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    Phenylcarboxylic acid derivatives
    2.
    发明授权
    Phenylcarboxylic acid derivatives 失效
    苯基羧酸衍生物

    公开(公告)号：US4999378A

    公开(公告)日：1991-03-12

    申请号：US372336

    申请日：1989-06-20

    申请人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    发明人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Shinichi Watanabe

    IPC分类号： C07C217/22 ,  C07C217/44 ,  C07C217/46 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C225/22 ,  C07C229/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/69 ,  C07C233/78 ,  C07C255/25 ,  C07C275/30 ,  C07D295/092 ,  C07D303/22 ,  C07D317/58 ,  C07D319/18

    CPC分类号： C07D295/088 ,  C07C217/22 ,  C07C217/44 ,  C07C217/46 ,  C07C217/84 ,  C07C217/86 ,  C07C217/90 ,  C07C225/22 ,  C07C229/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/69 ,  C07C233/78 ,  C07C255/25 ,  C07C275/30 ,  C07D303/22 ,  C07D317/58 ,  C07D319/18 ,  C07C2101/08 ,  C07C2101/14

    摘要： Phenylcarboxylic acid derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each H, halogen, alkyl, haloalkyl, alkanoyl, cycloalkyl, nitro, amino, --O--D--R.sup.5 (D is alkylene, R.sup.5 is H, amino, morpholino, carboxyl, phthalimido, phenyl, epoxy), substituted or unsubstituted phenoxy, substituted or unsubstituted phenylalkylamino, carboxylalkenyl, or both form alkylenedioxy; R.sup.3 is H, --E--R.sup.6 (E is alkylene, R.sup.6 is H, carboxyl, cyano, OH, phenylalkoxy, or halogen-substituted phenyl, or phenylcarbamoyl), --CO--G--R.sup.7 (G is alkylene, R.sup.7 is H, substituted or unsubstituted phenylcarbamoyl), substituted or unsubstituted benzoyl, alkenyl, carbamoyl, phenyl, or halophenyl; R.sup.4 is H or alkyl; A is alkylene, alkylene condensed with cycloalkyl ring, or alkenylene; B is alkylene or alkenylene; l is 0 or 1. Said compounds have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of artherosclerosis, prophylactic and treating agent of obesity, antidiabetics.

    摘要翻译： 具有下式的苯基羧酸衍生物：其中R1和R2各自为H，卤素，烷基，卤代烷基，烷酰基，环烷基，硝基，氨基，-OD-R5（D为亚烷基，R5为H，氨基，吗啉代，羧基 苯二甲酰亚氨基，苯基，环氧基），取代或未取代的苯氧基，取代或未取代的苯基烷基氨基，羧基烯基或二者形成亚烷基二氧基; R3是H，-E-R6（E是亚烷基，R6是H，羧基，氰基，OH，苯基烷氧基或卤素取代的苯基或苯基氨基甲酰基），-CO-G-R7（G是亚烷基，R7是H， 取代或未取代的苯基氨基甲酰基），取代或未取代的苯甲酰基，烯基，氨基甲酰基，苯基或卤代苯基; R4是H或烷基; A是亚烷基，与环烷基环稠合的亚烷基或亚烯基; B是亚烷基或亚烯基; l是0或1.所述化合物具有脂肪酸合成抑制活性，胆固醇合成抑制活性，可用作抗血脂药物，动脉粥样硬化的预防和治疗剂，肥胖症的预防和治疗剂，抗糖尿病药。

    Amino- or guanidino-phenylpropionic acid derivatives
    4.
    发明授权
    Amino- or guanidino-phenylpropionic acid derivatives 失效
    氨基或胍基 - 苯基丙酸衍生物

    公开(公告)号：US4182897A

    公开(公告)日：1980-01-08

    申请号：US917232

    申请日：1978-06-20

    申请人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Seizo Taira ,  Ryoji Matsui ,  Yojiro Sakurai ,  Toshiyuki Okutome

    发明人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Seizo Taira ,  Ryoji Matsui ,  Yojiro Sakurai ,  Toshiyuki Okutome

    IPC分类号： C07C205/56 ,  C07C279/18 ,  A61K31/24 ,  C07C101/447 ,  C07C129/12

    CPC分类号： C07C279/18 ,  C07C205/56 ,  Y10S514/822

    摘要： Amino- or guanidino-phenylpropionic ester derivatives represented by the formula: ##STR1## wherein R is --NH.sub.2 or ##STR2## R.sup.1 is hydrogen or a lower alkyl group, and R.sup.2 is an unsubstituted or a lower-alkyl-, carboxyalkyl-, lower-alkoxy-, lower-alkoxycarbonyl- or halogen-substituted phenyl group or an unsubstituted or a halogen-substituted naphthyl group, and acid addition salts thereof are novel compounds exhibiting a specific enzyme-inhibitory activity to proteolytic enzymes and, therefore, they are useful as the therapeutic agent of diseases induced by abnormal activation of these enzymes. The above-mentioned compounds can be produced by subjecting a nitrocinnamic acid derivative represented by the formula: ##STR3## and a phenol derivative or a naphthol derivative represented by the formula:HO--R.sup.2to an esterification in the conventional manner to obtain a nitrocinnamic ester derivative, then reducing the latter compound to obtain an aminophenylpropionic ester derivative and, if desired, reacting it with cyanamide to obtain a guanidino-phenylpropionic ester derivative and, if desired, further converting the reaction product to an acid addition salt.

