公开(公告)号：US08025960B2

公开(公告)日：2011-09-27

申请号：US10941746

申请日：2004-09-15

申请人： Robert S. Dubrow ,  Chunming Niu

发明人： Robert S. Dubrow ,  Chunming Niu

IPC分类号： A61F13/00 ,  B32B3/26 ,  A61M35/00

CPC分类号： B01D39/08 ,  B01D69/141 ,  B01D2239/0225 ,  B01D2239/0233 ,  B01D2239/0241 ,  B01D2239/025 ,  B01D2239/0428 ,  B01D2239/0492 ,  B01D2239/0613 ,  B01D2239/065 ,  B01D2239/1216 ,  B01D2323/283 ,  Y02E10/549 ,  Y10T428/249953 ,  Y10T428/24996 ,  Y10T442/30

摘要： Porous nanofiber bearing substrate materials are provided having enhanced surface area for a variety of applications including as electrical substrates, semipermeable membranes and barriers, structural lattices for tissue culturing and for composite materials, and the like.

摘要翻译： 提供多孔纳米纤维轴承衬底材料，其具有用于各种应用的增强的表面积，包括电底物，半透膜和屏障，用于组织培养的结构晶格和复合材料等。

公开(公告)号：US07972616B2

公开(公告)日：2011-07-05

申请号：US11330722

申请日：2006-01-12

申请人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

发明人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

IPC分类号： A61K33/38 ,  A61K9/70 ,  B32B5/16 ,  B32B37/00 ,  B22F7/04

CPC分类号： A61L31/10 ,  A61F13/02 ,  A61L27/34 ,  A61L2400/12 ,  A61L2420/04 ,  A61N1/05 ,  B82Y30/00 ,  Y10S977/762 ,  Y10S977/764 ,  Y10S977/773 ,  Y10S977/811 ,  Y10S977/813 ,  Y10S977/90 ,  Y10S977/904 ,  Y10S977/906 ,  Y10T428/12111 ,  Y10T428/249924 ,  Y10T428/29

摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

摘要翻译： 本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。 在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞 。

公开(公告)号：US07755038B2

公开(公告)日：2010-07-13

申请号：US12121008

申请日：2008-05-15

申请人： Chunming Niu ,  Robert Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

发明人： Chunming Niu ,  Robert Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

IPC分类号： H01J49/04

CPC分类号： A61L27/303 ,  A61L31/122 ,  H01J49/0418 ,  Y10S977/701 ,  Y10T428/12736 ,  Y10T428/12743

摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.

摘要翻译： 本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。 底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。 本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储， 光学和传感器。

公开(公告)号：US20110201984A1

公开(公告)日：2011-08-18

申请号：US13096919

申请日：2011-04-28

申请人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

发明人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

IPC分类号： A61L15/58

CPC分类号： A61L31/10 ,  A61F13/02 ,  A61L27/34 ,  A61L2400/12 ,  A61L2420/04 ,  A61N1/05 ,  B82Y30/00 ,  Y10S977/762 ,  Y10S977/764 ,  Y10S977/773 ,  Y10S977/811 ,  Y10S977/813 ,  Y10S977/90 ,  Y10S977/904 ,  Y10S977/906 ,  Y10T428/12111 ,  Y10T428/249924 ,  Y10T428/29

摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

摘要翻译： 本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。 在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞 。

公开(公告)号：US07339184B2

公开(公告)日：2008-03-04

申请号：US11117707

申请日：2005-04-29

申请人： Linda T. Romano ,  Jian Chen ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Stephen A. Empedocles ,  Jay L. Goldman ,  James M. Hamilton ,  David L. Heald ,  Francesco Lemmi ,  Chunming Niu ,  Yaoling Pan ,  George Pontis ,  Vijendra Sahi ,  Erik C. Scher ,  David P. Stumbo ,  Jeffery A. Whiteford

发明人： Linda T. Romano ,  Jian Chen ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Stephen A. Empedocles ,  Jay L. Goldman ,  James M. Hamilton ,  David L. Heald ,  Francesco Lemmi ,  Chunming Niu ,  Yaoling Pan ,  George Pontis ,  Vijendra Sahi ,  Erik C. Scher ,  David P. Stumbo ,  Jeffery A. Whiteford

