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    Mobile Communication Device, System, and Method
    2.
    发明申请
    Mobile Communication Device, System, and Method 审中-公开
    移动通信设备，系统和方法

    公开(公告)号：US20140203950A1

    公开(公告)日：2014-07-24

    申请号：US14234069

    申请日：2012-07-17

    申请人： Mark Zdeblick ,  Arna Diana Ionescu ,  William McAllister ,  Kit Yee Au-Yeung

    发明人： Mark Zdeblick ,  Arna Diana Ionescu ,  William McAllister ,  Kit Yee Au-Yeung

    IPC分类号： G08C17/02

    CPC分类号： G08C17/02 ,  A61B5/073 ,  A61B5/4833 ,  A61B5/6803 ,  A61B5/6898 ,  G06F19/321 ,  G06F19/3418 ,  G06F19/3456 ,  G16H20/10 ,  G16H30/20 ,  G16H40/67

    摘要： A mobile device for detecting an electrical signal generated by an ingestible event marker is disclosed. The mobile device includes a detection subsystem to receive an electrical signal generated by an ingestible event marker from a detection arrangement. A processing subsystem is coupled to the detection subsystem to decode the electrical signal. A radio subsystem is configured to transmit the decoded electrical signal to a wireless node. A system includes the mobile device and the detection arrangement. A method includes receiving the electrical signal generated by the ingestible event marker at the mobile device, decoding the electrical signal to extract information associated with the ingestible event marker, and transmitting the information to a wireless node.

    摘要翻译： 公开了一种用于检测由可摄入事件标记产生的电信号的移动设备。 移动设备包括检测子系统，用于从检测装置接收由可摄取事件标记产生的电信号。 处理子系统耦合到检测子系统以解码电信号。 无线电子系统被配置为将解码的电信号发送到无线节点。 一种系统包括移动设备和检测装置。 一种方法包括：在移动设备处接收由可摄取事件标记产生的电信号，解码电信号以提取与可摄取事件标记相关联的信息，以及将信息发送到无线节点。

    Detection of molecular binding events
    3.
    发明申请
    Detection of molecular binding events 审中-公开
    检测分子结合事件

    公开(公告)号：US20050069905A1

    公开(公告)日：2005-03-31

    申请号：US10676957

    申请日：2003-09-30

    申请人： Carl Myerholtz ,  May Tom-Moy ,  August Hidalgo ,  William McAllister

    发明人： Carl Myerholtz ,  May Tom-Moy ,  August Hidalgo ,  William McAllister

    IPC分类号： C12Q1/68 ,  G01N33/543 ,  C12M1/34

    CPC分类号： G01N33/5438 ,  C12Q1/6825

    摘要： A device for electronic detection of a target includes a probe, e.g. an oligonucleotide, attached to a pad of resistive material, wherein the pad is adjacent a first electrode and also is adjacent a second electrode. In use, the probe is contacted with a sample containing the target, e.g. a target nucleic acid, under conditions and for a time sufficient to allow target to bind the probe. An enhancement reaction is then applied to result in a change in an observable property of the device. The observable property is then monitored using measurement apparatus operably associated with the device. Typically, multiple devices will be present on an array of devices, allowing multiplex analysis of multiple different targets using a single array of devices.

    摘要翻译： 用于电子检测靶的装置包括探针，例如。 附着到电阻材料焊盘的寡核苷酸，其中所述焊盘与第一电极相邻并且还邻近第二电极。 在使用中，探针与含有靶标的样品接触。 在足以允许靶结合探针的条件下和足够时间的靶核酸。 然后应用增强反应以导致装置的可观察性质的变化。 然后使用与装置可操作地相关联的测量装置监测可观察的性质。 通常，多个设备将存在于设备阵列上，允许使用单个阵列阵列对多个不同目标进行多路复用分析。

    Chimera oligonucleotide and its utilization for obtaining transcripts of a nucleic acid
    10.
    发明授权
    Chimera oligonucleotide and its utilization for obtaining transcripts of a nucleic acid 失效
    嵌合体寡核苷酸及其用于获得核酸转录本的用途

    公开(公告)号：US5744308A

    公开(公告)日：1998-04-28

    申请号：US533912

    申请日：1995-09-26

    申请人： Fran.cedilla.oise Guillou-Bonnici ,  Philippe Cleuziat ,  Fran.cedilla.ois Mallet ,  Pierre Levasseur ,  William McAllister

    发明人： Fran.cedilla.oise Guillou-Bonnici ,  Philippe Cleuziat ,  Fran.cedilla.ois Mallet ,  Pierre Levasseur ,  William McAllister

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6865

    摘要： A chimera oligonucleotide is provided that can be used in a process for obtaining transcripts and/or amplification of a target sequence of a nucleic acid, having, at its 3' end, a downstream sequence. The oligonucleotide comprises successively, from 5' to 3', 1) a first oligonucleotide segment, of the DNA type, comprising a sense sequence of a promoter of an RNA polymerase, 2) a second oligonucleotide segment, of the DNA type, capable of hybridizing with the downstream sequence, and 3) a third oligonucleotide segment, of the RNA type, capable of hybridizing with a part of the target sequence contiguous to the downstream sequence, the third segment being blocked at 3'. A process using the chimera oligonucleotide and an enzyme system containing DNA polymerase activity, RNA polymerase activity, and a third activity, for example, an RNase H activity provides transcription products of the target. By adding a second chimera oligonucleotide capable of hybridizing with the complement of the target, cyclic amplification of the target and its complement are obtained.

    摘要翻译： 提供嵌合体寡核苷酸，其可用于获得在其3'末端具有下游序列的核酸的靶序列的转录物和/或扩增的方法。 所述寡核苷酸依次包含5'至3'，1）DNA型的第一寡核苷酸片段，其包含RNA聚合酶的启动子的有义序列，2）DNA型的第二寡核苷酸片段，能够 与下游序列杂交，以及3）能够与下游序列连续的靶序列的一部分杂交的RNA型的第三寡核苷酸片段，第3片段在3'处被阻断。 使用嵌合寡核苷酸的方法和含有DNA聚合酶活性，RNA聚合酶活性和第三活性的酶系统，例如RNase H活性提供靶标的转录产物。 通过添加能够与靶的补体杂交的第二嵌合寡核苷酸寡核苷酸寡核苷酸寡核苷酸，获得靶标及其互补序列的循环扩增。