公开(公告)号：US20240349607A1

公开(公告)日：2024-10-17

申请号：US18752757

申请日：2024-06-24

申请人： LG CHEM, LTD.

发明人： Jae Seung HA ,  Sujeong Geum ,  Seonwoo Kim ,  Woochul Lee ,  Woo Jin Cho ,  Yongbum Cha

IPC分类号： H10K85/60 ,  C07D307/79 ,  C07D307/91 ,  C07D333/54 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10 ,  C09K11/06 ,  H10K50/12

CPC分类号： H10K85/6574 ,  C07D307/79 ,  C07D307/91 ,  C07D333/54 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10 ,  C09K11/06 ,  H10K85/615 ,  H10K85/622 ,  H10K85/626 ,  H10K85/6572 ,  H10K85/6576 ,  C09K2211/1018 ,  H10K50/12

摘要： A compound of Chemical Formula 1:




wherein X1 is O or S; any one of R1 to R5 is a moiety bonded to L1 of the following Chemical Formula A at **:




Ar1 is a substituted or unsubstituted aryl group, Chemical Formula 1 comprises at least one deuterium, and the other substituents are as defined in the specification; and an organic light-emitting device including the same. When a compound of Chemical Formula 1 is included in an organic light emitting device, the device exhibits lower driving voltage, improved light efficiency, and improved service life characteristics.

公开(公告)号：US20240337931A1

公开(公告)日：2024-10-10

申请号：US18746861

申请日：2024-06-18

申请人： FUJIFILM Corporation

发明人： Masafumi KOJIMA ,  Akiyoshi GOTO

IPC分类号： G03F7/004 ,  C07C43/29 ,  C07C62/24 ,  C07C63/70 ,  C07C65/10 ,  C07C233/91 ,  C07C309/12 ,  C07C309/19 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C323/09 ,  C07C381/12 ,  C07D327/06 ,  C07D333/54 ,  C07D333/76

CPC分类号： G03F7/0045 ,  C07C43/29 ,  C07C62/24 ,  C07C63/70 ,  C07C65/10 ,  C07C233/91 ,  C07C309/12 ,  C07C309/19 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C323/09 ,  C07C381/12 ,  C07D327/06 ,  C07D333/54 ,  C07D333/76 ,  C07C2601/14 ,  C07C2603/56 ,  C07C2603/74

摘要： The actinic ray-sensitive or radiation-sensitive resin composition includes a resin, and an ionic compound having, in at least one of a cationic moiety or an anionic moiety, a group represented by —SF4R provides a very good pattern profile in the formation of an ultrafine pattern such as a line-and-space pattern of 25 nm or less, and a hole pattern having a hole diameter of 25 nm or less.

公开(公告)号：US20240018102A1

公开(公告)日：2024-01-18

申请号：US18033306

申请日：2021-10-21

申请人： Lhotse Bio, Inc.

发明人： Haizhen Zhang ,  Michael Hanson ,  Andrew Jennings ,  Hui Lei ,  Xichen Lin ,  Qiong Zhang ,  Alexandre Cote ,  Anatoly M. Ruvinsky

IPC分类号： C07D207/325 ,  C07D231/56 ,  C07D213/46 ,  C07D235/12 ,  C07D277/64 ,  C07D271/10 ,  C07D403/04 ,  C07D249/18 ,  C07D333/54 ,  C07D513/04 ,  A61P11/00 ,  C07D401/06 ,  C07D471/04

CPC分类号： C07D207/325 ,  C07D231/56 ,  C07D213/46 ,  C07D235/12 ,  C07D277/64 ,  C07D271/10 ,  C07D471/04 ,  C07D249/18 ,  C07D333/54 ,  C07D513/04 ,  A61P11/00 ,  C07D401/06 ,  C07D403/04

摘要： This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

公开(公告)号：US20230147360A1

公开(公告)日：2023-05-11

申请号：US17832388

申请日：2022-06-03

申请人： Genzyme Corporation

发明人： Junkai Liao ,  Mark Munson ,  Zhongli Gao ,  Gregory Hurlbut ,  Hans Peter Nestler ,  Ingrid Mechin ,  Martin Smrcina ,  Ronghua Li ,  Ryan Hartung ,  William Bock ,  Bertrand Vivet ,  Andrew Scholte

IPC分类号： C07D333/54 ,  C07D417/12 ,  C07D333/64 ,  C07D417/04 ,  C07D277/64 ,  A61K45/06

CPC分类号： C07D333/54 ,  C07D417/12 ,  C07D333/64 ,  C07D417/04 ,  C07D277/64 ,  A61K45/06

摘要： The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

公开(公告)号：US20230127951A1

公开(公告)日：2023-04-27

申请号：US18071473

申请日：2022-11-29

申请人： Samsung Display Co., LTD.

