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    Bead-Based Multiplexed Analytical Methods and Instrumentation
    1.
    发明申请
    Bead-Based Multiplexed Analytical Methods and Instrumentation 审中-公开
    基于珠的多重分析方法和仪器

    公开(公告)号：US20100130369A1

    公开(公告)日：2010-05-27

    申请号：US12596897

    申请日：2008-03-24

    申请人： Alexander Shenderov ,  Richard Kouri ,  Varvara Grichko

    发明人： Alexander Shenderov ,  Richard Kouri ,  Varvara Grichko

    IPC分类号： C40B30/00 ,  C40B50/08

    CPC分类号： C12Q1/6837 ,  C12Q2563/179 ,  C12Q2563/155 ,  C12Q2531/125

    摘要： Various methods, such as a method of detecting SNPs, involving (a) introducing onto a droplet actuator a solution comprising genomic DNA, extension oligos and suspension array beads; (b) dispensing on the droplet actuator one bead per droplet; (c) cleaving DNA from the bead in each droplet; (d) amplifying the cleaved DNA; (e) detecting SNP signals and barcode signals from the amplified DNA.

    摘要翻译： 各种方法，例如检测SNP的方法，涉及（a）向液滴致动器引入包含基因组DNA，延伸寡核苷酸和悬浮阵列珠的溶液; （b）在液滴致动器上分配每个液滴一个珠; （c）在每个液滴中从珠中切割DNA; （d）扩增切割的DNA; （e）从扩增的DNA检测SNP信号和条形码信号。

    Sample Collector and Processor
    5.
    发明申请
    Sample Collector and Processor 审中-公开
    样品收集器和处理器

    公开(公告)号：US20100087012A1

    公开(公告)日：2010-04-08

    申请号：US12596902

    申请日：2008-04-23

    申请人： Alexander Shenderov

    发明人： Alexander Shenderov

    IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N1/28

    CPC分类号： G01N1/2202 ,  G01N2001/2217 ,  Y10T436/25375

    摘要： An aerosol sample collector with an air flow path comprising: (i) at a first segment thereof, a particle charging device, and (i) at a second segment thereof, deflection plates configured to focus particles of a desired charge into a preselected cross-section of the air flow path. The air flow path also includes charged substrates arranged at an outflow portion of the air flow path to collect charged particles on a collection surface of the charged substrates; and an exit path for flowing particles not in the preselected cross-section of the air flow path away from the charged substrates. Related methods are also provided.

    摘要翻译： 一种具有空气流动路径的气溶胶样品收集器，包括：（i）在其第一部分处具有颗粒充电装置，和（i）在其第二部分处，配置成将所需电荷的颗粒聚焦成预选交联的偏转板， 空气流路的截面。 空气流路还包括布置在空气流动路径的流出部分处的带电基板，以将带电粒子收集在带电基板的收集表面上; 以及用于使不在所述空气流路的预选横截面中的颗粒流过所述带电基板的出口路径。 还提供了相关方法。

    Imaging devices and methods
    6.
    发明申请
    Imaging devices and methods 失效
    成像设备和方法

    公开(公告)号：US20050046944A1

    公开(公告)日：2005-03-03

    申请号：US10911926

    申请日：2004-08-05

    申请人： Olga Shenderova ,  Gary McGuire ,  Alexander Shenderov

    发明人： Olga Shenderova ,  Gary McGuire ,  Alexander Shenderov

    IPC分类号： G02B27/44 ,  G06K9/40

    CPC分类号： G02B5/1842 ,  G02B5/188 ,  G02B27/4205

    摘要： An imaging device consistent with one of numerous embodiments has an opaque planar sheet with a plurality of pinholes defining a photon sieve in the sheet, wherein, the photon sieve comprises at least first and second regions. The first region exhibits a first focal length, a first field of view, a first transmissivity, a first resolution and a first wavelength, and the second region exhibiting a second focal length, a second field of view, a second transmissivity, a second resolution and a second wavelength. At least one of the first focal length, the first wavelength, the first transmissivity, the first resolution and the first field of view is different from the second focal length, the second wavelength, the second transmissivity, the second resolution and the second field of view. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    摘要翻译： 与许多实施例之一相一致的成像装置具有不透明平板，其具有在片材中限定光子筛的多个针孔，其中，光子筛包括至少第一和第二区域。 第一区域呈现第一焦距，第一视场，第一透射率，第一分辨率和第一波长，第二区域呈现第二焦距，第二视场，第二透射率，第二分辨率 和第二波长。 第一焦距，第一波长，第一透射率，第一分辨率和第一视场中的至少一个不同于第二焦距，第二波长，第二透射率，第二分辨率和第二场 视图。 该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

    Electrostatic actuators for microfluidics and methods for using same
    10.
    发明授权
    Electrostatic actuators for microfluidics and methods for using same 有权
    用于微流体的静电致动器及其使用方法

    公开(公告)号：US06773566B2

    公开(公告)日：2004-08-10

    申请号：US09943675

    申请日：2001-08-30

    申请人： Alexander Shenderov

    发明人： Alexander Shenderov

    IPC分类号： G01N2726

    CPC分类号： B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  F04B19/006

    摘要： An apparatus for inducing movement of an electrolytic droplet includes: a housing having an internal volume filled with a liquid immiscible with an electrolytic droplet; a distribution plate positioned within the chamber having an aperture and dividing the housing into upper and lower chambers; a lower electrode positioned below the lower chamber and the aperture in the distribution plate and being separated from the lower chamber by an overlying hydrophobic insulative layer; an upper electrode located above the upper chamber and the aperture of the distribution plate and being separated from the upper chamber by an underlying hydrophobic insulative layer; and first, second and third voltage generators that are electrically connected to, respectively, the lower and upper electrodes and the distribution plate. The voltage generators are configured to apply electrical potentials to the lower and upper electrodes and the distribution plate, thereby inducing movement of the electrolytic droplet between the hydrophobic layers.

    摘要翻译： 用于引起电解液滴运动的装置包括：壳体，其具有填充有与电解液滴不混溶的液体的内部体积; 位于所述腔室内的分配板具有孔，并将所述壳体分成上腔室和下腔室; 位于下腔室下方的下电极和分配板中的孔，并通过上覆的疏水绝缘层与下室隔开; 位于上室上方的上电极和分配板的孔，并通过下面的疏水绝缘层与上室隔离; 以及分别电连接到下电极和上电极以及分配板的第一，第二和第三电压发生器。 电压发生器被配置为向下电极和上电极和分配板施加电势，从而引起电解液滴在疏水层之间的移动。