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16 条记录 (耗时 0.02 秒)

    Fibrous adsorbent for hemoperfusion
    1.
    发明授权
    Fibrous adsorbent for hemoperfusion 失效
    用于血液灌注的纤维吸附剂

    公开(公告)号：US4248736A

    公开(公告)日：1981-02-03

    申请号：US258

    申请日：1979-01-02

    申请人： Yoshio Fuchigami ,  Toshihide Nakashima

    发明人： Yoshio Fuchigami ,  Toshihide Nakashima

    IPC分类号： A61M1/36 ,  B01D11/04

    CPC分类号： A61M1/3679 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3293 ,  Y10S502/519

    摘要： A hemoperfusion adsorbent is provided comprising a woven or knitted fibrous carbon adsorbent material having at least one coating thereon of a hydrophilic polymer. The adsorbent carbon fabric is preferably derived from a novolak-type phenolic resin. The hydrophilic polymer will preferably comprise a polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate, preferably with a copolymerizable monomer containing an epoxy moiety.

    摘要翻译： 提供了一种血液灌注吸附剂，其包括其上具有亲水性聚合物的至少一层涂层的机织或针织纤维状碳吸附材料。 吸附剂碳织物优选衍生自酚醛清漆型酚醛树脂。 亲水性聚合物优选包含通过聚合至少一种单体丙烯酸酯或甲基丙烯酸酯，优选与含有环氧部分的可共聚单体制备的聚合物。

    Peptide
    2.
    发明授权
    Peptide 失效
    肽

    公开(公告)号：US4889917A

    公开(公告)日：1989-12-26

    申请号：US265550

    申请日：1988-11-01

    申请人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Kiichiro Oka ,  Hideaki Yamada ,  Akira Kobayashi ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61K38/00 ,  A61M1/36 ,  A61P43/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705 ,  G01N33/564 ,  G01N33/566

    CPC分类号： C07K14/705 ,  A61M1/3679 ,  Y02P20/55

    摘要： A peptide is disclosed which is represented by the formula:H-X-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Leu-Asp-Y -Zwherein one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group, and two cysteinyl mercapto groups in the Cys-Cys moiety may be interlinked to each other to form a disulfide bond.

    摘要翻译： 公开了由下式表示的肽：HX-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Le-Asp- Y -Z其中X和Y中的一个代表单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基：其中n表示 1至17的范围）或通过选自上述类别的至少一种的2至10个氨基酸残基的肽键形成的肽残基，X和Y中的另一个表示选自以下的氨基酸残基： 由Asp，Glu，Lys和由式表示的二价基团，其中n表示1〜17的整数，或由2〜10个氨基酸的肽键形成的肽残基 选自上述类别中的至少一种的残基和Z表示羟基或氨基，并且Cys-Cys moie中的两个半胱氨酰巯基 ty可以彼此互连以形成二硫键。

    Wound covering material
    3.
    发明授权
    Wound covering material 失效
    伤口覆盖材料

    公开(公告)号：US4287177A

    公开(公告)日：1981-09-01

    申请号：US66699

    申请日：1979-08-15

    申请人： Toshihide Nakashima ,  Osamu Nakaji ,  Koichi Takakura ,  Takayoshi Suzuki

    发明人： Toshihide Nakashima ,  Osamu Nakaji ,  Koichi Takakura ,  Takayoshi Suzuki

    IPC分类号： C08L33/00 ,  A61K9/06 ,  A61K9/70 ,  A61L26/00 ,  C08L33/02 ,  C08L33/04 ,  A61K31/78

    CPC分类号： A61L26/008 ,  A61L26/0014 ,  A61L26/0071 ,  A61L26/0076 ,  Y10S424/13

    摘要： The present invention provides a covering material consisting essentially of a hydrophilic, water insoluble polymer (component A), a high boiling plasticizer and/or organic solvent (component B) for said component A, and an aqueous liquid (component C). Said covering material is useful as a protective covering material for forming a film or coat on the skin and/or wound surface in the treatment of burn. The material is characterized in that film or coat formation on the skin and/or wound surface can be realized in a short time.

    摘要翻译： 本发明提供了一种基本上由用于所述组分A的亲水性，水不溶性聚合物（组分A），高沸点增塑剂和/或有机溶剂（组分B）和水性液体（组分C）组成的覆盖材料。 所述覆盖材料可用作在烧伤治疗中在皮肤和/或伤口表面上形成膜或涂层的保护性覆盖材料。 该材料的特征在于可以在短时间内实现皮肤和/或伤口表面上的膜或涂层形成。

    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody
    5.
    发明授权
    Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
    特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤

    公开(公告)号：US5192684A

    公开(公告)日：1993-03-09

    申请号：US175304

    申请日：1988-03-30

    申请人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    发明人： Masao Tanihara ,  Hideaki Yamada ,  Toshihide Nakashima ,  Yoshiaki Omura ,  Koichi Takakura

    IPC分类号： A61B10/00 ,  A61K39/395 ,  A61P21/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/24 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/566 ,  G01N33/577

