公开(公告)号：US20240358893A1

公开(公告)日：2024-10-31

申请号：US18769827

申请日：2024-07-11

申请人： LYRA THERAPEUTICS, INC.

发明人： Changcheng You ,  Quynh Pham ,  Danny Concagh

IPC分类号： A61L27/34 ,  A61F2/18 ,  A61F2/90 ,  A61K31/58 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61M25/10 ,  A61M31/00

CPC分类号： A61L27/34 ,  A61F2/186 ,  A61F2/90 ,  A61K31/58 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61M25/10 ,  A61M31/002 ,  A61F2210/0004 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/604 ,  A61L2300/608 ,  A61M2025/105 ,  A61M2210/0681

摘要： This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.

公开(公告)号：US20240358714A1

公开(公告)日：2024-10-31

申请号：US18402042

申请日：2024-01-02

申请人： Allergan, Inc.

发明人： Patrick M. Hughes ,  Jie Shen ,  Michael R. Robinson ,  David F. Woodward ,  Robert M. Burk ,  Hui Liu ,  Jinping Wan ,  Chandrasekar Durairaj ,  Gyorgy F. Ambrus ,  Ke Wu ,  Danny T. Dinh

IPC分类号： A61K31/559 ,  A61F9/00 ,  A61F9/007 ,  A61K9/00 ,  A61K9/14 ,  A61K31/381 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61K31/559 ,  A61K9/0051 ,  A61K9/146 ,  A61K31/381 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61F9/0017 ,  A61F9/00781 ,  A61L2430/16

摘要： Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

公开(公告)号：US12129333B2

公开(公告)日：2024-10-29

申请号：US17416691

申请日：2018-12-21

申请人： POLYNOVO BIOMATERIALS PTY LIMITED

发明人： Timothy Graeme Moore

IPC分类号： C08G18/42 ,  C08G18/10 ,  C08G18/22 ,  C08G18/73 ,  C08J5/18 ,  A61L27/16 ,  A61L27/58 ,  B29C48/00 ,  B29C48/08 ,  B29C55/04 ,  B29C55/12 ,  B29C55/28 ,  B29K75/00

CPC分类号： C08G18/73 ,  C08G18/10 ,  C08G18/222 ,  C08G18/4277 ,  C08G18/428 ,  C08J5/18 ,  A61L27/16 ,  A61L27/58 ,  B29C48/0018 ,  B29C48/08 ,  B29C55/04 ,  B29C55/12 ,  B29C55/28 ,  B29K2075/00 ,  B29K2995/0051 ,  B29K2995/0053 ,  C08J2375/06

摘要： Provided are oriented biodegradable thermoplastic polyurethane films. The films may be prepared by extruding and drawing biodegradable polyurethane films. The polyurethanes may be prepared from biodegradable polyols and/or biodegradable chain extenders. The films possess high tensile strength yet are degradable under biological conditions. The films may be utilized in the fabrication of devices, particularly implantable medical devices.

公开(公告)号：US12123086B2

公开(公告)日：2024-10-22

申请号：US17185521

申请日：2021-02-25

申请人： BIOTRONIK AG

发明人： Heinz Mueller ,  Peter Uggowitzer ,  Joerg Loeffler

IPC分类号： C22F1/06 ,  A61F2/82 ,  A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  C22C23/02

CPC分类号： C22F1/06 ,  A61F2/82 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C22C23/02

摘要： A method for producing a magnesium alloy having improved mechanical and electrochemical properties. The method includes generating a high-purity magnesium by vacuum distillation. A billet of the alloy is generated by synthesis of the high-purity magnesium with 2.0 to 10.0% by weight Al, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, wherein the matrix of the alloy includes intermetallic phases formed of Mg and Al. The alloy is homogenized by annealing at a temperature between 150° C. and 450° C. The homogenized alloy is formed in the temperature range between 200° C. and 400° C.