IPC分类号： H01L29/00

CPC分类号： C30B29/605 ,  B82Y10/00 ,  C30B11/12 ,  H01L21/02439 ,  H01L21/02513 ,  H01L21/02521 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/02606 ,  H01L21/02639 ,  H01L21/02645 ,  H01L21/02653 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L29/125 ,  H01L29/66469 ,  H01L29/775 ,  H01L29/78684 ,  H01L29/7869 ,  H01L29/78696 ,  H01L51/0048 ,  Y10S977/762 ,  Y10S977/938 ,  Y10T428/139 ,  Y10T428/2902 ,  Y10T428/2949

摘要： The present invention is directed to methods to harvest, integrate and exploit nanomaterials, and particularly elongated nanowire materials. The invention provides methods for harvesting nanowires that include selectively etching a sacrificial layer placed on a nanowire growth substrate to remove nanowires. The invention also provides methods for integrating nanowires into electronic devices that include placing an outer surface of a cylinder in contact with a fluid suspension of nanowires and rolling the nanowire coated cylinder to deposit nanowires onto a surface. Methods are also provided to deposit nanowires using an ink-jet printer or an aperture to align nanowires. Additional aspects of the invention provide methods for preventing gate shorts in nanowire based transistors. Additional methods for harvesting and integrating nanowires are provided.

摘要翻译： 本发明涉及收获，整合和利用纳米材料，特别是细长的纳米线材料的方法。 本发明提供了收获纳米线的方法，其包括选择性地蚀刻放置在纳米线生长衬底上以去除纳米线的牺牲层。 本发明还提供了将纳米线整合到电子器件中的方法，包括将圆筒的外表面与纳米线的流体悬浮液接触并滚动纳米线涂覆的圆筒以将纳米线沉积到表面上。 还提供了使用喷墨打印机或孔径以纳米线排列纳米线的方法。 本发明的另外的方面提供了用于防止基于纳米线的晶体管中的栅极短路的方法。 提供了收获和集成纳米线的其他方法。

公开(公告)号：US07951422B2

公开(公告)日：2011-05-31

申请号：US11641939

申请日：2006-12-20

申请人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  David P. Stumbo ,  Alice Fischer-Colbrie ,  Vijendra Sahi ,  Virginia Robbins

发明人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  David P. Stumbo ,  Alice Fischer-Colbrie ,  Vijendra Sahi ,  Virginia Robbins

IPC分类号： C23C16/00

CPC分类号： C30B29/605 ,  B82Y30/00 ,  C30B11/12 ,  C30B29/06 ,  Y10T428/24917

摘要： The present invention is directed to systems and methods for nanowire growth and harvesting. In an embodiment, methods for nanowire growth and doping are provided, including methods for epitaxial oriented nanowire growth using a combination of silicon precursors, as well as us of patterned substrates to grow oriented nanowires. In a further aspect of the invention, methods to improve nanowire quality through the use of sacrifical growth layers are provided. In another aspect of the invention, methods for transferring nanowires from one substrate to another substrate are provided.

摘要翻译： 本发明涉及用于纳米线生长和收获的系统和方法。 在一个实施例中，提供了用于纳米线生长和掺杂的方法，包括使用硅前体的组合的外延取向纳米线生长的方法，以及我们用于生长取向的纳米线的图案化衬底。 在本发明的另一方面，提供了通过使用牺牲生长层来提高纳米线质量的方法。 在本发明的另一方面，提供了将纳米线从一个衬底转移到另一个衬底的方法。

公开(公告)号：US07105428B2

公开(公告)日：2006-09-12

申请号：US11117703

申请日：2005-04-29

申请人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay L. Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  Dave Stumbo

发明人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay L. Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  Dave Stumbo

IPC分类号： H01L21/20 ,  H01L21/477 ,  H01L21/31 ,  H01L23/48 ,  H01L29/40 ,  B01J27/22 ,  H01L21/44

CPC分类号： H01L29/0673 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B32/18 ,  C30B11/12 ,  C30B25/00 ,  C30B29/06 ,  C30B29/60 ,  C30B29/605 ,  H01L21/0237 ,  H01L21/02381 ,  H01L21/02422 ,  H01L21/02521 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02645 ,  H01L21/02653 ,  H01L29/0665 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7854 ,  H01L2924/0002 ,  Y10S438/962 ,  Y10S977/742 ,  Y10S977/743 ,  Y10S977/843 ,  Y10S977/891 ,  H01L2924/00

摘要： The present invention is directed to systems and methods for nanowire growth and harvesting. In an embodiment, methods for nanowire growth and doping are provided, including methods for epitaxial oriented nanowire growth using a combination of silicon precursors. In a further aspect of the invention, methods to improve nanowire quality through the use of sacrifical growth layers are provided. In another aspect of the invention, methods for transferring nanowires from one substrate to another substrate are provided.

