公开(公告)号：US08527057B2

公开(公告)日：2013-09-03

申请号：US12976650

申请日：2010-12-22

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： The present invention is an improved package and configuration for an implantable retinal prosthesis. The retinal prosthesis of the present invention includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package and inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

摘要翻译： 本发明是用于植入式视网膜假体的改进的包装和构造。 本发明的视网膜假体包括适于安装在视网膜附近的电极阵列，电子封装和感应接收线圈，其彼此相邻地安置在围绕巩膜的带上，使得假体巩膜上方的高度 被最小化。

公开(公告)号：US20110118807A1

公开(公告)日：2011-05-19

申请号：US12976650

申请日：2010-12-22

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61F9/08 ,  A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： The present invention is an improved package and configuration for an implantable retinal prosthesis. The retinal prosthesis of the present invention includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package and inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

摘要翻译： 本发明是用于植入式视网膜假体的改进的包装和构造。 本发明的视网膜假体包括适于安装在视网膜附近的电极阵列，电子封装和感应接收线圈，其彼此相邻地安置在围绕巩膜的带上，使得假体巩膜上方的高度 被最小化。

公开(公告)号：US07881799B2

公开(公告)日：2011-02-01

申请号：US11385315

申请日：2006-03-20

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkins ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： An improved package and configuration for an implantable retinal prosthesis includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package, and inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

摘要翻译： 用于可植入视网膜假体的改进的包装和构造包括适于安装在靠近视网膜的电极阵列，电子封装和在包围巩膜的带上彼此相邻安装的感应接收线圈，使得高于 假体的巩膜最小化。

公开(公告)号：US08473048B2

公开(公告)日：2013-06-25

申请号：US11385314

申请日：2006-03-20

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/375

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device of the present invention includes an eclectically non-conductive bass including electrically conductive vias through the substrate. A circuit is flip-chip bonded to a subset of the vias. A second circuit is wire bonded to another subset of the vias. Finally, a cover is bonded to the substrate such that the cover, substrate and vias form a hermetic package.

摘要翻译： 本发明是用于植入人体的改进的密封包装。 本发明的可植入装置包括包含通过基底的导电通路的折衷不导电的低音。 电路倒装芯片结合到通孔的子集。 第二电路被引线接合到通孔的另一子集。 最后，将覆盖物粘合到基底上，使得盖，基底和通孔形成密封包装。

公开(公告)号：US07873419B2

公开(公告)日：2011-01-18

申请号：US11927315

申请日：2007-10-29

申请人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J. Greenberg ,  Jerry Ok ,  Jordan Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： An improved package and configuration for an implantable retinal prosthesis includes an electrode array suitable to be mounted in close proximity to a retina, an electronics package, and an inductive receiving coil mounted next to each other on a strap surrounding the sclera so that the height above the sclera of the prosthesis is minimized.

摘要翻译： 用于植入式视网膜假体的改进的包装和构造包括适于安装在靠近视网膜的电极阵列，电子封装和在包围巩膜的带上彼此相邻安装的感应接收线圈，使得高于 假体的巩膜最小化。

公开(公告)号：US08532776B2

公开(公告)日：2013-09-10

申请号：US11924469

申请日：2007-10-25

申请人： Robert J Greenberg ,  Jerry Ok ,  Jordan Matthew Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

发明人： Robert J Greenberg ,  Jerry Ok ,  Jordan Matthew Neysmith ,  Kevin Wilkin ,  Neil Hamilton Talbot ,  Da-Yu Chang

IPC分类号： A61N1/375

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73253 ,  H01L2924/15311 ,  H01L2924/16251 ,  H01L2924/19104 ,  H01L2924/19107

摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device of the present invention includes an eclectically non-conductive bass including electrically conductive vias through the substrate. A circuit is flip-chip bonded to a subset of the vias. A second circuit is wire bonded to another subset of the vias. Finally, a cover is bonded to the substrate such that the cover, substrate and vias form a hermetic package.

公开(公告)号：US09569657B2

公开(公告)日：2017-02-14

申请号：US13567879

申请日：2012-08-06

申请人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

发明人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

IPC分类号： A61N1/36 ,  G06K9/00

CPC分类号： G06K9/00228 ,  A61N1/36046 ,  G06K9/00671

摘要： The present invention is a system for detecting, tracking and recognizing human faces in a visual prosthesis. In a visual prosthesis, the input camera is always higher resolution than the electrode array providing percepts to the subject. It is advantageous to detect, track and recognize human faces. Then information can be provided to the subject by highlighting the face in the visual scene, providing auditor or vibratory notice that a human face is in the visual scene, looking up the face in a database to state the name of the person in the visual scene, otherwise communication id like providing a custom vibratory pattern corresponding to known individuals (like custom ring tones associated with caller ID) or automatically zooming in on a face to aid the subject in identifying the face.

摘要翻译： 本发明是一种用于在视觉假体中检测，跟踪和识别人脸的系统。 在视觉假体中，输入摄像机总是比提供对被摄体感知的电极阵列更高的分辨率。 检测，跟踪和识别人脸是有利的。 然后可以通过突出显示视觉场景中的脸部，提供人脸在视觉场景中的审核员或振动通知，向数据库中提供信息，查看数据库中的脸部以说明视觉场景中的人的姓名 否则通信ID就像提供对应于已知个人的定制振动模式（例如与呼叫者ID相关联的自定义铃音）或者自动放大脸部以帮助被摄体识别脸部。

公开(公告)号：US20130035742A1

公开(公告)日：2013-02-07

申请号：US13567879

申请日：2012-08-06

申请人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

发明人： Neil Hamilton Talbot ,  Jerry Ok ,  Robert J. Greenberg ,  Gregoire Cosendai ,  Brian V. Mech ,  Avraham I. Caspi ,  Fatima Anaflous ,  Francesco Merlini ,  Kelly H. McClure

