公开(公告)号：US5939319A

公开(公告)日：1999-08-17

申请号：US634167

申请日：1996-04-18

申请人： Dennis Hlavinka ,  Frank Corbin

发明人： Dennis Hlavinka ,  Frank Corbin

IPC分类号： A61M1/02 ,  A61M1/36 ,  B04B5/04 ,  B04B11/04 ,  C12N1/00

CPC分类号： A61M1/3693 ,  A61M1/0227 ,  A61M1/0236 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  B04B5/0428 ,  B04B5/0442 ,  B04B2005/0471

摘要： An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. A saturated fluidized bed of first particles forms within the fluid chamber and obstructs flow of second particles through the chamber. Additive substances alter sedimentation velocity of the first particles to modify the filtration characteristics of the saturated fluidized bed.

公开(公告)号：US5928177A

公开(公告)日：1999-07-27

申请号：US712488

申请日：1996-09-11

申请人： James Brugger ,  Dan Lee Hendrickson ,  Jeff Burbank

发明人： James Brugger ,  Dan Lee Hendrickson ,  Jeff Burbank

IPC分类号： A61M1/10 ,  A61M1/16 ,  A61M1/36 ,  A61M25/00 ,  F04B43/12 ,  A61M37/00

CPC分类号： A61M1/10 ,  A61M1/1039 ,  A61M1/16 ,  A61M1/3639 ,  F04B43/1253 ,  F04B43/1284 ,  A61M2025/0002 ,  A61M2205/12

摘要： A pivotable cover secures a pump header or tubing to a peristaltic pump of a dialysis machine. The cover includes an integral raceway for engaging the pump header as a rotor of the peristaltic pump rotates along the integral raceway. The cover is pivoted away from the dialysis machine to separate the raceway from the rotor and provide substantial access for loading the pump header about the rotor. The cover is then closed to secure the pump header in place and properly position the integral raceway in relation to the pump rotor. If the pump header is connected to a blood tubing set, the cover also secures the blood tubing set in position against the dialysis machine. A detachable hinge connects the cover to the dialysis machine to allow the cover to be completely detached from the dialysis machine. The detachable cover provides complete access for cleaning the area surrounding the peristaltic pump rotor and the location where the blood tubing set is located.

摘要翻译： 可枢转的盖子将泵头或管道固定到透析机的蠕动泵。 盖子包括一个整体的滚道，用于在蠕动泵的转子沿整体滚道旋转时与泵头接合。 盖子离开透析机枢转，以将滚道与转子分离，并提供用于将泵头装载在转子周围的实质进入。 然后关闭盖子以将泵头固定到位，并将整体滚道相对于泵转子正确定位。 如果泵头连接到血管套管，则盖子还将血液管道固定在适合透析机的位置。 可拆卸的铰链将盖子连接到透析机器，以允许盖子与透析机完全分离。 可拆卸的盖子提供了清洁蠕动泵转子周围区域和血管套管所在位置的完整通道。

公开(公告)号：US5900726A

公开(公告)日：1999-05-04

申请号：US876445

申请日：1997-06-16

申请人： James M. Brugger ,  George W. Buffaloe, IV ,  Francis T. Ogawa

发明人： James M. Brugger ,  George W. Buffaloe, IV ,  Francis T. Ogawa

IPC分类号： A61M1/16 ,  A61M1/36 ,  G01F1/704 ,  G01F1/708 ,  G01N27/02 ,  G01N33/487 ,  G01N27/08

CPC分类号： A61M1/16 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/3669 ,  G01F1/7046 ,  G01F1/708 ,  G01F1/7088

摘要： A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the altered conductivity fluid to pass a conductivity measuring location. The measured conductivity is integrated over the time it takes to pass the conductivity measuring location. The integral is interpreted to determine the flow rate.