公开(公告)号：US08956637B2

公开(公告)日：2015-02-17

申请号：US13096919

申请日：2011-04-28

申请人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

发明人： Robert S. Dubrow ,  Lawrence A. Bock ,  R. Hugh Daniels ,  Veeral D. Hardev ,  Chunming Niu ,  Vijendra Sahi

IPC分类号： A61F13/00 ,  A61F13/06 ,  A61L26/00 ,  B32B19/04 ,  A61L31/10 ,  A61F13/02 ,  A61L27/34 ,  A61F5/40 ,  A61F15/00 ,  A61N1/05 ,  B82Y30/00

CPC分类号： A61L31/10 ,  A61F13/02 ,  A61L27/34 ,  A61L2400/12 ,  A61L2420/04 ,  A61N1/05 ,  B82Y30/00 ,  Y10S977/762 ,  Y10S977/764 ,  Y10S977/773 ,  Y10S977/811 ,  Y10S977/813 ,  Y10S977/90 ,  Y10S977/904 ,  Y10S977/906 ,  Y10T428/12111 ,  Y10T428/249924 ,  Y10T428/29

摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

摘要翻译： 本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。 在一个具体实施例中，公开了用于增强医疗装置植入物表面上的细胞功能的方法，其通常包括提供包括在其上的多个纳米纤维（例如，纳米线）的医疗装置植入物，并将医疗装置植入物暴露于诸如成骨细胞 。

公开(公告)号：US20090124034A1

公开(公告)日：2009-05-14

申请号：US12121008

申请日：2008-05-15

申请人： Chunming Niu ,  R. Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

发明人： Chunming Niu ,  R. Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

IPC分类号： H01L21/30

CPC分类号： A61L27/303 ,  A61L31/122 ,  H01J49/0418 ,  Y10S977/701 ,  Y10T428/12736 ,  Y10T428/12743

摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.

摘要翻译： 本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。 底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。 本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储， 光学和传感器。

公开(公告)号：US07273732B2

公开(公告)日：2007-09-25

申请号：US11490636

申请日：2006-07-21

申请人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay L. Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  Dave Stumbo

发明人： Yaoling Pan ,  Xiangfeng Duan ,  Robert S. Dubrow ,  Jay L. Goldman ,  Shahriar Mostarshed ,  Chunming Niu ,  Linda T. Romano ,  Dave Stumbo

IPC分类号： H01L51/40

CPC分类号： H01L29/0673 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B32/18 ,  C30B11/12 ,  C30B25/00 ,  C30B29/06 ,  C30B29/60 ,  C30B29/605 ,  H01L21/0237 ,  H01L21/02381 ,  H01L21/02422 ,  H01L21/02521 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02645 ,  H01L21/02653 ,  H01L29/0665 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7854 ,  H01L2924/0002 ,  Y10S438/962 ,  Y10S977/742 ,  Y10S977/743 ,  Y10S977/843 ,  Y10S977/891 ,  H01L2924/00

摘要： The present invention is directed to systems and methods for nanowire growth and harvesting. In an embodiment, methods for nanowire growth and doping are provided, including methods for epitaxial oriented nanowire growth using a combination of silicon precursors. In a further aspect of the invention, methods to improve nanowire quality through the use of sacrifical growth layers are provided. In another aspect of the invention, methods for transferring nanowires from one substrate to another substrate are provided.

摘要翻译： 本发明涉及用于纳米线生长和收获的系统和方法。 在一个实施方案中，提供了纳米线生长和掺杂的方法，包括使用硅前体的组合的用于外延取向的纳米线生长的方法。 在本发明的另一方面，提供了通过使用牺牲生长层来提高纳米线质量的方法。 在本发明的另一方面，提供了将纳米线从一个衬底转移到另一个衬底的方法。