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公开(公告)号:US06322683B1
公开(公告)日:2001-11-27
申请号:US09291808
申请日:1999-04-14
IPC分类号: G01N2726
CPC分类号: B01L3/502707 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487
摘要: Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional substrate layers, external sampling elements, e.g. capillaries, and the like. Preferred alignment structures include wells over which reservoirs are positioned, notches for use with alignment keys to align substrate layers or for receiving additional structural elements, and targets or guide holes for receiving tooling in further fabrication steps.
摘要翻译: 微流体装置通过制造用于对准要附接到在这些装置上的进一步制造步骤中使用的装置或工具的元件的结构来制造。 待连接的元件包括附加的基底层,外部取样元件, 毛细血管等。 优选的对准结构包括在其上定位储存器的孔,用于对齐键以对准衬底层或用于接收附加结构元件的凹口,以及用于在进一步制造步骤中接收工具的靶或引导孔。
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公开(公告)号:US06620625B2
公开(公告)日:2003-09-16
申请号:US09750450
申请日:2000-12-28
IPC分类号: G01N100
CPC分类号: G01N21/6452 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/02 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0819 , B01L2300/0861 , B01L2400/022 , B01L2400/0406 , C12Q2565/629 , C40B40/06 , C40B60/14 , G01N35/10 , G01N2001/028 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , Y10T436/25 , Y10T436/2575
摘要: Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.
摘要翻译: 超高产量系统和方法用于从基本上平面的库存储组件的表面采样大量不同的材料。 该系统和方法通常采用:具有用于进行取样材料分析的集成毛细管元件的微流体装置; 图书馆存储组件,例如平面固体基底,能够在小区域保留数千,数万和数十万种不同的材料; 用于允许通过微流体装置快速准确地取样材料的感测系统,以及用于控制和分析这些系统的整体操作的相关仪器。
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公开(公告)号:US07316801B2
公开(公告)日:2008-01-08
申请号:US10244227
申请日:2002-09-16
申请人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
CPC分类号: G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译: 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统,装置和方法。 多孔板沿着输送系统行进到具有微流体装置的测试台。 在测试台处,每个板从输送机中取出,多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后,板返回到输送系统。 可以沿输送机系统布置前后测试站,并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片,同时提供和/或容纳微流体装置和周围系统之间的电,光学,结构和其它界面连接。
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公开(公告)号:US06447661B1
公开(公告)日:2002-09-10
申请号:US09416288
申请日:1999-10-12
申请人: Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
发明人: Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
IPC分类号: G01N2726
CPC分类号: B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.
摘要翻译: 提供了方法,装置和系统,用于将大量不同的材料快速,有效和可再现地引入微流体分析装置。 特别地,改进的集成移液器芯片配置,例如 描述了能够对需要分析的极少量材料进行取样,将材料输送到微流体分析通道网络中并对材料进行所需分析的能力。
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公开(公告)号:US6132685A
公开(公告)日:2000-10-17
申请号:US132096
申请日:1998-08-10
申请人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
CPC分类号: G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译: 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统,装置和方法。 多孔板沿传送系统行进到具有微流体装置的测试台。 在试验台,每个板从输送机上取出,多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后,板返回到输送系统。 可以沿输送机系统布置前后测试站,并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片,同时提供和/或容纳微流体装置和周围系统之间的电,光学,结构和其它界面连接。
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公开(公告)号:US06495369B1
公开(公告)日:2002-12-17
申请号:US09545241
申请日:2000-04-07
申请人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人: Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号: G01N3502
CPC分类号: G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译: 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统,装置和方法。 多孔板沿着输送系统行进到具有微流体装置的测试台。 在测试台处,每个板从输送机中取出,多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后,板返回到输送系统。 可以沿输送机系统布置前后测试站,并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片,同时提供和/或容纳微流体装置和周围系统之间的电,光学,结构和其它界面连接。
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公开(公告)号:US6149787A
公开(公告)日:2000-11-21
申请号:US173469
申请日:1998-10-14
CPC分类号: B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L3/50273 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.
