TABLET QUICKLY DISINTEGRATING IN THE ORAL CAVITY AND METHOD FOR PRODUCING THE SAME
    5.
    发明申请
    TABLET QUICKLY DISINTEGRATING IN THE ORAL CAVITY AND METHOD FOR PRODUCING THE SAME 审中-公开
    片剂快速消毒口腔及其生产方法

    公开(公告)号:US20150320688A1

    公开(公告)日:2015-11-12

    申请号:US14806296

    申请日:2015-07-22

    摘要: The invention relates to a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient at a high content and a production method thereof. That is, the present invention provides a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient in not less than 25% of the total weight, having a disintegration time of within 40 seconds and an absolute hardness of 1.8 N/mm2 or more, which is obtained by granulating a powder containing an active ingredient with a binding solution containing mannitol and corn-derived pregelatinized starch, mixing the resulting granules with at least one kind of a disintegrant selected from cornstarch, hydroxypropylstarch, carmellose and crospovidone, and compression molding the mixture.

    摘要翻译: 本发明涉及一种在含有高含量活性成分的口腔内快速崩解的片剂及其制备方法。 也就是说,本发明提供一种片剂,其在含有活性成分的口腔中快速崩解,其含量不小于总重量的25%,崩解时间在40秒以内,绝对硬度为1.8N / mm2,或 通过将含有活性成分的粉末与含有甘露糖醇和玉米来源的预胶化淀粉的结合溶液制粒而得到的,将得到的颗粒与选自玉米淀粉,羟丙基淀粉,羧甲纤维素和交聚维酮中的至少一种崩解剂混合,并将其压缩 成型混合物。