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    Kind of thin films for microsystem technology and microstructuring and their use
    1.
    发明授权
    Kind of thin films for microsystem technology and microstructuring and their use 失效
    用于微系统技术和微结构化的薄膜及其用途

    公开(公告)号：US06821692B1

    公开(公告)日：2004-11-23

    申请号：US09230975

    申请日：1999-02-04

    申请人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

    发明人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

    IPC分类号： G03F7023

    CPC分类号： H01L21/02118 ,  B01J19/0046 ,  B01J2219/00527 ,  C12Q1/002 ,  H01L21/02282 ,  H01L21/312

    摘要： The present invention relates to novel thin layers for microsystem techniques and microstructuring. It is an object of the invention to provide thin layers which can be manufactured under less problems and more economically than the previous conventional layers, and which permit the use of existing technologies for microstructuring. The object is realized in that the thin layer is formed of an enzymatically degradable biopolymer in a range of layer thicknesses of from 30 nm to 3 &mgr;m. Biopolymeric thin layers manufactured according to the invention permit their application, after a respective structurizing, as test assays or in setting up substance libraries.

    摘要翻译： 本发明涉及用于微系统技术和微结构化的新型薄层。 本发明的一个目的是提供薄层，其可以在比以前的常规层更少的问题和更经济地制造，并且允许使用现有的技术来进行微结构化。 实现目的在于，薄层由层压厚度为30nm至3μm范围内的可酶促降解的生物聚合物形成。 根据本发明生产的生物聚合物薄层允许其在各自的结构化之后作为测试测定或在建立物质文库中的应用。

    Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries
    2.
    发明授权
    Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries 有权
    用于生产各种分子物质的结构化，自组织分子单层的方法，特别是物质文库

    公开(公告)号：US06558904B2

    公开(公告)日：2003-05-06

    申请号：US09355443

    申请日：1999-07-28

    申请人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

    发明人： Eugen Ermantraut ,  Johann Michael Köhler ,  Torsten Schulz ,  Klaus Wohlfart ,  Stefan Wölfl

    IPC分类号： C12P1934

    CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/047 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G03F7/00

    摘要： The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction. Said polymer mask (1) is sufficiently thin and flexible for it to adhere to the substrate (2) by adhesion, and the material selected for the polymer mask (1) is chemically stable; c) the sandwich constituted by the substrate (2) and polymer mask (1) is flooded with a first agent corresponding to the intended use, so as to create at least one first molecular monolayer in the areas defined by the mask openings; c1) depending on the monolayer structure to be created step c) is repeated using the first agent or one or more additional agents; and d) after carrying out the step described in c) or the steps described in c) and c1), the polymer mask is pulled off after modification of the substrate surface areas which were left uncovered by the mask openings and were subjected to the agent or agents.

    摘要翻译： 本发明涉及一种用于生产各种分子物质的结构化，自组织分子单层的方法。 本发明优选用于产生固相键合物质文库。 为此，提供a）适合于第一单层的基底（2） b）具有开口的微结构化聚合物掩模（1）在限定的方向上至少一次施加到该脱墨剂（2）。 所述聚合物掩模（1）足够薄并且柔性以使其通过粘附粘附到基底（2），并且选择用于聚合物掩模（1）的材料是化学稳定的; c）由基材（2）和聚合物掩模（1）构成的夹层用与预期用途相对应的第一试剂浸没，以便在由掩模开口限定的区域中产生至少一个第一分子单层; c1）取决于要产生的单层结构步骤c）使用第一试剂或一种或多种另外的试剂重复; 和d）在执行c）或c）和c1）中描述的步骤之后，在修改未被掩模开口未被覆盖的基材表面区域并经受试剂之后，将聚合物掩模拉离 或代理。

    Assays
    8.
    发明授权
    Assays 有权
    测定

    公开(公告)号：US08906303B2

    公开(公告)日：2014-12-09

    申请号：US12922383

    申请日：2009-03-16

    申请人： Eugen Ermantraut ,  Thomas Kaiser ,  Jens Tuchscheerer ,  Vico Baier ,  Torsten Schulz ,  Anke Wöstemeyer

    发明人： Eugen Ermantraut ,  Thomas Kaiser ,  Jens Tuchscheerer ,  Vico Baier ,  Torsten Schulz ,  Anke Wöstemeyer

    IPC分类号： G01N21/00 ,  B01L3/00

    CPC分类号： G01N33/58 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  Y10T436/25

    摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.

    摘要翻译： 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。 装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

    Assay devices and methods for the detection of analytes
    9.
    发明申请
    Assay devices and methods for the detection of analytes 有权
    用于检测分析物的检测装置和方法

    公开(公告)号：US20110071038A1

    公开(公告)日：2011-03-24

    申请号：US12385805

    申请日：2009-07-14

    申请人： Eugen Ermantraut ,  Torsten Schulz ,  Thomas Ellinger ,  Daniel Weicherding

    发明人： Eugen Ermantraut ,  Torsten Schulz ,  Thomas Ellinger ,  Daniel Weicherding

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： B01L3/502707 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0877 ,  B01L2400/0481 ,  C12Q1/6834

    摘要： The present invention relates to devices and methods for performing assays, especially for determining the presence and/or amount of one or more analytes. In particular, the invention relates to a device for the detection of analytes, comprising a reversibly compressible matrix located between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and wherein the distance between the first surface and the second surface is variable. The invention also relates to a corresponding method using such a device for the detection of one or more species of analytes.

    摘要翻译： 本发明涉及用于进行测定的装置和方法，特别是用于确定一种或多种分析物的存在和/或量。 特别地，本发明涉及一种用于检测分析物的装置，包括位于第一表面和第二表面之间的可逆压缩基质，其中第二表面位于与第一表面相对的位置，并且其中第一表面 并且第二表面是可变的。 本发明还涉及使用这种装置用于检测一种或多种分析物的相应方法。