发明人： Takuya UNO

IPC分类号： C07D409/12 ,  H01L51/00 ,  C07D413/10 ,  C07D405/10 ,  C07D405/12 ,  C07D407/14 ,  C07D407/12 ,  C07D407/04 ,  C07D409/14 ,  C07D417/10 ,  C07D333/54 ,  C07D409/10 ,  C07D409/04 ,  C07D405/04 ,  C07D307/79

摘要： An organic electroluminescence device includes a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer, and a second electrode disposed on the electron transport region, wherein the hole transport region includes a polycyclic compound represented by Formula 5 or Formula 6, thereby showing high emission efficiency.

公开(公告)号：US11622970B2

公开(公告)日：2023-04-11

申请号：US17241390

申请日：2021-04-27

申请人： PRELUDE THERAPEUTICS INCORPORATED

发明人： Jincong Zhuo ,  Andrew Paul Combs ,  Peng Wei ,  Jialiang Wang

IPC分类号： A61K31/635 ,  A61K45/06 ,  C07D213/81 ,  C07D333/54 ,  C07D249/04 ,  C07D215/48 ,  C07D241/24 ,  C07D239/69 ,  C07D295/096 ,  C07D261/18 ,  C07D231/14 ,  C07D495/04 ,  C07D309/04 ,  C07D401/04 ,  C07D471/04 ,  C07D519/00 ,  C07D401/12 ,  A61P35/00

摘要： The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

公开(公告)号：US20230097871A1

公开(公告)日：2023-03-30

申请号：US17629955

申请日：2020-07-29

申请人： TAISHO PHARMACEUTICAL CO., LTD.

发明人： Shoichi KURODA ,  Yuki KOBAYASHI ,  Kanako HATANAKA ,  Yuji ITO ,  Fumito UNEUCHI ,  Yuko UEHARA

IPC分类号： C07C275/16 ,  C07C275/26 ,  C07D213/40 ,  C07D209/44 ,  C07D209/14 ,  C07D309/14 ,  C07D319/18 ,  C07D307/79 ,  C07D333/54 ,  C07D471/04 ,  C07D231/56 ,  C07D335/02 ,  C07C311/01 ,  C07F9/38 ,  C07D257/04 ,  C07D271/113

摘要： The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.

公开(公告)号：US20220396551A1

公开(公告)日：2022-12-15

申请号：US17558877

申请日：2021-12-22

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Troy E. Messick ,  Garry R. Smith ,  Allen B. Reitz ,  Paul M. Lieberman ,  Mark E. McDonnell ,  Yan Zhang ,  Venkata Velvadapu

IPC分类号： C07D207/327 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/192 ,  A61K31/44 ,  C07C229/56 ,  C07C255/54 ,  C07C255/55 ,  C07C211/27 ,  C07C217/84 ,  C07C233/11 ,  C07C233/64 ,  C07C233/65 ,  C07C235/58 ,  C07C311/08 ,  C07C311/16 ,  C07C311/17 ,  C07C317/14 ,  C07D235/06 ,  C07D403/10 ,  C07D239/26 ,  C07D409/10 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04 ,  C07D209/08 ,  C07D295/155 ,  C07D213/55 ,  C07C53/18 ,  C07C63/66 ,  C07C65/19 ,  C07C65/28 ,  C07C229/64 ,  C07C317/44 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/70 ,  C07D213/64 ,  C07D213/74 ,  C07D215/14 ,  C07D231/12 ,  C07D249/06 ,  C07D277/30 ,  C07D307/79 ,  C07D333/54 ,  C07D401/04 ,  C07D401/10

摘要： Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.

公开(公告)号：US11447437B2

公开(公告)日：2022-09-20

申请号：US16784945

申请日：2020-02-07

申请人： CANON KABUSHIKI KAISHA

发明人： Yosuke Nishide ,  Naoki Yamada ,  Jun Kamatani

IPC分类号： C07C13/62 ,  C07C15/20 ,  C07C25/22 ,  C07D213/06 ,  C07D333/54 ,  C07D213/44 ,  C07D333/76 ,  H01L51/00

摘要： An organic compound is represented by formula (1). In the formula (1), R1 to R24 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aryloxy group, a silyl group, and a cyano group.

公开(公告)号：US11420929B2

公开(公告)日：2022-08-23

申请号：US17196873

申请日：2021-03-09

申请人： vTv Therapeutics LLC

发明人： Per Sauerberg ,  Pavel Pihera ,  Zdenek Polivka ,  Miroslav Havranek ,  Ingrid Pettersson ,  John Patrick Mogensen

IPC分类号： C07C69/736 ,  A61K31/5375 ,  A61K31/415 ,  C07C59/70 ,  C07C217/48 ,  C07C323/16 ,  C07C323/32 ,  C07D211/46 ,  C07D213/30 ,  C07D231/12 ,  C07D295/096 ,  C07D307/79 ,  C07D333/16 ,  C07D333/54 ,  C07D265/30 ,  C07D213/36 ,  C07D295/112 ,  C07D307/81 ,  C07D333/20 ,  A61K31/192 ,  A61K31/195 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5377

摘要： Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.