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公开(公告)号：US06504607B2
公开(公告)日：2003-01-07
申请号：US10004689
申请日：2001-12-04
IPC分类号： G01J330
CPC分类号： G01N27/44721
摘要： Systems and methods for analyzing a sample are disclosed. The system may include a light source operable to transmit light onto the sample, a detector operable to detect intensity of the light emitted from the sample, and a power modulator. The power modulator modulates the light source power such that light is emitted from the light source in more than one mode to reduce changes in the emitted light due to temperature changes in the light source.
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公开(公告)号：US06353475B1
公开(公告)日：2002-03-05
申请号：US09377891
申请日：1999-08-19
IPC分类号： G01N2101
CPC分类号： G01N27/44721
摘要： Systems and methods for analyzing a sample are disclosed. The system may include a light source operable to transmit light onto the sample, a detector operable to detect intensity of the light emitted from the sample, and a power modulator. The power modulator modulates the light source power such that light is emitted from the light source in more than one mode to reduce changes in the emitted light due to temperature changes in the light source.
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公开(公告)号：US07343248B2
公开(公告)日：2008-03-11
申请号：US11069632
申请日：2005-02-28
申请人： J. Wallace Parce , Morten J. Jensen
发明人： J. Wallace Parce , Morten J. Jensen
IPC分类号： G01N33/48
CPC分类号： B01L3/5027 , B01L2200/143 , G01N35/0092 , G01N2035/0093 , Y10T436/115831 , Y10T436/25375 , Y10T436/2575
摘要： Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequentially run past down a main channel to a detection zone of the microfluidic device in order to analyze the fluids. In order to increase the efficiency of the analysis, fluids can be processed in parallel by running one fluid down the main channel while another fluid is loaded to the main channel.
摘要翻译： 提供了控制分析仪器的技术。 可以使用一系列步骤来指定微流体装置的孔，将要施加到井中的流体的移动性以及施加移动性的持续时间。 例如，为了分析流体，流体可以顺序地沿主通道向下流动到微流体装置的检测区域。 为了提高分析效率，可以通过在主通道下方运行一个流体同时将另一个流体加载到主通道来并行处理流体。
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公开(公告)号：US06384401B1
公开(公告)日：2002-05-07
申请号：US09686269
申请日：2000-10-10
申请人： Morten J. Jensen
发明人： Morten J. Jensen
IPC分类号： G01V904
摘要： A method and apparatus for measuring very low light signals including integrating a signal from a photo diode, avalanche photo diode, photomultiplier tube or the like, digitally sampling the integrator output more than two times during each integration period, fitting a curve to the multiple digitized readings to calculate the integration slope for each integration period and determining the original signal from the calculated integration slope.
摘要翻译： 一种用于测量非常低的光信号的方法和装置，包括积分来自光电二极管，雪崩光电二极管，光电倍增管等的信号，在每个积分周期期间对积分器输出进行数字采样两次以上，将曲线拟合到多个数字化 读数计算每个积分周期的积分斜率，并从计算的积分斜率确定原始信号。
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公开(公告)号：US20110077480A1
公开(公告)日：2011-03-31
申请号：US12731010
申请日：2010-03-24
申请人： Daniel Bloom , Nicholas A. Nelson , Morten J. Jensen , Laurence R. Shea , Edward Paul Donlon , Joseph Anthony Vivolo , Stuart Taylor
发明人： Daniel Bloom , Nicholas A. Nelson , Morten J. Jensen , Laurence R. Shea , Edward Paul Donlon , Joseph Anthony Vivolo , Stuart Taylor
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150358 , A61B5/150755 , A61B5/150793 , A61B5/150809 , A61B5/150824 , A61B5/15087 , A61B5/150946 , A61B5/150961 , A61B5/1535 , A61B5/155 , A61B5/157 , A61B5/6866
摘要： Devices and methods for automatic monitoring of fluid of a patient are disclosed, comprising a patient line, a transfer disk which receives the fluid and controllably transfers the fluid to test substrates, and a sensor disk which houses the test substrates. The sterile transfer disk may be configured to maintain the sterility of the patient sampling assembly while transferring samples to non-sterile components, such as the sensor disk.
