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公开(公告)号:US06890492B1
公开(公告)日:2005-05-10
申请号:US09724276
申请日:2000-11-28
申请人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号: B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , B01F7/00
CPC分类号: B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译: 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成,筛选和表征特别有用,但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外,该装置可以包括用于独立地控制每个容器中的压力的装置,以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈,并提供了确定反应速率,产物产率和反应产物各种性质(包括粘度和分子量)的数据。 公开了基于计算机的方法,用于过程监控和控制,以及数据显示和分析。
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公开(公告)号:US06864092B1
公开(公告)日:2005-03-08
申请号:US09723926
申请日:2000-11-28
申请人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号: B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N31/10
CPC分类号: B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号:US06455316B1
公开(公告)日:2002-09-24
申请号:US09548848
申请日:2000-04-13
申请人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人: Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号: G01N3110
CPC分类号: B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253 , G01N35/1079 , Y10T436/11
摘要: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译: 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成,筛选和表征特别有用,但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外,该装置可以包括用于独立地控制每个容器中的压力的装置,以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈,并提供了确定反应速率,产物产率和反应产物各种性质(包括粘度和分子量)的数据。 公开了基于计算机的方法,用于过程监控和控制,以及数据显示和分析。
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公开(公告)号:US06548026B1
公开(公告)日:2003-04-15
申请号:US09177170
申请日:1998-10-22
IPC分类号: B01J1900
CPC分类号: B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253
摘要: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译: 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成,筛选和表征特别有用,但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外,该装置可以包括用于独立地控制每个容器中的压力的装置。 单独反应混合物的原位监测为过程控制器提供反馈,并提供了确定反应速率,产物产率和反应产物各种性质(包括粘度和分子量)的数据。
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公开(公告)号:US06818183B2
公开(公告)日:2004-11-16
申请号:US10134556
申请日:2002-04-29
申请人: Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人: Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号: G01N3348
CPC分类号: B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译: 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成,筛选和表征特别有用,但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外,该装置可以包括用于独立地控制每个容器中的压力的装置。 单独反应混合物的原位监测为过程控制器提供反馈,并提供了确定反应速率,产物产率和反应产物各种性质(包括粘度和分子量)的数据。
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公开(公告)号:US06528026B2
公开(公告)日:2003-03-04
申请号:US09417125
申请日:1998-11-19
申请人: Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人: Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号: G01N3300
CPC分类号: B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:US06881363B2
公开(公告)日:2005-04-19
申请号:US10291108
申请日:2002-11-08
申请人: Eric D. Carlson , Damian A. Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
发明人: Eric D. Carlson , Damian A. Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
IPC分类号: B01F5/10 , B01F7/00 , B01F7/08 , B01F13/10 , B01J19/00 , B01L3/00 , G01N1/28 , G01N35/00 , G01N35/02 , G01B1/00
CPC分类号: B01L3/5085 , B01F5/104 , B01F7/00341 , B01F7/00416 , B01F7/082 , B01F13/1013 , B01F13/1022 , B01J19/0046 , B01J2219/00274 , B01J2219/00756 , B01L2200/12 , B01L2300/0812 , B01L2300/0829 , G01N1/286 , G01N35/00 , G01N35/00009 , G01N35/021 , G01N2001/2866 , G01N2035/00495 , G01N2035/00534
摘要: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.
摘要翻译: 提供了用于材料样品库的制备,分析或两者的快速通量方法。 根据该方法,提供多个样品。 提供多个样品可以包括各种样品形成技术,包括但不限于挤出,研磨,压缩制备,旋转混合,微量离心,模塑和铸造。 优选地,样品被固化成适合于测试样品的性质或特性的近净形状构型。
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公开(公告)号:US20060133968A1
公开(公告)日:2006-06-22
申请号:US11272249
申请日:2005-11-10
申请人: G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
发明人: G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
IPC分类号: B01J19/00
CPC分类号: B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号:US07051581B2
公开(公告)日:2006-05-30
申请号:US10898772
申请日:2004-07-26
申请人: Paul Mansky , Damian A. Hajduk
发明人: Paul Mansky , Damian A. Hajduk
IPC分类号: G01N11/04
CPC分类号: G01N33/442 , B01J2219/00315 , B01J2219/00367 , B01J2219/00722 , C40B40/14 , C40B60/14 , G01N11/04 , G01N35/028 , G01N35/109
摘要: A library of materials is screened for viscosity. A library of materials is provided. The library is contacted with at least one capillary for applying a force through the materials. The relative flow resistance of the materials is measured in response to the force; and the materials in the library are ranked based on the monitored flow resistance.
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公开(公告)号:US06860148B2
公开(公告)日:2005-03-01
申请号:US09939139
申请日:2001-08-24
申请人: Mary Beth Kossuth , Damian A. Hajduk , Paul Mansky
发明人: Mary Beth Kossuth , Damian A. Hajduk , Paul Mansky
CPC分类号: G01N19/02 , B01J2219/00274 , G01N19/04 , G01N2203/0091 , G01N2203/0092 , G01N2203/0284
摘要: A method for screening fabric handle of an array of fabric samples (i.e., a plurality of fabric materials) comprising providing an array of at least two fabric samples, protruding the fabric samples through openings, and monitoring response of said fabric samples to the protrusions.
摘要翻译: 一种用于筛选织物样品阵列(即,多种织物材料)的织物手柄的方法,包括提供至少两种织物样品的阵列,通过开口突出织物样品,并监测所述织物样品对突起的响应。
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