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公开(公告)号:US20080051699A1
公开(公告)日:2008-02-28
申请号:US11718474
申请日:2005-11-18
申请人: Hye-Ok Choi , Gordon Knutson , Moses David
发明人: Hye-Ok Choi , Gordon Knutson , Moses David
IPC分类号: A61M37/00
CPC分类号: A61M37/0015 , A61K9/0021 , A61M2037/0023
摘要: A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate.
摘要翻译: 通过以类似刷子的方式使用柔性膜施加涂布液来涂布微针阵列的方法。 一种涂覆微针阵列的方法,包括:提供具有基底和多个微针的微针阵列; 提供柔性膜; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 执行将柔性膜的第一主表面与微针接触并移除柔性膜以与微针接触的转印步骤; 并允许载体液体蒸发。
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公开(公告)号:US20070139451A1
公开(公告)日:2007-06-21
申请号:US11313885
申请日:2005-12-20
申请人: Nanayakkara Somasiri , Moses David
发明人: Nanayakkara Somasiri , Moses David
IPC分类号: B32B3/10
CPC分类号: B01L3/502746 , B01L3/5025 , B01L3/502707 , B01L2300/0645 , B01L2300/069 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , B01L2400/088 , B32B3/266 , B32B5/022 , B32B5/08 , B32B15/08 , B32B15/14 , B32B15/20 , B32B23/02 , B32B27/08 , B32B27/28 , B32B27/281 , B32B2255/10 , B32B2255/20 , B32B2255/24 , B32B2262/0246 , B32B2262/04 , B32B2262/14 , B32B2307/202 , B32B2307/726 , B32B2307/728 , B32B2457/00 , C23C16/045 , Y10T428/24322
摘要: A microfluidic device comprising a multi-layer film having a conductive layer and a polymeric layer disposed adjacent the conductive layer, a microchannel extending through the multi-layer film, where the microchannel has a perimeter surface, and a hydrophilic layer disposed on the perimeter surface of the microchannel. The hydrophilic layer comprises at least about 20% by weight silicon and at least about 40% by weight oxygen.
摘要翻译: 一种微流体装置,包括具有导电层和邻近导电层设置的聚合物层的多层膜,延伸穿过多层膜的微通道,其中微通道具有周边表面,以及设置在周边表面上的亲水层 的微通道。 亲水层包含至少约20重量%的硅和至少约40重量%的氧。
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公开(公告)号:US20070045622A1
公开(公告)日:2007-03-01
申请号:US11553822
申请日:2006-10-27
申请人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
发明人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
CPC分类号: C07D275/06 , B82Y30/00 , C07C311/51 , C07D207/46 , G01N33/54353
摘要: Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonylaminocarbonyl group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a carbonylimino-containing connector group. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
摘要翻译: 描述了具有两个反应性官能团的化合物,其可用于在基材和含胺材料之间提供连接基团。 第一反应性官能团可用于提供与基底表面的附着。 第二反应性官能团是可与含胺材料,特别是伯脂肪族胺反应形成含羰基亚氨基的连接基团的N-磺酰基氨基羰基。 本发明还提供了将含胺材料固定在基材上的制品和方法。
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公开(公告)号:US20070281369A1
公开(公告)日:2007-12-06
申请号:US10596956
申请日:2004-12-17
申请人: Chad Carter , Moses David , Larry Dodge , Michael Free , Samuel Gason , John Huizinga , Raymond Johnston , Brinda Lakshmi , Patrick Mach , Larry Martin
发明人: Chad Carter , Moses David , Larry Dodge , Michael Free , Samuel Gason , John Huizinga , Raymond Johnston , Brinda Lakshmi , Patrick Mach , Larry Martin
IPC分类号: G01N29/02 , B01L3/00 , G01N33/543
CPC分类号: G01N29/022 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L3/523 , B01L2200/04 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/06 , B01L2300/0663 , B01L2300/0672 , B01L2300/069 , B01L2300/161 , B01L2400/0406 , B01L2400/0478 , B01L2400/0683 , B01L2400/086 , B01L2400/088 , C07C311/51 , C07D207/46 , C07D275/06 , G01N29/222 , G01N29/2462 , G01N2291/0255 , G01N2291/0256 , G01N2291/02881 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要: Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). A variety of techniques for modifying the effective mass of the target biological analytes in sample material are disclosed, including fractionating or disassembling the target biological analytes in the sample material (e.g., lysing the target biological analyte), adding a detectable mass to the target biological analyte or enhancing coupling of the target biological analyte (e.g., through the use of magnetic particles), exposing the sample material to a reagent that causes a change in at least detectable physical property in the sample material if the target biological analyte is present (e.g., a change in viscous, elastic, and/or viscoelastic properties), etc.