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公开(公告)号:US06827831B1
公开(公告)日:2004-12-07
申请号:US09646241
申请日:2000-09-13
申请人: Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
发明人: Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
IPC分类号: G01N2726
CPC分类号: G01N27/453 , B01J19/0093 , B01J2219/00853 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/0415 , G01N27/44743 , G01N27/44791 , Y10T436/2575
摘要: The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems (620) for controlling the performance of the processes carried out within the device, e.g., monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要翻译: 本发明总体上涉及用于将微流体装置与与这种装置结合使用的辅助系统进行接口的改进的方法,结构和系统。 这些系统通常包括用于控制在设备内执行的过程的性能的控制和监视系统(620),例如监视和控制环境条件并监视所执行的过程的结果,例如检测。
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公开(公告)号:US20120282540A1
公开(公告)日:2012-11-08
申请号:US13551230
申请日:2012-07-17
CPC分类号: H01M4/8605 , B82Y30/00 , H01M4/881 , H01M4/8846 , H01M4/8853 , H01M4/8867 , H01M4/90 , H01M4/9075 , H01M4/921 , H01M4/925 , H01M4/926 , H01M8/023 , H01M8/0232 , H01M8/0234 , H01M8/0236 , H01M8/0241 , H01M8/1004 , H01M8/1007 , H01M8/1011 , H01M8/1086 , Y02E60/523 , Y02P70/56 , Y10S977/762 , Y10S977/948
摘要: The present invention discloses nanowires for use in a fuel cell comprising a metal catalyst deposited on a surface of the nanowires. A membrane electrode assembly for a fuel cell is disclosed which generally comprises a proton exchange membrane, an anode electrode, and a cathode electrode, wherein at least one or more of the anode electrode and cathode electrode comprise an interconnected network of the catalyst supported nanowires. Methods are also disclosed for preparing a membrane electrode assembly and fuel cell based upon an interconnected network of nanowires.
摘要翻译: 本发明公开了一种用于燃料电池的纳米线,其包括沉积在纳米线表面上的金属催化剂。 公开了一种用于燃料电池的膜电极组件,其通常包括质子交换膜,阳极电极和阴极电极,其中阳极电极和阴极电极中的至少一个或多个包括催化剂负载的纳米线的互连网络。 还公开了基于互连的纳米线网络来制备膜电极组件和燃料电池的方法。
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公开(公告)号:US08252164B2
公开(公告)日:2012-08-28
申请号:US13113680
申请日:2011-05-23
申请人: Samuel Martin , Xiangfeng Duan , Katsumasa Fujii , James M. Hamilton , Hiroshi Iwata , Francisco Leon , Jeffrey Miller , Tetsu Negishi , Hiroshi Ohki , J. Wallace Parce , Cheri X. Y. Pereira , Paul John Schuele , Akihide Shibata , David P. Stumbo , Yasunobu Okada
发明人: Samuel Martin , Xiangfeng Duan , Katsumasa Fujii , James M. Hamilton , Hiroshi Iwata , Francisco Leon , Jeffrey Miller , Tetsu Negishi , Hiroshi Ohki , J. Wallace Parce , Cheri X. Y. Pereira , Paul John Schuele , Akihide Shibata , David P. Stumbo , Yasunobu Okada
IPC分类号: C25D13/02
CPC分类号: H01L29/0665 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L29/0673 , Y10S977/883
摘要: The present invention provides methods and systems for nanowire alignment and deposition. Energizing (e.g., an alternating current electric field) is used to align and associate nanowires with electrodes. By modulating the energizing, the nanowires are coupled to the electrodes such that they remain in place during subsequent wash and drying steps. The invention also provides methods for transferring nanowires from one substrate to another in order to prepare various device substrates. The present invention also provides methods for monitoring and controlling the number of nanowires deposited at a particular electrode pair, as well as methods for manipulating nanowires in solution.
摘要翻译: 本发明提供了用于纳米线对准和沉积的方法和系统。 使用通电(例如,交流电场)来使纳米线与电极对准和关联。 通过调节激励,纳米线耦合到电极,使得它们在随后的洗涤和干燥步骤期间保持在适当的位置。 本发明还提供了将纳米线从一个衬底转移到另一个衬底以便制备各种器件衬底的方法。 本发明还提供了用于监测和控制在特定电极对上沉积的纳米线的数量的方法,以及用于操纵溶液中的纳米线的方法。
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