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1.发明公开公开(公告)号：US20240352486A1
公开(公告)日：2024-10-24
申请号：US18754912
申请日：2024-06-26
发明人： Cliff BRANGWYNNE , Yongdae SHIN , Dan BRACHA
摘要： Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
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公开(公告)号：US20240344993A1
公开(公告)日：2024-10-17
申请号：US18523814
申请日：2023-11-29
发明人： Stephen Y. CHOU , Fei DING
CPC分类号： G01N21/658 , B29C33/56 , B29C37/0003 , B29C59/02 , B29C59/026 , G01N21/648 , G01N21/6486 , G03F7/0002 , B29C33/424 , B29C2059/023 , B29K2995/0005
摘要： Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.
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公开(公告)号：US12083230B2
公开(公告)日：2024-09-10
申请号：US17191341
申请日：2021-03-03
IPC分类号： A61K9/51 , B82Y5/00 , C08L89/00 , C09D189/00
CPC分类号： A61K9/5169 , B82Y5/00 , C08L89/00 , C09D189/00
摘要： In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.
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公开(公告)号：US20240281577A1
公开(公告)日：2024-08-22
申请号：US18170735
申请日：2023-02-17
摘要： Discontinuity modeling techniques of computing functions of a program are described. In one example, a program has a computing function that includes a discontinuity. An input is received by the data modeling system that identifies an axis. A plurality of samples is then generated by the data modeling system along the axis based on an output of the program. The samples are then used as a basis by the data modeling system to generate a data model that models the discontinuity. The data model includes, in one example, one or more gradients and models the discontinuity using a 1D box kernel.
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公开(公告)号：US20240271168A1
公开(公告)日：2024-08-15
申请号：US18443118
申请日：2024-02-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Yasuo YOSHIKUNI , Zong-Yen WU , Ping-Hung HSIEH , Sudharsan DWARAKNATH , Zengyi SHAO , Wan SUN , Joshua D. RABINOWITZ , Yihui SHEN
CPC分类号： C12P7/44 , C12N9/1029 , C12Y203/01182
摘要： The present invention provides for a genetically modified yeast host cell comprising a heterologous citramalate synthase, or multiple copies of a citramalate synthase, and knocked out or reduced in expression, or under conditional expression, for an endogenous or native pyruvate decarboxylase (PDC) gene; a method for constructing the genetically modified yeast host cell, and a method for producing citramalate using the genetically modified yeast host cell.
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公开(公告)号：US20240268402A1
公开(公告)日：2024-08-15
申请号：US18442060
申请日：2024-02-14
发明人： Justin E. Silpe , Bonnie L. Bassler
摘要： Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.
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公开(公告)号：US20240268013A1
公开(公告)日：2024-08-08
申请号：US18636858
申请日：2024-04-16
摘要： According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap. A total Lorentz force causes oppositely directed magnetic field lines to be expanded around a region of the gas injector to further create an azimuthal current in the form of an axially elongated current sheet that is unstable such that the axially elongated current sheet reconnects and breaks into plasmoids.
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公开(公告)号：US12049878B2
公开(公告)日：2024-07-30
申请号：US17896651
申请日：2022-08-26
发明人： Jacob Simmonds , Yevgeny Raitses
IPC分类号： F03H1/00
CPC分类号： F03H1/0068
摘要： Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.
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公开(公告)号：US12038489B2
公开(公告)日：2024-07-16
申请号：US17920202
申请日：2021-04-21
发明人： Alexei Goun , Herschel Rabitz
CPC分类号： G01R33/441 , G01R33/34015 , G01R33/3607
摘要： Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.
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10.发明公开公开(公告)号：US20240208815A1
公开(公告)日：2024-06-27
申请号：US18405407
申请日：2024-01-05
发明人： John T. Groves , Roy Xiao
IPC分类号： C01B11/02 , A61L2/18 , B01J31/18 , B01J31/22 , B01J31/26 , C02F1/76 , C02F103/02 , C07F15/02 , D21C9/14
CPC分类号： C01B11/024 , A61L2/18 , B01J31/2295 , B01J31/26 , C07F15/025 , D21C9/14 , B01J31/1815 , B01J31/183 , B01J2531/025 , B01J2531/842 , C02F1/76 , C02F2103/023 , C02F2303/04
摘要： Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
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