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21 条记录 (耗时 0.043 秒)

    1,5-Diphenylpyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing same
    8.
    发明授权
    1,5-Diphenylpyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing same 失效
    1,5-二苯基吡唑啉-3-酮化合物，其制备方法和中间体以及含有它们的药物组合物

    公开(公告)号：US4442102A

    公开(公告)日：1984-04-10

    申请号：US409631

    申请日：1982-08-19

    申请人： Henning Heinemann ,  Daniel Jasserand ,  Wolfgang Milkowski ,  Dimitri Yavordios ,  Horst Zeugner

    发明人： Henning Heinemann ,  Daniel Jasserand ,  Wolfgang Milkowski ,  Dimitri Yavordios ,  Horst Zeugner

    IPC分类号： A61K31/415 ,  A61K31/495 ,  A61P37/08 ,  C07D231/22 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D498/04 ,  C07D403/06 ,  C07D231/08

    CPC分类号： C07D401/12 ,  C07D231/22 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

    摘要： New 1,5-diphenylpyrazolin-3-one compounds and a method of preparing them are described. The compounds have the general formula I ##STR1## where R.sub.1 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxy, trifluoromethyl or lower alkanoyloxy radical, R.sub.2 is a hydrogen or halogen atom, or a lower alkyl, or lower alkoxy radical, or R.sub.1 and R.sub.2 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy radical, R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxy, trifluoromethyl or lower alkanoyloxy radical, R.sub.4 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy radical, or R.sub.3 and R.sub.4 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy radical, Z is an alkylene radical with 2 to 6 carbon atoms and R.sub.5 is an optionally substituted pyridyl radical, a thienyl radical or an optionally substituted phenyl radical. The compounds have pharmacological properties, for example antiallergic properties.

    摘要翻译： 描述了新的1,5-二苯基吡唑啉-3-酮化合物及其制备方法。 该化合物具有通式I，其中R 1是氢或卤素原子，或低级烷基，低级烷氧基，羟基，三氟甲基或低级烷酰氧基，R2是氢或卤素原子，或低级烷基，或 或低级烷氧基，或R 1和R 2与相邻的碳原子键合，并且一起表示亚甲二氧基或亚乙二氧基，R 3是氢或卤原子，或低级烷基，低级烷氧基，羟基，三氟甲基或低级烷酰氧基，R 4是 氢或卤素原子，或低级烷基，低级烷氧基，或者R 3和R 4与相邻的碳原子键合，并且一起表示亚甲二氧基或亚乙二氧基，Z是具有2-6个碳原子的亚烷基，R 5是任意取代的 吡啶基，噻吩基或任选取代的苯基。 这些化合物具有药理学性质，例如抗过敏性质。