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81.
公开(公告)号:US20180100865A1
公开(公告)日:2018-04-12
申请号:US15819500
申请日:2017-11-21
Applicant: VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
Inventor: Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC classification number: G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
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公开(公告)号:US20180088062A1
公开(公告)日:2018-03-29
申请号:US15717961
申请日:2017-09-28
Applicant: BRUKER JV ISRAEL LTD.
Inventor: Isaac Mazor , Yuri Vinshtein , Matthew Wormington , Nikolai Kasper
CPC classification number: G01N23/20091 , G01N23/20008 , G01N23/201 , G01N2223/0563 , G01S17/08 , G01S17/48 , G01S17/88
Abstract: Apparatus for X-ray scatterometry includes an X-ray source, which directs an X-ray beam to be incident at a grazing angle on an area of a surface of a sample, and an X-ray detector measures X-rays scattered from the area. A knife edge is arranged parallel to the surface of the sample in a location adjacent to the area so as to define a gap between the surface and the knife edge and to block a portion of the X-ray beam that does not pass through the gap. A motor moves the knife edge perpendicular to the surface so as to control a size of the gap. An optical rangefinder receives optical radiation reflected from the surface and outputs a signal indicative of a distance of the knife edge from the surface. Control circuitry drives the motor responsively to the signal in order to regulate the size of the gap.
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公开(公告)号:US09921173B2
公开(公告)日:2018-03-20
申请号:US14761315
申请日:2014-01-02
Applicant: The Nottingham Trent University , Cranfield University
Inventor: Paul Evans , Keith Rogers
IPC: G01N23/20 , G01N23/205 , G01N23/04 , H04N5/232 , H04N5/32
CPC classification number: G01N23/2055 , G01N23/046 , G01N23/20008 , G01N23/20083 , G01N2223/419 , G01N2223/64 , H04N5/23293 , H04N5/32
Abstract: A sample (106) is irradiated with electromagnetic radiation such as X-Rays and diffraction data is sampled at inner and outer caustic rims formed at a sensor surface (108) and defined by a continuum of Debye cones (130, 132) formed by diffraction of the incident radiation. Intensities of the inner and outer rims while translating and rotating the sample are converted using a tomographic technique into X-ray diffraction images and material discrimination is also possible.
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84.
公开(公告)号:US20180067126A1
公开(公告)日:2018-03-08
申请号:US15816505
申请日:2017-11-17
Applicant: VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
Inventor: Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC classification number: G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
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公开(公告)号:US09891584B2
公开(公告)日:2018-02-13
申请号:US14839738
申请日:2015-08-28
Applicant: Bosheng Zhang , Matthew D. Seaberg , Daniel E. Adams , Henry C. Kapteyn , Margaret M. Murnane
Inventor: Bosheng Zhang , Matthew D. Seaberg , Daniel E. Adams , Henry C. Kapteyn , Margaret M. Murnane
IPC: H04N19/124 , G01N23/20 , G01N23/2055 , G03H1/04 , G02B21/00 , G02B27/42 , G03H1/16 , G03F7/20 , G03F1/84 , G01N23/205 , H04N19/109 , G03H1/00 , G01N21/47 , G01N21/956
CPC classification number: G03H1/0443 , G01N21/4788 , G01N23/20 , G01N23/2055 , G01N2021/95676 , G01N2223/33 , G01N2223/345 , G01N2223/611 , G01N2223/6116 , G02B21/0016 , G02B27/4205 , G03F1/84 , G03F7/70625 , G03H1/0465 , G03H1/0866 , G03H1/16 , G03H2001/005 , G03H2001/0445 , G03H2001/0447 , G03H2001/045 , G03H2001/0456 , G03H2001/0473 , G03H2001/0825 , G03H2240/62 , G21K7/00 , G21K2207/005
Abstract: Apparatus and methods for coherent diffractive imaging with arbitrary angle of illumination incidence utilize a method of fast remapping of a detected diffraction intensity pattern from a detector pixel array (initial grid) to a uniform spatial frequency grid (final grid) chosen to allow for FFT on the remapped pattern. This is accomplished by remapping the initial grid to an intermediate grid chosen to result in a final grid that is linear in spatial frequency. The initial grid is remapped (generally by interpolation) to the intermediate grid that is calculated to correspond to the final grid. In general, the initial grid (x,y) is uniform in space, the intermediate grid ({tilde over (x)},{tilde over (y)}) is non-uniform in spatial frequency, and the final grid ({tilde over (f)}x,{tilde over (f)}y) is uniform in spatial frequency.
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公开(公告)号:US20180017510A1
公开(公告)日:2018-01-18
申请号:US15642533
申请日:2017-07-06
Applicant: United States Gypsum Company
Inventor: James W. Barber , Feng Peng
IPC: G01N23/22 , G01N1/40 , G01N23/20 , G01N23/225
CPC classification number: G01N23/2206 , G01N1/4005 , G01N15/0625 , G01N15/1456 , G01N15/1468 , G01N23/2005 , G01N23/20091 , G01N23/2251 , G01N2015/0061 , G01N2015/1497
Abstract: Provided is a method for detecting respirable participles in a bulk material comprising particles. The method comprises: analyzing morphology of the particles; analyzing chemical composition of the particles; creating a profile of the particles, wherein each particle in the profile is characterized by its shape, size and chemical composition; selecting particles from the profile which match the size and chemical composition of a respirable particle; and calculating a percentage of the respirable particles in the bulk material.
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87.
