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    High speed elastographic property mapping of lumens utilizing micropalpation delivered from an OCT-equipped catheter tip
    1.
    发明授权
    High speed elastographic property mapping of lumens utilizing micropalpation delivered from an OCT-equipped catheter tip 有权
    使用从装有OCT的导管尖端传送的微口腔的腔的高速弹性成像图

    公开(公告)号：US09138148B2

    公开(公告)日：2015-09-22

    申请号：US13285167

    申请日：2011-10-31

    申请人： John Sliwa ,  Yu Liu

    发明人： John Sliwa ,  Yu Liu

    IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/02 ,  A61M25/00

    CPC分类号： A61B5/0066 ,  A61B5/0053 ,  A61B5/02007 ,  A61B8/485 ,  A61M25/007 ,  A61M25/0082 ,  A61M29/02

    摘要： A method for performing elastographic deformation mapping of tissues and plaques comprises: introducing a distal portion of a catheter to an interior of an interior body of a patient; applying, from a palpator in the distal portion, one of a directed fluid or a mechanical indenter to produce a surface-applied palpation force to a target area of the interior body to mechanically displace the interior body and cause elastographic deformation of the target area of one or more surface and subsurface tissues and plaques; and directing and delivering an OCT (optical coherence tomography) beam, from an OCT imaging sensor in the distal portion, for OCT deformation detection including elastographic deformation measurement to provide elastographic mapping of the target area.

    摘要翻译： 用于执行组织和斑块的弹性变形映射的方法包括：将导管的远端部分引入患者的内部身体的内部; 从远端部分的触发器施加定向流体或机械压头中的一个，以产生对内部主体的目标区域的表面施加的触诊力，以机械地移动内部主体并引起目标区域的弹性变形 一个或多个表面和表面下组织和斑块; 并从远端部分的OCT成像传感器引导和传送OCT（光学相干断层摄影）用于OCT变形检测，包括弹性变形测量以提供目标区域的弹性图。

    Selectively switched gels for surgery, therapy and maintenance
    2.
    发明申请
    Selectively switched gels for surgery, therapy and maintenance 审中-公开
    选择性切换凝胶进行手术，治疗和维护

    公开(公告)号：US20070224169A1

    公开(公告)日：2007-09-27

    申请号：US11488945

    申请日：2006-07-18

    申请人： John Sliwa ,  Carol Tosaya ,  Bryan Oronsky

    发明人： John Sliwa ,  Carol Tosaya ,  Bryan Oronsky

    IPC分类号： A61K48/00 ,  A61K9/00

    CPC分类号： A61K9/06 ,  A61B8/0833 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/3413 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0095 ,  A61K49/226 ,  A61L27/50 ,  A61L27/52 ,  A61N5/02 ,  A61N7/02

    摘要： A gel-like material is provided, the gel-like material having an on-demand state-change capability, whether the on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Alternatively, the gel-like material may have a spatially and/or temporally selective state-change, whether on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Or, the gel-like material may selectively change state due to gel contacting diseased tissue having a natural thermal or compositional contrast or artificially induced thermal or compositional contrast capable of causing state-change via a state-change parameter, independent of an on-demand nature or a spatial/temporal selective nature.

    摘要翻译： 提供凝胶状材料，凝胶状材料具有按需状态变化能力，是否按需改变是初始状态，最终状态或两者，存在或递送的至少一些凝胶 正在经历变化。 或者，凝胶状材料可以具有空间和/或时间选择性状态变化，无论按需改变是初始状态，最终状态还是两者，存在或递送的至少一些凝胶发生变化。 或者，凝胶状材料可以选择性地改变状态，因为凝胶接触具有自然热或组成对比度或人为诱导的热或组成对比度的患病组织，其能够经由状态变化参数引起状态变化，而不依赖于按需 自然或空间/时间选择性。

    Optical techniques and system for 3-D characterization of ultrasound beams
    3.
    发明申请
    Optical techniques and system for 3-D characterization of ultrasound beams 有权
    超声波束三维表征的光学技术和系统

