公开(公告)号：US12117426B2

公开(公告)日：2024-10-15

申请号：US17272973

申请日：2019-08-30

申请人： SHIMADZU CORPORATION ,  THE UNIVERSITY OF TOKYO

发明人： Keiko Matsumoto ,  Yuta Shimanaka ,  Nozomu Kono ,  Hiroyuki Arai

IPC分类号： G01N30/34 ,  B01D15/40 ,  B01J20/24 ,  B01J20/32 ,  G01N30/06 ,  G01N30/16 ,  G01N30/72

CPC分类号： G01N30/34 ,  B01D15/40 ,  B01J20/24 ,  B01J20/3204 ,  G01N30/06 ,  G01N30/16 ,  G01N30/72

摘要： Provided is a method for separating PIPs by which isomers of PIPs can be separated without deacylating the PIPs. The method includes at least a separation step of injecting a sample containing a plurality of PIPs into an analysis flow path of a supercritical fluid chromatograph having a separation column filled with a separation medium containing β-cyclodextrin and separating the plurality of PIPs by supercritical fluid chromatography.

公开(公告)号：US20240189740A1

公开(公告)日：2024-06-13

申请号：US18437482

申请日：2024-02-09

申请人： Waters Technologies Corporation

发明人： Michael Donegan ,  Martin Gilar ,  Armand Gatien Ngounou Wetie

IPC分类号： B01D15/38 ,  G01N30/34

CPC分类号： B01D15/3828 ,  G01N30/34

摘要： The present disclosure discusses a method of separating a sample including oligonucleotides including coating a flow path of a chromatographic system; injecting the sample comprising oligonucleotides into the chromatographic system; flowing the sample through the chromatographic system; and separating the oligonucleotides. In some examples, the coating of the flow path is non-binding with respect to the analyte, such as oligonucleotides. Consequently, the analyte does not bind to the coating of the flow path. The non-binding coating eliminates the need for passivation, which can eliminate the formerly needed time to passivate as well. In addition, analyte can be recovered with a first injection in a system, such as chromatographic system.

公开(公告)号：US11988648B2

公开(公告)日：2024-05-21

申请号：US16760632

申请日：2018-07-25

申请人： Shimadzu Corporation

发明人： Daisuke Nakayama

IPC分类号： G01N30/24 ,  G01N30/34 ,  G01N30/02

CPC分类号： G01N30/24 ,  G01N30/34 ,  G01N2030/027

摘要： A liquid chromatograph includes: a feeding unit configured to feed a mobile phase prepared for an analysis; an analysis flow path provided with an analytical column for separating a sample and a detector for detecting sample components separated with the analytical column; a sample injection part configured to inject the sample into the analysis flow path; a measurement flow path provided separately from the analysis flow path and provided with a measuring instrument for measuring a preparation state of the mobile phase; and a status switching unit configured to selectively switch between an analysis state in which all of the mobile phase the from feeding unit flows through the analysis flow path and a measurement state in which at least a part of the mobile phase from the feeding unit flows through the measurement flow path.

公开(公告)号：US11899000B2

公开(公告)日：2024-02-13

申请号：US16011761

申请日：2018-06-19

申请人： WATERS TECHNOLOGIES CORPORATION

发明人： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC分类号： G01N30/64 ,  G01N30/86 ,  G01N30/34 ,  G01N30/88 ,  G01N21/53

CPC分类号： G01N30/64 ,  G01N30/34 ,  G01N30/8624 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8675 ,  G01N30/88 ,  G01N21/53 ,  G01N2030/8804

摘要： A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US20240009594A1

公开(公告)日：2024-01-11

申请号：US18474000

申请日：2023-09-25

申请人： Cytiva Sweden AB

发明人： Bjorn Markus Olovsson

IPC分类号： B01D15/16 ,  G01N30/32 ,  G01N30/34 ,  B01F23/40 ,  B01F25/31 ,  B01F35/21 ,  B01F35/221 ,  B01F35/71 ,  B01D15/22

CPC分类号： B01D15/166 ,  G01N30/32 ,  G01N30/34 ,  B01F23/49 ,  B01F25/31 ,  B01F35/2132 ,  B01F35/2133 ,  B01F35/2211 ,  B01F35/7176 ,  B01D15/22 ,  G01N2030/347 ,  B01D15/16 ,  G01N30/8658

摘要： A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.

公开(公告)号：US20230393042A1

公开(公告)日：2023-12-07

申请号：US18036646

申请日：2022-08-17

申请人： JIANGSU QLIFE MEDICAL TECHNOLOGY GROUP CO., LTD. ,  NANJING QLIFE MEDICAL TECHNOLOGY CO., LTD.

