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25 条记录 (耗时 0.011 秒)

    Halogenated hydrocarbons, useful as insecticide intermediates, and methods for their preparation
    7.
    发明授权
    Halogenated hydrocarbons, useful as insecticide intermediates, and methods for their preparation 失效
    用作杀虫剂中间体的卤代烃及其制备方法

    公开(公告)号：US4210611A

    公开(公告)日：1980-07-01

    申请号：US40455

    申请日：1979-05-18

    申请人： John Crosby ,  Bernard W. H. Terry

    发明人： John Crosby ,  Bernard W. H. Terry

    IPC分类号： B01J27/10 ,  C07B61/00 ,  C07C17/00 ,  C07C17/25 ,  C07C21/02 ,  C07C21/17 ,  C07C21/18 ,  C07C21/19 ,  C07C67/00 ,  C07C17/28

    CPC分类号： C07C21/19 ,  C07C17/25 ,  C07C21/18

    摘要： Halogenated hydrocarbons of formula:RR.sup.1 C.dbd.CH--CH.sub.2 CYZQandRR.sup.1 C.dbd.CH--CH.dbd.CYQ,and mixtures thereof, wherein Y is F, Cl or Br, R is hydrogen or a lower alkyl group, R.sup.1 is a lower alkyl group, Z is Y or Q and Q is W(CF.sub.2).sub.m -- in which W is hydrogen, F or Cl and m is 1 or 2, and a process for their preparation which comprises heating in a polar aprotic solvent, preferably in the presence of an alkali metal halide, a halogenated hydrocarbon of formula RR.sup.1 C--CHX--CH.sub.2 CYZQ wherein R,R.sup.1,Y,Z and Q have the previously defined meanings and X is Cl, Br or I, provided that X is always Br or I when at least one of Y and Z is Br.

    摘要翻译： 式：RR1C = CH-CH2CYZQ和RR1C = CH-CH = CYQ的卤代烃及其混合物，其中Y为F，Cl或Br，R为氢或低级烷基，R1为低级烷基，Z为 Y或Q和Q是W（CF 2）m-，其中W是氢，F或Cl，m是1或2，以及它们的制备方法，其包括在极性非质子溶剂中，优选在碱的存在下加热 金属卤化物，式RR1C-CHX-CH2CYZQ的卤代烃，其中R，R1，Y，Z和Q具有预先定义的含义，X是Cl，Br或I，条件是当X至少为 Y和Z是Br。

    Vinyl substituted radiohalogen and methods of use conjugates
    9.
    发明授权
    Vinyl substituted radiohalogen and methods of use conjugates 失效
    乙烯基取代的放射性卤素和使用共轭物的方法

    公开(公告)号：US4876081A

    公开(公告)日：1989-10-24

    申请号：US171731

    申请日：1988-04-05

    申请人： Daniel S. Wilbut ,  Hadley, Stephen W.

    发明人： Daniel S. Wilbut ,  Hadley, Stephen W.

    IPC分类号： C07C21/04 ,  A61K51/00 ,  A61K51/04 ,  A61K51/10 ,  C07B59/00 ,  C07C17/00 ,  C07C21/02 ,  C07C21/14 ,  C07C21/17 ,  C07C21/18 ,  C07C22/04 ,  C07C22/08 ,  C07C67/00 ,  C07F7/22 ,  C07K1/113 ,  C07K14/00 ,  C07K14/575 ,  C07K16/00 ,  G01N33/534 ,  G01N33/60

    CPC分类号： A61K51/1093 ,  A61K51/04 ,  A61K51/0406 ,  C07F7/2212 ,  A61K2121/00 ,  A61K2123/00 ,  Y10S530/866

    摘要： Vinyl radiohalogenated small molecules shown in formulas I and II: ##STR1## wherein *X is a radiohalogen, C.dbd.C is a double bonded set of sp.sup.2 hybridized carbon atoms, and substituents R.sub.1, R.sub.2, and Y are as defined below. R.sub.1 and R.sub.2 are substituents independently selected from among hydrogen; alkyl or substituted alkyl, provided that any sp.sup.2 or sp carbon atom substituted on the alkyl is separated from C.dbd.C by at least one fully substituted sp.sup.3 carbon atom; aryl or substituted aryl, provided that the aryl is bonded directly to C.dbd.C; heteroalkyl, provided, first, that no heteroatom of the heteroalkyl bonds directly to C.dbd.C and, second, that any sp.sup.2 or sp hybridized carbon bonded to a heteroatom of the heteroalkyl is not bonded directly to or otherwise conjugated with C.dbd.C and, third, that where a single sp.sup.3 carbon intervenes between C.dbd.C and an sp.sup.2 or sp carbon bonded to a heteroatom, that intervening sp.sup.3 carbon must be fully substituted; heteroaryl, provided that a heteroatom of the heteroaryl is not bonded directly with C.dbd.C; mixed alkylaryl, provided, first, that no heteroatom is bonded to C.dbd.C and, second, that either an aryl moiety of the mixed alkylaryl is directly bonded to C.dbd.C or that any aryl moiety is separated from C.dbd.C by at least one sp.sup.3 carbon atom and, where only one sp.sup.3 hybridized carbon atom intervenes between C.dbd.C and an aryl moiety, that intervening sp.sup.3 carbon must be fully substituted. Y is a substituent containing any of the groups described above for R.sub.1 and R.sub.2, except that Y cannot be hydrogen, and bearing a functional group suitable for binding to protein under conditions that preserve the biological activity of the protein. The compounds of formulas I and II can be coupled to proteins such as monoclonal antibodies to provide reagents for diagnostic and therapeutic applications. Also metalated precursors of compounds I and II, as well as radiopharmaceutical reagent kits containing any of the subject small molecules.

    Process for the preparation of primary tertiary allyl halides
    10.
    发明授权
    Process for the preparation of primary tertiary allyl halides 失效
    一级叔烯丙基卤化物的制备方法

    公开(公告)号：US4754087A

    公开(公告)日：1988-06-28

    申请号：US777848

    申请日：1985-09-19

    申请人： Michel Mulhauser

    发明人： Michel Mulhauser

    IPC分类号： C07C19/01 ,  B01J31/00 ,  B01J31/26 ,  B01J31/30 ,  C07B39/00 ,  C07B61/00 ,  C07C17/00 ,  C07C17/04 ,  C07C17/08 ,  C07C17/087 ,  C07C21/02 ,  C07C21/17 ,  C07C21/19 ,  C07C67/00

    CPC分类号： C07C17/04 ,  C07C17/08

    摘要： Primary and/or tertiary allyl halides are prepared by reaction of a hydrogen halide (e.g. hydrogen chloride) with a terminal conjugated diene (e.g. myrcene, .beta.-farnesene, .beta.-springene or 15-chloro-.beta.-springene) in the presence of, as catalyst, a cuprous halide together with a quaternary ammonium salt or a phosphonium salt containing at most 16 carbon atoms, or a salt of a tertiary amine containing at most 10 carbon atoms, the reaction being carried out in an organic solvent in which the catalyst complex is soluble.

    摘要翻译： 通过卤化氢（例如氯化氢）与末端共轭二烯（例如月桂烯，β-法呢烯，β-异戊烯或15-氯-β-异戊烯）的反应制备伯和/或叔烯丙基卤化物， 作为催化剂，卤化亚铜与含有至多16个碳原子的季铵盐或鏻盐，或含有至多10个碳原子的叔胺盐，该反应在有机溶剂中进行，其中催化剂 复合物是可溶的。