公开(公告)号：US5400354A

公开(公告)日：1995-03-21

申请号：US193681

申请日：1994-02-08

申请人： Michael Ludowise ,  Nick Holonyak, Jr. ,  Stephen J. Caracci ,  Michael R. Krames ,  Fred A. Kish

发明人： Michael Ludowise ,  Nick Holonyak, Jr. ,  Stephen J. Caracci ,  Michael R. Krames ,  Fred A. Kish

IPC分类号： H01L21/338 ,  H01L21/74 ,  H01L21/8252 ,  H01L29/10 ,  H01L29/51 ,  H01L33/30 ,  H01S5/00 ,  H01S5/20 ,  H01S5/22 ,  H01S5/223 ,  H01S5/323 ,  H01S3/19

CPC分类号： H01L29/513 ,  H01L21/746 ,  H01L21/8252 ,  H01L29/1054 ,  H01L29/517 ,  H01L29/66863 ,  H01L33/30 ,  H01S5/20 ,  H01S5/22 ,  H01S5/2231 ,  H01S5/2059 ,  H01S5/2205 ,  H01S5/2214 ,  H01S5/32391

摘要： A fabrication method for providing a semiconductor light-emitting device includes growing a plurality of layers on a semiconductor substrate, including forming a lower cladding layer and an active region for generating lightwaves. A laminated cladding structure is formed on the active region. The laminated cladding structure includes a lower layer that is substantially aluminum-free to inhibit oxidation and includes an upper layer that is aluminum-bearing in order to promote oxidation. The upper layer of the lamination is oxidized along selected first regions and is selectively masked to prevent oxidation for second regions. The oxidation of the first region is carried out under conditions such that a native oxide is formed throughout the thickness of the first regions. Electrical current to the active region for operating the light-emitting device is channeled via the unoxidized region of the upper layer of the lamination. In a preferred embodiment, the device is an InGaAsP-AlInAs-InP laser. Other electronic devices, such as FETs, can be also formed using the top-down approach. Preferably, oxidation is limited to an upper III-V semiconductor layer by forming a lower III-V semiconductor layer that includes In and/or P. Lateral oxidation can also be realized using this approach.

摘要翻译： 一种用于提供半导体发光器件的制造方法包括在半导体衬底上生长多个层，包括形成下覆盖层和用于产生光波的有源区。 在有源区上形成层叠包层结构。 层压包覆结构包括基本上不含铝的下层以抑制氧化，并且包括为了促进氧化而成为铝的上层。 叠层的上层被沿选定的第一区氧化，并被选择性地掩蔽以防止第二区的氧化。 第一区域的氧化在使得在第一区域的整个厚度上形成天然氧化物的条件下进行。 通过层压的上层的未氧化区域引导到用于操作发光器件的有源区的电流。 在优选实施例中，器件是InGaAsP-AlInAs-InP激光器。 也可以使用自顶向下的方法形成诸如FET的其它电子器件。 优选地，通过形成包括In和/或P的下III-V半导体层，氧化被限制在上III-V半导体层。也可以使用这种方法实现侧向氧化。

公开(公告)号：US5403775A

公开(公告)日：1995-04-04

申请号：US260067

申请日：1994-06-15

申请人： Nick Holonyak, Jr. ,  Fred A. Kish ,  Stephen J. Caracci

发明人： Nick Holonyak, Jr. ,  Fred A. Kish ,  Stephen J. Caracci

IPC分类号： H01L21/316 ,  H01S5/026 ,  H01S5/10 ,  H01S5/40 ,  H01L21/20

CPC分类号： H01L21/02178 ,  H01L21/02241 ,  H01L21/02255 ,  H01L21/31666 ,  H01S5/10 ,  H01S5/1021 ,  H01S5/026 ,  H01S5/1028 ,  H01S5/1071 ,  H01S5/4031 ,  H01S5/4056 ,  H01S5/4068

摘要： The disclosure is directed to improved techniques and devices employing an aluminum-bearing III-V semiconductor material and a native oxide of aluminum that is formed in the semiconductor material. Effective optical confinement, tailored to obtain desired operating conditions, can be achieved with a thick native oxide of aluminum that extends through at least one-third of the thickness of the aluminum-bearing layer in which the native oxide is formed. The resultant lateral index step can be made quite large and employed for devices such as ring lasers.

