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    Controlled drug delivery using polymer/pluronic blends
    1.
    发明授权
    Controlled drug delivery using polymer/pluronic blends 失效
    使用聚合物/ pluronic混合物控制药物递送

    公开(公告)号：US5330768A

    公开(公告)日：1994-07-19

    申请号：US726349

    申请日：1991-07-05

    申请人： Tae G. Park ,  Smadar Cohen ,  Robert S. Langer

    发明人： Tae G. Park ,  Smadar Cohen ,  Robert S. Langer

    IPC分类号： A61K9/16 ,  A61K9/70

    CPC分类号： A61K9/7007 ,  A61K9/1641 ,  A61K9/1647 ,  Y10S514/963 ,  Y10S514/964

    摘要： A new series of degradable polymeric matrices were prepared by blending polymers that degrade by hydrolysis such as poly(L-lactic acid)(PLA), and nonionic Pluronic.TM. surfactants, block copolymers of polyethyleneoxide (PEO) and polypropyleneoxide (PPO). The water content of the polymer blend films was controlled by mixing different types of block copolymers and by adjusting their amount. In aqueous solution, the blends revealed the typical liquid-crystalline phase transition of Pluronic.TM. polymers, suggesting the formation of a gel-like structure within the polymer skeleton. Poly(lactic acid) degradation rates were not affected by the blending procedure, although the hydration degree in these matrices was higher. When used as drug-releasing matrices, these blends extended protein release and minimized the initial protein burst, as compared to the pure polymer.

    摘要翻译： 通过混合通过水解降解的聚合物如聚（L-乳酸）（PLA）和非离子Pluronic TM表面活性剂，聚环氧乙烷（PEO）和聚环氧丙烷（PPO）的嵌段共聚物）来制备新的可降解聚合物基质系列。 通过混合不同类型的嵌段共聚物并通过调节它们的量来控制聚合物共混物膜的含水量。 在水溶液中，共混物显示Pluronic TM聚合物的典型液晶相变，表明在聚合物骨架内形成凝胶状结构。 尽管这些基质中的水合度较高，但聚（乳酸）降解速率不受共混程序的影响。 当用作药物释放基质时，与纯聚合物相比，这些共混物延长了蛋白质释放并使初始蛋白质爆发最小化。

    Oral delivery of vaccines using polymerized liposomes
    2.
    发明授权
    Oral delivery of vaccines using polymerized liposomes 失效
    使用聚合脂质体口服输送疫苗

    公开(公告)号：US5762904A

    公开(公告)日：1998-06-09

    申请号：US786617

    申请日：1997-01-17

    申请人： Junichi Okada ,  Smadar Cohen ,  Robert S. Langer

    发明人： Junichi Okada ,  Smadar Cohen ,  Robert S. Langer

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61M36/12

    CPC分类号： A61K9/1273 ,  Y10S424/812 ,  Y10T428/2984

    摘要： Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized liposomes containing a biologically active substance to be delivered to a patient are disclosed. The polymerized liposomes are prepared by polymerizing double bond-containing liposomes. The polymerization can be initiated with a source of radiation and/or a free radical initiator. Biologically active substances can be incorporated into both the hydrophilic and hydrophobic layers of the liposomes, either during or after polymerization. The polymerized liposomes can be administered orally to a patient in need of the biologically active substance to be delivered. Examples demonstrate enhanced stability.

    摘要翻译： 聚合的脂质体，制备聚合的脂质体并将生物活性物质并入聚合的脂质体内的方法，以及施用含有待递送给患者的生物活性物质的聚合脂质体的方法。 通过聚合含双键的脂质体制备聚合的脂质体。 可以用辐射源和/或自由基引发剂引发聚合。 在聚合过程中或之后，生物活性物质可以并入脂质体的亲水层和疏水层中。 聚合的脂质体可以口服给予需要递送的生物活性物质的患者。 实例表明增强的稳定性。

    Polymeric microparticles containing agents for imaging
    5.
    发明授权
    Polymeric microparticles containing agents for imaging 失效
    含有成像剂的聚合物微粒

    公开(公告)号：US5562099A

    公开(公告)日：1996-10-08

    申请号：US292522

    申请日：1994-08-18

    申请人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    发明人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K49/22 ,  A61K51/12 ,  B01J13/14 ,  C08G79/02 ,  C12N11/04 ,  A61K49/00

    CPC分类号： B82Y5/00 ,  A61K49/223 ,  A61K49/225 ,  A61K49/226 ,  A61K51/1258 ,  A61K9/1271 ,  A61K9/1641 ,  A61K9/5031 ,  B01J13/14 ,  C08G79/025 ,  C12N11/04 ,  A61K2123/00 ,  Y10S977/753

    摘要： Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microparticles is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microparticles are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microparticles can optionally be linked with ligands that minimize tissue adhesion or that target the microparticles to specific regions.

    摘要翻译： 公开了组合物，制备方法和使用造影剂填充的聚合物微粒用于成像的方法。 在一个优选的实施方案中，空气封装的微粒通过与多价离子例如钙的接触通过离子交换胶凝合成聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's） 离子。 在优选的实施方案中，微粒的平均尺寸小于7μm，使得它们适于静脉内注射。 聚合物微粒对于成像是稳定的，并且在体外和体内均显示出高回波性。 由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。 微粒可任选地与使组织粘附最小化或将微粒靶向特定区域的配体连接。

    Gas-filled polymeric microbubbles for ultrasound imaging
    6.
    发明授权
    Gas-filled polymeric microbubbles for ultrasound imaging 失效
    用于超声成像的气体填充聚合物微泡

    公开(公告)号：US5487390A

    公开(公告)日：1996-01-30

    申请号：US182216

    申请日：1994-01-14

    申请人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    发明人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K49/22 ,  A61K51/12 ,  B01J13/14 ,  C08G79/02 ,  C12N11/04 ,  A61B8/14

    CPC分类号： A61K9/1271 ,  A61K49/223 ,  A61K49/225 ,  A61K49/226 ,  A61K51/1258 ,  A61K9/1641 ,  A61K9/5031 ,  B01J13/14 ,  C08G79/025 ,  C12N11/04 ,  A61K2123/00 ,  Y10S977/753 ,  Y10S977/929 ,  Y10T428/2987

    摘要： Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microcapsules is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microcapsules are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microcapsules can optionally be linked with ligands that minimize tissue adhesion or that target the microcapsules to specific regions.

    摘要翻译： 公开了组合物，制备方法和使用空气填充的聚合物微胶囊用于超声成像的方法。 通过与多价离子如钙离子接触，通过离子交换胶凝聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's））形成空气封装的微胶囊。 在优选的实施方案中，微胶囊的平均尺寸小于7μm，使得它们适合静脉内注射。 聚合物微胶囊在体外和体内都能稳定成像并显示高回波性。 由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。 微胶囊可以任选地与使组织粘附最小化或将微胶囊靶向特定区域的配体连接。