摘要翻译: 公开了使用由传感器产生的声 - 机械能来检测样品材料内目标生物分析物的检测系统和方法。 声机械能可以使用诸如例如剪切水平声表面波传感器(例如LSH-SAW传感器)的表面声波传感器的声 - 机械传感器来提供。 公开了用于改变样品材料中目标生物分析物的有效质量的各种技术,包括分离或分解样品材料中的目标生物分析物(例如,裂解靶生物分析物),向目标生物体中加入可检测的物质 分析物或增强靶生物分析物的耦合(例如,通过使用磁性颗粒),如果存在目标生物分析物,将样品材料暴露于导致样品材料中至少可检测的物理性质变化的试剂(例如 ,粘性,弹性和/或粘弹性的变化)等
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公开(公告)号:US20050112672A1
公开(公告)日:2005-05-26
申请号:US10987522
申请日:2004-11-12
申请人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
发明人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
IPC分类号: C07C311/51 , C07D207/46 , C07D275/06 , G01N33/543 , C12Q1/68 , C12M1/34
CPC分类号: G01N33/54353 , B82Y30/00 , B82Y40/00 , C07C311/51 , C07D207/46 , C07D275/06
摘要: Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonylaminocarbonyl group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a carbonylimino-containing connector group. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
摘要翻译: 描述了具有两个反应性官能团的化合物,其可用于在基材和含胺材料之间提供连接基团。 第一反应性官能团可用于提供与基底表面的附着。 第二反应性官能团是可与含胺材料,特别是伯脂肪族胺反应形成含羰基亚氨基的连接基团的N-磺酰基氨基羰基。 本发明还提供了将含胺材料固定在基材上的制品和方法。
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公开(公告)号:US20070020451A1
公开(公告)日:2007-01-25
申请号:US11185078
申请日:2005-07-20
申请人: Raghunath Padiyath , Moses David
发明人: Raghunath Padiyath , Moses David
CPC分类号: C08J7/045 , B05D1/62 , B05D7/546 , B05D7/58 , C08J7/123 , C23C16/26 , C23C16/545 , H01L51/448 , H01L51/5243 , H01L51/5256 , Y10T428/26 , Y10T428/265 , Y10T428/30 , Y10T428/31504 , Y10T428/31935
摘要: A barrier assembly having a flexible or rigid substrate overcoated with an all polymer multilayer stack. A multilayer on the substrate includes alternating diamond-like glass or carbon layers with polymer layers. Another multilayer includes alternating polymer layers using different types of polymers. The barrier layers can be used to mount, cover, encapsulate or form composite assemblies for protection of moisture or oxygen sensitive articles
摘要翻译: 具有用全部聚合物多层堆叠外涂的柔性或刚性基材的阻挡组件。 衬底上的多层包括具有聚合物层的交替的类金刚石玻璃或碳层。 另一种多层包括使用不同类型聚合物的交替聚合物层。 阻挡层可用于安装,覆盖,包封或形成复合组件,以保护水分或氧敏感物品
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公开(公告)号:US20050227076A1
公开(公告)日:2005-10-13
申请号:US10987075
申请日:2004-11-12
申请人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
发明人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
IPC分类号: B32B27/00 , C07D207/00 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/76 , C07D211/88 , C07D275/06 , C07D403/12 , C07D471/08
CPC分类号: C07D207/404 , B82Y30/00 , B82Y40/00 , C07D209/48 , C07D209/76 , C07D211/88 , C07D275/06 , C07D403/12 , C07D471/08 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0427 , Y10T428/2982 , Y10T428/2998 , Y10T428/31616 , Y10T428/31623 , Y10T428/31721 , Y10T428/31786
摘要: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
