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1.发明授权公开(公告)号：US12098119B2
公开(公告)日：2024-09-24
申请号：US17293917
申请日：2018-05-14
发明人： Jian Zhang , Yinyi Chen , Cong Ruan , Xiuyan Yang , Chengxiang Wang , Qiufen Zhang , Jialin Shang , Xinyuan Xu
IPC分类号： C07C303/38 , C07C311/37 , C07C311/44
CPC分类号： C07C303/38 , C07C311/37 , C07C311/44
摘要： Disclosed by the present invention are an SIRT6 small-molecule allosteric activator and the application thereof and provided is an SIRT6 small-molecule allosteric activator that contains a derivative as shown in formula (1) or a pharmacologically acceptable salt thereof as the active ingredient. The SIRT6 small-molecule allosteric activator designed and synthesized in the present invention has high efficacy and low toxicity, may significantly activate SIRT6 activity during in vitro experiments, and has great importance in the development of pharmaceuticals for relevant diseases.
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2.发明授权公开(公告)号：US10442759B2
公开(公告)日：2019-10-15
申请号：US15755356
申请日：2016-11-25
发明人： Qidong You , Zhengyu Jiang , Mengchen Lu , Zhiyun Chen , Haopeng Sun , Xiaojin Zhang , Xiaoke Guo , Xiaoli Xu
IPC分类号： C07C311/21 , C07C303/38 , C07C311/29 , C07D257/04 , A61P9/10 , A61P25/28 , A61P3/10 , A61P11/00 , A61P25/16 , C07C303/08 , C07C311/46
摘要： Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.
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公开(公告)号：US10208210B2
公开(公告)日：2019-02-19
申请号：US15329408
申请日：2015-07-29
IPC分类号： C09D5/16 , B01D17/02 , C09D7/00 , C07C229/12 , C07C227/16 , C07C233/05 , C07C231/02 , C07C311/05 , C07C303/38 , C07C309/13 , C07C303/02 , C07D211/38 , C07D265/30 , C07D207/10 , C07D241/04 , C02F1/40 , C09D7/40 , C07C303/22 , C07C303/40 , C07C309/04 , C07C309/29 , C07C311/03 , C07C227/06 , C07C227/08 , C07C227/18 , C07C229/06 , C07C231/12 , C07C233/08 , C08K5/17 , C09D201/00 , C09K3/00 , C08L101/00 , C09D7/20
摘要： The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.
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公开(公告)号：US10071956B2
公开(公告)日：2018-09-11
申请号：US15326379
申请日：2015-07-15
申请人： SRF Limited
发明人： Thirupathi Arumugam , Mariano Patrick Philips , Dilli Babu , Maheshwaran Chellaiah , Sarathy Iyengar , Rajdeep Anand
IPC分类号： C07C303/38 , C07C311/48
CPC分类号： C07C303/38 , C07C311/48
摘要： The present invention provides a process for the preparation of dibenzenesulfonimide.
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公开(公告)号：US09861977B2
公开(公告)日：2018-01-09
申请号：US15078209
申请日：2016-03-23
发明人： Rameshwar Yadav
IPC分类号： H01M8/10 , C08G75/30 , B01J39/18 , C07C311/09 , C07C303/38 , C07C311/11 , C08G61/12 , C08F114/26 , B01J39/04 , B01J39/20 , H01M8/0239
CPC分类号： B01J39/20 , B01J39/05 , B01J41/12 , C07C303/38 , C07C303/40 , C07C311/09 , C07C311/11 , C08F8/30 , C08F8/34 , C08F114/26 , C08G61/121 , C08G2261/1452 , C08G2261/334 , C08G2261/516 , C08G2261/74 , H01M8/0239 , H01M8/103 , H01M8/1032 , H01M8/1039 , H01M2250/20 , Y02T90/32 , C07C311/48
摘要： A multi-acid monomer disclosed herein has the formula wherein R is one or more units of a non-SO2F or non-SO2Cl portion of a polymer precursor in sulfonyl fluoride or sulfonyl chloride form, X is a non-sulfonyl halide group of a multi-sulfonyl halide compound having a minimum of two acid giving groups, and Y is remaining sulfonyl halide groups of the multi-sulfonyl halide compound.
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公开(公告)号：US20170210912A1
公开(公告)日：2017-07-27
申请号：US15329408
申请日：2015-07-29
IPC分类号： C09D5/16 , B01D17/02 , C09D7/00 , C07C229/12 , C07C227/16 , C07C233/05 , C07C231/02 , C07C311/05 , C07C303/38 , C07C309/13 , C07C303/02 , C07D211/38 , C07D265/30 , C07D207/10 , C07D241/04 , C02F1/40
CPC分类号： C09D5/1625 , B01D17/02 , C02F1/40 , C07C227/06 , C07C227/08 , C07C227/16 , C07C227/18 , C07C229/06 , C07C229/12 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/08 , C07C303/02 , C07C303/22 , C07C303/38 , C07C303/40 , C07C309/04 , C07C309/13 , C07C309/29 , C07C311/03 , C07C311/05 , C07D207/10 , C07D211/38 , C07D241/04 , C07D265/30 , C08K5/17 , C08L101/00 , C09D5/16 , C09D7/20 , C09D7/40 , C09D201/00 , C09K3/00 , Y02W10/37
摘要： The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.