公开(公告)号：US5800978A

公开(公告)日：1998-09-01

申请号：US475835

申请日：1995-06-07

申请人： Raymond P. Goodrich, Jr. ,  Samuel O. S. Coker ,  Francoise Arnaud ,  Roger W. Hackett

发明人： Raymond P. Goodrich, Jr. ,  Samuel O. S. Coker ,  Francoise Arnaud ,  Roger W. Hackett

IPC分类号： C12N5/06 ,  A01N1/02 ,  C12N5/00 ,  G01N31/00

CPC分类号： A01N1/0221 ,  A01N1/02 ,  A01N1/0284 ,  Y10T436/108331

摘要： A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.

公开(公告)号：US5762805A

公开(公告)日：1998-06-09

申请号：US480489

申请日：1995-06-07

申请人： Lori A. Truitt ,  Frank Corbin, III ,  Donn D. Lobdell ,  Douglas P. Miller ,  Keith Manica ,  George J. Eilers ,  Steven H. Johnson ,  Lawrence L. Leppert

发明人： Lori A. Truitt ,  Frank Corbin, III ,  Donn D. Lobdell ,  Douglas P. Miller ,  Keith Manica ,  George J. Eilers ,  Steven H. Johnson ,  Lawrence L. Leppert

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  C07K14/47 ,  C07K16/40 ,  C12N9/64 ,  G01N33/573 ,  G01N33/68 ,  B01D61/00 ,  B01D61/32

CPC分类号： A61M1/16 ,  A61M1/1643 ,  A61M1/3431 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3468 ,  A61M1/3643 ,  C07K14/4711 ,  C07K16/40 ,  C12N9/6421 ,  G01N33/573 ,  G01N33/6896 ,  A61M1/3413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3393 ,  A61M2205/505 ,  A61M2209/084 ,  Y10S210/929

摘要： Blood from a patient is treated extracorporeally by any selected one of a plurality of predetermined treatments. Each of the treatments involves the flow of blood from the patient into a primary chamber of a filtration unit, past a semipermeable membrane located in the filtration unit which separates the primary chamber from a secondary chamber of the filtration unit, out the filtration unit and back to the patient. A replacement fluid is selectively and controllably added to the blood, as required for the selected treatment. A secondary fluid is controllably and selectively introduced into the secondary chamber of the filtration unit for controllably collecting material passing across the semipermeable membrane from the blood or for supplying material to pass across the semipermeable membrane into the blood as required for the selected treatment. Materials are removed from the secondary chamber and collected in accordance with the selected treatment. Blood leaks into the secondary chamber are automatically detected and the rates of blood and fluid flow automatically adjusted in response thereto. An apparatus which automatically performs and monitors the selected treatment is also described.

摘要翻译： 来自患者的血液通过多种预定治疗中的任意选择进行体外治疗。 每个处理涉及从患者流入到过滤单元的主室中的血液，通过位于过滤单元中的半透膜，该过滤单元将主室与过滤单元的次室分离出过滤单元和背部 给病人 根据所选择的处理的要求，将替代液体选择性地和可控地添加到血液中。 二次流体被可控地和选择性地引入过滤单元的次级室中，用于可控地从血液中收集穿过半透膜的材料，或者用于供应材料以通过所选择的处理所需的半透膜进入血液。 根据所选择的处理将材料从次级室除去并收集。 自动检测血液泄漏到二次腔室中，血液和流体流量自动调节。 还描述了自动执行和监视所选择的处理的装置。

公开(公告)号：US5658240A

公开(公告)日：1997-08-19

申请号：US327521

申请日：1994-10-21

申请人： Steven Gage Urdahl ,  Timothy Michael Gordon ,  Thomas James Minyard ,  Emery Joseph Stephans

发明人： Steven Gage Urdahl ,  Timothy Michael Gordon ,  Thomas James Minyard ,  Emery Joseph Stephans

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00

CPC分类号： A61M1/02 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3696 ,  A61M1/387 ,  A61M1/30 ,  A61M1/3643 ,  A61M2205/12 ,  A61M2205/50

摘要： A blood component collection system with optimization capabilities. In one embodiment, the blood component collection system includes a central input station (e.g., computer) and a plurality of blood component collection assemblies. These blood component collection assemblies include a blood component collection device and an operator interface module (e.g., computer). Various types of data are maintained on the collection procedures performed in the blood component collection system and are utilized to generate various types of reports for optimizing system operations.

