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    Systems and method of a gated electrospray interface with variable flow rate for high throughput mass spectrometric analysis
    1.
    发明授权
    Systems and method of a gated electrospray interface with variable flow rate for high throughput mass spectrometric analysis 有权

    公开(公告)号：US07095017B2

    公开(公告)日：2006-08-22

    申请号：US10939753

    申请日：2004-09-13

    申请人： Steven A. Hofstadler ,  Jared J. Drader ,  Kristin A. Sannes-Lowery ,  Richard H. Griffey

    发明人： Steven A. Hofstadler ,  Jared J. Drader ,  Kristin A. Sannes-Lowery ,  Richard H. Griffey

    IPC分类号： H01J49/00

    CPC分类号： H01J49/04

    摘要： The present disclosure is related to improved systems and methods for delivering samples for high-throughput mass spectrometric analysis to an atmospheric-pressure ionization source. In an exemplary embodiment, the system includes a solvent reservoir for storing a solvent solution, a first valve which is coupled to the solvent reservoir, first and second pumps for delivering solvent solution and which are coupled to the first valve and which the delivery flow rate of the first pump is greater than the delivery flow rate of the second pump, an injection system having a sample injector and an second valve which is coupled to the first valve and which is capable of being coupled to can be couple to an electrospray ionization source. In another embodiment, the system can also include an atmospheric-pressure ionization chamber, an atmospheric-pressure ionization sprayer and a nebulizer gas source and a voltage supply source. In yet another embodiment, the system may further include a puffer valve that is coupled to the nebulizer gas source and the atmospheric-pressure ionization sprayer and a gas puffer that is coupled to the puffer valve. A distal end of the gas puffer may be located within the atmospheric-pressure ionization chamber and aligned with the distal end of the atmospheric-pressure ionization sprayer and the puffer valve may control the delivery of the nebulizer gas to the atmospheric-pressure ionization sprayer and the gas puffer.

    Sample processing units, systems, and related methods
    6.
    发明授权
    Sample processing units, systems, and related methods 有权
    样品处理单元，系统和相关方法

    公开(公告)号：US08252599B2

    公开(公告)日：2012-08-28

    申请号：US13221608

    申请日：2011-08-30

    申请人： Steven A. Hofstadler ,  Jared J. Drader ,  Jose R. Gutierrez ,  Paul J. Gleason ,  Rex O. Bare ,  Robert D. Miller ,  Jeffrey C. Smith

    发明人： Steven A. Hofstadler ,  Jared J. Drader ,  Jose R. Gutierrez ,  Paul J. Gleason ,  Rex O. Bare ,  Robert D. Miller ,  Jeffrey C. Smith

    IPC分类号： C12M1/00 ,  G01N31/00 ,  G01N31/22 ,  G01N9/00

    CPC分类号： G01N1/10 ,  G01N1/02 ,  G01N35/0098 ,  G01N35/025 ,  G01N2035/00524

    摘要： Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

    摘要翻译： 提供了用于混合和净化材料（如流体材料）的样品处理单元。 样品处理单元通常包括被配置为容纳包含磁响应颗粒的样品和相对于容器处于基本固定位置的一个或多个磁体的容器。 样品处理单元还通常包括输送机构，其构造成将容器输送到与磁体磁连通的位置，例如使得当添加其它材料时，具有捕获的分析物的磁响应颗粒可以保留在容器内 到和/或从容器中取出。 此外，样品处理单元还通常包括旋转机构，其被配置为旋转容器，例如以实现设置在容器内的样品材料的混合。 还提供了相关的载体机构，样品处理站，系统和方法。