摘要翻译： 公开了一种用于患者流体自动监测的装置和方法，包括患者线，接收流体并可控制地将流体转移到测试基底的转移盘以及容纳测试基底的传感器盘。 无菌转移盘可以被配置为在将样品转移到非无菌组件（例如传感器盘）的同时保持患者采样组件的无菌性。
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公开(公告)号：US07518726B2
公开(公告)日：2009-04-14
申请号：US11404043
申请日：2006-04-12
IPC分类号： G01B11/00
CPC分类号： G01B11/002 , B01L3/5027 , B01L3/502715 , B01L2200/025 , B01L2300/0816 , G01N21/645 , G01N2021/0162 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0627 , G02B21/16
摘要： An optical detection system for a microfluidic device and a dry-focus microfluidic device compatible with the compact optical detection system are described. The system includes an LED; means for collimating light emitted by the LED; an aspherical, fused-silica objective lens; means for directing the collimated light through the objective onto a microfluidic device; and means for detecting a fluorescent signal emitted from the microfluidic device. The working distance between the objective and the device allows light from an external LED or laser to be brought in along a diagonal path to illuminate the microfluidic device. The dry-focus microfluidic device includes multiple channels and multiple closed optical alignment marks having curved walls. At least one of the channels is positioned between at least two of the marks. The marks are illuminated for alignment and focusing purposes by light brought in on a diagonal path from an external white LED.
摘要翻译： 描述了用于微流体装置的光学检测系统和与紧凑型光学检测系统兼容的干焦微流体装置。 该系统包括一个LED; 用于准直LED发出的光的装置; 非球面，熔融二氧化硅物镜; 用于将准直光通过物镜引导到微流体装置上的装置; 以及用于检测从微流体装置发射的荧光信号的装置。 物镜与设备之间的工作距离允许来自外部LED或激光器的光沿着对角线路进入以照亮微流体装置。 干焦微流体装置包括具有弯曲壁的多个通道和多个封闭的光学对准标记。 至少一个通道位于至少两个标记之间。 通过从外部白色LED的对角线路上引入的光照亮标记以进行对准和聚焦。
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公开(公告)号：US06498497B1
公开(公告)日：2002-12-24
申请号：US09374878
申请日：1999-08-13
IPC分类号： G01R3500
CPC分类号： G01N27/44721 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/148 , B01L2400/0415 , G01N27/44791
摘要： A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.
摘要翻译： 公开了用于进行筛选测定的微流控制器和检测器系统和方法。 微流控制器和检测器系统包括流体芯片，其包括至少两个相交通道和检测区域，流体方向系统，包括被配置为与所述至少两个相交通道电接触的电接口， 邻近所述检测区域，以及控制系统，其耦合到所述光学块并适于从所述光学块接收和分析数据。 电接口通常包括被配置为与交叉通道电接触并且耦合到用于向电极提供电输入的电极通道的电极。 可选地提供参考通道以校准电极通道。
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公开(公告)号：US07155344B1
公开(公告)日：2006-12-26
申请号：US09361478
申请日：1999-07-26
申请人： J. Wallace Parce , Morten J. Jensen
发明人： J. Wallace Parce , Morten J. Jensen
IPC分类号： G01N33/48
CPC分类号： B01L3/5027 , B01L2200/143 , G01N35/0092 , G01N2035/0093 , Y10T436/115831 , Y10T436/25375 , Y10T436/2575
摘要： Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequentially run past down a main channel to a detection zone of the microfluidic device in order to analyze the fluids. In order to increase the efficiency of the analysis, fluids can be processed in parallel by running one fluid down the main channel while another fluid is loaded to the main channel.
摘要翻译： 提供了控制分析仪器的技术。 可以使用一系列步骤来指定微流体装置的孔，将要施加到井中的流体的移动性以及施加移动性的持续时间。 例如，为了分析流体，流体可以顺序地沿主通道向下流动到微流体装置的检测区域。 为了提高分析效率，可以通过在主通道下方运行一个流体同时将另一个流体加载到主通道来并行处理流体。
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公开(公告)号：US06881312B2
公开(公告)日：2005-04-19
申请号：US10319045
申请日：2002-12-13
申请人： Anne R. Kopf-Sill , Andrea W. Chow , Peter C. Jann , Morten J. Jensen , Michael Spaid , Colin B. Kennedy , Michael J. Kennedy
发明人： Anne R. Kopf-Sill , Andrea W. Chow , Peter C. Jann , Morten J. Jensen , Michael Spaid , Colin B. Kennedy , Michael J. Kennedy
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N27/447 , G01N35/00 , G01N37/00 , G01N27/26
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
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公开(公告)号：US06620625B2
公开(公告)日：2003-09-16
申请号：US09750450
申请日：2000-12-28
IPC分类号： G01N100
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/02 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0819 , B01L2300/0861 , B01L2400/022 , B01L2400/0406 , C12Q2565/629 , C40B40/06 , C40B60/14 , G01N35/10 , G01N2001/028 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , Y10T436/25 , Y10T436/2575
摘要： Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.
摘要翻译： 超高产量系统和方法用于从基本上平面的库存储组件的表面采样大量不同的材料。 该系统和方法通常采用：具有用于进行取样材料分析的集成毛细管元件的微流体装置; 图书馆存储组件，例如平面固体基底，能够在小区域保留数千，数万和数十万种不同的材料; 用于允许通过微流体装置快速准确地取样材料的感测系统，以及用于控制和分析这些系统的整体操作的相关仪器。
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