

公开(公告)号：US20110202036A1

公开(公告)日：2011-08-18

申请号：US12879638

申请日：2010-09-10

申请人： Jim Boyko ,  Grace Kim ,  Heejin Lee ,  Michael J. Cima ,  Jennie Kwo

发明人： Jim Boyko ,  Grace Kim ,  Heejin Lee ,  Michael J. Cima ,  Jennie Kwo

IPC分类号： A61M31/00 ,  A61M25/00 ,  A61M5/32

CPC分类号： A61L29/16 ,  A61M25/007 ,  A61M25/0662 ,  A61M31/002 ,  A61M31/007 ,  A61M2210/1085

摘要： A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.

摘要翻译： 一种方法通过尿道递送可植入装置并进入膀胱。 将部署仪器插入到尿道中，将可植入装置插入到展开仪器中，并将流体流注入到展开仪器中。 流体流将可植入装置从展开器械驱动到膀胱中。 将部署仪器从尿道中取出，将可植入装置完全植入膀胱。

公开(公告)号：US20110196187A1

公开(公告)日：2011-08-11

申请号：US12704092

申请日：2010-02-11

申请人： Florian Niklas Ludwig ,  Syed Faiyaz Ahmed Hossainy ,  Bjorn Svensson ,  Adam Sharkawy ,  Michael J. Cima ,  Omid C. Farokhzad ,  Jesus Magana ,  Randolf Von Oepen ,  Mina Chow ,  William E. Webler, JR. ,  Travis R. Yribarren ,  Kevin J. Ehrenreich

发明人： Florian Niklas Ludwig ,  Syed Faiyaz Ahmed Hossainy ,  Bjorn Svensson ,  Adam Sharkawy ,  Michael J. Cima ,  Omid C. Farokhzad ,  Jesus Magana ,  Randolf Von Oepen ,  Mina Chow ,  William E. Webler, JR. ,  Travis R. Yribarren ,  Kevin J. Ehrenreich

IPC分类号： A61N2/00

CPC分类号： A61N2/002

摘要： Apparatuses for delivering compositions of matter comprising a magnetically sensitive drug carrier and a related drug and methods for causing the drug carriers to localize within the patient using an internal or external magnetic field are described.

摘要翻译： 描述用于递送包含磁敏感药物载体和相关药物的物质组合物的装置和使用内部或外部磁场使药物载体定位在患者体内的方法。

公开(公告)号：US20110187015A1

公开(公告)日：2011-08-04

申请号：US12979484

申请日：2010-12-28

申请人： WENDY E. PRYCE LEWIS ,  MICHAEL J. CIMA ,  CHARLES W ROWE ,  PETER A. MATERNA

发明人： WENDY E. PRYCE LEWIS ,  MICHAEL J. CIMA ,  CHARLES W ROWE ,  PETER A. MATERNA

IPC分类号： A61K9/20

CPC分类号： A61K9/20 ,  A61J3/10 ,  A61K9/2095 ,  B29C64/00 ,  B29C64/165 ,  B29C67/0051 ,  B29C67/0081 ,  B29L2031/753 ,  B33Y70/00 ,  B33Y80/00

摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.

摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。