    公开(公告)号：US20070204671A1

    公开(公告)日：2007-09-06

    申请号：US11642989

    申请日：2006-12-21

    申请人： John Sliwa ,  Prasanna Hariharan ,  Ronald Robinson ,  Matthew Myers ,  Subha Maruvada ,  Rupak Banerjee ,  Gerald Harris

    发明人： John Sliwa ,  Prasanna Hariharan ,  Ronald Robinson ,  Matthew Myers ,  Subha Maruvada ,  Rupak Banerjee ,  Gerald Harris

    IPC分类号： G01H9/00

    CPC分类号： G01H9/00

    摘要： A system for optically characterizing an acoustic beam generally includes an immersant, which is an immersion medium seeded with a plurality of seed particles that respond to illumination with fluorescence indicative of at least one parameter of the immersant such as flow or temperature. Optical transmitters illuminate the immersant slicewise, and optical receptors receive the fluorescence in order to generate a three-dimensional map of the parameter over time. A processor back-calculates one or more characteristics of an acoustic beam that results in the map. The processor initially generates a behavior model of an acoustic beam propagating in the immersant by utilizing initial guesses for the characteristics. The initial guess model is compared to the map, and an optimization routine is used to refine the initial guesses. The process repeats iteratively with refined guesses until the difference between the model and the map is minimized.

    摘要翻译： 用于光学表征声束的系统通常包括浸渍介质，浸渍介质接种多个种子颗粒，所述种子颗粒响应于指示浸入物的至少一个参数（例如流动或温度）的荧光。 光发射器照射浸入式切片，光学受体接收荧光，以便随时间生成参数的三维图。 处理器返回计算导致地图的声波束的一个或多个特性。 处理器最初通过利用特征的初始猜测来生成在沉浸物中传播的声束的行为模型。 将初始猜测模型与地图进行比较，并使用优化程序来优化初始猜测。 该过程用精确的猜测重复迭代，直到模型和地图之间的差异最小化。

    Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy
    4.
    发明申请
    Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy 审中-公开
    用于治疗肥胖症或脂肪沉积物或用于递送化妆品或其他身体治疗的超声波装置和方法

    公开(公告)号：US20060094988A1

    公开(公告)日：2006-05-04

    申请号：US11262452

    申请日：2005-10-27

    申请人： Carol Tosaya ,  Lee Blumenfeld ,  John Sliwa

    发明人： Carol Tosaya ,  Lee Blumenfeld ,  John Sliwa

    IPC分类号： A61H1/00

    CPC分类号： A61H23/0245 ,  A61N7/00 ,  A61N2007/0008

    摘要： Obesity or fat deposits are treated with ultrasound. In one embodiment, a waveguide-based apparatus and method are disclosed for applying ultrasound to a treatment-subject for the purpose of providing treatment or therapy for obesity, fat-deposits, cosmetic benefit or other bodily therapy tasks. In another embodiment, a novel apparatus and method are disclosed for providing at least one such treatment or therapy using a liquid-based waveguide. In yet another embodiment, a wearable apparatus is disclosed that incorporates a waveguide of the invention. Any of the embodiments has application to hospital use, clinical use or home use, for example, and the place of use will likely be determined by which treatment mechanism is employed and at what power-level.

    摘要翻译： 用超声治疗肥胖或脂肪沉积物。 在一个实施例中，公开了一种基于波导的装置和方法，用于向治疗对象施加超声波，目的是为肥胖，脂肪沉积，美容益处或其他身体治疗任务提供治疗或治疗。 在另一个实施例中，公开了一种新颖的装置和方法，用于使用基于液体的波导提供至少一种这样的治疗或治疗。 在另一个实施例中，公开了一种包含本发明的波导的可穿戴设备。 任何实施例都可以应用于医院使用，临床使用或家庭使用，例如，使用地点可能由采用哪种治疗机制以及在什么功率级别来确定。

    Acoustic transducer for pulse-echo monitoring and control of thermally ablative lesioning in layered and nonlayered tissues, catheter contact monitoring, tissue thickness measurement and pre-pop warning
    5.
    发明授权
    Acoustic transducer for pulse-echo monitoring and control of thermally ablative lesioning in layered and nonlayered tissues, catheter contact monitoring, tissue thickness measurement and pre-pop warning 有权
    用于脉冲回波监测和控制层状和非层状组织中热烧蚀损伤的声学传感器，导管接触监测，组织厚度测量和弹前预警

