Epoxysuccinic acid derivatives
    2.
    发明授权
    Epoxysuccinic acid derivatives 失效
    环氧琥珀酸衍生物

    公开(公告)号:US4393228A

    公开(公告)日:1983-07-12

    申请号:US880180

    申请日:1978-02-22

    CPC分类号: C07D303/48

    摘要: The epoxysuccinic acid derivatives of this invention are prepared by esterification of an epoxysuccinic acid or a halide thereof, by partial hydrolysis of an epoxysuccinic acid diester, by amidation of an epoxysuccinic acid monoester, or by hydrolysis of an epoxysuccinic acid amide monoester. These epoxysuccinic acid derivatives have excellent thiol protease inhibitory activity and anti-inflammatory activity without the acceleration of vascular permeability.

    摘要翻译: 本发明的环氧琥珀酸衍生物通过环氧琥珀酸或其卤化物的酯化,环氧琥珀酸二酯的部分水解,环氧琥珀酸单酯的酰胺化,或通过环氧琥珀酸酰胺单酯的水解而制得。 这些环氧琥珀酸衍生物具有优异的硫醇蛋白酶抑制活性和抗炎活性,而不加速血管通透性。