发明人： Xiaoliang CHENG ,  Jing YU ,  Yue ZHOU ,  Wei ZHANG ,  Kejia ZHENG

IPC分类号： G01N1/42 ,  G01N1/34 ,  G01N30/72 ,  G01N30/34 ,  C12N9/76 ,  C12N9/06

CPC分类号： G01N1/42 ,  G01N1/34 ,  G01N30/72 ,  G01N30/34 ,  G01N2001/4088 ,  C12N9/0032 ,  C12Y304/21004 ,  C12Y105/03004 ,  C12N9/6427

摘要： The invention discloses a pretreatment method, a preservation method, an automatic treatment system and a detection method for a urine sample, and directs to the technical field of biological detection. The pretreatment method comprises subjecting a urine sample after protein lysis to a reductive alkylation treatment, followed by protein enrichment and enzymolysis. The protein enrichment is performed on the sample after the reductive alkylation treatment using a PVDF filter plate for protein enrichment; The invention also provides an automatic treatment system and an automatic sample treatment method. The treatment system greatly reduces the labor intensity of people, is beneficial to facilitate the treatment efficiency of urine sample treatment, meets the requirements of high-flux and automated pretreatment of the proteomics, and accommodates the reproducibility and flux of current clinical needs.

公开(公告)号：US11835497B2

公开(公告)日：2023-12-05

申请号：US17869244

申请日：2022-07-20

申请人： Activated Research Company, LLC

发明人： Andrew Jones ,  Tommy Saunders ,  Mike Hofflander

IPC分类号： G01N30/64 ,  G01N30/38 ,  G01N30/34 ,  G01N30/02 ,  G01N30/84

CPC分类号： G01N30/64 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/347 ,  G01N2030/8417 ,  G01N2030/8447 ,  G01N2030/8494

摘要： In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable.

公开(公告)号：US20230358771A1

公开(公告)日：2023-11-09

申请号：US17928527

申请日：2021-01-18

申请人： SHIMADZU CORPORATION

发明人： Tomohiro KAWASE ,  Yugo HASE ,  Takayuki NAKATANI

IPC分类号： G01N35/00 ,  G01N30/34

CPC分类号： G01N35/00732 ,  G01N30/34 ,  G01N2030/8804

摘要： Identification information for identifying each analysis appliance and consumable information representing a usage state of a consumable included in each analysis appliance are acquired by an information acquirer from a control device. The identification information and the consumable information acquired by the information acquirer are held by an information holder. A display controller causes a display device to display a list screen of identification information held by the information holder. Further, the display controller causes a usage state of a consumable for each analysis appliance to be displayed on the list screen based on consumable information held by the information holder.

公开(公告)号：US11808252B2

公开(公告)日：2023-11-07

申请号：US17054788

申请日：2018-05-16

申请人： SHIMADZU CORPORATION

发明人： Keisuke Ogawa

IPC分类号： F04B1/00 ,  G01N30/02 ,  G01N30/32 ,  F04B13/02 ,  F04B49/06 ,  G01N30/34

CPC分类号： F04B1/00 ,  F04B13/02 ,  F04B49/065 ,  G01N30/02 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/326 ,  G01N2030/328 ,  G01N2030/347

摘要： The liquid delivery device includes a liquid delivery controller configured to operate, in a complementary manner, a primary plunger pump and a secondary plunger pump of each of a first liquid delivery pump and a second liquid delivery pump so that the first liquid delivery pump and the second liquid delivery pump perform continuous liquid delivery at a preset flow rate to each other, and a forcible synchronization part configured to forcibly synchronize operation states of the secondary plunger pumps of the first liquid delivery pump and the second liquid delivery pump by operating the primary plunger pump and the secondary plunger pump of the first liquid delivery pump and the second liquid delivery pump at the calculated operation speed.

公开(公告)号：US20230236158A1

公开(公告)日：2023-07-27

申请号：US18157219

申请日：2023-01-20

申请人： Korea University Research and Business Foundation ,  BERTIS INC.

发明人： Sang-Won LEE ,  Chaewon KANG

IPC分类号： G01N30/20 ,  G01N30/34

CPC分类号： G01N30/20 ,  G01N30/34 ,  G01N2030/027

摘要： Disclosed are a mutually independent dual online liquid chromatography device and a control method thereof. The mutually independent dual online liquid chromatography device according to the present disclosure includes a first pump configured to inject a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump configured to inject the first solvent or the mixed solution containing the first solvent and the second solvent; a sample inlet valve to which the first pump and a sample injector configured to inject a sample are connected; a first column valve to which a first sample separation column is connected; a second column valve to which a second sample separation column is connected; and a column selection valve to which the second pump is connected, and interposed between the sample inlet valve, and the first column valve and the second column valve to inject the sample fed from the sample inlet valve onto any one of the first sample separation column and the second sample separation column to separate and analyze the sample in one sample separation column while allowing for wash and equilibration, sample injection and isocratic elution of the other sample separation column.