    摘要翻译： 由下式表示的氨基或胍基 - 苯基丙酸酯衍生物：其中R是-NH 2或R 1是氢或低级烷基，R 2是未取代的或低级烷基 - 羧基烷基 - 低级 - 烷氧基 - ，低级烷氧基羰基或卤素取代的苯基或未取代的或卤素取代的萘基，其酸加成盐是对蛋白水解酶具有特异性酶抑制活性的新化合物，因此它们是有用的 作为由这些酶的异常活化引起的疾病的治疗剂。 上述化合物可以通过将下式所示的硝基肉桂酸衍生物和由式HO-R2表示的酚衍生物或萘酚衍生物以常规方式进行酯化而制得，得到硝基肌氨酸酯 衍生物，然后还原后一种化合物以获得氨基苯基丙酸酯衍生物，并且如果需要，可与氰酰胺反应，得到胍基 - 苯基丙酸酯衍生物，如果需要，将反应产物进一步转化成酸加成盐。

    Pyrazolotriazine compounds
    5.
    发明授权
    Pyrazolotriazine compounds 失效
    吡唑并三嗪化合物

    公开(公告)号：US4824834A

    公开(公告)日：1989-04-25

    申请号：US105581

    申请日：1987-10-08

    申请人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Hiroshi Kiyokawa ,  Satoshi Yamada

    发明人： Setsuro Fujii ,  Hiroyuki Kawamura ,  Hiroshi Kiyokawa ,  Satoshi Yamada

    IPC分类号： A61K31/53 ,  A61P19/06 ,  A61P43/00 ,  C07D487/04

    CPC分类号： C07D487/04 ,  Y02P20/582

    摘要： Pyrazolotriazine compounds of the formula: ##STR1## wherein R.sup.1 is OH or alkanoyloxy; R.sup.2 is H, OH, or SH; R.sup.3 is (1) unsaturated N- or S-containing heterocyclic group optionally having 1-2 substituents of halogen, nitro or phenylthio, (2) naphthyl, (3) phenyl optionally having 1-3 substituents of (i) alkyl, (ii) phenyl, (iii) alkoxycarbonyl, (iv) cyano, (v) nitro, (vi) alkoxy, (vii) phenylalkoxy (viii) phenylthio-alkyl, (ix) phenoxy, (x) ##STR2## R is alkyl, halo-substituted alkyl, phenyl optionally having 1-3 substituents, or pyridyl, and l is 0, 1 or 2, (xi) halogen, (xii) phenylalkyl, (xiii) carboxy, (xiv) alkanoyl, (xv) benzoyl optionally having 1-3 substituents, (xvi) amino, (xvii) OH, (xviii) alkanoyloxy, (xix) ##STR3## or (xx) ##STR4## (A is alkylene), said compounds having a xanthine oxidase inhibitory activity and are useful for the prophylaxis and treatment of gout.

    摘要翻译： 下式的吡唑并三嗪化合物：其中R1是OH或烷酰氧基; R2是H，OH或SH; R3是（1）任选具有1-2个卤素取代基的不饱和N-或S-杂环基，硝基或苯硫基，（2）萘基，（3）任选具有1-3个（i）烷基取代基的苯基，（ii） ）苯基，（iii）烷氧基羰基，（iv）氰基，（ⅴ）硝基，（vi）烷氧基，（i）苯基烷氧基（ii）苯硫基烷基，（ix）苯氧基，（Ⅹ） 取代的烷基，任选具有1-3个取代基的苯基或吡啶基，l是0,1或2，（xi）卤素，（xii）苯基烷基，（xiii）羧基，（xiv）烷酰基，（xv） 1-3取代基，（xvi）氨基，（xvii）OH，（xviii）烷酰氧基，（xix）或（xx）（A是亚烷基），所述化合物具有黄嘌呤氧化酶抑制活性， 用于预防和治疗痛风。

