Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof
    2.
    发明申请
    Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof 有权
    单一病毒颗粒的纳米阵列,其制造和使用的方法和仪器

    公开(公告)号:US20070129321A1

    公开(公告)日:2007-06-07

    申请号:US11506200

    申请日:2006-08-18

    IPC分类号: A61K31/70 A01N43/04

    摘要: A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

    摘要翻译: 一种新颖的配位化学或金属离子结合方法,用于通过包括Dip Pen Nanoithography在内的光刻技术生成的纳米阵列模板上控制病毒颗粒(如TMV)的位点分离和取向。 通过使用许多病毒中固有的表面化学,使用金属离子或无机配位化学来固定个体病毒颗粒,而不需要进行遗传修饰。 由于病毒架构与组成这些阵列的特征之间的大小不匹配,单粒子控制将能够进行涉及病毒的各种研究,这些病毒是微不足道的。 这些包括:单粒子,单细胞感染性研究,材料合成和分子电子学模板等结构的探索,以及旨在了解表面呈现如何影响其生物活性的研究。 这是在单粒子水平上的这种控制的开创性例子,因此在生物系统中商业使用纳米阵列。

    Methods utilizing scanning probe microscope tips and products thereof or produced thereby
    4.
    发明申请
    Methods utilizing scanning probe microscope tips and products thereof or produced thereby 有权
    使用扫描探针显微镜尖端及其产品或由其制造的方法

    公开(公告)号:US20050172704A1

    公开(公告)日:2005-08-11

    申请号:US10951031

    申请日:2004-09-28

    摘要: The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN, including submicrometer combinatorial arrays, and kits, devices and software for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip. Finally, the invention provides AFM tips coated with the hydrophobic compounds.

    摘要翻译: 本发明提供了称为“浸笔”纳米光刻(DPN)的光刻方法。 DPN使用扫描探针显微镜(SPM)尖端(例如,原子力显微镜(AFM)尖端)作为“笔”,固态基底(例如,金)作为“纸”,并且具有化学亲和力的分子 固态基板为“墨水”。 在DPN中使用分子从SPM尖端到固体基质的毛细管传输,以直接写入由亚微米尺寸的相对小的分子集合组成的图案,使得DPN可用于制造各种微尺寸和纳米尺寸的器件。 本发明还提供由DPN图案化的衬底,包括亚微米组合阵列,以及用于执行DPN的试剂盒,装置和软件。 本发明还提供了一种在空气中进行AFM成像的方法。 该方法包括用疏水性化合物涂覆AFM尖端,选择疏水性化合物,使得与使用未涂覆的AFM尖端进行的AFM成像相比,使用涂覆的AFM尖端进行的AFM成像得到改善。 最后,本发明提供涂覆有疏水化合物的AFM尖端。

    PATTERNING OF SOLID STATE FEATURES BY DIRECT WRITE NANOLITHOGRAPHIC PRINTING
    5.
    发明申请
    PATTERNING OF SOLID STATE FEATURES BY DIRECT WRITE NANOLITHOGRAPHIC PRINTING 有权
    通过直写写纳印刷印刷固体状态特征

    公开(公告)号:US20080044575A1

    公开(公告)日:2008-02-21

    申请号:US11847263

    申请日:2007-08-29

    IPC分类号: B05D5/00

    摘要: The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron. The present invention also includes a device comprising an organic/inorganic composite nanoscale region chemically bonded to a substrate, wherein the nanoscale region, wherein the nanoscale region has a nanometer scale dimension other than height.

    摘要翻译: 本发明包括在衬底上制造有机/无机复合纳米结构的方法,其包括使用浸渍笔纳米光刻法在衬底上沉积具有嵌段共聚物和无机前体的溶液。 纳米结构包括具有小于1微米的宽度/直径的线和/或点的阵列。 本发明还包括一种包括化学键合到基底上的有机/无机复合纳米尺度区域的器件,其中所述纳米尺度区域,其中所述纳米尺度区域具有除了高度之外的纳米尺度尺寸。

    Surface and site-specific polymerization by direct-write lithography
    7.
    发明申请
    Surface and site-specific polymerization by direct-write lithography 失效
    通过直写光刻技术进行表面和位点特异性聚合

    公开(公告)号:US20050272885A1

    公开(公告)日:2005-12-08

    申请号:US10893543

    申请日:2004-07-19

    摘要: Polymeric microstructures and nanostructures can be prepared with use of a tip to pattern a surface. A tip can be used to pattern a structure which can initiate polymerization. The structure can be then exposed to monomer to induce polymerization at the structure. Alternatively, a tip can be used to pattern a surface with a monomer in which the surface is treated with polymerization catalyst so that polymerization occurs at the patterning site. Ring-opening metathesis polymerization can be carried out with use of the tip to control the polymerization. The tip can be a sharp tip as used in for example an atomic force microscope tip. Norbornene types of monomers can be used. Biological macromolecules can be also prepared.