    CPC分类号： C07K16/286

    摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

    摘要翻译： 通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。 上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的， 从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。 也鉴定了上述杂交瘤。

    Restorative composition for hard tissue and dispensing apparatus therefor
    8.
    发明授权
    Restorative composition for hard tissue and dispensing apparatus therefor 失效
    用于硬组织的修复组合物及其分配装置

    公开(公告)号：US5814681A

    公开(公告)日：1998-09-29

    申请号：US652599

    申请日：1996-06-13

    申请人： Kenichi Hino ,  Toshihide Nakashima

    发明人： Kenichi Hino ,  Toshihide Nakashima

    IPC分类号： A61L24/00 ,  A61L27/46 ,  A61L25/00 ,  A61K6/08 ,  C08K3/32

    CPC分类号： A61L27/46 ,  A61L24/0084 ,  A61L2430/02

    摘要： A restorative composition for hard tissue, comprising a paste (A) containing an inorganic calcium phosphate powder, a polymerizable monomer mixture and a polymerization initiator, and a paste (B) containing an inorganic calcium phosphate powder, a polymerizable monomer mixture and a polymerization accelerator, wherein the content of the inorganic calcium phosphate powder in each paste is 75-85% by weight, and each monomer mixture contains a monomer of the formula (1): ##STR1## and a monomer of the formula (2): ##STR2## the content of the monomer (1) accounting for 40-65% by weight of the monomer mixture as a whole. The composition can well adhere to the bone and has a sufficient water resistance. As it generates little heat upon hardening, it is less detrimental to the patient's tissues. Furthermore, the paste has an appropriate consistency, which facilitates homogeneous mixing of the paste and application of the resultant mixture to the affected part by the use of a dispensing apparatus. Thus, the restorative composition can be used not only as a bone cement but also as a filler for the defected part of the bone, a bone prosthesis or an artificial bone.

    摘要翻译： PCT No.PCT / JP95 / 02110 Sec。 371日期：1996年6月13日 102（e）日期1996年6月13日PCT提交1995年10月13日PCT公布。 出版物WO96 / 日本1996年04月25日用于硬组织的修复组合物，包含含有无机磷酸钙粉末的糊剂（A），可聚合单体混合物和聚合引发剂，以及含有无机磷酸钙粉末，可聚合单体 混合物和聚合促进剂，其中每个糊料中的无机磷酸钙粉末的含量为75-85重量％，并且每个单体混合物含有式（1）的单体：（1）和单体 式（2）：单体（1）的含量占单体混合物整体重量的40-65％。 组合物可以很好地粘附在骨上并具有足够的耐水性。 由于硬化时几乎不产生热量，因此对患者的组织不太有害。 此外，糊料具有适当的稠度，其有助于浆料的均匀混合并且通过使用分配装置将所得混合物施加到患部。 因此，修复组合物不仅可以用作骨水泥，而且可以用作骨，骨假体或人造骨的缺损部分的填充物。

    Vehicular constant speed cruising control device
    9.
    发明授权
    Vehicular constant speed cruising control device 失效
    车速恒速巡航控制装置

    公开(公告)号：US5609546A

    公开(公告)日：1997-03-11

    申请号：US548878

    申请日：1995-10-26

    申请人： Yoshinari Torii ,  Toshihide Nakashima

    发明人： Yoshinari Torii ,  Toshihide Nakashima

    IPC分类号： B60K31/00 ,  B60K31/04 ,  B60W10/04 ,  B60W10/10 ,  B60W10/11 ,  F02D29/00 ,  F02D29/02 ,  F16H59/08 ,  F16H59/66 ,  F16H61/02 ,  F16H61/16 ,  B60K41/04

    CPC分类号： B60K31/047 ,  B60W2550/142 ,  F16H2059/083 ,  F16H59/66 ,  F16H61/0213 ,  F16H61/16 ,  Y10T477/676 ,  Y10T477/693 ,  Y10T477/693754

    摘要： When an overdrive cut is performed to an automatic transmission control when climbing uphill slopes, the actuator position An is stored in overdrive cut aperture storage value C with overdrive cut demands to the automatic transmission executed until the actuator position changes by a first predetermined value Ct1. If the condition C-An>Ct1 is satisfied for a predetermined period of time T0 until timer counter TMR becomes zero, then restoration to overdrive is allowed. Accordingly, even when cruising along long uphill roads, up-shifts to overdrive are prohibited during this time and because there are no up-shifts to overdrive during this time, vehicular speed does not change in fixed periods and thus, a high-level of passenger comfort is achieved.

    摘要翻译： 当爬上坡时对自动变速箱控制进行过载切断时，致动器位置A被存储在超速切割孔径存储值C中，对执行自动变速器的过载切断要求直到致动器位置改变第一预定值Ct1。 如果条件C-An> Ct1满足预定时间段T0，直到定时器计数器TMR变为零，则允许恢复到过驱动。 因此，即使在长时间的高速公路上巡航，在这段时间内也禁止上转到超速行驶，由于这段时间内没有高速行驶，车辆速度在固定时间内并没有变化，因此高层次 乘客舒适度达到。