    公开(公告)号：US08628473B2

    公开(公告)日：2014-01-14

    申请号：US13085867

    申请日：2011-04-13

    申请人： John Sliwa ,  Zhenyi Ma ,  Stephen Morse

    发明人： John Sliwa ,  Zhenyi Ma ,  Stephen Morse

    IPC分类号： A61B8/00

    CPC分类号： A61B8/12 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4272 ,  A61B8/445 ,  A61B8/4477 ,  A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00577 ,  A61B2090/3784 ,  A61N7/022 ,  F04C2270/041

    摘要： An ablation catheter with acoustic monitoring comprises an elongated catheter body; a distal member disposed adjacent a distal end and including an ablation element to ablate a biological member at a target region outside the catheter body; and one or more acoustic transducers each configured to direct an acoustic beam toward a respective target ablation region and receive reflection echoes therefrom. The distal member includes a transducer housing in which the acoustic transducers are disposed, the transducer housing including at least one transducer window which is the only portion in the distal member through which the acoustic beam passes, at least the at least one transducer window portion of the distal member being made of a material comprising at least 50% carbon by volume, the transducer window material having an acoustic impedance between that of the acoustic transducers and that of the biological member.

    摘要翻译： 具有声学监测的消融导管包括细长导管体; 远端构件邻近远端设置并且包括消融元件以在导管主体外部的目标区域处烧蚀生物构件; 以及一个或多个声学换能器，每个声学换能器被配置为将声束引向相应的目标消融区域并且从其接收反射回波。 远端构件包括换能器壳体，声学换能器设置在其中，换能器壳体包括至少一个换能器窗口，其是声束通过的远端构件中的唯一部分，至少一个换能器窗口部分 所述远端构件由包含至少50体积％碳的材料制成，所述换能器窗口材料在所述声学换能器和所述生物构件的声学阻抗之间具有声阻抗。

    Optical feedback RF ablator and ablator tip
    8.
    发明授权
    Optical feedback RF ablator and ablator tip 有权
    光反馈射频消融器和消音器尖端

    公开(公告)号：US08986292B2

    公开(公告)日：2015-03-24

    申请号：US13085789

    申请日：2011-04-13

    申请人： John Sliwa ,  Stephen Morse ,  Zhenyi Ma

    发明人： John Sliwa ,  Stephen Morse ,  Zhenyi Ma

    IPC分类号： A61B18/18 ,  A61B18/14 ,  A61B5/00 ,  A61B18/00

    CPC分类号： A61B18/1492 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/4836 ,  A61B5/6852 ,  A61B2017/00061 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00738 ,  A61B2018/1472 ,  A61B2218/002 ,  A61B2562/0233 ,  A61B2576/00

    摘要： An ablation catheter comprises an elongated catheter body; at least one ablation element disposed in a distal portion which is adjacent the distal end of the catheter body; an illumination optical element disposed in the distal portion, the illumination optical element being light-transmissive to emit light from the illumination optical element to the targeted tissue region; and a collection optical element disposed in the distal portion, the collection optical element being light-transmissive to collect one or more of returned, backscattered or newly excited light from the targeted tissue region. The illumination or excitation optical element and the collection optical element are axially spaced from one another and axially optically isolated from one another within the distal portion to substantially prevent light from traveling between the illumination optical element and the collection optical element along a path within the distal portion.

    摘要翻译： 消融导管包括细长的导管体; 至少一个消融元件设置在与导管主体的远端相邻的远侧部分中; 所述照明光学元件设置在所述远侧部分中，所述照明光学元件是透光的，以将光从所述照明光学元件发射到所述目标组织区域; 以及收集光学元件，其设置在所述远端部分中，所述收集光学元件是透光的，以收集来自所述目标组织区域的返回的，后向散射的或新激发的光的一种或多种。 照明或激发光学元件和收集光学元件彼此轴向间隔开并且在远端部分内彼此轴向光学隔离，以基本上防止光在照明光学元件和收集光学元件之间沿着远端内的路径行进 一部分。