公开(公告)号:US20180017477A1
公开(公告)日:2018-01-18
申请号:US15649626
申请日:2017-07-13
Applicant: John Mauro & Associates, LLC
Inventor: John Mauro
CPC classification number: G01N15/0618 , G01N15/02 , G01N23/20 , G01N2015/0046 , G01N2223/638 , G01N2223/641 , G01N2223/652 , G01T1/178
Abstract: A continuous alpha monitor includes an air intake mechanism, which in turn includes an air mover and an air flowrate monitor, an air intake prefilter that limits particulates in the air intake mechanism to an aerodynamic diameter of 10 microns or less, and a particle size detector mounted downstream of the air intake prefilter, the air particle size detector providing a distribution of aerodynamic diameters of particulates in air passing the prefilter, the particulates including depleted uranium particulates. The monitor further includes a sample filter mechanism that collects the particulates; a detector mechanism that detects alpha radiation emitted by the collected particulates; a dust loading mechanism that computes a dust thickness on the sample filter mechanism; and an output mechanism that provides an indication of alpha concentration detected by the detector mechanism.
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公开(公告)号:US09861330B2
公开(公告)日:2018-01-09
申请号:US13878841
申请日:2011-10-17
Applicant: Ewald Rössl
Inventor: Ewald Rössl
CPC classification number: A61B6/484 , A61B6/032 , A61B6/06 , A61B6/4035 , A61B6/4291 , G01N23/046 , G01N23/20075 , G21K1/06 , G21K1/067
Abstract: The present invention relates to differential phase-contrast imaging, in particular to a structure of a diffraction grating, e.g. an analyzer grating and a phase grating, for X-ray differential phase-contrast imaging. In order to provide enhanced phase-gradient based image data, a diffraction grating (14, 15) for X-ray differential phase-contrast imaging, is provided with a first sub-area (23) comprising at least one portion (24) of a first grating structure (26) and at least one portion (28) of a second grating structure (30). The first grating structure comprises a plurality of bars (34) and gaps (36) with a first grating orientation GO1 (37), being arranged periodically, wherein the bars are arranged such that they change the phase and/or amplitude of an X-ray radiation and wherein the gaps are X-ray transparent. The second grating structure comprises a plurality of bars (40) and gaps (42) with a second grating orientation GO2 (44), being arranged periodically, wherein the bars are arranged such that they change the phase and/or amplitude of an X-ray radiation and wherein the gaps are X-ray transparent. The first grating orientation GO1 is different than the second grating orientation GO2. Thus, phase-gradient based image information can be acquired for different directions without the necessity to rotate or pivot any of the respective gratings between the acquisition steps, for example.
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89.
公开(公告)号:US20180005737A1
公开(公告)日:2018-01-04
申请号:US15541505
申请日:2015-12-28
Applicant: DOWA ELECTRONICS MATERIALS CO., LTD.
Inventor: Kenji SAKANE , Tetsuya KAWAHITO
IPC: H01F1/03 , G11B5/842 , H01F1/00 , C01G49/06 , C01G51/00 , B82Y25/00 , H01F1/147 , G11B5/714 , B82Y40/00 , H01F1/153 , C01G53/00 , C01G23/00 , C01G45/00 , G01N23/20
CPC classification number: H01F1/0315 , B82Y25/00 , B82Y30/00 , B82Y40/00 , C01G23/003 , C01G45/006 , C01G49/0018 , C01G49/02 , C01G49/06 , C01G51/00 , C01G51/006 , C01G53/006 , C01P2002/52 , C01P2002/72 , C01P2004/04 , C01P2004/64 , C01P2006/42 , G01N23/20075 , G11B5/70642 , G11B5/712 , G11B5/714 , G11B5/842 , H01F1/0054 , H01F1/14725 , H01F1/15366
Abstract: An iron-based oxide magnetic particle powder has a narrow particle size distribution a small content of fine particles that do not contribute to magnetic recording characteristics, and a narrow coercive force distribution, to enhance magnetic recording medium density. Neutralizing an aqueous solution containing a trivalent iron ion and an ion of the metal substituting a part of the Fe sites by adding an alkali to make pH of 1.5 or more and 2.5 or less, adding a hydroxycarboxylic acid, and further neutralizing by adding an alkali to make pH of 8.0 or more and 9.0 or less are performed at 5° C. or more and 25° C. or less. A formed iron oxyhydroxide precipitate containing the substituting metal element is rinsed with water, then coated with silicon oxide, and then heated thereby providing e-type iron-based oxide magnetic particle powder. The rinsed precipitate may be subjected to a hydrothermal treatment.
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90.
公开(公告)号:US20170369793A1
公开(公告)日:2017-12-28
申请号:US15700089
申请日:2017-09-09
Applicant: CHIYODA CORPORATION
Inventor: Kenichi IMAGAWA , Haruto KOBAYASHI , Akihiro MUTO , Shinichi INOUE
Abstract: A hydrogenation catalyst with a small amount of supported metal that is excellent in stability and inhibition of side reactions is provided. The catalyst hydrogenates an aromatic hydrocarbon compound into an alicyclic hydrocarbon compound, and a Group X metal represented by nickel is supported in a composite support including at least alumina and titania. The composite support preferably includes at least an alumina substrate coated with titania. It is also preferable that the Group X metal is prereduced by hydrogen. In the case that the Group X metal is nickel, the nickel content is preferably 5-35 wt % as nickel oxide in the catalyst. The substrate includes, for example, a porous structure formed by a plurality of needle-shaped or column-shaped intertwined three-dimensionally.
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