    摘要翻译: 可以使用尖端来制备聚合物微结构和纳米结构以对表面进行图案化。 尖端可用于图案化可引发聚合的结构。 然后将该结构暴露于单体以在结构处引发聚合。 或者,可以使用尖端来用表面用聚合催化剂处理的单体对表面进行图案化,使得在图案化位点发生聚合。 可以使用尖端进行开环易位聚合以控制聚合。 尖端可以是例如原子力显微镜尖端中使用的尖锐尖端。 可以使用降冰片烯类型的单体。 还可制备生物大分子。

    ETCHING AND HOLE ARRAYS
    8.
    发明申请
    ETCHING AND HOLE ARRAYS 失效
    蚀刻和孔阵列

    公开(公告)号:US20080182079A1

    公开(公告)日:2008-07-31

    申请号:US11770477

    申请日:2007-06-28

    IPC分类号: B32B5/00 C23F1/00

    摘要: Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.

    摘要翻译: 包括在基底表面上图案化第一化合物的平版印刷和纳米光刻方法,将基底表面的未图案化区域暴露于第二化合物并除去第一化合物同时保留第二化合物。 所得到的孔图案可以用作用于对衬底的图案化区域进行化学蚀刻或在衬底的图案化区域上的金属沉积的模板。

    Nanotube assembly
    9.
    发明申请
    Nanotube assembly 失效
    纳米管总成

    公开(公告)号:US20070154714A1

    公开(公告)日:2007-07-05

    申请号:US11633095

    申请日:2006-12-04

    IPC分类号: B32B9/00 B05D5/00 B05D3/00

    摘要: Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

    摘要翻译: 提供纳米管和碳纳米管的精确对准,定位,成形和连接的方法和制品。 一种制品,包括:包含至少两个不同表面区域的固体表面,包括:包含外边界并适于碳纳米管吸附的第一表面区域和适于防止碳纳米管吸附的第二表面区域,第二表面区域 形成与第一区域的外边界的界面的至少一个碳纳米管,其至少部分地选择性地吸附在界面处。 可以控制表面上的图案的形状和尺寸以及碳纳米管的长度以提供选择性界面吸附。

    Phase separation in patterned structures
    10.
    发明申请
    Phase separation in patterned structures 失效
    图案结构中的相分离

    公开(公告)号:US20070087172A1

    公开(公告)日:2007-04-19

    申请号:US11480557

    申请日:2006-07-05

    IPC分类号: A61L33/00 B05D5/00 B05D3/00

    摘要: Novel phase-separation behavior by a mixture, including binary mixture, of patterning compounds, including alkanethiols, when deposited onto a surface, including a gold surface, using micro and nano-deposition tools such as tip and stamp methods like micro-contact printing (μCP), and Dip-Pen Nanolithography (DPN). This behavior is significantly different than that observed in the bulk. This behavior was demonstrated using three examples of compounds: 16-mercaptohexadecanoic acid (MHA), 1-octadecanethiol (ODT), and CF3(CF2)11(CH2)2SH (PFT). The identity of the resulting segregated structure was confirmed by lateral force microscopy (LFM), and by selective metal-organic coordination chemistry. This phenomenon is exploited to print sub-100 nm wide alkanethiol features via conventional μCP and to form sub-15 nm features using DPN printing, which is below the ultimate resolution of both these techniques. These nano-patterned materials also can serve as templates for constructing more complex architectures.

    摘要翻译: 当使用微型和纳米沉积工具(诸如尖端和印模方法,如微接触印刷)沉积到包括金表面在内的表面上时,包括二醇混合物的混合物(包括二醇混合物)的新型相分离行为(包括烷基硫醇) muCP)和Dip Pen Nanoithography(DPN)。 这种行为与大量观察到的显着不同。 使用化合物的三个实例证明了这一行为:16-巯基十六烷酸(MHA),1-十八烷硫醇(ODT)和CF 3 N(CF 2)11 (CH 2)2 SH(PFT)。 通过横向力显微镜(LFM)和选择性金属 - 有机配位化学证实了所得到的分离结构的身份。 这种现象被用于通过常规的muCP打印亚100nm宽的链烷硫醇特征,并且使用DPN印刷形成低于15nm的特征,其低于这两种技术的最终分辨率。 这些纳米图案材料也可以用作构建更复杂结构的模板。