    Die cushion controller
    6.
    发明授权
    Die cushion controller 有权
    模具缓冲控制器

    公开(公告)号：US07845205B2

    公开(公告)日：2010-12-07

    申请号：US11550330

    申请日：2006-10-17

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： B21J9/18 ,  B21J7/46

    CPC分类号： G05B19/19 ,  B21D24/02 ,  G05B2219/42087 ,  G05B2219/42123 ,  G05B2219/45143

    摘要： A die cushion controller, for driving a die cushion, disposed in opposition to a slide of a press machine, by controlling a servo motor, including: a pressure command portion which prepares a pressure command value for exerting a predetermined pressure to a press material disposed between the slide and the die cushion; a pressure detecting portion which detects an actual pressure exerted on the press material; a speed correction value preparing portion which prepares a speed correction value by multiplying a differential value of the pressure command value prepared by the pressure command portion by a coefficient; and a first speed command portion which prepares a speed command value to be instructed to the servo motor based on the pressure command value prepared by the pressure command portion, the actual pressure detected by the pressure detecting portion, and the speed correction value prepared by the speed correction value preparing portion.

    摘要翻译： 一种模具缓冲控制器，用于通过控制伺服电动机来驱动与冲压机的滑动相对设置的模具缓冲垫，包括：压力指令部分，其为制备的压力材料制备用于施加预定压力的压力指令值 滑块和模座之间; 压力检测部，其检测施加在所述挤压材料上的实际压力; 速度校正值准备部，其通过将由所述压力指令部准备的所述压力指令值的差分值乘以系数来准备速度校正值; 以及第一速度指令部，其基于由压力指令部准备的压力指令值，由压力检测部检测出的实际压力和由该压力指令部分准备的速度修正值，准备要指示给伺服电动机的速度指令值 速度校正值准备部。

    Controller
    8.
    发明授权
    Controller 有权
    控制器

    公开(公告)号：US07657356B2

    公开(公告)日：2010-02-02

    申请号：US11289319

    申请日：2005-11-30

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： G06F19/00

    CPC分类号： G05B19/416 ,  G05B2219/37388 ,  G05B2219/43058 ,  Y10T483/1702 ,  Y10T483/1733

    摘要： An acceleration detection unit for detecting acceleration is mounted on a driven body. When a previous block is a positioning command, the system waits till the detected value of acceleration detected by the acceleration detection unit becomes equal to or less than a set value αs after the distribution of the movement command of the positioning command is ended. If the detected value of acceleration becomes equal to or less than the set value αs, the distribution of the movement command of the next block is started. Because the cutting feed, etc., is started after the detected value of acceleration has become equal to or less than the set value αs and the vibrations stopped, machining can be conducted with high accuracy.

    摘要翻译： 用于检测加速度的加速度检测单元安装在被驱动体上。 当前一块是定位命令时，在定位命令的移动指令的分配结束之后，系统等待直到由加速度检测单元检测到的加速度的检测值变为等于或小于设定值αα。 如果检测到的加速度值等于或小于设定值ααα，则开始下一个程序段的移动指令的分配。 由于在加速度的检测值变得等于或小于设定值αα并且振动停止之后开始切削进给等，因此可以高精度地进行加工。

    Die cushion mechanism, and apparatus and method for controlling the same
    9.
    发明授权
    Die cushion mechanism, and apparatus and method for controlling the same 有权
    模具缓冲机构及其控制装置及方法

    公开(公告)号：US07631528B2

    公开(公告)日：2009-12-15

    申请号：US11265187

    申请日：2005-11-03

    申请人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    发明人： Yasusuke Iwashita ,  Tadashi Okita ,  Hiroyuki Kawamura ,  Satoshi Ikai

    IPC分类号： B21D55/00 ,  B21C51/00 ,  B21J9/18

    CPC分类号： G05B19/19 ,  B21D24/02 ,  G05B2219/42123 ,  G05B2219/42275

    摘要： A control apparatus for controlling a die cushion mechanism including a servo-motor as a drive source and producing a force adapted to be applied outside. The control apparatus includes a force commanding section for commanding a force to be produced by the die cushion mechanism; a force detecting section for detecting a force produced by the die cushion mechanism; a force controlling section for executing a force control on the servo-motor, based on a force command value commanded by the force commanding section and a force detected value detected by the force detecting section; and an abnormality preventing section for preventing, in association with a control state of the servo-motor, the die cushion mechanism from producing an abnormal force.

    摘要翻译： 一种用于控制模具缓冲机构的控制装置，其包括作为驱动源的伺服电动机，并产生适于施加到外部的力。 控制装置包括用于指示由模具缓冲机构产生的力的力指令部分; 用于检测由模具缓冲机构产生的力的力检测部分; 力控制部，其基于由所述力指令部所指示的力指令值和由所述力检测部检测到的力检测值，对所述伺服电动机进行力控制; 以及防止与伺服电动机的控制状态相关联的模具缓冲机构产生异常力的异常防止部。