公开(公告)号：US20100158816A1

公开(公告)日：2010-06-24

申请号：US12716891

申请日：2010-03-03

申请人： Kenichi Kawabata ,  Koji HIRATA ,  Kazuaki Sasaki

发明人： Kenichi Kawabata ,  Koji HIRATA ,  Kazuaki Sasaki

IPC分类号： A61B8/00

CPC分类号： A61K41/0033 ,  A61B5/4839 ,  A61B8/481

摘要： This invention provides a gas bubble-generating agent that can be used as a contrast medium or a blocking agent in vivo. Such gas bubble-generating agent is produced by a method for producing a gas bubble-generating agent comprising the following steps of: (a) preparing a mixed solution of an amphiphilic substance, an amphiphilic substance comprising a water-soluble polymer chemically bound thereto, a hardly water-soluble substance having a boiling point of lower than 60° C. at atmospheric pressure, and a physiologically acceptable isotonic solution; (b) pressurizing the mixed solution; and (c) centrifuging the mixed solution after the step of pressurization, wherein a molar concentration of the amphiphilic substance in the mixed solution prepared in step (a) is 10 times or more higher than that of the amphiphilic substance comprising a water-soluble polymer chemically bound thereto.

摘要翻译： 本发明提供了可用作造影剂或封闭剂的气泡产生剂。 这种气泡生成剂是通过气泡发生剂的制造方法制造的，其特征在于，包括以下步骤：（a）制备两亲物质，包含化学键合的水溶性聚合物的两亲物质， 在大气压下沸点低于60℃的几乎不溶于水的物质，以及生理上可接受的等渗溶液; （b）对混合溶液加压; 和（c）在加压步骤之后离心混合溶液，其中在步骤（a）中制备的混合溶液中的两亲物质的摩尔浓度比包含水溶性聚合物的两亲物质的摩尔浓度高10倍或更多 化学结合。

公开(公告)号：US06572839B2

公开(公告)日：2003-06-03

申请号：US09801844

申请日：2001-03-09

申请人： Nami Sugita ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Isao Sakata

发明人： Nami Sugita ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Isao Sakata

IPC分类号： A61B800

CPC分类号： A61K31/353 ,  A61B8/4444 ,  A61N7/00 ,  C07D311/86

摘要： A sensitizer for tumor treatment has a structure such that a lipophilic group and a hydrophilic group are bound to one and the same carbon atom in a compound containing a xanthene dye structure. It is important that the lipophilic group and hydrophilic group are bound to one and the same carbon atom; if they are separated from each other, no sufficient effect is obtained. Thus, the sensitizer possesses both lipophilicity and hydrophilicity. This sensitizer has a function of promoting acoustic cavitation and a function of revealing an antitumor effect and is an agent highly accumulable in tumor tissues. Thus, this sensitizer is highly selective for tumor tissues and enables the treatment of malignant tumor using ultrasound.

摘要翻译： 用于肿瘤治疗的敏化剂具有使亲油基团和亲水基团与含有呫吨染料结构的化合物中的同一个碳原子结合的结构。 重要的是亲脂基团和亲水基团与同一个碳原子结合; 如果它们彼此分离，则不能获得足够的效果。 因此，敏化剂具有亲油性和亲水性。 这种敏化剂具有促进声孔的功能和显示抗肿瘤作用的功能，并且是在肿瘤组织中高度累积的药剂。 因此，这种敏化剂对于肿瘤组织是高度选择性的并且能够使用超声治疗恶性肿瘤。

公开(公告)号：US08460191B2

公开(公告)日：2013-06-11

申请号：US11914962

申请日：2006-05-18

申请人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

发明人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

IPC分类号： A61B8/00

CPC分类号： A61B8/5207 ,  A61B5/11 ,  A61B8/08 ,  A61B8/461 ,  A61B8/463 ,  G06T5/50 ,  G06T7/223 ,  G06T2207/10132 ,  G06T2207/30101

摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.

摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

公开(公告)号：US07074427B2

公开(公告)日：2006-07-11

申请号：US10198178

申请日：2002-07-19

申请人： Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki

发明人： Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki

IPC分类号： A61K9/48 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50

CPC分类号： A61K41/0033

摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.

公开(公告)号：US06511428B1

公开(公告)日：2003-01-28

申请号：US09830423

申请日：2001-04-26

申请人： Takashi Azuma ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Katsuhiro Kuroda ,  Ryuichi Shinomura ,  Yuichi Miwa ,  Kazunari Ishida ,  Jun Kubota

发明人： Takashi Azuma ,  Kenichi Kawabata ,  Shinichiro Umemura ,  Kazuaki Sasaki ,  Katsuhiro Kuroda ,  Ryuichi Shinomura ,  Yuichi Miwa ,  Kazunari Ishida ,  Jun Kubota

IPC分类号： A61B800

CPC分类号： A61N7/022 ,  A61B8/12 ,  A61B2017/00154 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2090/378 ,  A61B2090/3782

摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.

摘要翻译： 超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。 超声波换能器在具有成像超声波探头的施加器内部。 另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。 成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。 超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。 结果，点状声源图像被叠加并显示在超声断层图像上。

公开(公告)号：US20090048516A1

公开(公告)日：2009-02-19

申请号：US11914962

申请日：2006-05-18

申请人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

发明人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

IPC分类号： A61B8/00

CPC分类号： A61B8/5207 ,  A61B5/11 ,  A61B8/08 ,  A61B8/461 ,  A61B8/463 ,  G06T5/50 ,  G06T7/223 ,  G06T2207/10132 ,  G06T2207/30101

摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.

摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

公开(公告)号：US06216538B1

公开(公告)日：2001-04-17

申请号：US08742695

申请日：1996-11-04

申请人： Kenji Yasuda ,  Shin-ichiro Umemura ,  Kenichi Kawabata ,  Kazuo Takeda ,  Kenko Uchida ,  Yoshinori Harada ,  Masao Kamahori ,  Kazuaki Sasaki

发明人： Kenji Yasuda ,  Shin-ichiro Umemura ,  Kenichi Kawabata ,  Kazuo Takeda ,  Kenko Uchida ,  Yoshinori Harada ,  Masao Kamahori ,  Kazuaki Sasaki

IPC分类号： G01H1700

CPC分类号： B01D21/283 ,  G10K15/00

摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.

摘要翻译： 超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合 由多个超声波振荡器产生的超声波。 彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

公开(公告)号：US08822837B2

公开(公告)日：2014-09-02

申请号：US13310959

申请日：2011-12-05

申请人： Hiroyuki Uematsu ,  Kenichi Kawabata

发明人： Hiroyuki Uematsu ,  Kenichi Kawabata

IPC分类号： H05K1/16 ,  H05K3/42 ,  H05K1/18 ,  H05K3/00

CPC分类号： H05K1/115 ,  H01L2224/04105 ,  H05K1/185 ,  H05K1/188 ,  H05K3/0035 ,  H05K3/0038 ,  H05K3/427 ,  H05K2201/0187 ,  H05K2201/09563 ,  H05K2203/095 ,  Y10T29/4913 ,  Y10T29/49146 ,  Y10T29/49147 ,  Y10T29/49165

摘要： A wiring board or an electronic component embedded substrate includes a substrate that includes a resin containing a plurality of fillers; and a via that is electrically connected to at least one interconnect provided to the substrate, wherein the via includes a mix area in which metal is provided between the fillers on an inner radial side with respect to the substrate. A method of manufacturing a wiring board or an electronic component embedded substrate includes preparing a substrate that includes a resin containing a plurality of fillers; forming a via formation hole in the substrate; performing an ashing process on at least an inner wall of the via formation hole; and performing electroless plating an the inner wall of the via formation hole.