IPC分类号： A61F9/08 ,  A61N1/36

CPC分类号： G06K9/00228 ,  A61N1/36046 ,  G06K9/00671

摘要： The present invention is a system for detecting, tracking and recognizing human faces in a visual prosthesis. In a visual prosthesis, the input camera is always higher resolution than the electrode array providing percepts to the subject. It is advantageous to detect, track and recognize human faces. Then information can be provided to the subject by highlighting the face in the visual scene, providing auditor or vibratory notice that a human face is in the visual scene, looking up the face in a database to state the name of the person in the visual scene, otherwise communication id like providing a custom vibratory pattern corresponding to known individuals (like custom ring tones associated with caller ID) or automatically zooming in on a face to aid the subject in identifying the face.

摘要翻译： 本发明是一种用于在视觉假体中检测，跟踪和识别人脸的系统。 在视觉假体中，输入摄像机总是比提供对被摄体感知的电极阵列更高的分辨率。 检测，跟踪和识别人脸是有利的。 然后可以通过突出显示视觉场景中的脸部，提供人脸在视觉场景中的审核员或振动通知，向数据库中提供信息，查看数据库中的脸部以说明视觉场景中的人的姓名 否则通信ID就像提供对应于已知个人的定制振动模式（例如与呼叫者ID相关联的自定义铃音）或者自动放大脸部以帮助被摄体识别脸部。

公开(公告)号：US20100197082A1

公开(公告)日：2010-08-05

申请号：US12726274

申请日：2010-03-17

申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

IPC分类号： H01L21/56

CPC分类号： A61N1/375 ,  A61N1/3754 ,  H01L23/291 ,  H01L23/3107 ,  H01L24/03 ,  H01L24/05 ,  H01L24/12 ,  H01L24/85 ,  H01L2224/0345 ,  H01L2224/0347 ,  H01L2224/0401 ,  H01L2224/05083 ,  H01L2224/05124 ,  H01L2224/05147 ,  H01L2224/05164 ,  H01L2224/05166 ,  H01L2224/05187 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/13099 ,  H01L2224/13164 ,  H01L2224/13169 ,  H01L2224/85 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/04941 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/351 ,  H01L2924/04953 ,  H01L2924/00 ,  H01L2224/48 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2224/45099

摘要： An implantable hermetically sealed microelectronic device and method of manufacture are disclosed. The microelectronic device of the present invention is hermetically encased in a insulator, such as alumina formed by ion bean assisted deposition (“IBAD”), with a stack of biocompatible conductive layers extending from a contact pad on the device to an aperture in the hermetic layer. In a preferred embodiment, one or more patterned titanium layers are formed over the device contact pad, and one or more platinum layers are formed over the titanium layers, such that the top surface of the upper platinum layer defines an external, biocompatible electrical contact for the device. Preferably, the bottom conductive layer is larger than the contact pad on the device, and a layer in the stack defines a shoulder.

摘要翻译： 公开了可植入气密微电子器件及其制造方法。 本发明的微电子器件气密地封装在诸如由离子豆辅助沉积（“IBAD”）形成的氧化铝之类的绝缘体中，一堆生物相容的导电层从器件上的接触垫延伸到密封的孔 层。 在优选实施例中，在器件接触焊盘上形成一个或多个图案化的钛层，并且在钛层上形成一个或多个铂层，使得上铂层的顶表面限定外部的生物相容的电接触， 装置。 优选地，底部导电层大于器件上的接触焊盘，并且堆叠中的层限定了肩部。

公开(公告)号：US08524311B1

公开(公告)日：2013-09-03

申请号：US11926459

申请日：2007-10-29

申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Brian V. Mech

发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Brian V. Mech

IPC分类号： A61N1/04

CPC分类号： H05K3/0011 ,  A61N1/0543 ,  H05K3/0035 ,  H05K3/064 ,  H05K2203/0736 ,  H05K2203/095

摘要： Polymer materials make useful materials as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision. Regardless of which polymer is used, the basic construction method is the same. A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. A method for manufacturing a flexible circuit electrode array, comprises: a) depositing a metal trace layer on an insulator polymer base layer; b) applying a layer of photoresist on said metal trace layer and patterning said metal trace layer and forming metal traces on said insulator polymer base layer; and c) activating said insulator polymer base layer and depositing a top insulator polymer layer and forming one single insulating polymer layer with said base insulator polymer layer; wherein the insulator polymer layers were treated at a temperature from 80-150° C. and then at a temperature from 230-350° C.

摘要翻译： 聚合物材料作为电极阵列体用于神经刺激。 它们对视网膜刺激特别有用，以产生人造视力。 不管使用哪种聚合物，基本的施工方法是一样的。 放置一层聚合物。 将一层金属施加到聚合物上并图案化以产生用于那些电极的电极和引线。 将第二层聚合物施加在金属层上并图案化以留下电极的开口，或稍后通过诸如激光烧蚀的手段产生开口。 因此阵列及其供电电缆由单体形成。 一种制造柔性电路电极阵列的方法，包括：a）在绝缘体聚合物基层上沉积金属迹线层; b）在所述金属迹线层上施加一层光致抗蚀剂，并图案化所述金属迹线层并在所述绝缘体聚合物基底层上形成金属迹线; 以及c）激活所述绝缘体聚合物基层并沉积顶绝缘体聚合物层并与所述基础绝缘体聚合物层形成一个单一绝缘聚合物层; 其中绝缘体聚合物层在80-150℃的温度下然后在230-350℃的温度下进行处理