摘要翻译: 描述了具有两个反应性官能团的化合物,其可以用作系链化合物以将含胺材料固定在基材上。 第一反应性官能团可用于提供与基底表面的附着。 第二反应性官能团是可与含胺材料,特别是伯脂肪族胺反应的N-磺酰基二亚胺酰亚胺基团,以在基材和含胺材料之间形成连接基团。 本发明还提供了将含胺材料固定在基材上的制品和方法。
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公开(公告)号:US20050107615A1
公开(公告)日:2005-05-19
申请号:US10713174
申请日:2003-11-14
申请人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
发明人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
IPC分类号: C07C311/51 , C07D207/46 , C07D275/06 , G01N33/543 , C07F9/02 , C07C39/54 , C07D43/02
CPC分类号: C07D275/06 , B82Y30/00 , C07C311/51 , C07D207/46 , G01N33/54353
摘要: Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonylaminocarbonyl group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a carbonylimino-containing connector group. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
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公开(公告)号:US20070154937A1
公开(公告)日:2007-07-05
申请号:US11686018
申请日:2007-03-14
申请人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
发明人: Karl Benson , Moses David , Cary Kipke , Brinda Lakshmi , Charles Leir , George Moore , Rahul Shah
IPC分类号: C12Q1/68 , G01N33/53 , C12M1/34 , C07D209/90 , C07D209/48
CPC分类号: C07D207/404 , B82Y30/00 , C07D209/48 , C07D209/76 , C07D211/88 , C07D403/12 , C07D471/08 , Y10T428/31616 , Y10T428/31623
摘要: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
摘要翻译: 描述了具有两个反应性官能团的化合物,其可以用作系链化合物以将含胺材料固定在基材上。 第一反应性官能团可用于提供与基底表面的附着。 第二反应性官能团是可与含胺材料,特别是伯脂肪族胺反应的N-磺酰基二亚胺酰亚胺基团,以在基材和含胺材料之间形成连接基团。 本发明还提供了将含胺材料固定在基材上的制品和方法。
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公开(公告)号:US20060139754A1
公开(公告)日:2006-06-29
申请号:US11023857
申请日:2004-12-28
申请人: Chester Bacon , Seth Kirk , Moses David , Michael Currens , Osei Owusu
发明人: Chester Bacon , Seth Kirk , Moses David , Michael Currens , Osei Owusu
IPC分类号: G02B5/124
CPC分类号: G02B5/124
摘要: A prismatic retroreflective article has a transparent body portion and a layer of internally reflecting cube-corner optical elements having an open air-exposed rear surface at least a portion of which is more hydrophobic, more oleophobic, or both more hydrophobic and more oleophobic than the underlying cube-corner optical element. The article may be made by providing a transparent body portion bearing a layer of internally reflecting open air-exposed cube-corner optical elements; treating or coating at least a portion of the cube-corner elements to make the treated or coated portion more hydrophobic, more oleophobic, or both more hydrophobic and more oleophobic than the underlying cube-corner optical elements; and leaving such treated or coated portion exposed to the open air.
摘要翻译: 棱镜式回射制品具有透明主体部分和内部反射立体角光学元件层,其具有暴露于露天的后表面,其至少一部分疏水性更强,疏油性更强,或者疏水性更好,疏油性更强。 底层立体角光学元件。 该制品可以通过提供一个透明的主体部分制成,该透明主体部分带有内部反射的暴露于露天的立体角光学元件层; 处理或涂覆至少一部分立体角元件以使经处理或涂覆的部分比下面的立体角光学元件更疏水,疏油或更疏水并且更疏油; 并将这种经处理或涂覆的部分暴露于露天。
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