摘要翻译： 具有优化能力的血液成分收集系统。 在一个实施例中，血液成分收集系统包括中央输入站（例如，计算机）和多个血液成分收集组件。 这些血液成分收集组件包括血液成分收集装置和操作者界面模块（例如计算机）。 在血液成分收集系统中执行的采集程序上保持各种类型的数据，并且用于生成用于优化系统操作的各种类型的报告。

公开(公告)号：US5653681A

公开(公告)日：1997-08-05

申请号：US475019

申请日：1995-06-06

申请人： Bruce S. Ellingboe

发明人： Bruce S. Ellingboe

IPC分类号： A61M1/36 ,  A61M5/168 ,  A61M5/172 ,  A61M37/00 ,  A61M31/00

CPC分类号： A61M5/16827 ,  A61M1/361 ,  A61M1/3664 ,  A61M5/1723 ,  A61M2205/366 ,  A61M2209/082 ,  Y10S128/03

摘要： A method and system are disclosed for more accurate administration of a composition being infused into a body fluid having formed elements. The improved accuracy is due to a correction factor that corrects for the relative impermeability of the formed elements to the infused composition. In one embodiment, the infusion system is a cardioplegia system in which a controller receives information pertaining to the hematocrit and initial blood potassium concentration and adjusts blood flow rate and crystalloid (KCl) solution flow rate so as to obtain the desired resulting potassium concentration in the cardioplegia. The invention further includes an infusion system that comprises a controller which uses an equation that relates the correction factor to an index of formed elements in the body fluid, such as the hematocrit. The equation is determined empirically from a series of experiments in which the resulting concentration of the substance infused into the body fluid is correlated to a formed element index of the body fluid, such as hematocrit.

摘要翻译： 公开了一种方法和系统，用于更精确地施用注入具有形成元件的体液中的组合物。 改进的精确度是由于校正因子，其校正了形成的元件对于输注的组合物的相对不渗透性。 在一个实施例中，输注系统是心脏停搏系统，其中控制器接收关于血细胞比容和初始血液钾浓度的信息，并且调节血液流速和晶体（KCl）溶液流速，以获得所需的所得钾浓度 心麻痹 本发明还包括输注系统，其包括控制器，该控制器使用将校正因子与体液中形成的元件的指数（例如血细胞比容）相关联的方程式。 该方程式是从一系列实验确定的，其中输入体液中的物质的浓度与体液的形成的元素指数（例如血细胞比容）相关。

公开(公告)号：US5650071A

公开(公告)日：1997-07-22

申请号：US481755

申请日：1995-06-07

申请人： James Brugger ,  Dan Lee Hendrickson ,  Roy Sven Hovland

发明人： James Brugger ,  Dan Lee Hendrickson ,  Roy Sven Hovland

IPC分类号： A61M1/14 ,  A61M1/36 ,  A61M39/10 ,  A61M37/00 ,  B01D11/00 ,  B01D61/00 ,  C02F1/44

CPC分类号： A61M1/3643 ,  A61M1/3647 ,  A61M2205/123 ,  A61M39/10

摘要： A technique for automatically priming and recirculating sterile fluid through an extracorporeal circuit of a dialysis machine having a blood pump, a dialyzer, and a blood tubing set including an arterial line for drawing blood from a patient and a venous line for returning the blood to the patient. The dialysis machine selectively opens and closes clamps on the arterial and venous lines and further operates a waste valve for selectively opening and closing a waste line leading to a waste drain. A connector attaches both the arterial and venous lines to the waste line downstream of the arterial and venous clamps and upstream of the waste valve. The dialysis machine automatically operating the blood pump, the clamps and the waste valve to flush the dialyzer and the blood tubing set with the sterile fluid and direct the used fluid down the waste drain. The dialysis machine then operating the blood pump and the clamps to again fill the dialyzer and the blood tubing set with additional sterile fluid and recirculate the sterile fluid through the extracorporeal circuit without the assistance of a dialysis machine operator. The dialysis machine further providing the operator with an indication when the recirculation process is complete. The connector being either one component of the disposable blood tubing set or a permanent component fixed to the dialysis machine.