公开(公告)号：US12115282B2

公开(公告)日：2024-10-15

申请号：US18063600

申请日：2022-12-08

申请人： Research Institute at Nationwide Children's

发明人： Christopher Breuer ,  Robert Strouse ,  Yong Ung-Lee ,  Cameron Best ,  Narutoshi Hibino

IPC分类号： A61L27/38 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  B33Y10/00 ,  B33Y80/00 ,  D01D5/00

CPC分类号： A61L27/3834 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  B33Y10/00 ,  B33Y80/00 ,  D01D5/0076 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/416 ,  A61L27/18 ,  C08L67/04 ,  A61L27/18 ,  C08L77/00 ,  A61L27/18 ,  C08L85/02

摘要： It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

公开(公告)号：US12109334B2

公开(公告)日：2024-10-08

申请号：US18159412

申请日：2023-01-25

申请人： Washington University

发明人： Matthew R. MacEwan

IPC分类号： A61L27/18 ,  A61F13/02 ,  A61L15/26 ,  A61L15/44 ,  A61L15/64 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L31/04 ,  B29C48/18 ,  B32B5/02 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  D01D5/00 ,  D04H1/728 ,  D04H3/16

CPC分类号： A61L31/04 ,  A61L15/26 ,  A61L15/44 ,  A61L15/64 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  B29C48/18 ,  B32B5/022 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  D01D5/0007 ,  D01D5/0038 ,  D01D5/0061 ,  D01D5/0076 ,  D04H1/728 ,  D04H3/16 ,  A61F13/02 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61L2430/32 ,  B32B2250/20 ,  B32B2262/0276 ,  B32B2307/518 ,  B32B2307/54 ,  B32B2307/726 ,  B32B2307/7265 ,  B32B2556/00 ,  D10B2509/00 ,  A61L15/26 ,  C08L67/04 ,  A61L27/18 ,  C08L67/04

摘要： A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

公开(公告)号：US20240299623A1

公开(公告)日：2024-09-12

申请号：US18262004

申请日：2021-11-25

申请人： ANPOLY

发明人： Dong Soo HWANG ,  Tae Il KIM ,  Hyung Joon CHA

IPC分类号： A61L27/28 ,  A61L27/56 ,  A61L27/58

CPC分类号： A61L27/28 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/604 ,  A61L2400/18

摘要： The present invention provides a composite for controlling the degradation of transient electronics, wherein the composite can control the degradation time of transient electronics, which are absorbed in the body and degrade after a predetermined time elapses, and thus can greatly improve the utility of the transient electronics. Moreover, the composite can degrade in the body through biodegradation, and has excellent flexibility and biocompatibility, and thus has sufficient biological stability and biocompatibility.

公开(公告)号：US20240285832A1

公开(公告)日：2024-08-29

申请号：US18585241

申请日：2024-02-23

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

发明人： Sung Min RHEE ,  Jae Yun KIM ,  Pil Seon IM

IPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/58

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/58 ,  A61L2430/10

摘要： The present disclosure relates to a scaffold with atelocollagen inserted into a porous hyaluronic acid polymer for treatment and recovery of tendon or ligament diseases. The scaffold enhances the efficacy of hyaluronic acid and atelocollagen through slow and prolonged secretion at the suture site, thereby creating a synergistic effect. Additionally, the porous scaffold with high mechanical properties binds the suture site of a ruptured tendon and provides a microenvironment for the regeneration process of surrounding cells, thereby making it useful for the treatment and recovery of tendon or ligament diseases.

公开(公告)号：US20240277896A1

公开(公告)日：2024-08-22

申请号：US18568815

申请日：2022-06-09

申请人： FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2) ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)

发明人： Salvio SUÁREZ GARCÍA ,  Javier SAIZ POSEU ,  Daniel RUIZ MOLINA

IPC分类号： A61L27/34 ,  A61L24/00 ,  A61L24/04 ,  A61L27/54 ,  A61L27/58 ,  C08G65/40 ,  C08G65/48 ,  C08G73/02

CPC分类号： A61L27/34 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L27/54 ,  A61L27/58 ,  C08G65/4075 ,  C08G65/48 ,  C08G73/0206 ,  C08G73/0213 ,  C08G73/0253 ,  C08G2150/00 ,  C08G2170/80 ,  C08G2230/00

摘要： The present invention provides a process for preparing a self-standing catecholamine-based membrane, the process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. The resulting self-standing catecholamine-based membrane was robust, easy to handle and manipulate, highly flexible and adaptable to any kind of surface without breaking, and adhesive. In addition, the free-standing membrane of the invention shows a Janus character, with an unexpected nanopatterning in the water-contact side which endows the membranes of the invention with a higher roughness surface, something of value to promote cell adhesion.

公开(公告)号：US12064534B2

公开(公告)日：2024-08-20

申请号：US17695964

申请日：2022-03-16

申请人： University of Massachusetts

发明人： Jie Song ,  Pingsheng Liu

IPC分类号： A61L27/44 ,  A61K38/18 ,  A61K38/30 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/58 ,  A61K38/18 ,  A61K38/1875 ,  A61K38/30 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02

摘要： The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.