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公开(公告)号：US08685616B2
公开(公告)日：2014-04-01
申请号：US12997132
申请日：2009-06-10
IPC分类号： G03F7/004 , C07C303/38 , G03F7/039
CPC分类号： G03F7/027 , C07C303/38 , C07C309/65 , C07C309/73 , C07C309/75 , C07C311/48 , C07C381/12 , C07C2602/42 , C07D333/46 , G03F7/0045 , G03F7/0046 , G03F7/039 , G03F7/0397 , Y10S430/106 , Y10S430/12 , Y10S430/122 , Y10S430/123
摘要： The present invention provides photoacid generators for use in chemically amplified resists and lithographic processes using the same.
摘要翻译： 本发明提供用于化学放大抗蚀剂的光酸产生剂和使用其的光刻法。
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公开(公告)号：US20120232104A1
公开(公告)日：2012-09-13
申请号：US13477336
申请日：2012-05-22
申请人： Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
发明人： Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
IPC分类号： A61K31/196 , C07C311/29 , A61K31/24 , C07D413/04 , A61K31/422 , C07D409/04 , A61K31/506 , A61K31/4155 , C07D213/79 , C07D213/803 , A61K31/44 , C07C303/38 , C07C303/40 , C07D257/04 , A61K31/41 , C07D271/07 , A61K31/4245 , C07D291/04 , A61P3/10 , A61P3/08 , A61P3/04 , A61P9/12 , A61P3/00 , A61P3/06 , A61P1/16 , A61P9/10 , A61P9/04 , A61P13/12 , C07C311/21
CPC分类号： C07D413/04 , C07C311/21 , C07C311/29 , C07D257/04 , C07D271/07 , C07D291/04 , C07D409/04
摘要： The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型磺酰胺衍生物，其中R2，R3，R4，A，X，Y1，Y2，Y3，Y4和Z1如说明书和权利要求书中所定义，以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1，可用作药物。
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公开(公告)号：US20120196884A1
公开(公告)日：2012-08-02
申请号：US13378503
申请日：2010-06-14
申请人： Jarkko Tapani Koivunen , Jani Korhonen , Anne Marjamäki , Liisa Nissinen , Marjo Pihlavisto , Olli Taneli Pentikäinen
发明人： Jarkko Tapani Koivunen , Jani Korhonen , Anne Marjamäki , Liisa Nissinen , Marjo Pihlavisto , Olli Taneli Pentikäinen
IPC分类号： A61K31/18 , C07D209/42 , A61K31/404 , C07D231/18 , A61K31/415 , C07D409/04 , A61K31/4155 , C07D413/04 , A61K31/422 , A61K31/4436 , C07D401/04 , A61K31/4439 , C07D417/04 , A61K31/427 , A61K31/4245 , C07D333/34 , A61K31/381 , C07D233/84 , A61K31/4164 , C07D409/14 , C07D277/36 , C07D319/18 , A61K31/357 , C07D213/71 , A61K31/4418 , C07D213/54 , A61K31/506 , C07D231/12 , A61K31/4535 , A61P7/02 , A61P29/00 , A61P35/00 , A61P9/00 , A61P1/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/06 , A61P37/08 , C07C303/40 , C07C303/38 , C07C311/44 , C07C311/29 , A61K31/277 , C07C311/21
CPC分类号： C07D213/75 , C07C311/21 , C07C311/29 , C07C311/47 , C07D209/08 , C07D213/34 , C07D213/40 , C07D213/71 , C07D213/76 , C07D231/12 , C07D231/18 , C07D231/38 , C07D231/40 , C07D233/84 , C07D277/36 , C07D319/18 , C07D333/34 , C07D401/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to sulphonamide derivatives, whith a urea moiety. The invention also relates to the use of the derivatives as inhibitors of collagen receptor integrins, especially α2β1 integrin inhibitors e.g. in connection with diseases and medical conditions that involve the action of cells and platelets expressing collagen receptors, their use as a medicament, e.g. for the treatment of thrombosis, inflammation, cancer and vascular diseases, pharmaceutical compositions containing them and a process for preparing them. The sulphonamide derivatives have the general formula (I) or (I′).
摘要翻译： 本发明涉及一种尿素部分的磺酰胺衍生物。 本发明还涉及衍生物作为胶原受体整合素抑制剂的用途，特别是α2和bgr1整联蛋白抑制剂。 涉及涉及表达胶原受体的细胞和血小板的作用的疾病和医学病症，它们作为药物的用途，例如， 用于治疗血栓形成，炎症，癌症和血管疾病，含有它们的药物组合物及其制备方法。 磺酰胺衍生物具有通式（I）或（I'）。
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10.发明授权Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives 失效制备N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基） - 对硝基苯磺酰胺衍生物的方法公开(公告)号：US08076513B2
公开(公告)日：2011-12-13
申请号：US12597088
申请日：2008-04-25
IPC分类号： C07C303/38 , C07C311/18
CPC分类号： C07C303/38 , C07C311/48
摘要： A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives in which a (1-benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid derivative is reacted with a p-nitrophenylsulfonyl halide to provide the desired product in a high yield and degree of purity.
摘要翻译： 制备N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基） - 对硝基苯磺酰胺衍生物的方法，其中（1-苄基-2-羟基-3-异丁基氨基 - 丙基） - 氨基甲酸 酸衍生物与对硝基苯基磺酰卤反应，以高产率和纯度提供所需产物。
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