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1.发明授权公开(公告)号：US07862000B2
公开(公告)日：2011-01-04
申请号：US11701917
申请日：2007-02-02
IPC分类号： F16K1/00
CPC分类号： F16K7/126 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0478 , B01L2400/0638 , F16K99/0001 , F16K99/0015 , F16K2099/008
摘要： A microfluidic structure and method, where the structure comprises a featureless gasket layer allowing for efficient and reproducible structure production and assembly. Layering methods allow for the use of a variety of device materials and easy assembly.
摘要翻译： 微流体结构和方法，其中结构包括无特征的垫片层，其允许有效且可重复的结构生产和组装。 分层方法允许使用各种装置材料并易于装配。
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2.发明授权Method and apparatus for the mechanical actuation of valves in fluidic devices 失效用于流体装置中阀门机械致动的方法和装置公开(公告)号：US08480053B2
公开(公告)日：2013-07-09
申请号：US11514396
申请日：2006-08-30
IPC分类号： F16K7/04
CPC分类号： B01L3/502738 , B01L3/5027 , B01L3/502707 , B01L3/502723 , B01L3/567 , B01L2300/0816 , B01L2300/0887 , B01L2400/046 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0034 , F16K99/0046 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/8593
摘要： Mechanical actuation of valves in flexible fluidic structures allows for the regulation of fluid flow. In accordance with the disclosure herein, a fluidic structure is provided wherein mechanical actuation is conferred using a pin to actuate a flexible layer to occlude fluid flow in a fluid channel.
摘要翻译： 柔性流体结构中的阀的机械致动允许调节流体流动。 根据本文的公开内容，提供流体结构，其中使用销赋予机械致动来致动柔性层以阻塞流体通道中的流体流动。
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公开(公告)号：US08206593B2
公开(公告)日：2012-06-26
申请号：US11792168
申请日：2005-12-05
申请人： Chung-cheng Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
发明人： Chung-cheng Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译： 提供了用于进行化学反应的新型微流体装置。 该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。
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公开(公告)号：US20080281090A1
公开(公告)日：2008-11-13
申请号：US11792168
申请日：2005-12-05
申请人： Cheng-Chung Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
发明人： Cheng-Chung Lee , Guodong Sui , Arkadij Elizarov , Hartmuth C. Kolb , Jiang Huang , James R. Heath , Michael E. Phelps , Stephen R. Quake , Hsian-rong Tseng , Paul Wyatt , Antoine Daridon
IPC分类号： C07H5/02 , B01J19/00 , B01D15/04 , C07C211/43
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译： 提供了用于进行化学反应的新型微流体装置。 该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。
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5.发明申请Microfluidic Chip Capable of Synthesizing Radioactively Labeled Molecules on a Scale Suitable for Human Imaging With Positron Emission Tomography 有权具有合适放射性标记分子的微流控芯片，适用于具有正电子发射断层扫描的人体成像公开(公告)号：US20120101268A1
公开(公告)日：2012-04-26
申请号：US13286418
申请日：2011-11-01
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。
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6.发明授权Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography 有权能够以适合于使用正电子发射断层扫描的人成像的量表合成放射性标记分子的微流控芯片公开(公告)号：US08075851B2
公开(公告)日：2011-12-13
申请号：US11540344
申请日：2006-09-29
IPC分类号： B01L3/00
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。
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7.发明授权Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography 有权能够以适合于使用正电子发射断层扫描的人成像的量表合成放射性标记分子的微流控芯片公开(公告)号：US08658112B2
公开(公告)日：2014-02-25
申请号：US13286418
申请日：2011-11-01
IPC分类号： G01N33/00
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。
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8.发明申请MICROFLUIDIC RADIOSYNTHESIS OF A RADIOLABELED COMPOUND USING ELECTROCHEMICAL TRAPPING AND RELEASE 审中-公开使用电化学捕获和释放的无定形化合物的微流体放射线公开(公告)号：US20090095635A1
公开(公告)日：2009-04-16
申请号：US12176296
申请日：2008-07-18
申请人： Arkadij M. Elizarov , Hartmuth C. Kolb , R. Michael van Dam , James R. Heath , Brian Edgecombe , Farshad Motamedi , Anthony Stephen , Michael A. Giardello
发明人： Arkadij M. Elizarov , Hartmuth C. Kolb , R. Michael van Dam , James R. Heath , Brian Edgecombe , Farshad Motamedi , Anthony Stephen , Michael A. Giardello
IPC分类号： C25B3/08
CPC分类号： C07B59/00
摘要： Methods and apparatus enable radiosynthesis of radiolabeled compounds using electrochemical trapping and release. The trapping and release of radioactive isotopes all occur inside a microreactor, a vial or similar device, thus eliminating the need for azeotropic drying and several dead-end filling steps, as well as the necessity to move concentrated radioisotopes from one compartment of the chip to another. These and other features allow radioisotope enrichment to be carried out internally within a radiochemical synthesis chip, providing faster and more robust operation, as well as producing very high radiochemical labeling yields.
摘要翻译： 方法和装置能够使用电化学捕获和释放来放射性标记化合物的放射合成。 放射性同位素的捕获和释放都发生在微反应器，小瓶或类似装置内，因此不需要共沸干燥和几个死端填充步骤，以及将浓缩放射性同位素从芯片的一个室移动到 另一个。 这些和其他特征允许放射性同位素富集在放射化学合成芯片内部进行，提供更快和更强的操作，以及产生非常高的放射化学标记产率。
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公开(公告)号：US08586348B2
公开(公告)日：2013-11-19
申请号：US13240347
申请日：2011-09-22
申请人： Jun Wang , James R. Heath
发明人： Jun Wang , James R. Heath
CPC分类号： G01N33/54386 , B01L3/502753 , B01L3/502776 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0883 , B01L2400/0406 , B01L2400/0487 , B01L2400/0633 , B01L2400/086
摘要： Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further adapted to detect a target material comprised within one of the fluid components. The method comprises providing a channel, the channel having a dimension which is a function of a dimension of one of the fluid components and deliver the fluid through the channel at a set flow rate.
摘要翻译： 本文提供了用于控制流体的不同流体组分的流动的微流体装置和相关方法。 微流体装置包括输入通道，聚焦通道和测定通道。 微流体装置适于将流体分离成至少两个流体组分，并且还适于检测包含在流体组分之一内的目标材料。 该方法包括提供通道，通道具有作为流体部件中的一个的尺寸的函数的尺寸，并以设定的流速输送通过通道的流体。
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10.发明申请公开(公告)号：US20120097204A1
公开(公告)日：2012-04-26
申请号：US13278074
申请日：2011-10-20
申请人： Jen-Kan Yu , Slobodan Mitrovic , James R. Heath
发明人： Jen-Kan Yu , Slobodan Mitrovic , James R. Heath
IPC分类号： H01L35/02 , H01L21/265 , B32B3/24 , H01L21/22
CPC分类号： H01L35/26 , B82Y10/00 , B82Y30/00 , B82Y40/00 , Y10T428/24273 , Y10T428/24298
摘要： A nanomesh phononic structure includes: a sheet including a first material, the sheet having a plurality of phononic-sized features spaced apart at a phononic pitch, the phononic pitch being smaller than or equal to twice a maximum phonon mean free path of the first material and the phononic size being smaller than or equal to the maximum phonon mean free path of the first material.
摘要翻译： 纳米级声子结构包括：包括第一材料的片材，该片材具有以声子间距间隔开的多个声子大小的特征，声子间距小于或等于第一材料的最大声子平均自由程的两倍 并且声子尺寸小于或等于第一材料的最大声子平均自由程。
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