摘要翻译： 本公开涉及采用铝 - III型半导体材料和形成在半导体材料中的铝的天然氧化物的改进的技术和装置。 用于获得所需操作条件而定制的有效光学限制可以通过延伸穿过其中形成天然氧化物的含铝层的厚度的至少三分之一的厚的铝的自然氧化物来实现。 所得到的横向折射率步骤可以做得相当大，并且用于诸如环形激光器的器件。

公开(公告)号：US5327448A

公开(公告)日：1994-07-05

申请号：US860454

申请日：1992-03-30

申请人： Nick Holonyak, Jr. ,  Fred A. Kish ,  Stephen J. Caracci

发明人： Nick Holonyak, Jr. ,  Fred A. Kish ,  Stephen J. Caracci

IPC分类号： H01L21/316 ,  H01S5/026 ,  H01S5/10 ,  H01S5/40 ,  H01S3/19

CPC分类号： H01L21/02178 ,  H01L21/02241 ,  H01L21/02255 ,  H01L21/31666 ,  H01S5/10 ,  H01S5/1021 ,  H01S5/026 ,  H01S5/1028 ,  H01S5/1071 ,  H01S5/4031 ,  H01S5/4056 ,  H01S5/4068

摘要： The disclosure is directed to improved techniques and devices employing an aluminum-bearing III-V semiconductor material and a native oxide of aluminum that is formed in the semiconductor material. Effective optical confinement, tailored to obtain desired operating conditions, can be achieved with a thick native oxide of aluminum that extends through at least one-third of the thickness of the aluminum-bearing layer in which the native oxide is formed. The resultant lateral index step can be made quite large and employed for devices such as ring lasers.

摘要翻译： 本公开涉及采用铝 - III型半导体材料和形成在半导体材料中的铝的天然氧化物的改进的技术和装置。 用于获得所需操作条件而定制的有效光学限制可以通过延伸穿过其中形成天然氧化物的含铝层的厚度的至少三分之一的厚的铝的自然氧化物来实现。 所得到的横向折射率步骤可以做得相当大，并且用于诸如环形激光器的器件。

公开(公告)号：US20090247427A1

公开(公告)日：2009-10-01

申请号：US12480886

申请日：2009-06-09

申请人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

发明人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

IPC分类号： C40B60/12

CPC分类号： G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

公开(公告)号：US07999944B2

公开(公告)日：2011-08-16

申请号：US12256852

申请日：2008-10-23

申请人： Stephen J. Caracci ,  Michael J. Dailey, Jr. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

发明人： Stephen J. Caracci ,  Michael J. Dailey, Jr. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

IPC分类号： G01N21/55

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/45

摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

摘要翻译： 本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。 在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

公开(公告)号：US07741598B2

公开(公告)日：2010-06-22

申请号：US12402901

申请日：2009-03-12

申请人： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

发明人： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

IPC分类号： G01J1/04 ,  G01J1/58

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

摘要翻译： 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

公开(公告)号：US07062135B2

公开(公告)日：2006-06-13

申请号：US10392077

申请日：2003-03-19

申请人： Stephen J. Caracci ,  Alain R. E. Carre ,  Adam J. Fusco

发明人： Stephen J. Caracci ,  Alain R. E. Carre ,  Adam J. Fusco

IPC分类号： G02B6/02 ,  G02B6/16 ,  G02B6/42 ,  C03B37/00 ,  B29D11/00

CPC分类号： G02B6/32

摘要： The present invention provides methods for forming convex and concave elements on the ends of supporting members. A convex element may be formed by forming a droplet on the end of the supporting member, then curing the droplet. The size of the droplet may be controlled using evaporation of a solvent from the droplet. In another aspect of the invention, an optical element may be formed by forming a droplet on the end of the supporting member, contacting the droplet with a mold, and curing the droplet, thereby forming an element with a curvature opposite that of the mold. When the supporting member is an optical fiber, the elements formed by the methods of the present invention are useful as lenses and mirrors in micro-optic devices.

公开(公告)号：US06816653B2

公开(公告)日：2004-11-09

申请号：US10373994

申请日：2003-02-25

申请人： Alfredo D. Botet ,  Stephen J. Caracci ,  Adam J. Fusco ,  Sean M. Garner ,  Cheng-Chung Li ,  Daniel R. Sempolinski

发明人： Alfredo D. Botet ,  Stephen J. Caracci ,  Adam J. Fusco ,  Sean M. Garner ,  Cheng-Chung Li ,  Daniel R. Sempolinski

IPC分类号： G02B630

CPC分类号： G02B6/3652 ,  G02B6/138 ,  G02B6/30 ,  G02B6/3692

摘要： Articles and methods for manufacturing pigtailed planar optical devices are disclosed. The articles and methods include providing a tool including a substrate having a stepped region. The tool is capable of forming elements such as grippers or waveguides on a device substrate having different heights.

摘要翻译： 公开了制造尾纤平面光学器件的制品和方法。 制品和方法包括提供包括具有阶梯状区域的基板的工具。 该工具能够在具有不同高度的器件衬底上形成诸如夹持器或波导的元件。

公开(公告)号：US20120010105A1

公开(公告)日：2012-01-12

申请号：US13237316

申请日：2011-09-20

申请人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

发明人： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

IPC分类号： C40B60/12 ,  C40B30/10 ,  C40B30/00

CPC分类号： G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

公开(公告)号：US20100105148A1

公开(公告)日：2010-04-29

申请号：US12256852

申请日：2008-10-23

申请人： Stephen J. Caracci ,  Michael J. Dailey, JR. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

发明人： Stephen J. Caracci ,  Michael J. Dailey, JR. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

IPC分类号： G01N21/00 ,  G01N21/45 ,  G01N21/41

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/45

摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

摘要翻译： 本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。 在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。