摘要翻译： 布线基板或电子部件嵌入基板包括：基板，其具有含有多个填料的树脂; 以及通孔，其电连接到提供给基板的至少一个互连件，其中所述通孔包括混合区域，在所述混合区域中，在相对于所述基板的内径向侧的所述填料之间设置有金属。 制造布线板或电子部件嵌入式基板的方法包括制备包括含有多种填料的树脂的基板; 在所述基板中形成通孔形成孔; 在通孔形成孔的至少内壁上进行灰化处理; 并且对通孔形成孔的内壁进行化学镀。

公开(公告)号：US08530752B2

公开(公告)日：2013-09-10

申请号：US12632948

申请日：2009-12-08

申请人： Kenichi Kawabata ,  Takaaki Morita

发明人： Kenichi Kawabata ,  Takaaki Morita

IPC分类号： H05K1/16

CPC分类号： H05K3/4652 ,  H01L23/49822 ,  H01L23/5389 ,  H01L24/24 ,  H01L24/82 ,  H01L2224/24226 ,  H01L2224/2518 ,  H01L2224/82039 ,  H01L2224/82047 ,  H01L2224/92 ,  H01L2224/92244 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01015 ,  H01L2924/01024 ,  H01L2924/01029 ,  H01L2924/0103 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01061 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/19041 ,  H05K1/185 ,  H05K3/0044 ,  H05K3/0058 ,  H05K3/4602 ,  H05K3/4682 ,  H05K3/4688 ,  H05K2201/0358 ,  H05K2201/09518 ,  H05K2201/09527 ,  H05K2201/09563 ,  H05K2203/0152 ,  H05K2203/025 ,  H05K2203/0554 ,  H05K2203/1105 ,  H05K2203/1476 ,  H05K2203/1572 ,  Y10T29/49128 ,  Y10T428/24917 ,  H01L2224/83 ,  H01L2224/82 ,  H01L2924/00

摘要： A multilayer circuit board comprises core layers 101 and 102 made of a core material impregnated with resin, resin layers 111 and 112 interposed between the core layers 101 and 102, a wiring pattern 140 embedded in the resin layers 111 and 112. The core layers 101 and 102 have a thickness of 100 μm or smaller, whereby the entire board can significantly be thinned. Furthermore, the less strong resin layers 111 and 112 are interposed between the hard core layers 101 and 102, whereby the entire board has increased strength.

摘要翻译： 多层电路板包括由浸渍有树脂的芯材制成的芯层101和102，插入在芯层101和102之间的树脂层111和112，嵌入在树脂层111和112中的布线图案140.芯层101 102的厚度为100μm以下，从而能够使整个基板变薄。 此外，较不强的树脂层111和112插入在硬芯层101和102之间，由此整个板具有增加的强度。

公开(公告)号：US08204429B2

公开(公告)日：2012-06-19

申请号：US12324542

申请日：2008-11-26

申请人： Kenichi Kawabata

发明人： Kenichi Kawabata

IPC分类号： G03G15/00 ,  B65H29/30

CPC分类号： G03G15/234 ,  G03G2215/00654

摘要： In an image forming apparatus, a recording head discharges liquid droplets onto a sheet conveyed on a conveying belt to form an image on the sheet. A sheet discharge device is provided downstream from the conveying belt in a sheet conveyance direction and is intermittently driven independently of and in synchronization with the conveying belt to convey the sheet in a sheet discharging direction. A voltage application device applies a voltage to a charger. A distance between the charger and a nip portion formed between a pressing member and the conveying belt for duplex printing is set so that a voltage applied by the voltage application device increases a charged potential of the conveying belt in an area electrostatically attracting a trailing end of a predetermined sheet and a leading end of a subsequent sheet.

摘要翻译： 在图像形成装置中，记录头将液滴排放到在传送带上传送的片材上，以在片材上形成图像。 片材排出装置在片材输送方向上设置在输送带的下游，并且与输送带独立地且与其同步地间歇地驱动，以将片材沿片材排出方向输送。 电压施加装置向充电器施加电压。 设置充电器和形成在按压构件和用于双面打印的输送带之间的夹持部之间的距离，使得由施加电压装置施加的电压在静电吸引尾部的区域中增加输送带的带电电位 预定片材和后续片材的前端。