摘要翻译： 一种用于通过具有血泵，透析器和血液管组的透析机的体外循环自动引发和循环无菌液体的技术，所述血液泵，透析器和血液管组包括用于从患者抽取血液的动脉线和用于将血液返回到 患者。 透析机选择性地打开和关闭动脉和静脉管路上的夹子，并进一步操作废气阀，以选择性地打开和关闭导致排泄物的废液管线。 连接器将动脉和静脉线连接到动脉和静脉夹钳下游以及废气阀上游的废物管线。 透析机自动操作血液泵，夹具和废气阀，以冲洗透析器和用无菌流体组合的血管，并将废水导向排水管。 透析机然后操作血液泵和夹子，以再次填充透析器和具有额外的无菌流体的血液管，并且在无需透析机操作者的帮助下将无菌流体再循环通过体外循环。 透析机进一步向操作者提供循环过程完成时的指示。 连接器是一次性血液管组的一个部件或固定到透析机的永久部件。

公开(公告)号：US5643681A

公开(公告)日：1997-07-01

申请号：US473723

申请日：1995-06-07

申请人： Marc Voorhees ,  Lloyd Forrestal ,  Harold Fisher

发明人： Marc Voorhees ,  Lloyd Forrestal ,  Harold Fisher

IPC分类号： A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  B01D67/00 ,  C08G77/42 ,  C08J7/00 ,  C09D183/10 ,  B32B27/32 ,  B32B27/36

CPC分类号： B01D67/0088 ,  A61L27/34 ,  A61L31/10 ,  A61L33/068 ,  C09D183/10 ,  Y10T428/249978 ,  Y10T428/24998 ,  Y10T428/249992 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31681 ,  Y10T428/31786 ,  Y10T428/31797

摘要： The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

摘要翻译： 与血液接触使用的聚合物和金属制品的生物相容性可以通过如上所述涂覆制品而大大改善。 涂层材料是聚内酯 - 聚硅氧烷 - 聚内酯型的三嵌段共聚物。 最佳生物相容性由最佳表面浓度的涂层提供。 可以如所述涂覆多孔膜，提供改善的血液氧合器，血液透析器等的生物相容性。

公开(公告)号：US5629871A

公开(公告)日：1997-05-13

申请号：US486942

申请日：1995-06-07

申请人： Steve Love ,  Jim Rosa ,  Robert Chambers

发明人： Steve Love ,  Jim Rosa ,  Robert Chambers

IPC分类号： A61M1/14 ,  A61M1/16 ,  G07C3/00

CPC分类号： G07C3/00 ,  A61M1/16 ,  A61M2205/702

摘要： The wear on components in a dialysis machine is analyzed for the purpose of making repair and maintenance decisions. The actual performance of components is used to establish a test value. The test value is compared to a threshold value which represents the limits of normal performance of the component. Each instance where the test value exceeds the threshold value is counted and a maintenance count value is developed. The maintenance count value represents the number of abnormal performance events, and the maintenance count value is used to make maintenance and repair decisions. The test value developed for each component varies according to the type of component. The maintenance count values may be displayed for use by service personnel.

摘要翻译： 分析透析机中组件的磨损，以进行维修和维护决定。 组件的实际性能用于建立测试值。 将测试值与表示组件正常性能极限的阈值进行比较。 对测试值超过阈值的每个实例进行计数，并开发维护计数值。 维护计数值表示异常性能事件的数量，维护计数值用于进行维护和修理决策。 为每个组件开发的测试值根据组件的类型而变化。 维护计数值可能显示供维修人员使用。